55 research outputs found
Impacto de la geometrĂa del septo en el fenĂłmeno de succiĂłn del ventrĂculo derecho
El impacto del fenĂłmeno de interdependencia ventricular en la funciĂłn diastĂłlica del VD no es bien conocido. El VD es capaz de facilitar el llenado generando presiĂłn (P) negativa al inicio de la diĂĄstole pero los mecanismos implicados en este fenĂłmeno estĂĄn aĂșn por dilucidar. Nos propusimos analizar la contribuciĂłn de las fuerzas de retroceso elĂĄstico al llenado del VD y su relaciĂłn con la geometrĂa del septo
Variation in Nicotine Metabolization According to Biological Factors and Type of Nicotine Consumer
This study aims to describe the nicotine metabolite ratio among tobacco smokers and electronic cigarette (e-cigarette) users and nonusers. We analyzed pooled data from a longitudinal and a cross-sectional study of the adult population from the city of Barcelona. The final sample included information on 166 smokers, 164 e-cigarettes users with nicotine, 41 e-cigarette users without nicotine, 95 dual users (users of both products), and 508 nonusers. We used log-linear models to control for the potential confounding effect of the daily number of cigarettes smoked. Salivary nicotine metabolic rate assessment included the rate of nicotine metabolism (cotinine/nicotine) and the nicotine metabolite ratio (trans-3âČ-hydroxycotinine/cotinine). Exclusive users of e-cigarette without nicotine have the lowest rate of nicotine metabolism (Geometric mean: 0.08, p-values < 0.001) while cigarette smokers have the highest (Geometric mean: 2.08, p-values < 0.001). Nonusers have lower nicotine metabolic rate than cigarette smokers (Geometric means: 0.23 vs. 0.18, p-value < 0.05). Younger individuals (18â44 years) have a higher rate of nicotine metabolism than older individuals (45â64 years and 65â89) (Geometric means: 0.53 vs. 0.42 and 0.31, respectively, p-values < 0.01) and individuals with lower body mass index (21â25 kg/m2) have a higher rate of nicotine metabolism than the rest (26â30 kg/m2 and 31â60 kg/m2) (Geometric means: 0.52 vs. 0.35 and 0.36, respectively-values < 0.01). Nicotine metabolic rates are useful biomarkers when reporting smoking status and biological differences between individuals
Assessment of diastolic chamber properties of the right ventricle by global fitting of pressure-volume data and conformational analysis of 3D + T echocardiographic sequences
Assessment of diastolic chamber properties of the right ventricle by global fitting of pressure-volume data and conformational analysis of 3D + T echocardiographic sequence
Mortonâs Extension on Hallux Rigidus Pathology
Study design, case-control study: Background, Mortonâs extension (ME) is a kind of orthotic
that has been used as a conservative treatment of painful hallux rigidus (HR) osteoarthritis, but only
their effects on first metatarsophalangeal joint (MPJ) mobility and position in healthy subjects have
been studied, but not on its applied pulled tension forces neither in subjects with HR. Objectives:
This study sought to understand how MEâs orthotics with three different thicknesses could influence
the kinematic first MPJ by measuring hallux dorsiflexion using Jackâs test and a digital algometer
with a rigid strip anchored to the iron hookâs extremity and comparing subjects with healthy first
MPJ mobility to those with HR.We aimed to clarify whether tension values were different between
healthy and HR subjects. Methods: Fifty-eight subjects were selected, of whom thirty were included
in the case group according to HR criteria and twenty-eight were included in the control group. A
digital algometer (FPXŸŸ 25,Wagner InstrumentsŸŸ, Greenwich, CT, USA) was used to assess the
pulled tension values (kgf) of the first MPJ during Jackâs test. Results: The pulled tension values were
highly reliable (ICC > 0.963). There were no statistically significant differences between the pulled
tension values for the different ME conditions in the case (p = 0.969) or control (p = 0.718) groups.
However, as itâs expected, there were statistically significant differences comparing all pulled tension
values between case and control group subjects (p < 0.001). Conclusions: Different MEâs thicknesses
had no influence on the pulled effort applied during the dorsiflexion Jackâs test between the healthy
and HR groups; therefore, it can be prescribed without joint-care danger. In addition, it is proven
that there is greater resistance to performing Jackâs test in the HR group than in the healthy group,
regardless of MEâs orthotics. Furthermore, it is shown that the digital algometer device is a valid tool
to detect the first MPJ restriction and is more reliable than other tests
Development of Proteomics-Based Fungicides: New Strategies for Environmentally Friendly Control of Fungal Plant Diseases
Proteomics has become one of the most relevant high-throughput technologies. Several approaches have been used for studying, for example, tumor development, biomarker discovery, or microbiology. In this âpost-genomicâ era, the relevance of these studies has been highlighted as the phenotypes determined by the proteins and not by the genotypes encoding them that is responsible for the final phenotypes. One of the most interesting outcomes of these technologies is the design of new drugs, due to the discovery of new disease factors that may be candidates for new therapeutic targets. To our knowledge, no commercial fungicides have been developed from targeted molecular research, this review will shed some light on future prospects. We will summarize previous research efforts and discuss future innovations, focused on the fight against one of the main agents causing a devastating crops disease, fungal phytopathogens
Compilation of parameterized seismogenic sources in Iberia for the SHARE European-scale seismic source model.
Abstract: SHARE (Seismic Hazard Harmonization in Europe) is an EC-funded project (FP7) that aims to evaluate European seismic hazards using an integrated, standardized approach. In the context of SHARE, we are compiling a fully-parameterized active fault database for Iberia and the nearby offshore region. The principal goal of this initiative is for fault sources in the Iberian region to be represented in SHARE and incorporated into the source model that will be used to produce seismic hazard maps at the European scale. The SHARE project relies heavily on input from many regional experts throughout the Euro-Mediterranean region. At the SHARE regional meeting for Iberia, the 2010 Working Group on Iberian Seismogenic Sources (WGISS) was established; these researchers are contributing to this large effort by providing their data to the Iberian regional integrators in a standardized format. The development of the SHARE Iberian active fault database is occurring in parallel with IBERFAULT, another ongoing effort to compile a database of active faults in the Iberian region.
The SHARE Iberian active fault database synthesizes a wide range of geological and geophysical observations on active seismogenic sources, and incorporates existing compilations (e.g., Cabral, 1995; Silva et al., 2008), original data contributed directly from researchers, data compiled from the literature, parameters estimated using empirical and analytical relationships, and, where necessary, parameters derived using expert judgment. The Iberian seismogenic source model derived for SHARE will be the first regional-scale source model for Iberia that includes fault data and follows an internationally standardized approach (Basili et al., 2008; 2009). This model can be used in both seismic hazard and risk analyses and will be appropriate for use in Iberian- and European-scale assessments
CSVS, a crowdsourcing database of the Spanish population genetic variability
The knowledge of the genetic variability of the local
population is of utmost importance in personalized
medicine and has been revealed as a critical
factor for the discovery of new disease variants.
Here, we present the Collaborative Spanish
Variability Server (CSVS), which currently contains
more than 2000 genomes and exomes of unrelated Spanish individuals. This database has been generated
in a collaborative crowdsourcing effort collecting
sequencing data produced by local genomic
projects and for other purposes. Sequences have
been grouped by ICD10 upper categories. A web interface
allows querying the database removing one
or more ICD10 categories. In this way, aggregated
counts of allele frequencies of the pseudo-control
Spanish population can be obtained for diseases belonging
to the category removed. Interestingly, in addition
to pseudo-control studies, some population
studies can be made, as, for example, prevalence of
pharmacogenomic variants, etc. In addition, this genomic
data has been used to define the first Spanish
Genome Reference Panel (SGRP1.0) for imputation.
This is the first local repository of variability entirely
produced by a crowdsourcing effort and constitutes
an example for future initiatives to characterize local
variabilityworldwide. CSVS is also part of the GA4GH
Beacon network.Spanish Ministry of Economy and Competitiveness
SAF2017-88908-R
PT17/0009/0006
PI19/00321
CIBERER ACCI-06/07/0036
PI14-948
PI171659Regional Government of Madrid, RAREGenomicsCM
B2017/BMD3721
B2017/BMD-3721European Union (EU)European Union (EU)
676559University Chair UAM-IIS-FJD of Genomic MedicineRamon Areces Foundatio
Detection of High Level of Co-Infection and the Emergence of Novel SARS CoV-2 Delta-Omicron and Omicron-Omicron Recombinants in the Epidemiological Surveillance of Andalusia
Recombination is an evolutionary strategy to quickly acquire new viral properties inherited from the parental lineages. The systematic survey of the SARS-CoV-2 genome sequences of the Andalusian genomic surveillance strategy has allowed the detection of an unexpectedly high number of co-infections, which constitute the ideal scenario for the emergence of new recombinants. Whole genome sequence of SARS-CoV-2 has been carried out as part of the genomic surveillance programme. Sample sources included the main hospitals in the Andalusia region. In addition to the increase of co-infections and known recombinants, three novel SARS-CoV-2 delta-omicron and omicron-omicron recombinant variants with two break points have been detected. Our observations document an epidemiological scenario in which co-infection and recombination are detected more frequently. Finally, we describe a family case in which co-infection is followed by the detection of a recombinant made from the two co-infecting variants. This increased number of recombinants raises the risk of emergence of recombinant variants with increased transmissibility and pathogenicity.This research was funded by Spanish Ministry of Science and Innovation (grant PID2020-117979RB-I00), the Instituto de Salud Carlos III (ISCIII), co-funded with European Regional Development Funds (ERDF) (grant IMP/00019), and has also been funded by ConsejerĂa de Salud y Familias, Junta de AndalucĂa (grants COVID-0012-2020, PS-2020-342 and IE19_259 FPS).Peer reviewe
Compilation of parameterized seismogenic sources in Iberia for the SHARE European-scale seismic source model
Jardins per a la salut
Facultat de FarmĂ cia, Universitat de Barcelona. Ensenyament: Grau de FarmĂ cia. Assignatura: BotĂ nica farmacĂšutica. Curs: 2014-2015. Coordinadors: Joan Simon, CĂšsar BlanchĂ© i Maria Bosch.Els materials que aquĂ es presenten sĂłn el recull de les fitxes botĂ niques de 128 espĂšcies presents en el JardĂ Ferran Soldevila de lâEdifici HistĂČric de la UB. Els treballs han estat realitzats manera individual per part dels estudiants dels grups M-3 i T-1 de lâassignatura BotĂ nica FarmacĂšutica durant els mesos de febrer a maig del curs 2014-15 com a resultat final del Projecte dâInnovaciĂł Docent «Jardins per a la salut: aprenentatge servei a BotĂ nica farmacĂšutica» (codi 2014PID-UB/054). Tots els treballs sâhan dut a terme a travĂ©s de la plataforma de GoogleDocs i han estat tutoritzats pels professors de lâassignatura. Lâobjectiu principal de lâactivitat ha estat fomentar lâaprenentatge autĂČnom i col·laboratiu en BotĂ nica farmacĂšutica. TambĂ© sâha pretĂšs motivar els estudiants a travĂ©s del retorn de part del seu esforç a la societat a travĂ©s dâuna experiĂšncia dâAprenentatge-Servei, deixant disponible finalment el treball dels estudiants per a poder ser consultable a travĂ©s dâuna Web pĂșblica amb la possibilitat de poder-ho fer in-situ en el propi jardĂ mitjançant codis QR amb un smartphone
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