Nachbildungen von ›originalen‹ Tanagrafiguren der Kunsthandlung Fritz Gurlitt, Berlin 1882-1886

From 1881 to 1886 the Berlin art dealer Fritz Gurlitt offered for sale replicas of the so-called Tanagra figurines that were handmade and colored copies of terracottas in the museums of Berlin, Paris, London, and St. Petersburg. Thirty of these figurines are still preserved in the Archaeological Collection of the University of Rostock. The current exhibition “Echt Antik! Terrakotten für Salon und Museum” at the German Amber Museum (Deutsches Bernsteinmuseum) in Ribnitz-Damgarten presents these figurines and traces their journey from the excavations at Tanagra to their reproduction for the bourgeois salon (http://www.deutsches-bernsteinmuseum.de/sonderausstellungen.html)

Telekommunikationsverhalten im europäischen Forschungsnetzwerk EARN: Ein Prototyp eines dynamischen Modells

Series: Discussion Papers of the Institute for Economic Geography and GIScienc

Combined geophysical prospection of kurgans on the Uzun Rama plateau in the Caucasus, Azerbaijan: first results

In November 2021, a geophysical prospection using magnetics, electromagnetics, and ground penetrating radar, as well as a surface archaeological survey and aerial photography were conducted in the kurgan area on the Uzun-Rama plateau in central Azerbaijan. These non-destructive investigations aim to obtain information on the morphology, structure and spatial distribution of the urgans in order to classify them according to various features. The preliminary results show that increased magnetic field intensity, increased electrical conductivity, and increased reflection energy in the GPR are observed in the top region of the kurgans, which contain information about the burial chamber

Zuchtwertschätzung Schweres Warmblut: Neuetablierung einer Zuchtwertschätzung für das Sächsisch-Thüringische Schwere Warmblut

Die Schriftenreihe informiert über die Neuetablierung einer Zuchtwertschätzung für das Sächsisch-Thüringische Schwere Warmblut. Sie beschreibt das methodische Vorgehen zur Entwicklung und die genutzte Datengrundlage. Es werden Ergebnisse aus der Entwicklungsphase und dem ersten Schätzlauf vorgestellt. Zu den gezeigten Ergebnissen gehören genetische Korrelationen, Erblichkeiten, Zuchtwerte und Sicherheiten sowie genetische Trends. Die Schriftenreihe richtet sich an ambitionierte Pferdezüchter, Forschende und Lehrende. Redaktionsschluss: 21.04.202

Intensification of agriculture in southwestern Germany between the Bronze Age and Medieval period, based on archaeobotanical data from Baden-Württemberg

A system of farming with an alternation of land use between being cultivated or left fallow as grassland (Feldgraswirtschaft) developed in southwestern Germany since the Bronze Age. It involved fallow periods, where the arable land is left without crops in order to let it recover its fertility for several years while becoming grassland. This led to regeneration of the topsoil humus, which could later be mobilized by cultivation. With later farming systems, the supply of nutrients needed for crops could also be provided by manuring, which allowed shorter fallow periods but required the production of manure. Such cultivation systems with short or even without fallow phases and with intensive manuring are known from the medieval period as one, two or three field systems of agriculture and their development was an important step towards the intensification of farming. The current study considers on-site plant macrofossil data from archaeological sites as well as the off-site pollen data from cores in Baden-Württemberg in order to recognize the main changes towards agricultural intensification through time from the Bronze Age up to medieval times. The various landscape types included in the study area also reveal their different agricultural histories of intensification. In lowlands with good soils, the intensification can be recognized earlier and more strongly than in uplands or other marginal areas. The main shift towards intensification took place in the Roman period, which is also confirmed by written sources of the time that mention manuring as well as a kind of two field system and alternation between grassland and arable land.publishedVersio

Cochlea-Specific Deletion of Cav1.3 Calcium Channels Arrests Inner Hair Cell Differentiation and Unravels Pitfalls of Conditional Mouse Models

Inner hair cell (IHC) Cav1.3 Ca2+ channels are multifunctional channels mediating Ca2+ influx for exocytosis at ribbon synapses, the generation of Ca2+ action potentials in pre-hearing IHCs and gene expression. IHCs of deaf systemic Cav1.3-deficient (Cav1.3-/-) mice stay immature because they fail to up-regulate voltage- and Ca2+-activated K+ (BK) channels but persistently express small conductance Ca2+-activated K+ (SK2) channels. In pre-hearing wildtype mice, cholinergic neurons from the superior olivary complex (SOC) exert efferent inhibition onto spontaneously active immature IHCs by activating their SK2 channels. Because Cav1.3 plays an important role for survival, health and function of SOC neurons, SK2 channel persistence and lack of BK channels in systemic Cav1.3-/- IHCs may result from malfunctioning neurons of the SOC. Here we analyze cochlea-specific Cav1.3 knockout mice with green fluorescent protein (GFP) switch reporter function, Pax2::cre;Cacna1d-eGFPflex/flexand Pax2::cre;Cacna1d-eGFPflex/-. Profound hearing loss, lack of BK channels and persistence of SK2 channels in Pax2::cre;Cacna1d-eGFPflex/- mice recapitulated the phenotype of systemic Cav1.3-/- mice, indicating that in wildtype mice, regulation of SK2 and BK channel expression is independent of Cav1.3 expression in SOC neurons. In addition, we noticed dose-dependent GFP toxicity leading to death of basal coil IHCs of Pax2::cre;Cacna1d-eGFPflex/flex mice, likely because of high GFP concentration and small repair capacity. This and the slower time course of Pax2-driven Cre recombinase in switching two rather than one Cacna1d-eGFPflex allele lead us to study Pax2::cre;Cacna1d-eGFPflex/- mice. Notably, control Cacna1d-eGFPflex/- IHCs showed a significant reduction in Cav1.3 channel cluster sizes and currents, suggesting that the intronic construct interfered with gene translation or splicing. These pitfalls are likely to be a frequent problem of many genetically modified mice with complex or multiple gene-targeting constructs or fluorescent proteins. Great caution and appropriate controls are therefore required

ADAM23 is a common risk gene for canine idiopathic epilepsy

Background: Idiopathic or genetic adult-onset epilepsy is a common neurological disorder in domestic dogs. Genetic association has been reported only with ADAM23 on CFA 37 in few breeds. To identify novel epilepsy genes, we performed genome-wide association (GWA) analyses in four new breeds, and investigated the association of the previously reported ADAM23 haplotype with the epilepsy phenotype in eight breeds. Results: GWA analysis did not reveal new epilepsy loci. ADAM23 association (p < 0.05) was identified in five breeds. Combined analysis of all eight breeds showed significant association (p = 4.6e(-6), OR 1.9). Conclusions: Our results further support the role of ADAM23 in multiple breeds as a common risk gene for epilepsy with low penetrance. The lack of findings in the GWA analyses points towards inefficient capture of genetic variation by the current SNP arrays, causal variant(s) with low penetrance and possible phenocopies. Future work will include studies on ADAM23 function and expression in canine neurons, as well as whole-genome sequencing in order to identify additional IE genes

Trace Metals and Their Isotopes in the Tropical Atlantic Ocean - Cruise No. M81/1, February 04 – March 08, 2010, Las Palmas (Canary Islands, Spain) – Port of Spain (Trinidad & Tobago)

Summary Meteor Cruise M81/1 was dedicated to the investigation of the distribution of dissolved and particulate trace metals and their isotopic compositions (TEIs) in the full water column of the tropical Atlantic Ocean and their driving factors including main external inputs and internal cycling and ocean circulation. The research program is embedded in the international GEOTRACES program (e.g. Henderson et al., 2007), which this cruise was an official part of and thus corresponds to GEOTRACES cruise GA11. This cruise was completely dedicated to the trace metal clean and contamination-free sampling of waters and particulates for subsequent analyses of the TEIs in the home laboratories of the national and international participants. Besides a standard rosette for the less contaminant prone metals, trace metal clean sampling was realized by using a dedicated and coated trace metal clean rosette equipped with Teflon-coated GO-FLO bottles operated via a polyester coated cable from a mobile winch that was thankfully made available by the U.S. partners of the GEOTRACES program for this cruise. The particulate samples were also collected under trace metal clean conditions using established in-situ pump systems. The cruise track led the cruise southward from the Canary Islands to 11°S and then continued northwestward along the northern margin of South America until it reached Port of Spain, Trinidad & Tobago. The track crossed areas of major external inputs including exchange with the volcanic Canary Islands, the Saharan dust plume, as well as the plume of the Amazon outflow. In terms of internal cycling the equatorial high biological productivity band, as well as increased productivity associated with the Amazon Plume were covered. All major water masses contributing the Atlantic Meridional Overturning Circulation, as well as the distinct narrow equatorial surface and subsurface east-west current bands were sampled. A total of 17 deep stations were sampled for the different dissolved TEIs, which were in most cases accompanied by particulate sampling. In addition, surface waters were continuously sampled under trace metal clean conditions using a towed fish

Low Penetrance, Broad Resistance, and Favorable Outcome of Interleukin 12 Receptor β1 Deficiency: Medical and Immunological Implications

The clinical phenotype of interleukin 12 receptor β1 chain (IL-12Rβ1) deficiency and the function of human IL-12 in host defense remain largely unknown, due to the small number of patients reported. We now report 41 patients with complete IL-12Rβ1 deficiency from 17 countries. The only opportunistic infections observed, in 34 patients, were of childhood onset and caused by weakly virulent Salmonella or Mycobacteria (Bacille Calmette-Guérin -BCG- and environmental Mycobacteria). Three patients had clinical tuberculosis, one of whom also had salmonellosis. Unlike salmonellosis, mycobacterial infections did not recur. BCG inoculation and BCG disease were both effective against subsequent environmental mycobacteriosis, but not against salmonellosis. Excluding the probands, seven of the 12 affected siblings have remained free of case-definition opportunistic infection. Finally, only five deaths occurred in childhood, and the remaining 36 patients are alive and well. Thus, a diagnosis of IL-12Rβ1 deficiency should be considered in children with opportunistic mycobacteriosis or salmonellosis; healthy siblings of probands and selected cases of tuberculosis should also be investigated. The overall prognosis is good due to broad resistance to infection and the low penetrance and favorable outcome of infections. Unexpectedly, human IL-12 is redundant in protective immunity against most microorganisms other than Mycobacteria and Salmonella. Moreover, IL-12 is redundant for primary immunity to Mycobacteria and Salmonella in many individuals and for secondary immunity to Mycobacteria but not to Salmonella in most

Safety and clinical outcomes of rituximab therapy in patients with different autoimmune diseases: experience from a national registry (GRAID)

Introduction: Evidence from a number of open-label, uncontrolled studies has suggested that rituximab may benefit patients with autoimmune diseases who are refractory to standard-of-care. The objective of this study was to evaluate the safety and clinical outcomes of rituximab in several standard-of-care-refractory autoimmune diseases (within rheumatology, nephrology, dermatology and neurology) other than rheumatoid arthritis or non-Hodgkin's lymphoma in a real-life clinical setting. Methods: Patients who received rituximab having shown an inadequate response to standard-of-care had their safety and clinical outcomes data retrospectively analysed as part of the German Registry of Autoimmune Diseases. The main outcome measures were safety and clinical response, as judged at the discretion of the investigators. Results: A total of 370 patients (299 patient-years) with various autoimmune diseases (23.0% with systemic lupus erythematosus, 15.7% antineutrophil cytoplasmic antibody-associated granulomatous vasculitides, 15.1% multiple sclerosis and 10.0% pemphigus) from 42 centres received a mean dose of 2,440 mg of rituximab over a median (range) of 194 (180 to 1,407) days. The overall rate of serious infections was 5.3 per 100 patient-years during rituximab therapy. Opportunistic infections were infrequent across the whole study population, and mostly occurred in patients with systemic lupus erythematosus. There were 11 deaths (3.0% of patients) after rituximab treatment (mean 11.6 months after first infusion, range 0.8 to 31.3 months), with most of the deaths caused by infections. Overall (n = 293), 13.3% of patients showed no response, 45.1% showed a partial response and 41.6% showed a complete response. Responses were also reflected by reduced use of glucocorticoids and various immunosuppressives during rituximab therapy and follow-up compared with before rituximab. Rituximab generally had a positive effect on patient well-being (physician's visual analogue scale; mean improvement from baseline of 12.1 mm). Conclusions: Data from this registry indicate that rituximab is a commonly employed, well-tolerated therapy with potential beneficial effects in standard of care-refractory autoimmune diseases, and support the results from other open-label, uncontrolled studies