Aprendemos letras y sus sonidos : Learning letters and their sounds : an interactive experience

The purpose for the creation of this multimedia project is to assist the native Spanish speaker, at the pre-primer level, to acquire phonemic awareness and phonics skills through the use of multimedia. The CD-ROM project will be used as a supplement to the Bilingual Language Arts Program used in the classroom. The lack of Bilingual multimedia phonics CD-ROMS was a catalyst for the inception and creation for the promotion of learning the Spanish alphabet and their sounds for the beginning stages for reading instruction. The lack of access to technology is also another purpose for the creation of this multimedia project. Technology can serve as one of the equalizing factors in access to education. Native Spanish speakers are at the end of the Digital Divide, with this project that divide will be somewhat closed, at least in the classroom utilizing i

Formación de profesionales socialmente responsables en la Universidad Autónoma del Estado de México

Artículo publicado en revista Humanidades MédicasLa igualdad de oportunidades y la equidad en el ingreso a las Instituciones de Educación Superior debe ser una norma a cumplir para que las universidades sean consideradas como socialmente responsables; y la aceptación, reconocimiento y valoración de estudiantes procedentes de diversas culturas, como es el caso de las indígenas, deben ser parte de las enseñanzas y de la formación de valores que se estén desarrollando en estos espacios educativos

Valores sociales y métodos de enseñanza: lo que deben mejorar los docentes universitarios desde la visión de los estudiantes

Artículo relacionado con valoresResultados de investigación en torno a los saberes disciplinarios, profesionales, laborales, pedagógicos, didácticos e incluso axiológicos que deben dominar los docentes universitarios, desde la visión de los estudiantes; se resaltan los saberes específicos relativos a la unidad de aprendizaje que imparten, los métodos de enseñanza -dinámicos, prácticos-, así como los valores que se deben desarrollar y compartir

Nivel de agotamiento en los cuidadores familiares del paciente con enfermedad renal crónica de la Clínica de Hemodiálisis “Centro de Diálisis Nefro - Continente” Lima – Perú 2017

Publicación a texto completo no autorizada por el autorDetermina el nivel de agotamiento en los cuidadores familiares del paciente con enfermedad renal crónica de la Clínica de Hemodiálisis “Centro de Diálisis Nefro-Continente”. Desarrolla un estudio de tipo cuantitativo, método descriptivo de corte transversal. La muestra fue obtenida mediante el muestreo de población infinita conformada por 70 cuidadores familiares. La técnica fue la entrevista y el instrumento la escala de zarit validado modificado. Los datos fueron sometidos al programa de Excel, con la finalidad de determinar sus dimensiones expresadas en niveles (no sobrecarga, sobre carga leve, sobrecarga intensa). Encuentra que del 100% (70), 53% (37) tienen sobrecarga leve, 44% (31) no sobrecarga y 3% (02) sobrecarga intensa. En la dimensión física existe 52%(36) sobrecarga leve, 30%(21) no sobrecarga y 18%(13) sobrecarga intensa. En la dimensión psicológica 50%(35) tienen sobrecarga leve, 40%(28) sobrecarga intensa; 10%(07) no sobrecarga y en la dimensión social 50%(35) sobrecarga leve, 25%(18) no sobrecarga, 25%(17) sobrecarga intensa. Concluye que los cuidadores familiares del paciente con enfermedad renal crónica de la Clínica de Hemodiálisis “Centro de Diálisis Nefro-Continente”, presentan en mayor porcentaje una sobrecarga leve, en los ítems de inseguridad por tener que cuidar, angustia por el futuro y sensación de verguenza.Trabajo académic

Mitochondrial and autophagic alterations in human-derived cell models of Parkinson's disease related to LRRK2 (G2019S) and GBA (N370S) mutations

[eng] Parkinson's disease (PD) is the second most common neurodegenerative disease, and the most common movement disorder in the world population. In most cases its aetiology is still unknown, however, mitochondrial alterations and autophagy deregulations are some of the molecular mechanisms that are altered in this disease. These molecular alterations of PD are not limited only to the destruction of dopaminergic neurons in the substantia nigra pars compacta, but they have also been described in the peripheral nervous system and the organs that it innervates. There is also evidence of the presence of other molecular alterations in diverse tissues, such as dysfunction of Complex I of the mitochondrial respiratory chain and accumulation of alpha synuclein in fibroblasts of patients with PD. One of the great difficulties the research and understanding of the mechanisms that lead to PD is the inaccessibility of the target tissue of the disease. In the best of cases, autopsy tissue from patients with advanced PD is available, leaving a question mark about the molecular processes of prodromal and early stages of the disease. Animal models have helped to unravel some questions, but the development of accessible and replicable cell models, preferably at low cost, is much needed. It is in this context that the cellular models obtained from PD patients and from asymptomatic carriers of genes associated with the disease are of great importance and require validation. The present thesis consists of the study of two cell models obtained from patients with PD associated with the LRRK2 mutation (G2019S), asymptomatic carriers of LRRK2 (G2019S) and homozygous and heterozygous carriers of GBA (N370S); which are the genes most frequently associated with familial PD and the most important genetic risk factor for PD, respectively. First, the mitochondrial and autophagic profile of fibroblasts derived from the skin of asymptomatic carriers of the LRRK2 (G2019S) mutation and with PD were analysed. The analysis was carried out under two conditions, keeping the fibroblasts in a standard culture medium (DMEM with 25mM glucose) and after subjecting them to a mitochondrial challenge for 24 hours (DMEM with 10mM galactose), in order to simulate the oxidative environment of neurons. dopaminergic. In this study, a genotype-phenotype correlation was confirmed in fibroblasts obtained from asymptomatic carriers of the LRRK2 (G2029S) mutation and patients with PD linked to this same mutation, and it was demonstrated that a mitochondrial and autophagic function profile allows to differentiate between groups. The second study explored the genotype-phenotype correlation in a cellular model characterized by neurospheres, a conglomerate of cells obtained from the dedifferentiation of human adipocytes into neuronal stem cells, and its relationship with the onset of macroautophagy in subjects carrying the mutation GBA (N370S). The main finding of this study is that mitochondrial dysfunction preceded alterations of macroautogphagic flux in subjects carrying the GBA (N370S) mutation. In conclusion, the study of asymptomatic subjects carrying mutations associated with PD represents a relevant study method that shows initial molecular alterations and the presence of compensatory mechanisms that can be studied for the development of preventive strategies and treatments in early stages of the disease.[spa] La enfermedad de Parkinson (EP) es el trastorno de movimiento más frecuente en la población mundial. Considerada mayoritariamente idiopática y multifactorial, alteraciones mitocondriales y en la regulación autofagica son algunos de los mecanismos moleculares que se han encontrado alterados en la etiopatología de la enfermedad. El descubrimiento de genes relacionados a formas familiares de EP, del cual LRRK2 es el más frecuente, y los genes que aumentan el riesgo de padecer la enfermedad, como GBA, han abierto un campo de estudio en el cual se pueden analizar los mecanismos moleculares que llevan a la neurodegeneración en formas genéticas de la EP. La presente tesis consiste en el estudio de dos modelos celulares obtenidos a partir de portadores asintomáticos de LRRK2(G2019S) (NMLRRK2(G2019S)), pacientes con EP asociada a la mutación LRRK2(G2019S) (PDLRRK2(G2019S)), así como de portadores homozigotos y heterozigotos de GBA(N370S). El primer estudio analizó el perfil mitocondrial y autofágico de fibroblastos NMLRRK2(G2019S) y PDLRRK2(G2019S). El análisis se realizó en dos condiciones, en un medio de cultivo estándar (DMEM, glucosa 25mM) y tras someterlos 24 horas a un reto mitocondrial (DMEM, galactosa 10mM), simulando el ambiente oxidativo de las neuronas dopaminérgicas. En este estudio se confirmó una correlación genotipo-fenotipo en fibroblastos obtenidos de ambos grupos y una función mitocondrial y autofágica que permite diferenciarlos entre ellos. El segundo estudio exploró la correlación genotipo-fenotipo en un modelo celular caracterizado por neuroesferas, un conglomerado de células obtenido a partir de la desdiferenciación de adipocitos humanos en células madres neuronales, y su relación con el inicio de la macroautofagia en sujetos portadores de la mutación GBA(N370S). El hallazgo principal de este segundo estudio es que la disfunción mitocondrial precede a las alteraciones del flujo macroautofágico en sujetos portadores de la mutación GBA(N370S). El estudio de sujetos asintomáticos portadores de mutaciones asociadas a PD representa un relevante método de estudio que evidencia alteraciones moleculares iniciales y la presencia de mecanismos compensatorios que pueden ser estudiados para el desarrollo de estrategias preventivas y tratamientos en lateabas tempranas de la enfermedad

A avaliação das aprendizagens no ensino superior: a perspectiva dos estudantes

Nesta comunicação, divulgamos alguns resultados preliminares de um estudo mais vasto realizado no âmbito de uma dissertação de Mestrado em Ciências da Educação – área de especialização em Avaliação. Este estudo pretende conhecer as representações e experiências dos estudantes do Ensino Superior relativamente às práticas de avaliação das aprendizagens. Os resultados demonstram que os alunos associam à avaliação as ideias de reflexão, verificação de conhecimentos, aprendizagem e sucesso. Para além disso, na perspectiva dos alunos, os métodos de avaliação mais utilizados são os realizados em grupo e mais práticos, tais como apresentações orais em grupo, trabalhos experimentais em grupo, relatórios e trabalhos de projecto em grupo. Dos dados decorre ainda a importância da avaliação no sentido de esta potenciar a autonomia do aluno, a aplicação do conhecimento em situações reais, bem como desenvolver competências técnicas e transversai

Estimates of the likelihood of threats are related to intolerance of uncertainty and learning

In the present experiment, we assessed the relationship between intolerance of uncertainty and expectancy ratings of threats both in the presence of conditioned stimuli (CS) that signalled the delivery of an aversive unconditioned stimulus (US), and after making an avoidance response. Participants learned the relationship between several pictures serving as CSs and an aversive sound serving as the US, and learned to avoid the US through a procedure including alternating pavlovian and negative reinforcement training phases. Expectancy ratings were measured on every training trial. Our results only showed a significant association between intolerance of uncertainty and expectancy ratings made after avoidance responses. This association was found only when the avoidance response was made in the presence of CSs signalling that the aversive sound was avoidable. The increase in intolerance of uncertainty was related to lower expectancy ratings in good learners, and to higher expectancy ratings in bad learners. These results are tentatively explained by invoking a view of intolerance of uncertainty as an exaggerated reaction to uncertainty aimed at learning to avoid threats.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech. Ministerio de Ciencia y Competitividad. Proyecto Nacional I+D+i. PSI2014-56061

Assessment in higher education

This article reports on research on assessment of student learning in higher education in the Portuguese context. The current educational paradigm is based upon different roles for both student and Faculty within the context of the Bologna process. The student is seen as a key element in the teaching/learning process and the builder of active learning. This implies new methods for teaching and learning, which are based upon a flexible curriculum including new forms for assessing learning. The main goals of the study reported in this paper are: i) to get to know the perspectives of students about assessment in higher education (after the implementation of the Bologna process); ii) to identify methods of assessing learning in higher education; iii) to identify the potential and difficulties associated with different modes of assessment of learning in higher education from the perspective of the students

University teachers’ perceptions about assessment practices: a study in five Portuguese universities

This paper looks at how Portuguese university teachers look at assessment in Higher Education. It focuses on their perspectives about assessment in higher education after the implementation of the Bologna Process, the connection between assessment, teaching and learning process and the selection of criteria and methods of assessment. Data were collected through face-to-face interviews and online open-ended questionnaires in five Portuguese Public Universities in different fields of knowledge. In total, 57 teachers participated in this study. Findings are presented according the categories emerging from the data. Issues of change in assessment practices, the connection between teaching, learning and assessment as well as difficulties to assessing students’ work are analysed. Implications of the findings are discussed.CIEC – Research Centre on Child Studies, IE, UMinho (FCT R&D unit 317), PortugalNational Funds through the FCT (Foundation for Science and Technology) and co-financed by European Regional Development Funds (FEDER) through the Competitiveness and Internationalization Operational Program (POCI) with the reference POCI-01-0145-FEDER-007562This work is funded by FCT - Fundação para a Ciência e a Tecnologia (National Foundation for Science and Technology) within the context of a PhD (SFRH/BD/76175/2011).info:eu-repo/semantics/publishedVersio

Undergraduates’ views of assessment in higher education: a study carried out in Portugal

This paper looks at how undergraduates look at assessment in Higher Education. It focuses on their views about assessment practices in five Portuguese public universities. The main purpose is to look at the students’ perceptions of assessment in higher education taking into account the assessment methods used, the influence of assessment in their motivation to learn as well as self-regulation of the learning process. Data were collected through questionnaires in five Portuguese Public Universities in different fields of knowledge. An intervention project focused on Assessment for Learning (AfL), with students enrolled at an Engineering programme, in one public university in Portugal, in one course with student-centred methodologies and AfL practices was also carried out and evaluated. Preliminary findings are presented according the categories emerging from the data. Issues of assessment methods, the connection between teaching, learning and assessment as well as the impact of AfL environments on students’ perceptions are analysed. Implications of the findings for assessment, teaching and learning process are discussed.This work is funded by FEDER Funds through the COMPETE Programme and by National Funds through the FCT - Fundação para a Ciência e a Tecnologia (National Foundation for Science and Technology) within the context of the project "Assessment in Higher Education: the potential of alternative methods" (PTDC/MHCCED/2703/2014)