Corporéité et liens affectifs féminins: itinéraire d’un rituel pour Diane Nemorensis et Mater Matuta à Satricum

The religious practices performed in Lazio, for Diane of Nemi, andfor Mater Matuta at Satricum, are well known thanks to literarysources whose details are sufficient to reconstruct them. Theyteach us that these rituals were performed by a group of women toreplay a particular scene in various stages that can be completed orcorroborated by archeology, but they do not necessarily insist onthe importance of their bodies, nor on the emotional ties existingbetween the various devotees. Yet this is one of the foundations ofthe practice, so that the expected result is positively realized. If theyare palpable in one of the two rituals, they are barely mentioned inthe second, which is why they will be the focus of all the attention inthis article

Why has the American Trade Balance Continued Deteriorating since 2002 despite the Depreciation of the U.S. Dollar?

The American trade deficit has grown continually since 2002, reaching a record high in 2005, even though the U.S. dollars four-year decline has had a positive impact, estimated at nearly 1% of GDP, as expected from the J-curve mechanism Improved non oil terms of trade, and cyclical divergence between the United States and the rest of the world, have also been favourable to the American trade balance. However, other factors have offset these positive effects. The United States energy bill and the initial low import coverage ratio. The remaining source of deficit growth, is due to unexplained factors such as "non-price competitiveness". The American trade balance is expected to remain at the same level as 2006. Simulations suggest that in the short term, only a slowdown of the American economy (- 1% growth) could lead to a significant reduction in its trade deficit (by - 0.4% in 2007).Trade deficit, J Curve, Trade Elasticities, Exchange Rate Pass-Through, US Dollar, Global Imbalances

Identification of a non-exported Plasmepsin V substrate that functions in the parasitophorous vacuole of malaria parasites.

In the manuscript, the authors investigate the role of the protease Plasmepsin V in the parasite-host interaction. Whereas processing by Plasmepsin V was previously thought to target a protein for export into the host cell, the authors now show that there are proteins cleaved by this protease that are not exported but instead function at the host-parasite interface. This changes the view of this protease, which turns out to have a much broader role than anticipated. The result shows that the protease may have a function much more similar to that of related organisms. The authors also investigate the requirements for protein export by analyzing exported and non-exported proteins and find commonalities between the proteins of each set that further our understanding of the requirements for protein export

Improved binary artificial fish swarm algorithm for the 0–1 multidimensional knapsack problems

The 0–1 multidimensional knapsack problem (MKP) arises in many fields of optimization and is NP-hard. Several exact as well as heuristic methods exist. Recently, an artificial fish swarm algorithm has been developed in continuous global optimization. The algorithm uses a population of points in space to represent the position of fish in the school. In this paper, a binary version of the artificial fish swarm algorithm is proposed for solving the 0–1 MKP. In the proposed method, a point is represented by a binary string of 0/1 bits. Each bit of a trial point is generated by copying the corresponding bit from the current point or from some other specified point, with equal probability. Occasionally, some randomly chosen bits of a selected point are changed from 0 to 1, or 1 to 0, with an user defined probability. The infeasible solutions are made feasible by a decoding algorithm. A simple heuristic add_item is implemented to each feasible point aiming to improve the quality of that solution. A periodic reinitialization of the population greatly improves the quality of the solutions obtained by the algorithm. The proposed method is tested on a set of benchmark instances and a comparison with other methods available in literature is shown. The comparison shows that the proposed method gives a competitive performance when solving this kind of problems.Fundação para a Ciência e a Tecnologia (FCT

Deciphering the Role of Protein Phosphatases in Apicomplexa: The Future of Innovative Therapeutics?

Parasites belonging to the Apicomplexa phylum still represent a major public health and world-wide socioeconomic burden that is greatly amplified by the spread of resistances against known therapeutic drugs. Therefore, it is essential to provide the scientific and medical communities with innovative strategies specifically targeting these organisms. In this review, we present an overview of the diversity of the phosphatome as well as the variety of functions that phosphatases display throughout the Apicomplexan parasites' life cycles. We also discuss how this diversity could be used for the design of innovative and specific new drugs/therapeutic strategies

Peptides derived from Plasmodium falciparum leucine-rich repeat 1 bind to serine/threonine phosphatase type 1 and inhibit parasite growth in vitro.

International audienceThe biogenesis of protein phosphatase 1 (PP1) holoenzyme in eukaryotes requires diverse regulatory subunit proteins (RSPs) that bind to the highly conserved PP1 catalytic subunit (PP1c) and direct its spatiotemporal activity as well as its specificity. Several studies demonstrated that most RSPs share a canonical common binding motif, the RVXF motif, which is present in ~85% of RSPs and is considered as the main contributor for the interaction to PP1c.1 In Plasmodium falciparum (Pf), our earlier studies revealed that leucine-rich repeat 1 (LRR1), one of the major RSPs of PfPP1 and an ortholog of human and yeast Sds22, lacks the RVXF motif. The amino acids sequence of PfLRR1 exhibits nine leucine-rich repeats (LRRs) and a hydrophobic region at the C-terminal end, known as the LRR cap motif.2 In this work, we identified the PP1-binding peptides of PfLRR1 and examined their capacity to affect Pf growth

Physical and optical properties of 2010 Eyjafjallajökull volcanic eruption aerosol: ground-based, Lidar and airborne measurements in France

International audienceDuring the Eyjafjallajökull eruption (14 April to 24 May 2010), the volcanic aerosol cloud was observed across Europe by several airborne in situ and ground-based remote-sensing instruments. On 18 and 19 May, layers of depolarizing particles (i.e. non-spherical particles) were detected in the free troposphere above the Puy de Dôme station, (PdD, France) with a Rayleigh-Mie LIDAR emitting at a wavelength of 355 nm, with parallel and crossed polarization channels. These layers in the free troposphere (FT) were also well captured by simulations with the Lagrangian particle dispersion model FLEXPART, which furthermore showed that the ash was eventually entrained into the planetary boundary layer (PBL). Indeed, the ash cloud was then detected and characterized with a comprehensive set of in situ instruments at the Puy de Dôme station (PdD). In agreement with the FLEXPART simulation, up to 65 μg m−3 of particle mass and 2.2 ppb of SO2 were measured at PdD, corresponding to concentrations higher than the 95 percentile of 2 yr of measurements at PdD. Moreover, the number concentration of particles increased to 24 000 cm−3, mainly in the submicronic mode, but a supermicronic mode was also detected with a modal diameter of 2 μm. The resulting optical properties of the ash aerosol were characterized by a low scattering Ångström exponent (0.98), showing the presence of supermicronic particles. For the first time to our knowledge, the combination of in situ optical and physical characterization of the volcanic ash allowed the calculation of the mass-to-extinction ratio (η) with no assumptions on the aerosol density. The mass-to-extinction ratio was found to be significantly different from the background boundary layer aerosol (max: 1.57 g m−2 as opposed to 0.33 ± 0.03 g m−2). Using this ratio, ash mass concentration in the volcanic plume derived from LIDAR measurements was found to be 655 ± 23 μg m−3 when the plume was located in the FT (3000 m above the sea level - a.s.l.). This ratio could also be used to retrieve an aerosol mass concentration of 579 ± 60 μg m−3 on 19 April, when LIDAR observations detected the ash cloud at 3000 m a.s.l. in correspondence with model simulations (FLEXPART). On 22 April, another ash plume entered the BL, and although it was more diluted than during the May episode, the French research aircraft ATR42 that passed over Clermont-Ferrand in the PBL confirmed the presence of particles with a supermicronic mode, again with a modal diameter at 2 μm. This data set combining airborne, ground-based and remote sensing observations with dispersion model simulations shows an overall very good coherence during the volcanic eruption period, which allows a good confidence in the characteristics of the ash particles that can be derived from this unique data set

Solving large 0–1 multidimensional knapsack problems by a new simplified binary artificial fish swarm algorithm

The artificial fish swarm algorithm has recently been emerged in continuous global optimization. It uses points of a population in space to identify the position of fish in the school. Many real-world optimization problems are described by 0-1 multidimensional knapsack problems that are NP-hard. In the last decades several exact as well as heuristic methods have been proposed for solving these problems. In this paper, a new simpli ed binary version of the artificial fish swarm algorithm is presented, where a point/ fish is represented by a binary string of 0/1 bits. Trial points are created by using crossover and mutation in the different fi sh behavior that are randomly selected by using two user de ned probability values. In order to make the points feasible the presented algorithm uses a random heuristic drop item procedure followed by an add item procedure aiming to increase the profit throughout the adding of more items in the knapsack. A cyclic reinitialization of 50% of the population, and a simple local search that allows the progress of a small percentage of points towards optimality and after that refines the best point in the population greatly improve the quality of the solutions. The presented method is tested on a set of benchmark instances and a comparison with other methods available in literature is shown. The comparison shows that the proposed method can be an alternative method for solving these problems.The authors wish to thank three anonymous referees for their comments and valuable suggestions to improve the paper. The first author acknowledges Ciˆencia 2007 of FCT (Foundation for Science and Technology) Portugal for the fellowship grant C2007-UMINHO-ALGORITMI-04. Financial support from FEDER COMPETE (Operational Programme Thematic Factors of Competitiveness) and FCT under project FCOMP-01-0124-FEDER-022674 is also acknowledged