The AGeS2 (Awards for Geochronology Student research 2) Program: Supporting Community Geochronology Needs and Interdisciplinary Science

Geochronology is essential in the geosciences. It is used to resolve the durations and rates of earth processes, as well as test causative relationships among events. Such data are increasingly required to conduct cutting-edge, transformative, earth-science research. The growing need for geochronology is accompanied by strong demand to enhance the ability of labs to meet this pressure and to increase community awareness of how these data are produced and interpreted. For example, a 2015 National Science Foundation (NSF) report on opportunities and challenges for U.S. geochronology research noted: While there has never been a time when users have had greater access to geo-chronologic data, they remain, by and large, dissatisfied with the available style/ quantity/cost/efficiency (Harrison et al., 2015, p. 1). And the 2012 National Research Council NROES (New Research Opportunities in the Earth Sciences) report (Lay et al., 2012, p. 82) recommended: [NSF] EAR should explore new mechanisms for geochronology laboratories that will service the geochronology requirements of the broad suite of research opportunities while sustaining technical advances in methodologies. The AGeS (Awards for Geochronology Student research) program is one way that these calls are being answered

An Imbalancing Act: The Delayed Dynamic Response of the Kaskawulsh Glacier to Sustained Mass Loss

The Kaskawulsh Glacier is an iconic outlet draining the icefields of the St. Elias Mountains in Yukon, Canada. We determine and attempt to interpret its catchment-wide mass budget since 2007. Using SPOT5/6/7 data we estimate a 2007–18 geodetic balance of −0.46 ± 0.17 m w.e. a−1. We then compute balance fluxes and observed ice fluxes at nine flux gates to examine the discrepancy between the climatic mass balance and internal mass redistribution by glacier flow. Balance fluxes are computed using a fully distributed mass-balance model driven by downscaled and bias-corrected climate-reanalysis data. Observed fluxes are calculated using NASA ITS_LIVE surface velocities and glacier cross-sectional areas derived from ice-penetrating radar data. We find the glacier is still in the early stages of dynamic adjustment to its mass imbalance. We estimate a committed terminus retreat of ~23 km under the 2007–18 climate and a lower bound of 46 km3 of committed ice loss, equivalent to ~15% of the total glacier volume

Post-Laramide, Eocene epeirogeny in central Colorado—The result of a mantle drip?

The Southern Rocky Mountains first rose during the Laramide Orogeny (ca. 75–45 Ma), but today's mountains and adjacent Great Plains owe their current height to later epeirogenic surface uplift. When and why epeirogeny affected the region are controversial. Sedimentation histories in two central Colorado basins, the South Park–High Park and Denver basins, shifted at 56–54 Ma from an orogenic to an epeirogenic pattern, suggesting central Colorado experienced epeirogeny at that time. To interrogate that hypothesis, we analyzed thermal histories for seven samples from central Colorado's Arkansas Hills and High Park using thermochronometers with closure temperatures below ~180 °C, enabling us to track sample exhumation from ~5–7 km depth. Three samples are from the Cretaceous Whitehorn pluton, and four are Precambrian granitoids. All zircon and titanite (U-Th)/He dates (ZHe and THe) and one apatite fission-track (AFT) date are similar to the 67 Ma pluton emplacement age. Whitehorn dates using the lower-temperature apatite (U-Th)/He (AHe) thermochronometer are 55–41 Ma. These data require two exhumation episodes, one ca. 67–60 Ma, the second beginning at 54–46 Ma. The pluton reached the surface by 37 Ma, based on the age of volcanic tuff filling a pluton-cutting paleovalley. The Precambrian samples do not further refine this thermal history owing to the comparatively higher He closure temperature of their more radiation-damaged apatite. Laramide crustal shortening caused 67–60 Ma exhumation. Arkansas Hills shortening ended before 67 Ma, so shortening could not have caused the exhumation event that began 54–46 Ma; thermochronology supports the Eocene epeirogeny hypothesis. Epeirogeny affected >2.0 × 104 km2, from the Sawatch Range to the Denver Basin. We attribute epeirogeny to an Eocene mantle drip that likely triggered subsequent drips, causing younger exhumation events in adjacent areas

Cenozoic Exhumation Across the High Plains of Southeastern Colorado from (U-Th)/He Thermochronology

Colorado&rsquo;s High Plains stand at anomalously high elevations (~1300&ndash;2100 m) for their continental interior setting, but when and why this region became elevated is poorly understood. The Cenozoic history of the High Plains is also likely linked with that of the Rocky Mountains, where the timing and cause(s) of uplift are similarly debated. We present apatite (U-Th)/He (AHe) data for 10 samples from Tertiary intrusives along a ~200 km west-to-east transect across the High Plains of southeastern Colorado to constrain the timing of exhumation and to gain insight into when and why regional elevation gain occurred. Mean sample AHe dates for the ~24&ndash;22 Ma East Spanish Peak pluton and associated radial dikes from the westernmost High Plains are 18.8 &plusmn; 1.4 to 14.1 &plusmn; 1.7 Ma, recording substantial postemplacement erosion. AHe results for the mafic to ultramafic Apishapa Dikes (oldest ~37 Ma, youngest ~14 Ma) located ~20&ndash;40 km farther north and east on the High Plains range from 12.0 &plusmn; 1.4 to 6.2 &plusmn; 1.9 Ma, documenting continued exhumation on the western High Plains during the ~12&ndash;5 Ma deposition of the Ogallala Formation farther east and suggesting that the western limit of Ogallala deposition was east of the Apishapa Dikes. In far southeastern Colorado, the Two Buttes lamprophyre was emplaced at 36.8 &plusmn; 0.4 Ma and yields a Late Oligocene AHe date of 27.1 &plusmn; 4 Ma. Here, the Ogallala Formation unconformably overlies Two Buttes, indicating that the regional ~12 Ma age for the base of the Ogallala is a minimum age for the exposure of the pluton at the surface. The AHe data presented here document that kilometer-scale erosion affected all of the southeastern Colorado High Plains in Oligo-Miocene time. While exhumation can have multiple possible causes, we favor contemporaneous surface uplift capable of elevating the region to modern heights. &nbsp;</p

Cenozoic Exhumation Across the High Plains of Southeastern Colorado from (U-Th)/He Thermochronology

Colorado’s High Plains stand at anomalously high elevations (~1300–2100 m) for their continental interior setting, but when and why this region became elevated is poorly understood. The Cenozoic history of the High Plains is also likely linked with that of the Rocky Mountains, where the timing and cause(s) of uplift are similarly debated. We present apatite (U-Th)/He (AHe) data for 10 samples from Tertiary intrusives along a ~200 km west-to-east transect across the High Plains of southeastern Colorado to constrain the timing of exhumation and to gain insight into when and why regional elevation gain occurred. Mean sample AHe dates for the ~24–22 Ma East Spanish Peak pluton and associated radial dikes from the westernmost High Plains are 18.8 ± 1.4 to 14.1 ± 1.7 Ma, recording substantial postemplacement erosion. AHe results for the mafic to ultramafic Apishapa Dikes (oldest ~37 Ma, youngest ~14 Ma) located ~20–40 km farther north and east on the High Plains range from 12.0 ± 1.4 to 6.2 ± 1.9 Ma, documenting continued exhumation on the western High Plains during the ~12–5 Ma deposition of the Ogallala Formation farther east and suggesting that the western limit of Ogallala deposition was east of the Apishapa Dikes. In far southeastern Colorado, the Two Buttes lamprophyre was emplaced at 36.8 ± 0.4 Ma and yields a Late Oligocene AHe date of 27.1 ± 4 Ma. Here, the Ogallala Formation unconformably overlies Two Buttes, indicating that the regional ~12 Ma age for the base of the Ogallala is a minimum age for the exposure of the pluton at the surface. The AHe data presented here document that kilometer-scale erosion affected all of the southeastern Colorado High Plains in Oligo-Miocene time. While exhumation can have multiple possible causes, we favor contemporaneous surface uplift capable of elevating the region to modern heights

River patterns reveal two stages of landscape evolution at an oblique convergent margin, Marlborough Fault System, New Zealand

Here we examine the landscape of New Zealand's Marlborough Fault System (MFS), where the Australian and Pacific plates obliquely collide, in order to study landscape evolution and the controls on fluvial patterns at a long-lived plate boundary. We present maps of drainage anomalies and channel steepness, as well as an analysis of the plan-view orientations of rivers and faults, and we find abundant evidence of structurally controlled drainage that we relate to a history of drainage capture and rearrangement in response to mountain-building and strike-slip faulting. Despite clear evidence of recent rearrangement of the western MFS drainage network, rivers in this region still flow parallel to older faults, rather than along orthogonal traces of younger, active strike-slip faults. Such drainage patterns emphasize the importance of river entrenchment, showing that once rivers establish themselves along a structural grain, their capture or avulsion becomes difficult, even when exposed to new weakening and tectonic strain. Continued flow along older faults may also indicate that the younger faults have not yet generated a fault damage zone with the material weakening needed to focus erosion and reorient rivers. Channel steepness is highest in the eastern MFS, in a zone centered on the Kaikōura ranges, including within the low-elevation valleys of main stem rivers and at tributaries near the coast. This pattern is consistent with an increase in rock uplift rate toward a subduction front that is locked on its southern end. Based on these results and a wealth of previous geologic studies, we propose two broad stages of landscape evolution over the last 25 million years of orogenesis. In the eastern MFS, Miocene folding above blind thrust faults generated prominent mountain peaks and formed major transverse rivers early in the plate collision history. A transition to Pliocene dextral strike-slip faulting and widespread uplift led to cycles of river channel offset, deflection and capture of tributaries draining across active faults, and headward erosion and captures by major transverse rivers within the western MFS. We predict a similar landscape will evolve south of the Hope Fault, as the locus of plate boundary deformation migrates southward into this region with time.</p

Second trimester inflammatory and metabolic markers in women delivering preterm with and without preeclampsia.

ObjectiveInflammatory and metabolic pathways are implicated in preterm birth and preeclampsia. However, studies rarely compare second trimester inflammatory and metabolic markers between women who deliver preterm with and without preeclampsia.Study designA sample of 129 women (43 with preeclampsia) with preterm delivery was obtained from an existing population-based birth cohort. Banked second trimester serum samples were assayed for 267 inflammatory and metabolic markers. Backwards-stepwise logistic regression models were used to calculate odds ratios.ResultsHigher 5-α-pregnan-3β,20α-diol disulfate, and lower 1-linoleoylglycerophosphoethanolamine and octadecanedioate, predicted increased odds of preeclampsia.ConclusionsAmong women with preterm births, those who developed preeclampsia differed with respect metabolic markers. These findings point to potential etiologic underpinnings for preeclampsia as a precursor to preterm birth

PRN OPINION PAPER: Application of precision medicine across pharmacy specialty areas

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/149551/1/jac51107_am.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/149551/2/jac51107.pd

Adiposity, hormone replacement therapy use and breast cancer risk by age and hormone receptor status: a large prospective cohort study

INTRODUCTION: Associations of hormone-receptor positive breast cancer with excess adiposity are reasonably well characterized; however, uncertainty remains regarding the association of body mass index (BMI) with hormone-receptor negative malignancies, and possible interactions by hormone replacement therapy (HRT) use. METHODS: Within the European EPIC cohort, Cox proportional hazards models were used to describe the relationship of BMI, waist and hip circumferences with risk of estrogen-receptor (ER) negative and progesterone-receptor (PR) negative (n = 1,021) and ER+PR+ (n = 3,586) breast tumors within five-year age bands. Among postmenopausal women, the joint effects of BMI and HRT use were analyzed. RESULTS: For risk of ER-PR- tumors, there was no association of BMI across the age bands. However, when analyses were restricted to postmenopausal HRT never users, a positive risk association with BMI (third versus first tertile HR = 1.47 (1.01 to 2.15)) was observed. BMI was inversely associated with ER+PR+ tumors among women aged ≤49 years (per 5 kg/m2 increase, HR = 0.79 (95%CI 0.68 to 0.91)), and positively associated with risk among women ≥65 years (HR = 1.25 (1.16 to 1.34)). Adjusting for BMI, waist and hip circumferences showed no further associations with risks of breast cancer subtypes. Current use of HRT was significantly associated with an increased risk of receptor-negative (HRT current use compared to HRT never use HR: 1.30 (1.05 to 1.62)) and positive tumors (HR: 1.74 (1.56 to 1.95)), although this risk increase was weaker for ER-PR- disease (Phet = 0.035). The association of HRT was significantly stronger in the leaner women (BMI ≤22.5 kg/m2) than for more overweight women (BMI ≥25.9 kg/m2) for, both, ER-PR- (HR: 1.74 (1.15 to 2.63)) and ER+PR+ (HR: 2.33 (1.84 to 2.92)) breast cancer and was not restricted to any particular HRT regime. CONCLUSIONS: An elevated BMI may be positively associated with risk of ER-PR- tumors among postmenopausal women who never used HRT. Furthermore, postmenopausal HRT users were at an increased risk of ER-PR- as well as ER+PR+ tumors, especially among leaner women. For hormone-receptor positive tumors, but not for hormone-receptor negative tumors, our study confirms an inverse association of risk with BMI among young women of premenopausal age. Our data provide evidence for a possible role of sex hormones in the etiology of hormone-receptor negative tumors