1,294 research outputs found
Systematic Blueshift of Line Profiles in the Type IIn Supernova 2010jl: Evidence for Post-Shock Dust Formation?
Type IIn SNe show spectral evidence for strong interaction between their
blast wave and dense circumstellar material (CSM) around the progenitor star.
SN2010jl was the brightest core-collapse SN in 2010, and it was a Type IIn
explosion with strong CSM interaction. Andrews et al. recently reported
evidence for an IR excess in SN2010jl, indicating either new dust formation or
the heating of CSM dust in an IR echo. Here we report multi-epoch spectra of
SN2010jl that reveal the tell-tale signature of new dust formation:
emission-line profiles becoming systematically more blueshifted as the red side
of the line is blocked by increasing extinction. The effect is seen clearly in
the intermediate-width (400--4000 km/s) component of H beginning
roughly 30d after explosion. Moreover, we present near-IR spectra demonstrating
that the asymmetry in the hydrogen-line profiles is wavelength dependent,
appearing more pronounced at shorter wavelengths. This evidence suggests that
new dust grains had formed quickly in the post-shock shell of SN 2010jl arising
from CSM interaction. Since the observed dust temperature has been attributed
to an IR echo and not to new dust, either (1) IR excess emission at m is not a particularly sensitive tracer of new dust formation in SNe, or
(2) some assumptions about expected dust temperatures might require further
study. Lastly, we discuss one possible mechanism other than dust that might
lead to increasingly blueshifted line profiles in SNeIIn, although the
wavelength dependence of the asymmetry argues against this hypothesis in the
case of SN2010jl.Comment: 6 pages, 4 figures, submitted to A
Evidence for Pre-Existing Dust in the Bright Type IIn SN 2010jl
SN 2010jl was an extremely bright, Type IIn SNe which showed a significant IR
excess no later than 90 days after explosion. We have obtained Spitzer 3.6 and
4.5 \mum and JHK observations of SN 2010jl \sim90 days post explosion. Little
to no reddening in the host galaxy indicated that the circumstellar material
lost from the progenitor must lie in a torus inclined out of the plane of the
sky. The likely cause of the high mid-IR flux is the reprocessing of the
initial flash of the SN by pre-existing circumstellar dust. Using a 3D Monte
Carlo Radiative Transfer code, we have estimated that between 0.03-0.35 Msun of
dust exists in a circumstellar torus around the SN located 6 \times 10 ^17 cm
away from the SN and inclined between 60-80\cdot to the plane of the sky. On
day 90, we are only seeing the illumination of approximately 5% of this torus,
and expect to see an elevated IR flux from this material up until day \sim 450.
It is likely this dust was created in an LBV-like mass loss event of more than
3 Msun, which is large but consistent with other LBV progenitors such as {\eta}
Carinae.Comment: Accepted in A
Optical and Infrared Analysis of Type II SN 2006BC
We present nebular phase optical imaging and spectroscopy and near/mid-IR
imaging of the Type II SN 2006bc. Observations reveal the central wavelength of
the symmetric H line profile to be red-shifted with respect to the host
galaxy H emission by day 325. Such an phenomenon has been argued to
result from an asymmetric explosion in the iron-peak elements resulting in a
larger mass of Ni and higher excitation of hydrogen on the far side of
the SN explosion. We also observe a gradual blue-shifting of this H
peak which is indicative of dust formation in the ejecta. Although showing a
normal peak brightness, V -17.2, for a core-collapse SN, 2006bc fades by
6 mag during the first 400 days suggesting either a relatively low
Ni yield, an increase in extinction due to new dust, or both. A short
duration flattening of the light curve is observed from day 416 to day 541
suggesting an optical light echo. Based on the narrow time window of this echo,
we discuss implications on the location and geometry of the reflecting ISM.
With our radiative transfer models, we find an upper limit of 2 x 10
M of dust around SN 2006bc. In the event that all of this dust were
formed during the SN explosion, this quantity of dust is still several orders
of magnitude lower than that needed to explain the large quantities of dust
observed in the early universe.Comment: 6 pages, 10 figures, accepted for publication in Ap
Daphnia magna modifies its gene expression extensively in response to caloric restriction revealing a novel effect on haemoglobin isoform preference
Caloric restriction (CR) produces clear phenotypic effects within and between generations of the model crustacean Daphnia magna . We have previously established that micro RNAs and cytosine methylation change in response to CR in this organism, and we demonstrate here that CR has a dramatic effect on gene expression. Over 6000 genes were differentially expressed between CR and well‐fed D. magna , with a bias towards up‐regulation of genes under caloric restriction. We identified a highly expressed haemoglobin gene that responds to CR by changing isoform proportions. Specifically, a transcript containing three haem‐binding erythrocruorin domains was strongly down‐regulated under CR in favour of transcripts containing fewer or no such domains. This change in the haemoglobin mix is similar to the response to hypoxia in Daphnia, which is mediated through the transcription factor hypoxia‐inducible factor 1, and ultimately the mTOR signalling pathway. This is the first report of a role for haemoglobin in the response to CR. We also observed high absolute expression of super‐oxide dismutase (SOD) in normally‐fed individuals, which contrasts with observations of high SOD levels under CR in other taxa. However, key differentially expressed genes, like SOD, were not targeted by differentially expressed micro‐RNAs. Whether the link between Haemoglobin and CR occurs in other organisms, or is related to the aquatic lifestyle, remains to be tested. It suggests that one response to CR may be to simply transport less oxygen and lower respiration
Acceleration of hippocampal atrophy rates in asymptomatic amyloidosis
Increased rates of brain atrophy measured from serial magnetic resonance imaging precede symptom onset in Alzheimer's disease and may be useful outcome measures for prodromal clinical trials. Appropriate trial design requires a detailed understanding of the relationships between β-amyloid load and accumulation, and rate of brain change at this stage of the disease. Fifty-two healthy individuals (72.3 ± 6.9 years) from Australian Imaging, Biomarkers and Lifestyle Study of Aging had serial (0, 18 m, 36 m) magnetic resonance imaging, (0, 18 m) Pittsburgh compound B positron emission tomography, and clinical assessments. We calculated rates of whole brain and hippocampal atrophy, ventricular enlargement, amyloid accumulation, and cognitive decline. Over 3 years, rates of whole brain atrophy (p < 0.001), left and right hippocampal atrophy (p = 0.001, p = 0.023), and ventricular expansion (p < 0.001) were associated with baseline β-amyloid load. Whole brain atrophy rates were also independently associated with β-amyloid accumulation over the first 18 months (p = 0.003). Acceleration of left hippocampal atrophy rate was associated with baseline β-amyloid load across the cohort (p < 0.02). We provide evidence that rates of atrophy are associated with both baseline β-amyloid load and accumulation, and that there is presymptomatic, amyloid-mediated acceleration of hippocampal atrophy. Clinical trials using rate of hippocampal atrophy as an outcome measure should not assume linear decline in the presymptomatic phase
Helicobacter pylori-induced gastric pathology: insights from in vivo and ex vivo models
Gastric colonization with Helicobacter pylori induces diverse human pathological conditions, including superficial gastritis, peptic ulcer disease, mucosa-associated lymphoid tissue (MALT) lymphoma, and gastric adenocarcinoma and its precursors. The treatment of these conditions often relies on the eradication of H. pylori, an intervention that is increasingly difficult to achieve and that does not prevent disease progression in some contexts. There is, therefore, a pressing need to develop new experimental models of H. pylori-associated gastric pathology to support novel drug development in this field. Here, we review the current status of in vivo and ex vivo models of gastric H. pylori colonization, and of Helicobacter-induced gastric pathology, focusing on models of gastric pathology induced by H. pylori, Helicobacter felis and Helicobacter suis in rodents and large animals. We also discuss the more recent development of gastric organoid cultures from murine and human gastric tissue, as well as from human pluripotent stem cells, and the outcomes of H. pylori infection in these systems
Acceleration of hippocampal atrophy rates in asymptomatic amyloidosis.
Increased rates of brain atrophy measured from serial magnetic resonance imaging precede symptom onset in Alzheimer's disease and may be useful outcome measures for prodromal clinical trials. Appropriate trial design requires a detailed understanding of the relationships between β-amyloid load and accumulation, and rate of brain change at this stage of the disease. Fifty-two healthy individuals (72.3 ± 6.9 years) from Australian Imaging, Biomarkers and Lifestyle Study of Aging had serial (0, 18 m, 36 m) magnetic resonance imaging, (0, 18 m) Pittsburgh compound B positron emission tomography, and clinical assessments. We calculated rates of whole brain and hippocampal atrophy, ventricular enlargement, amyloid accumulation, and cognitive decline. Over 3 years, rates of whole brain atrophy (p < 0.001), left and right hippocampal atrophy (p = 0.001, p = 0.023), and ventricular expansion (p < 0.001) were associated with baseline β-amyloid load. Whole brain atrophy rates were also independently associated with β-amyloid accumulation over the first 18 months (p = 0.003). Acceleration of left hippocampal atrophy rate was associated with baseline β-amyloid load across the cohort (p < 0.02). We provide evidence that rates of atrophy are associated with both baseline β-amyloid load and accumulation, and that there is presymptomatic, amyloid-mediated acceleration of hippocampal atrophy. Clinical trials using rate of hippocampal atrophy as an outcome measure should not assume linear decline in the presymptomatic phase
A Spitzer Survey for Dust in Type IIn Supernovae
Recent observations suggest that Type IIn supernovae (SNe IIn) may exhibit
late-time (>100 days) infrared (IR) emission from warm dust more than other
types of core-collapse SNe. Mid-IR observations, which span the peak of the
thermal spectral energy distribution, provide useful constraints on the
properties of the dust and, ultimately, the circumstellar environment,
explosion mechanism, and progenitor system. Due to the low SN IIn rate (<10% of
all core-collapse SNe), few IR observations exist for this subclass. The
handful of isolated studies, however, show late-time IR emission from warm dust
that, in some cases, extends for five or six years post-discovery. While
previous Spitzer/IRAC surveys have searched for dust in SNe, none have targeted
the Type IIn subclass. This article presents results from a warm Spitzer/IRAC
survey of the positions of all 68 known SNe IIn within a distance of 250 Mpc
between 1999 and 2008 that have remained unobserved by Spitzer more than 100
days post-discovery. The detection of late-time emission from ten targets
(~15%) nearly doubles the database of existing mid-IR observations of SNe IIn.
Although optical spectra show evidence for new dust formation in some cases,
the data show that in most cases the likely origin of the mid-IR emission is
pre-existing dust, which is continuously heated by optical emission generated
by ongoing circumstellar interaction between the forward shock and
circumstellar medium. Furthermore, an emerging trend suggests that these SNe
decline at ~1000--2000 days post-discovery once the forward shock overruns the
dust shell. The mass-loss rates associated with these dust shells are
consistent with luminous blue variable (LBV) progenitors.Comment: Accepted for publication to ApJ, 17 pages, 10 figures, 10 table
SN 2007od: A Type IIP SN with Circumstellar Interaction
SN 2007od exhibits characteristics that have rarely been seen in a Type IIP
supernova (SN). Optical V band photometry reveals a very steep brightness
decline between the plateau and nebular phases of ~4.5 mag, likely due to SN
2007od containing a low mass of 56Ni. The optical spectra show an evolution
from normal Type IIP with broad Halpha emission, to a complex, four component
Halpha emission profile exhibiting asymmetries caused by dust extinction after
day 232. This is similar to the spectral evolution of the Type IIn SN 1998S,
although no early-time narrow (~200 km s-1) Halpha component was present in SN
2007od. In both SNe, the intermediate-width Halpha emission components are
thought to arise in the interaction between the ejecta and its circumstellar
medium (CSM). SN 2007od also shows a mid-IR excess due to new dust. The
evolution of the Halpha profile and the presence of the mid-IR excess provide
strong evidence that SN 2007od formed new dust before day 232. Late-time
observations reveal a flattening of the visible lightcurve. This flattening is
a strong indication of the presence of a light echo, which likely accounts for
much of the broad, underlying Halpha component seen at late-times. We believe
the multi-peaked Halpha emission is consistent with the interaction of the
ejecta with a circumstellar ring or torus (for the inner components at \pm1500
km s-1), and a single blob or cloud of circumstellar material out of the plane
of the CSM ring (for the outer component at -5000 km s-1). The most probable
location for the formation of new dust is in the cool dense shell created by
the interaction between the expanding ejecta and its CSM. Monte Carlo radiative
transfer modeling of the dust emission from SN 2007od implies that up to 4x
10-4Msun of new dust has formed. This is similar to the amounts of dust formed
in other CCSNe such as SNe 1999em, 2004et, and 2006jc.Comment: 35 pages, 6 figures. Accepted for publication in Ap
The effects of the spontaneous presence of a spouse/partner and others on cardiovascular reactions to an acute psychological challenge
The presence of supportive others has been associated with attenuated cardiovascular reactivity in the laboratory. The effects of the presence of a spouse and others in a more naturalistic setting have received little attention. Blood pressure and heart rate reactions to mental stress were recorded at home in 1028 married/partnered individuals. For 112 participants, their spouse/partner was present; for 78, at least one other person was present. Women tested with a spouse/partner present showed lower magnitude systolic blood pressure and heart rate reactivity than those tested without. Individuals tested with at least one nonspousal other present also displayed attenuated reactivity. This extends the results of laboratory studies and indicates that the spontaneous presence of others is associated with a reduction in cardiovascular reactivity in an everyday environment; spouse/partner presence would appear to be especially effective for women.\ud
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