Subsonic aerodynamic characteristics of a proposed advanced manned launch system orbiter configuration

The Advanced Manned Launch System is a proposed near-term technology, two-stage, fully reusable launch system that consists of an unmanned glide-back booster and a manned orbiter. An orbiter model that featured a large fuselage and an aft delta wing with tip fins was tested in the Langley 7- by 10-Foot High-Speed Tunnel. A crew cabin, large payload fairing, and crew access tunnel were mounted on the upper body. The results of the investigation indicated that the configuration was longitudinally stable to an angle of attack of about 6 deg about a center-of-gravity position of 0.7 body length. The model had an untrimmed lift-drag ratio of 6.6, but could not be trimmed at positive lift. The orbiter model was also directionally unstable. The payload fairing was responsible for about half the instability. The tip-fin controllers, which are designed as active controls to produce artificial directional stability, were effective in producing yawing moment, but sizable adverse rolling moment occurred at angles of attack above 6 deg. Differential deflection of the elevon surfaces was effective in producing rolling moment with only small values of adverse yawing moment

Subsonic maneuver capability of a supersonic cruise fighter wing concept

A theoretical and experimental investigation was conducted of the subsonic maneuver capability of a fighter wing concept designed for supersonic cruise. To improve the subsonic maneuver capability, the wing utilized full-span leading- and trailing-edge flaps that were designed with the aid of a subsonic-analysis computer program. Wind-tunnel tests were made at Mach numbers of 0.3, 0.5, and 0.7. Force and moment data obtained were compared with theoretical predictions of Mach 0.5 from two subsonic-analysis computer programs. The two theoretical programs gave a good prediction of the lift and drag characteristics but only a fair prediction of the pitching moment. The experimental results of this study show that with the proper combination of leading- and trailing-edge flap deflections, a suction parameter of nearly 90 percent can be attained at a Mach number of 0.5 and a lift coefficient of 0.73; this is a three-fold improvement from 30 percent for the basic wing

Reynolds number effects on the transonic aerodynamics of a slender wing-body configuration

Aerodynamic forces and moments for a slender wing-body configuration are summarized from an investigation in the Langley National Transonic Facility (NTF). The results include both longitudinal and lateral-directional aerodynamic properties as well as slideslip derivatives. Results were selected to emphasize Reynolds number effects at a transonic speed although some lower speed results are also presented for context. The data indicate nominal Reynolds number effects on the longitudinal aerodynamic coefficients and more pronounced effects for the lateral-directional aerodynamic coefficients. The Reynolds number sensitivities for the lateral-directional coefficients were limited to high angles of attack

A study to determine methods of improving the subsonic performance of a proposed Personnel Launch System (PLS) concept

An investigation has been conducted in the Langley 7- by 10-Foot High Speed Wind Tunnel to determine the longitudinal and lateral directional aerodynamic characteristics of a series of personnel launch system concepts. This series of configurations evolved during an effort to improve the subsonic characteristics of a proposed lifting entry vehicle (designated the HL-20). The primary purpose of the overall investigation was to provide a vehicle concept which was inherently stable and trimable from entry to landing while examining methods of improving subsonic aerodynamic performance

Subsonic longitudinal and lateral-directional characteristics of a forward-swept-wing fighter configuration at angles of attack up to 47 deg

Subsonic lateral-direction and longitudinal characteristics of a forward-swept-wing fighter configuration were examined in wind-tunnel tests at Mach numbers of 0.2 and 0.5 for angles of attack from -7 to 47 deg. and over a sidelslip range of +/- 15 deg. The effects of a canard, strakes, vertical tail, and leading- and trailing-edge flaps are examined. The canard and strakes both reduce asymmetric moments and side forces at zero sideslip for angles of attack up to about 30 deg. The canard has a small influence on lateral-directional stability; however, strakes produce a substantial reduction in lateral stability for angles of attack greater than about 20 deg. The vertical tail improves directional stability for angles of attack up to 30 deg. Deflection of the leading-edge flap to 20 deg. at high angles of attack on the strake and canard configurations degrades lateral and directional stability. Deflection of the trailing-edge flap to 20 deg. on the canard configuration generally increases lateral and directional stability at high angles of attack. Leading- and trailing-edge flaps on the wing-body and canard configurations are effective for increased lift only for angles of attack up to about 40 deg. The leading-edge flap remains effective on the strake configuration over the entire angle-of-attack range tested

1951: Abilene Christian College Bible Lectures - Full Text

Delivered in the Auditorium of Abilene Christian College Abilene, Texas February 18-22, 1951 Price, $3.00 FIRM FOUNDATION PUBLISHING HOUSE Austin, Texa

Meta-analysis of genome-wide association studies from the CHARGE consortium identifies common variants associated with carotid intima media thickness and plaque

Carotid intima media thickness (cIMT) and plaque determined by ultrasonography are established measures of subclinical atherosclerosis that each predicts future cardiovascular disease events. We conducted a meta-analysis of genome-wide association data in 31,211 participants of European ancestry from nine large studies in the setting of the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium. We then sought additional evidence to support our findings among 11,273 individuals using data from seven additional studies. In the combined meta-analysis, we identified three genomic regions associated with common carotid intima media thickness and two different regions associated with the presence of carotid plaque (P < 5 × 10 -8). The associated SNPs mapped in or near genes related to cellular signaling, lipid metabolism and blood pressure homeostasis, and two of the regions were associated with coronary artery disease (P < 0.006) in the Coronary Artery Disease Genome-Wide Replication and Meta-Analysis (CARDIoGRAM) consortium. Our findings may provide new insight into pathways leading to subclinical atherosclerosis and subsequent cardiovascular events

Genetic Association for Renal Traits among Participants of African Ancestry Reveals New Loci for Renal Function

Chronic kidney disease (CKD) is an increasing global public health concern, particularly among populations of African ancestry. We performed an interrogation of known renal loci, genome-wide association (GWA), and IBC candidate-gene SNP association analyses in African Americans from the CARe Renal Consortium. In up to 8,110 participants, we performed meta-analyses of GWA and IBC array data for estimated glomerular filtration rate (eGFR), CKD (eGFR <60 mL/min/1.73 m2), urinary albumin-to-creatinine ratio (UACR), and microalbuminuria (UACR >30 mg/g) and interrogated the 250 kb flanking region around 24 SNPs previously identified in European Ancestry renal GWAS analyses. Findings were replicated in up to 4,358 African Americans. To assess function, individually identified genes were knocked down in zebrafish embryos by morpholino antisense oligonucleotides. Expression of kidney-specific genes was assessed by in situ hybridization, and glomerular filtration was evaluated by dextran clearance. Overall, 23 of 24 previously identified SNPs had direction-consistent associations with eGFR in African Americans, 2 of which achieved nominal significance (UMOD, PIP5K1B). Interrogation of the flanking regions uncovered 24 new index SNPs in African Americans, 12 of which were replicated (UMOD, ANXA9, GCKR, TFDP2, DAB2, VEGFA, ATXN2, GATM, SLC22A2, TMEM60, SLC6A13, and BCAS3). In addition, we identified 3 suggestive loci at DOK6 (p-value = 5.3×10−7) and FNDC1 (p-value = 3.0×10−7) for UACR, and KCNQ1 with eGFR (p = 3.6×10−6). Morpholino knockdown of kcnq1 in the zebrafish resulted in abnormal kidney development and filtration capacity. We identified several SNPs in association with eGFR in African Ancestry individuals, as well as 3 suggestive loci for UACR and eGFR. Functional genetic studies support a role for kcnq1 in glomerular development in zebrafish

Hundreds of variants clustered in genomic loci and biological pathways affect human height

Most common human traits and diseases have a polygenic pattern of inheritance: DNA sequence variants at many genetic loci influence the phenotype. Genome-wide association (GWA) studies have identified more than 600 variants associated with human traits, but these typically explain small fractions of phenotypic variation, raising questions about the use of further studies. Here, using 183,727 individuals, we show that hundreds of genetic variants, in at least 180 loci, influence adult height, a highly heritable and classic polygenic trait. The large number of loci reveals patterns with important implications for genetic studies of common human diseases and traits. First, the 180 loci are not random, but instead are enriched for genes that are connected in biological pathways (P = 0.016) and that underlie skeletal growth defects (P < 0.001). Second, the likely causal gene is often located near the most strongly associated variant: in 13 of 21 loci containing a known skeletal growth gene, that gene was closest to the associated variant. Third, at least 19 loci have multiple independently associated variants, suggesting that allelic heterogeneity is a frequent feature of polygenic traits, that comprehensive explorations of already-discovered loci should discover additional variants and that an appreciable fraction of associated loci may have been identified. Fourth, associated variants are enriched for likely functional effects on genes, being over-represented among variants that alter amino-acid structure of proteins and expression levels of nearby genes. Our data explain approximately 10% of the phenotypic variation in height, and we estimate that unidentified common variants of similar effect sizes would increase this figure to approximately 16% of phenotypic variation (approximately 20% of heritable variation). Although additional approaches are needed to dissect the genetic architecture of polygenic human traits fully, our findings indicate that GWA studies can identify large numbers of loci that implicate biologically relevant genes and pathways.