Systematic review of Lamendin’s dental age estimation method

Aim: determine the effectiveness of Lamendin’s method of age estimation, by conducting a systematic review. Methods: for the meta-analysis, we researched studies with the aim of showing the effectiveness of the method by comparing the chronological and estimated ages of the sample. Three database were consulted (MEDLINE, LILACS and EMBASE). We excluded studies with historical samples, those that changed the technique, analyzed other aspects of the method without presenting results on effectiveness, and that presented the sample in a single group with individuals under 25 years of age. The quality evidence scale QUADAS was used with some modifications. The final sample consisted of eight studies. Results: the results showed that the studies identified could be methodologically careless and that the method was ineffective in the elderly, but produced good estimates for adults in other age-ranges. There are discrepancies in the literature as regards the age at which the method works best. Relevance: Lamendin technique studies should have a stricter methodological approach and the technique should be tested before being used in a given population, in order to verify the age at which the results are more accurate

Currículo e MST: conflitos de saberes e estratégias na produção de sujeitos

Este artigo trata dos conflitos em torno dos saberes disponibilizados nos currículos de duas escolas do Movimento dos Trabalhadores Rurais Sem Terra (MST) e das estratégias ali inscritas para a produção de sujeitos. Insere-se no campo do currículo na vertente pós-crítica, incorporando ferramentas conceituais dos Estudos Culturais e dos estudos de Michel Foucault. O argumento desenvolvido é o de que apesar de as relações de poder-saber forjadas no currículo das escolas investigadas serem marcadas pela presença predominante dos conhecimentos autorizados, há ali um esforço de ensinar outros saberes que contribuem para disponibilizar algumas posições de sujeito que são de importância estratégica para a produção do sujeito Sem Terra

an obscure but present danger in regions endemic for Dengue and Chikungunya viruses

BACKGROUND: The impact of SARS-CoV-2 in regions endemic for both Dengue and Chikungunya is still not fully understood. Considering that symptoms/clinical features displayed during Dengue, Chikungunya and SARS-CoV-2 acute infections are similar, undiagnosed cases of SARS-CoV-2 in co-endemic areas may be more prevalent than expected. This study was conducted to assess the prevalence of covert cases of SARS-CoV-2 among samples from patients with clinical symptoms compatible with either Dengue or Chikungunya viral infection in the state of Espírito Santo, Brazil. METHODS: Presence of immunoglobulin G (IgG) antibody specific to SARS-CoV-2 nucleoprotein was detected using a chemiluminescent microparticle immunoassay in samples from 7,370 patients, without previous history of COVID-19 diagnosis, suspected of having either Dengue (n = 1,700) or Chikungunya (n = 7,349) from December 1st, 2019 to June 30th, 2020. FINDINGS: Covert cases of SARS-CoV-2 were detected in 210 (2.85%) out of the 7,370 serum samples tested. The earliest undiagnosed missed case of COVID-19 dated back to a sample collected on December 18, 2019, also positive for Dengue Virus. Cross-reactivity with either Dengue virus or other common coronaviruses were not observed. INTERPRETATION: Our findings demonstrate that concomitant Dengue or Chikungunya outbreaks may difficult the diagnosis of SARS-CoV-2 infections. To our knowledge, this is the first study to demonstrate, with a robust sample size (n = 7,370) and using highly specific and sensitive chemiluminescent microparticle immunoassay method, that covert SARS-CoV-2 infections are more frequent than previously expected in Dengue and Chikungunya hyperendemic regions. Moreover, our results suggest that SAR-CoV-2 cases were occurring prior to February, 2020, and that these undiagnosed missed cases may have contributed to the fast expansion of SARS-CoV-2 outbreak in Brazil. Data presented here demonstrate that in arboviral endemic regions, SARS-CoV-2 infection must be always considered, regardless of the existence of a previous positive diagnosis for Dengue or Chikungunya.publishersversionpublishe

Liver transplant after SARS-CoV-2 infection: A systematic review

Background: The Coronavirus 19 (COVID-19) pandemic has dramatically impacted liver organ transplantation. The American Society of Transplantation recommends a minimum of 28 days after symptom resolution for organ donation. However, the exact time for transplantation for recipients is unknown. Considering that mortality on the waiting list for patients with MELD >25 or fulminant hepatitis is higher than that of COVID-19, the best time for surgery after SARS-CoV-2 infection remains undetermined. This study aims to expand the current knowledge regarding the Liver Transplantation (LT) time for patients after COVID-19 and to provide transplant physicians with essential decision-making tools to manage these critically ill patients during the pandemic. Methods: Systematic review of patients who underwent liver transplantation after diagnosis of COVID-19. The MEDLINE, PubMed, Cochrane, Lilacs, Embase, and Scielo databases were searched until June 20, 2021. The MESH terms used were “COVID-19” and “Liver transplantation”. Results: 558 articles were found; of these 13 articles and a total of 18 cases of COVID-19 prior to liver transplantation were reported. The mean age was 38.7±14.6, with male prevalence. Most had mild symptoms of COVID. Five patients have specific treatment for COVID-19 with convalescent plasm or remdesivir/oseltamivir, just one patient received hydroxychloroquine, and 12 patients received only symptomatic treatment. The median time between COVID-19 to LT was 19 days (13.5‒44.5). Deceased donor liver transplantation accounted for 61% of cases, while living donor transplantation was 39%. Conclusion: Despite the concerns regarding the postoperative evolution, the mortality of patients with high MELD or fulminant hepatitis transplanted shortly after COVID-19 diagnosis does not seem to be higher. (PROSPERO, registration number = CRD42021261790

Giant hepatic extra-gastrointestinal stromal tumor treated with cytoreductive surgery and adjuvant systemic therapy : a case report and review of literature

BACKGROUND Primary extra-gastrointestinal stromal tumors (E-GIST) of the liver are rare. The clinical presentation may range from asymptomatic to bleeding or manifestations of mass effect. Oncologic surgery followed by adjuvant therapy with imatinib is the standard of care. However, under specific circumstances, a cytoreductive approach may represent a therapeutic option. We describe herein the case of an 84-year-old woman who presented with a tender, protruding epigastric mass. Abdominal computed tomography scan revealed a large, heterogeneous mass located across segments III, IV, V, and VIII of the liver. The initial approach was transarterial embolization of the tumor, which elicited no appreciable response. Considering the large size and central location of the tumor and the advanced age of the patient, non-anatomic complete resection was indicated. Due to substantial intraoperative bleeding and hemodynamic instability, only a near-complete resection could be achieved. Histopathology and immunohistochemical staining confirmed the diagnosis of primary E-GIST of the liver. Considering the risk/benefit ratio for therapeutic options, debulking surgery may represent a strategy to control pain and prolong survival. CASE SUMMARY Here, we present a case report of a patient diagnosed with E-GIST primary of the liver, which was indicated a cytoreductive surgery and adjuvant therapy with imatinib. CONCLUSION E-GIST primary of the liver is a rare conditional, the treatment is with systemic therapy and total resection surgery. However, a cytoreductive surgery will be necessary when a complete resection is no possible

LA SUINCULTURA DE SUBSISTENCIA COMO UNA ALTERNATIVA DE GENERACIÓN DE INGRESOS EN LAS SERTÃO DE PARAÍBA: UN ESTUDIO DE CASO

No Nordeste é habitual suinocultura de subsistência, porém, sabe-se pouco sobre aspectos socioeconômicos. Objetivou-se avaliar a importância socioeconômica da criação de suínos para criadores urbanos, bem como analisar o manejo empregado e os impactos que uma criação extensiva de animais pode causar. A pesquisa foi desenvolvida no município de Pombal, Paraíba, aplicando um questionário semiestruturado para 55 produtores de suínos da região. Os dados obtidos foram utilizados para traçar o perfil socioeconômico e ambiental das produções. Observou-se que a faixa etária dos criadores varia de 25 a 63 anos, 71,8% são do sexo masculino e 28,2% do sexo feminino, 44,7% são analfabetos ou semianalfabetos. O tempo médio de criação de suínos é de 2 a 4 anos, 61,73% dos criadores fornecem restos de comida como única alimentação. Quanto às dejeções dos suínos, não existe manejo adequado em 100% das instalações, prejudicando as propriedades químicas e biológicas do solo e da água. A falta de assistência técnica e de políticas públicas eficazes faz com que a criação de suínos se torne uma ameaça ao meio ambiente e a própria saúde. Portanto, a infraestrutura da pocilga comunitária dos criadores de suínos de Pombal-PB não atende aos requisitos mínimos de bem estar animal

Desafios do impresso ao digital: questões contemporâneas de informação e conhecimento

428 p., il. ; Documento TécnicoEsta publicação, como o próprio título traduz, concentra o seu foco em temas emergentes da sociedade da informação e do conhecimento, na qual, pelo impulso das tecnologias de informação e comunicação (TICs) e da globalização, informação e conhecimento são potencializados e assumem novo papel no mundo contemporâneo. Um dos objetivos desta coletânea é propiciar, aos interessados e estudiosos de questões de informação e conhecimento, uma perspectiva abrangente, às vezes instigante e não convencional de alguns de seus aspectos.UNESC

Diagnóstico laboratorial para identificação da Leucemia Mieloide Aguda através da técnica de imunofenotipagem

Leucemia mieloide aguda (LMA) consiste em uma neoplasia maligna das células do tecido hematopoiético com proliferação clonal, bloqueio maturativo das células e substituição difusa da medula óssea por células neoplásicas. Via de regra, metade das pessoas acometidas pela LMA manifesta os sintomas três meses antes de a doença ser de fato diagnosticada e, diante disso, a imunofenotipagem se torna atraente, pois, além de ser uma metodologia ágil para ser incorporada na prática médica de rotina, é uma metodologia direcionada à caracterização fenotípica de células e capaz de revelar informações importantes para o diagnóstico, como o estágio de maturação das populações celulares analisadas, a presença de células com fenótipo significativamente anormal, além de avaliar a presença de marcadores associados ao prognóstico ou até mesmo que são alvos terapêuticos. O presente trabalho visa compilar e analisar as principais características da patologia e do diagnóstico da LMA por imunofenotipagem abordadas em livros científicos e artigos acadêmicos