How To Build Enterprise Data Models To Achieve Compliance To Standards Or Regulatory Requirements (and share data).

Sharing data between organizations is challenging because it is difficult to ensure that those consuming the data accurately interpret it. The promise of the next generation WWW, the semantic Web, is that semantics about shared data will be represented in ontologies and available for automatic and accurate machine processing of data. Thus, there is inter-organizational business value in developing applications that have ontology-based enterprise models at their core. In an ontology-based enterprise model, business rules and definitions are represented as formal axioms, which are applied to enterprise facts to automatically infer facts not explicitly represented. If the proposition to be inferred is a requirement from, say, ISO 9000 or Sarbanes-Oxley, inference constitutes a model-based proof of compliance. In this paper, we detail the development and application of the TOVE ISO 9000 Micro-Theory, a model of ISO 9000 developed using ontologies for quality management (measurement, traceability, and quality management system ontologies). In so doing, we demonstrate that when enterprise models are developed using ontologies, they can be leveraged to support business analytics problems - in particular, compliance evaluation - and are sharable

Staying in place during times of change in Arctic Alaska: The implications of attachment,alternatives, and buffering

The relationship between stability and change in social-ecological systems has received considerable attention in recent years, including the expectation that significant environmental changes will drive observable consequences for individuals, communities, and populations. Migration, as one example of response to adverse economic or environmental changes, has been observed in many places, including parts of the Far North. In Arctic Alaska, a relative lack of demographic or migratory response to rapid environmental and other changes has been observed. To understand why Arctic Alaska appears different, we draw on the literature on environmentally driven migration, focusing on three mechanisms that could account for the lack of response: attachment, the desire to remain in place, or the inability to relocate successfully; alternatives, ways to achieve similar outcomes through different means; and buffering, the reliance on subsidies or use of reserves to delay impacts. Each explanation has different implications for research and policy, indicating a need to further explore the relative contribution that each makes to a given situation in order to develop more effective responses locally and regionally. Given that the Arctic is on the front lines of climate change, these explanations are likely relevant to the ways changes play out in other parts of the world. Our review also underscores the importance of further attention to the details of social dynamics in climate change impacts and responses

Rosetta-Alice Observations of Exospheric Hydrogen and Oxygen on Mars

The European Space Agency's Rosetta spacecraft, en route to a 2014 encounter with comet 67P/Churyumov-Gerasimenko, made a gravity assist swing-by of Mars on 25 February 2007, closest approach being at 01:54UT. The Alice instrument on board Rosetta, a lightweight far-ultraviolet imaging spectrograph optimized for in situ cometary spectroscopy in the 750-2000 A spectral band, was used to study the daytime Mars upper atmosphere including emissions from exospheric hydrogen and oxygen. Offset pointing, obtained five hours before closest approach, enabled us to detect and map the HI Lyman-alpha and Lyman-beta emissions from exospheric hydrogen out beyond 30,000 km from the planet's center. These data are fit with a Chamberlain exospheric model from which we derive the hydrogen density at the 200 km exobase and the H escape flux. The results are comparable to those found from the the Ultraviolet Spectrometer experiment on the Mariner 6 and 7 fly-bys of Mars in 1969. Atomic oxygen emission at 1304 A is detected at altitudes of 400 to 1000 km above the limb during limb scans shortly after closest approach. However, the derived oxygen scale height is not consistent with recent models of oxygen escape based on the production of suprathermal oxygen atoms by the dissociative recombination of O2+.Comment: 17 pages, 8 figures, accepted for publication in Icaru

Myasthenia gravis-like syndrome induced by expression of interferon gamma in the neuromuscular junction.

Abnormal humoral responses toward motor end plate constituents in muscle induce myasthenia gravis (MG). To study the etiology of this disease, and whether it could be induced by host defense molecules, we examined the consequences of interferon (IFN) gamma production within the neuromuscular junction of transgenic mice. The transgenic mice exhibited gradually increasing muscular weakness, flaccid paralysis, and functional disruption of the neuromuscular junction that was reversed after administration of an inhibitor of acetylcholinesterase, features which are strikingly similar to human MG. Furthermore, histological examination revealed infiltration of mononuclear cells and autoantibody deposition at motor end plates. Immunoprecipitation analysis indicated that a previously unidentified 87-kD target antigen was recognized by sera from transgenic mice and also by sera from the majority of human MG patients studied. These results suggest that expression of IFN-gamma at motor end plates provokes an autoimmune humoral response, similar to human MG, thus linking the expression of this factor with development of this disease

168 COVID-19 mRNA vaccine booster cutaneous reactions reported to the AAD/ILDS dermatology registry

Background: In summer 2021, several countries including the U.S. authorized COVID-19 mRNA vaccine booster doses ≥6 months after completion of a patient’s primary vaccine series. The aim of this study was to characterize vaccine cutaneous reactions following a booster dose of mRNA vaccine reported to the American Academy of Dermatology (AAD) & International League of Dermatologic Societies (ILDS) COVID-19 Dermatology registry. Methods: In December 2020, the AAD/ILDS registry was adapted to include COVID-19 vaccine skin reactions. In September 2021 the registry also solicited COVID-19 vaccine booster reactions either as new cases or updates to existing entries. Results: From Dec 2020-Jan 2022, 994 cases of vaccine skin reactions were entered in the registry, of which 44 records indicated the presence or absence of cutaneous reactions following a booster dose. Of 44 records, 31(71%) developed a cutaneous reaction to the booster dose and 29% developed a reaction to the 1st and/or 2nd dose but not the booster. Of the 31 patients who developed a reaction to the booster dose, 22 reacted to the booster alone, 1 reacted to the 1st & booster, 3 reacted to the 2nd & booster, and 5 reacted to all three doses. The most common morphologies among all booster reactions were local injection site reactions (n=31), delayed large local reaction (n=7), erythromelalgia (n=3), and vesicular reactions (n=3). Conclusion: Booster reactions represent a small portion of COVID vaccine reactions in the registry. Infrequent reporting could be due slow booster uptake, reporter fatigue, and/or booster reactions may truly be less frequent than reactions to the initial series. Dermatologists should be aware that cutaneous reactions to boosters are possible, even when reactions to dose 1 & 2 did not occur; none of the reactions were life-threatening

Cold and COVID: Recurrent Pernio during the COVID-19 Pandemic

Pernio is a commonly reported cutaneous manifestation of SARS-CoV-2 infection.(1) Our international registry of COVID-19 dermatologic manifestations has collected 1,176 total cases of COVID-19 skin manifestations, including 619 cases of pernio in suspected or confirmed COVID-19 patients.(1) Most patients with new-onset pernio were entered into the registry after the first pandemic wave (79% in March-May 2020). Starting in September 2020, the registry received reports of a subset of these patients who developed recurrent pernio in the following months

Media representation of regulated incivilities: Relevant actors, problems, solutions and the role played by experts in the Flemish press

This article analyses the representations of regulated nuisance in a section of Flemish newspapers over time. It identifies the groups of people who have been successful in conveying messages in and through Flemish press news, and explores the way they have represented problems of, and suggested solutions to, regulated incivilities over the years. Furthermore, against the backdrop of newsmaking criminology, it considers whether and how crime and justice experts have contributed to shaping the Flemish media discourse on regulated incivilities over time. Overall the analysis of press news has found that the press, by giving coverage to the voices of local institutional actors, has promoted the criminalization of nuisance and, especially, of physical incivilities. The views of criminological experts, by contrast, have remained marginal. The article concludes by suggesting how such findings present a new set of empirical and conceptual challenges for newsmaking criminology, and more generally, for public criminology

Two Messages from the President of the United States Communicating Additional Correspondence in Relation to the Adjustment of the Northeastern Boundary, and the Occupation of the Disputed Territory

Correspondence authored by President Van Buren, American Secretary of State, John Forsyth, Maine Governor, John Fairfield, British Envoy Henry S. Fox, and others regarding the occupation and movement of British soldiers in the disputed territory along the northeastern boundary of the State of Maine between Maine and modern-day New Brunswick, Canada. The border issue was resolved on August 9, 1842 with the Webster-Ashburton Treaty.https://digitalcommons.library.umaine.edu/mainebicentennial/1051/thumbnail.jp

An Ethnohistorical Perspective on Cheyenne Demography

Administrative censuses of the Southern Cheyenne Indians from 1880,1891, and 1900 permit family reconstitution, identification of residence groups, and comparisons of fertility between monogamous and polygynous women, when the records are approached by ethnohistori cal methods. This approach includes an awareness of the aboriginal adoption practices, kinship system, and naming practices. It is argued that the biases and distortions of administrative records can be effectively corrected to add to our store of information on band and tribal societies.Yeshttps://us.sagepub.com/en-us/nam/manuscript-submission-guideline