39 research outputs found
Editorial: public health pharmacogenomics and the design principles for global public goods – moving genomics to responsible innovation
- Author
- Publication venue
- 'Bentham Science Publishers Ltd.'
- Publication date
- 01/03/2013
- Field of study
The James Webb Space Telescope Mission
- Author
- Abbott Randy
- Abell James S.
- Abernathy Mark
- Abney Faith E.
- Abraham John G.
- Abraham Roberto
- Abul-Huda Yasin M.
- Acton Scott
- Adams Cynthia K.
- Adams Evan
- Adler David S.
- Adriaensen Maarten
- Aguilar Jonathan Albert
- Ahmed Mansoor
- Ahmed Nasif S.
- Ahmed Tanjira
- Alarcon Rafael Ramos
- Albat Rüdeger
- Albert Loïc
- Alberts Stacey
- Aldridge David
- Allen Mary Marsha
- Allen Shaune S.
- Altenburg Martin
- Altunc Serhat
- Alvarez Jose Lorenzo
- Ambrose Leslie L.
- Anandakrishnan Satya M.
- Andersen Gregory C.
- Anderson Harry James
- Anderson Jay
- Anderson Kristen
- Anderson Sara M.
- Aprea Julio
- Archer Benita J.
- Arenberg Jonathan W.
- Argyriou Ioannis
- Arribas Santiago
- Artigau Étienne
- Arvai Amanda Rose
- Atcheson Paul
- Atkinson Charles B.
- Averbukh Jesse
- Aymergen Cagatay
- Bacinski John J.
- Baggett Wayne E.
- Bagnasco Giorgio
- Baker Lynn L.
- Balzano Vicki Ann
- Banks Kimberly A.
- Baran David A.
- Barker Elizabeth A.
- Barrett Larry K.
- Barringer Bruce O.
- Barto Allison
- Bast William
- Baudoz Pierre
- Baum Stefi
- Beatty Thomas G.
- Beaulieu Mathilde
- Bechtold Kathryn
- Beck Tracy
- Beddard Megan M.
- Beichman Charles
- Bellagama Larry
- Bely Pierre
- Berger Timothy W.
- Bergeron Louis E.
- Bertch Maria D.
- Beskow Charlotte
- Betz Laura E.
- Biagetti Carl P.
- Birkmann Stephan
- Bjorklund Kurt F.
- Blackwood James D.
- Blazek Ronald Paul
- Blossfeld Stephen
- Bluth Marcel
- Boccaletti Anthony
- Boegner Jr. Martin E.
- Bohlin Ralph C.
- Boia John Joseph
- Bonaventura N.
- Bond Nicholas A.
- Bosley Kari Ann
- Boucarut Rene A.
- Bouchet Patrice
- Bouwman Jeroen
- Bower Gary
- Bowers Ariel S.
- Bowers Charles W.
- Boyce Leslye A.
- Boyer Christine T.
- Boyer Martha L.
- Boyer Michael
- Boyer Robert
- Bradley Larry D.
- Brady Gregory R.
- Brandl Bernhard R.
- Brannen Judith L.
- Breda David
- Bremmer Harold G.
- Brennan David
- Bresnahan Pamela A.
- Bright Stacey N.
- Broiles Brian J.
- Bromenschenkel Asa
- Brooks Brian H.
- Brooks Keira J.
- Brown Bob
- Brown Bruce
- Brown Thomas M.
- Bruce Barry W.
- Bryson Jonathan G.
- Bujanda Edwin D.
- Bullock Blake M.
- Bunker A. J.
- Bureo Rafael
- Burt Irving J.
- Bush James Aaron
- Bushouse Howard A.
- Bussman Marie C.
- Böker Torsten
- Cabaud Olivier
- Cale Steven
- Calhoon Charles D.
- Calvani Humberto
- Canipe Alicia M.
- Caputo Francis M.
- Cara Mihai
- Carey Larkin
- Case Michael Eli
- Cesari Thaddeus
- Cetorelli Lee D.
- Chance Don R.
- Chandler Lynn
- Chaney Dave
- Chapman George N.
- Charlot S.
- Chayer Pierre
- Cheezum Jeffrey I.
- Chen Bin
- Chen Christine H.
- Cherinka Brian
- Chichester Sarah C.
- Chilton Zachary S.
- Chittiraibalan Dharini
- Clampin Mark
- Clark Charles R.
- Clark Kerry W.
- Clark Stephanie M.
- Claybrooks Edward E.
- Cleveland Keith A.
- Cohen Andrew L.
- Cohen Lester M.
- Coleman Benee L.
- Colina Luis
- Colón Knicole D.
- Comber Brian J.
- Comeau Thomas M.
- Comer Thomas
- Connolly Dennis C.
- Conroy Kyle E.
- Contos Adam R.
- Contreras James
- Cook Neil J.
- Cooper James L.
- Cooper Rachel Aviva
- Correia Michael F.
- Correnti Matteo
- Cossou Christophe
- Costanza Brian F.
- Costas Maria Begoña Vila
- Coulais Alain
- Cox Colin R.
- Coyle Ray T.
- Cracraft Misty M.
- Crew Keith A.
- Curtis Gary J.
- Cusveller Bianca
- Dailey Christopher T.
- Darveau-Bernier Antoine
- Daugeron Frédéric
- Davidson Greg S.
- Davies James E.
- Davis Katherine Anne
- Davis Michael S.
- Day Ratna
- de Chambure Daniel
- de Jong Pauline
- De Marchi Guido
- De Meester Wim
- de Oliveira Catarina Alves
- Dean Bruce H.
- Decker John E.
- del Pino Bruno Rodríguez
- Delisa Amy S.
- Dell Lawrence C.
- Dellagatta Gail
- Dembinska Franciszka
- Demosthenes Sandor
- Dencheva Nadezhda M.
- Deneu Philippe
- DePriest William W.
- Deschenes Jeremy
- Dethienne Nathalie
- Detre Örs Hunor
- Diaz Rosa Izela
- Dicken Daniel
- DiFelice Audrey S.
- Dillman Matthew
- Disharoon Maureen O.
- Dixon William V.
- Doggett Jesse B.
- Dominguez Keisha L.
- Donaldson Thomas S.
- Doria-Warner Cristina M.
- Doty Heather
- Douglas Jr. Robert E.
- Doyon René
- Dressler Alan
- Driggers Jennifer
- Driggers Phillip A.
- Dunn Jamie L.
- DuPrie Kimberly C.
- Dupuis Jean
- Durning John
- Dutta Sanghamitra B.
- Earl Nicholas M.
- Eccleston Paul
- Ecobichon Pascal
- Egami Eiichi
- Ehrenwinkler Ralf
- Eisenhamer Jonathan D.
- Eisenhower Michael
- Eisenstein Daniel J.
- Elie Michelle L.
- Elliott James
- Elliott Kyle Wesley
- Engesser Michael
- Espinoza Néstor
- Etienne Odessa
- Etxaluze Mireya
- Evans Leah
- Fabreguettes Luce
- Falcolini Massimo
- Falini Patrick R.
- Fatig Curtis
- Feeney Matthew
- Feinberg Lee D.
- Fels Raymond
- Ferdous Nazma
- Ferguson Henry C.
- Ferrarese Laura
- Ferreira Marie-Héléne
- Ferruit Pierre
- Ferry Malcolm
- Filippazzo Joseph Charles
- Firre Daniel
- Fix Mees
- Flagey Nicolas
- Flanagan Kathryn A.
- Fleming Scott W.
- Florian Michael
- Flynn James R.
- Foiadelli Luca
- Fontaine Mark R.
- Fontanella Erin Marie
- Forshay Peter Randolph
- Fortner Elizabeth A.
- Fox Ori D.
- Framarini Alexandro P.
- Francisco John I.
- Franck Randy
- Franx Marijn
- Franz David E.
- Friedman Scott D.
- Friend Katheryn E.
- Frost James R.
- Fu Henry
- Fullerton Alexander W.
- Gaillard Lionel
- Galkin Sergey
- Gallagher Ben
- Galyer Anthony D.
- Gardner Jonathan P.
- Gardner Lisa E.
- Garland Dennis
- Garrett Bruce Albert
- Gasman Danny
- Gastaud René
- Gaudreau Daniel
- Gauthier Peter Timothy
- Geers Vincent
- Geithner Paul H.
- Gennaro Mario
- Gerber John
- Gereau John C.
- Giampaoli Robert
- Giardino Giovanna
- Gibbons Paul C.
- Gilbert Karolina
- Gilman Larry
- Girard Julien H.
- Giuliano Mark E.
- Gkountis Konstantinos
- Glasse Alistair
- Glassmire Kirk Zachary
- Glauser Adrian Michael
- Glazer Stuart D.
- Goldberg Joshua
- Golimowski David A.
- Gonzaga Shireen P.
- Gordon Karl D.
- Gordon Shawn J.
- Goudfrooij Paul
- Gough Michael J.
- Graham Adrian J.
- Grau Christopher M.
- Green Joel David
- Greene Gretchen R.
- Greene Thomas P.
- Greenfield Perry E.
- Greenhouse Matthew A.
- Greve Thomas R.
- Greville Edgar M.
- Grimaldi Stefano
- Groe Frank E.
- Groebner Andrew
- Grumm David M.
- Grundy Timothy
- Guillard Pierre
- Guldalian John
- Gunn Christopher A.
- Gurule Anthony
- Gutman Irvin Meyer
- Guy Paul D.
- Guyot Benjamin
- Gáspár András
- Güdel Manuel
- Hack Warren J.
- Haderlein Peter
- Hagan James B.
- Hagedorn Andria
- Hainline Kevin
- Haley Craig
- Hamel Zaky El
- Hami Maryam
- Hamilton Forrest Clifford
- Hammann Jeffrey
- Hammel Heidi B.
- Hanley Christopher J.
- Hansen Carl August
- Hardy Bruce
- Harnisch Bernd
- Harr Michael Hunter
- Harris Pamela
- Hart Jessica Ann
- Hartig George F.
- Hasan Hashima
- Hashim Kathleen Marie
- Hashimoto Ryan
- Haskins Sujee J.
- Hawkins Robert Edward
- Hayden Brian
- Hayden William L.
- Healy Mike
- Hecht Karen
- Heeg Vince J.
- Hejal Reem
- Helm Kristopher A.
- Hengemihle Nicholas J.
- Henning Thomas
- Henry Alaina
- Henry Ronald L.
- Henshaw Katherine
- Hernandez Scarlin
- Herrington Donald C.
- Heske Astrid
- Hesman Brigette Emily
- Hickey David L.
- Hilbert Bryan N.
- Hines Dean C.
- Hinz Michael R.
- Hirsch Michael
- Hitcho Robert S.
- Hodapp Klaus
- Hodge Philip E.
- Hoffman Melissa
- Holfeltz Sherie T.
- Holler Bryan Jason
- Hoppa Jennifer Rose
- Horner Scott
- Howard Joseph M.
- Howard Richard J.
- Huber Jean M.
- Hunkeler Joseph S.
- Hunter Alexander
- Hunter David Gavin
- Hurd Spencer W.
- Hurst Brendan J.
- Hutchings John B.
- Hylan Jason E.
- Ignat Luminita Ilinca
- Illingworth Garth
- Irish Sandra M.
- Isaacs III John C.
- Jackson Jr. Wallace C.
- Jaffe Daniel T.
- Jahic Jasmin
- Jahromi Amir
- Jakobsen Peter
- James Bryan
- James John C.
- James LeAndrea Rae
- Jamieson William Brian
- Jandra Raymond D.
- Jayawardhana Ray
- Jedrzejewski Robert
- Jeffers Basil S.
- Jensen Peter
- Joanne Egges
- Johns Alan T.
- Johnson Carl A.
- Johnson Eric L.
- Johnson Patricia
- Johnson Phillip Stephen
- Johnson Thomas K.
- Johnson Timothy W.
- Johnstone Doug
- Jollet Delphine
- Jones Danny P.
- Jones Gregory S.
- Jones Olivia C.
- Jones Ronald A.
- Jones Vicki
- Jordan Ian J.
- Jordan Margaret E.
- Jue Reginald
- Jurkowski Mark H.
- Justis Grant
- Justtanont Kay
- Kaleida Catherine C.
- Kalirai Jason S.
- Kalmanson Phillip Cabrales
- Kaltenegger Lisa
- Kammerer Jens
- Kan Samuel K.
- Kanarek Graham Childs
- Kao Shaw-Hong
- Karakla Diane M.
- Karl Hermann
- Kassin Susan A.
- Kauffman David D.
- Kavanagh Patrick
- Kelley Leigh L.
- Kelly Douglas M.
- Kendrew Sarah
- Kennedy Herbert V.
- Kenny Deborah A.
- Keski-Kuha Ritva A.
- Keyes Charles D.
- Khan Ali
- Kidwell Richard C.
- Kimble Randy A.
- King James S.
- King Richard C.
- Kinzel Wayne M.
- Kirk Jeffrey R.
- Kirkpatrick Marc E.
- Klaassen Pamela
- Klingemann Lana
- Klintworth Paul U.
- Knapp Bryan Adam
- Knight Scott
- Knollenberg Perry J.
- Knutsen Daniel Mark
- Koehler Robert
- Koekemoer Anton M.
- Kofler Earl T.
- Kontson Vicki L.
- Kovacs Aiden Rose
- Kozhurina-Platais Vera
- Krause Oliver
- Kriss Gerard A.
- Krist John
- Kristoffersen Monica R.
- Krogel Claudia
- Krueger Anthony P.
- Kulp Bernard A.
- Kumari Nimisha
- Kwan Sandy W.
- Kyprianou Mark
- Labador Aurora Gadiano
- Labiano Álvaro
- Lafrenière David
- Lagage Pierre-Olivier
- Laidler Victoria G.
- Laine Benoit
- Laird Simon
- Lajoie Charles-Philippe
- Lallo Matthew D.
- Lam May Yen
- LaMassa Stephanie Marie
- Lambros Scott D.
- Lampenfield Richard Joseph
- Lander Matthew Ed
- Langston James Hutton
- Larson Kirsten
- Larson Melora
- LaVerghetta Robert Joseph
- Law David R.
- Lawrence Jon F.
- Lee David W.
- Lee Janice
- Lee Yat-Ning Paul
- Leisenring Jarron
- Leveille Michael Dunlap
- Levenson Nancy A.
- Levi Joshua S.
- Levine Marie B.
- Lewis Dan
- Lewis Jake
- Lewis Nikole
- Libralato Mattia
- Lidon Norbert
- Liebrecht Paula Louisa
- Lightsey Paul
- Lilly Simon
- Lim Frederick C.
- Lim Pey Lian
- Ling Sai-Kwong
- Link Lisa J.
- Link Miranda Nicole
- Lipinski Jamie L.
- Litten Oi In Tam
- Liu XiaoLi
- Lo Amy S.
- Lobmeyer Lynette
- Logue Ryan M.
- Long Chris A.
- Long Douglas R.
- Long Ilana D.
- Long Knox S.
- Lotz Jennifer M.
- Love-Pruitt Jennifer M.
- Lubskiy Michael
- Luers Edward B.
- Luetgens Robert A.
- Luevano Annetta J.
- Lui Sarah Marie G. Flores
- Lund III James M.
- Lundquist Ray A.
- Lunine Jonathan
- Lynch Richard J.
- López-Caniego Marcos
- Lützgendorf Nora
- MacDonald Alex J.
- MacDonald Kenneth
- Macias Matthew J.
- Maciel Cleyciane Da Costa
- Macklis Keith I.
- Maghami Peiman
- Maharaja Rishabh Y.
- Maiolino Roberto
- Makrygiannis Konstantinos G.
- Malla Sunita Giri
- Malumuth Eliot M.
- Manjavacas Elena
- Marini Andrea
- Marrione Amanda
- Marston Anthony
- Martel André R
- Martin Didier
- Martin Peter G.
- Martinez Kristin L.
- Marín Macarena García
- Maschmann Marc
- Masci Gregory L.
- Masetti Margaret E.
- Maszkiewicz Michael
- Mather John C.
- Matthews Gary
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- McCarthy Donald W.
- McCaughrean Mark J.
- McClare Leslie A.
- McClare Michael D.
- McCloskey John C.
- McClurg Taylore D.
- McCoy Martin
- McElwain Michael W.
- McGregor Roy D.
- McGuffey Douglas B.
- McKay Andrew G.
- McKenzie William K.
- McLean Brian
- McMaster Matthew
- McNeil Warren
- Mehalick Kimberly L.
- Meixner Margaret
- Meléndez Marcio
- Menzel Michael P.
- Menzel Michael T.
- Merz Matthew
- Mesterharm David D.
- Meyer Michael R.
- Meyett Michele L.
- Meza Luis E.
- Midwinter Calvin
- Milam Stefanie N.
- Miller Jay Todd
- Miller William C.
- Miskey Cherie L.
- Misselt Karl
- Mitchell Eileen P.
- Mohan Martin
- Montoya Emily E.
- Moran Michael J.
- Morishita Takahiro
- Moro-Martín Amaya
- Morrison Debra L.
- Morrison Jane
- Morse Ernie C.
- Moschos Michael
- Moseley S. H.
- Mosier Gary E.
- Mosner Peter
- Mountain Matt
- Muckenthaler Jason S.
- Mueller Donald G.
- Mueller Migo
- Muhiem Daniella
- Mullally Susan Elizabeth
- Mullen Stephanie M.
- Munger Alan J
- Murphy Jess
- Murray Katherine T.
- Muzerolle James C.
- Mycroft Matthew
- Myers Andrew
- Myers Carey R.
- Myers Fred Richard R.
- Myers Richard
- Myrick Kaila
- Mühlmann Prisca
- Nagle IV Adrian F.
- Nayak Omnarayani
- Naylor Bret
- Neff Susan G.
- Neira Irma Aracely Quispe
- Nelan Edmund P.
- Nella John
- Nguyen Duy Tuong
- Nguyen Michael N.
- Nickson Bryony
- Nidhiry John Joseph
- Niedner Malcolm B.
- Nieto-Santisteban Maria
- Nikolov Nikolay K.
- Nishisaka Mary Ann
- Noriega-Crespo Alberto
- Noriega-Crespo Alberto
- Nota Antonella
- O'Brien Marcus B.
- O'Mara Robyn C.
- O'Shaughnessy Brian Patrick
- O'Sullivan Brian
- Oboryshko Michael
- Ochs William R.
- Offenberg Joel D.
- Ogle Patrick Michael
- Ohl Raymond G.
- Olmsted Joseph Hamden
- Osborne Shannon Barbara
- Otor O. Justin
- Ottens Richard
- Ouellette Nathalie N. -Q.
- Outlaw Daria J.
- Owens Beverly A.
- Pacifici Camilla
- Page James Christophe
- Paranilam James G.
- Park Sang
- Parrish Keith A.
- Paschal Laura
- Patapis Polychronis
- Patel Jignasha
- Patrick Keith
- Pattishall Jr. Robert A.
- Paul Douglas William
- Paul Shirley J.
- Pauly Tyler Andrew
- Pavlovsky Cheryl M.
- Pedder Andrew H.
- Peek Matthew Weldon
- Pelham Patricia A.
- Penanen Konstantin
- Perriello Beth A.
- Perrin Marshall D.
- Perrine Richard F.
- Perrygo Chuck
- Peslier Muriel
- Petach Michael
- Peterson Karla A.
- Peña-Guerrero Maria
- Pfarr Tom
- Pierson James M.
- Pietraszkiewicz Martin
- Pilchen Guy
- Pipher Judy L.
- Pirzkal Norbert
- Pitman Joseph T.
- Plate Maurice te
- Player Danielle M.
- Plesha Rachel
- Plitzke Anja
- Pohner John A.
- Poletis Karyn Konstantin
- Pollizzi Joseph A.
- Polster Ethan
- Pontius James T.
- Pontoppidan Klaus
- Porges Susana C.
- Potter Gregg D.
- Prescott Stephen
- Proffitt Charles R.
- Pueyo Laurent
- Radich Armando
- Rager Reiko T.
- Rameau Julien
- Ramey Deborah D.
- Rampini Riccardo
- Rapp Robert
- Rashford Robert A.
- Rauscher Bernard J.
- Ravindranath Swara
- Rawle Timothy
- Rawlings Tynika N.
- Ray Tom
- Regan Michael W.
- Rehm Brian
- Rehm Kenneth D.
- Reid Neill
- Reis Alain Conde
- Reis Carl A.
- Renk Florian
- Reoch Tom B.
- Ressler Michael
- Rest Armin W.
- Reynolds Paul J.
- Richon Joel G.
- Richon Karen V.
- Ridgaway Michael
- Riedel Adric Richard
- Rieke George H.
- Rieke Marcia
- Rifelli Richard E.
- Rigby Jane R.
- Riggs Catherine S.
- Ringel Nancy J.
- Ritchie Christine E.
- Rix Hans-Walter
- Robberto Massimo
- Robinson Michael S.
- Robinson Orion
- Rock Frank W.
- Rodriguez David R.
- Roellig Thomas
- Rohrbach Scott O.
- Roman Anthony J.
- Romelfanger Frederick J.
- Romo Jr. Felipe P.
- Rosales Jose J.
- Rose Perry
- Roteliuk Anthony F.
- Roth Marc N.
- Rothwell Braden Quinn
- Rouzaud Sylvain
- Rowe Jason
- Rowlands Neil
- Roy Arpita
- Royer Pierre
- Rui Chunlei
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- Rumpl William
- Russ Melissa L.
- Ryan Michael B.
- Ryan Richard M.
- Saad Karl
- Sabata Modhumita
- Sabatino Rick
- Sabbi Elena
- Sabelhaus Phillip A.
- Sabia Stephen
- Sahu Kailash C.
- Saif Babak N.
- Salvignol Jean-Christophe
- Samara-Ratna Piyal
- Samuelson Bridget S.
- Sanders Felicia A.
- Santos Tony Dos
- Sappington Bradley
- Sargent B. A.
- Sauer Arne
- Savadkin Bruce J.
- Sawicki Marcin
- Schappell Tina M.
- Scheffer Caroline
- Scheithauer Silvia
- Scherer Ron
- Schiff Conrad
- Schlawin Everett
- Schmeitzky Olivier
- Schmitz Tyler S.
- Schmude Donald J.
- Schneider Analyn
- Schreiber Jürgen
- Schroeven-Deceuninck Hilde
- Schultz John J.
- Schwab Ryan
- Schwartz Curtis H.
- Scoccimarro Dario
- Scott John F.
- Scott Michelle B.
- Seaton Bonita L.
- Seely Bruce S.
- Seery Bernard
- Seidleck Mark
- Sembach Kenneth
- Shanahan Clare Elizabeth
- Shaughnessy Bryan
- Shaw Richard A.
- Shay Christopher Michael
- Sheehan Even
- Sheth Kartik
- Shih Hsin-Yi
- Shivaei Irene
- Siegel Noah
- Sienkiewicz Matthew G.
- Simmons Debra D.
- Simon Bernard P.
- Sirianni Marco
- Sivaramakrishnan Anand
- Slade Jeffrey E.
- Sloan G. C.
- Slocum Christine E.
- Slowinski Steven E.
- Smith Corbett T.
- Smith Eric P.
- Smith Erin C.
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- Smith Robert
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- Sokol Jeff
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- Sontag Christopher D.
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- Southwood Dana M.
- Spain Kay
- Sparmo Joseph
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- Starr Carl W.
- Stassi Diane Y.
- Steck Jane A.
- Steeley Christine D.
- Stephens Matthew A.
- Stephenson Ralph J.
- Stewart Alphonso C.
- Stiavelli Massimo
- Stockman Jr. Hervey
- Strada Paolo
- Straughn Amber N.
- Streetman Scott
- Strickland David Kendal
- Strobele Jingping F.
- Stuhlinger Martin
- Stys Jeffrey Edward
- Such Miguel
- Sukhatme Kalyani
- Sullivan Joseph F.
- Sullivan Pamela C.
- Sumner Sandra M.
- Sun Fengwu
- Sunnquist Benjamin Dale
- Swade Daryl Allen
- Swam Michael S.
- Swenton Diane F.
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- Tamas Laszlo
- Tao Andrew
- Taylor David K.
- Taylor Joanna M.
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- Telfer Randal C.
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- Thatte Deepashri G.
- Thompson Christopher Lee
- Thompson Linda M.
- Thomson Shaun R.
- Thronson Harley
- Tierney C. M.
- Tikkanen Tuomo
- Tinnin Lee
- Tippet William Thomas
- Todd Connor William
- Tran Hien D.
- Trauger John
- Trejo Edwin Gregorio
- Truong Justin Hoang Vinh
- Tsukamoto Christine L.
- Tufail Yasir
- Tumlinson Jason
- Tustain Samuel
- Tyra Harrison
- Ubeda Leonardo
- Underwood Kelli
- Uzzo Michael A.
- Vaclavik Steven
- Valenduc Frida
- Valenti Jeff A.
- Van Campen Julie
- van de Wetering Inge
- Van Der Marel Roeland P.
- van Dishoeck Ewine F.
- van Haarlem Remy
- Van Tea Mason
- Vandenbussche Bart
- Vanterpool Dona D.
- Vernoy Michael R.
- Volk Kevin
- Voorzaat Piet
- Voyton Mark F.
- Vydra Ekaterina
- Waddy Darryl J.
- Waelkens Christoffel
- Wahlgren Glenn Michael
- Walker Jr. Frederick E.
- Wander Michel
- Warfield Christine K.
- Warner Gerald
- Wasiak Francis C.
- Wasiak Matthew F.
- Wehner James
- Weiler Kevin R.
- Weilert Mark
- Weiss Stanley B.
- Wells Martyn
- Welty Alan D.
- Wheate Lauren
- Wheeler Thomas P.
- White Christy L.
- Whitehouse Paul
- Whiteleather Jennifer Margaret
- Whitman William Russell
- Williams Christina C.
- Willmer Christopher N. A.
- Willott Chris J.
- Willoughby Scott P.
- Wilson Andrew
- Wilson Debra
- Wilson Donna V.
- Windhorst Rogier
- Wislowski Emily Christine
- Wolfe David J.
- Wolfe Michael A.
- Wolff Schuyler
- Wondel Amancio
- Woo Cindy
- Woods Robert T.
- Worden Elaine
- Workman William
- Wright Gillian S.
- Wu Carl
- Wu Chi-Rai
- Wun Dakin D.
- Wymer Kristen B.
- Yadetie Thomas
- Yan Isabelle C.
- Yang Keith C.
- Yates Kayla L.
- Yeager Christopher R.
- Yerger Ethan John
- Young Erick T.
- Young Gary
- Yu Gene
- Yu Susan
- Zak Dean S.
- Zeidler Peter
- Zepp Robert
- Zhou Julia
- Zincke Christian A.
- Zonak Stephanie
- Zondag Elisabeth
- Álvarez-Márquez Javier
- Östlin Göran
- Publication venue
- Publication date
- 10/04/2023
- Field of study
Twenty-six years ago a small committee report, building on earlier studies,
expounded a compelling and poetic vision for the future of astronomy, calling
for an infrared-optimized space telescope with an aperture of at least 4m.
With the support of their governments in the US, Europe, and Canada, 20,000
people realized that vision as the 6.5m James Webb Space Telescope. A
generation of astronomers will celebrate their accomplishments for the life of
the mission, potentially as long as 20 years, and beyond. This report and the
scientific discoveries that follow are extended thank-you notes to the 20,000
team members. The telescope is working perfectly, with much better image
quality than expected. In this and accompanying papers, we give a brief
history, describe the observatory, outline its objectives and current observing
program, and discuss the inventions and people who made it possible. We cite
detailed reports on the design and the measured performance on orbit.Comment: Accepted by PASP for the special issue on The James Webb Space
Telescope Overview, 29 pages, 4 figure
Hyperoxemia and excess oxygen use in early acute respiratory distress syndrome : Insights from the LUNG SAFE study
- Author
- Abad Ricardo Diaz
- Abe Toshikazu
- Abroug Fekri
- Adams John C.
- Adamsson Richard O.
- Adolfsson Anne
- Aguilar Ronald Zumaran
- Aguirre Janet S.
- Aguirre-Bermeo Hernan
- Aisa Tharwat M.
- Aisiku Imo
- Ajetunmobi Olaitan O.
- Aker Mustafa
- Akyol Onat O.
- Al Dorzi Hasan M.
- Al Jabbary Ahmed S.
- Albaiceta Guillermo M.
- Albarrak Mohamad M.
- Albiero Daniela
- Alda Rosa S.
- Alejandro Risso V.
- Alexander Peter
- Algaba Ángela
- Aliaga Felipe A.
- Alisasis Alain U.
- Allan Russell M.
- Allue Raquel Montoiro
- Almekhlafi Ghaleb
- Alonso Javier G.
- Altaf Wahid
- Alvarez António M.
- Alvarez Javier
- Amin Pravin
- Amir Fahd
- Amor Abdellatif Benslama Mourad
- An Youzhong
- Andersen Finn H.
- Andoh Kohkichi
- Andruszkiewicz Pawel
- Aneman Anders
- Antonelli Massimo M.
- Antônio Ana Carolina P.
- Aoki Nobumasa
- Appelberg Henrik
- Arabi Yaasen
- Arabi Yaseen M.
- Araujo Ana M.
- Arizmendi Alfons
- Arnal Jean-Michel
- Artiga Maria Jose D.
- Artigas Antonio
- Ascoli Aline
- Au Siu-Ming
- Avila Luis E.
- Azad Raman
- Azevedo Luciano Cesar
- Baboi Loredana
- Badie Julio C.
- Bailey Irene M.
- Bailey Mathew B.
- Bajwa Ed
- Balkhi Hicham
- Baltus Thomas
- Banner-Goodspeed Valerie M.
- Barberet Guillaume
- Baron Rebecca M.
- Baronia Arvind K.
- Barratt-Due Andreas
- Barros Filipa M.
- Barros Nelson C.
- Batra Hitesh
- Battle Ceri E.
- Bauer Philippe R.
- Beck Eduardo
- Beck Oliver
- Bedreag Ovidiu H.
- Beegle Scott H.
- Beitler Jeremy R.
- Bellani Giacomo
- Bellani Giacomo
- Beloncle Francois
- Beraldo Daniel O.
- Berghe Caroline
- Berkelmans Frantz
- Besset Sebastien L.
- Bettini Lisandro R.
- Beuret Pascal
- Bezzi Marco G.
- Bhardwaj Vallish K.
- Bhowmick Kaushik
- Biehler Jerome
- Bigot Charlene
- Bihari Shailesh
- Biondi Rodrigo S.
- Biscione Roberto R.
- Bisso Mariano Carboni
- Black Colin S.
- Blakeman Thomas C.
- Bolon Stefan
- Borello Silvina A.
- Borotto Erika E.
- Botteri Marco
- Bouchoucha Slaheddine
- Boukhazna Messabi
- Bouw Maria J.
- Boyd Owen
- Bramall Jon
- Braschi Antonio
- Brazzi Luca
- Breen Dorothy M.
- Briquet Anais
- Brito Vania A.
- Brizuela Matias
- Brochard Laurent
- Brochard Laurent
- Broman Lars M.
- Brown Samuel M.
- Browne Troy S.
- Bruhn Alejandro R.
- Brunettini Barbara
- Bruns Monique M.
- Buensuseso Juan A.
- Bugedo Guillermo
- Buise Marc P.
- Bulpa Pierre A.
- Bumbasierevic Vesna
- Bumbasirevic Vesna
- Burtenshaw Andrew J.
- Burtin Philippe
- Buzancais Gautier
- Béduneau Gaetan
- Camsooksai Julie
- Canestrini Sergio
- Cani Alma
- Carbayo-Gorriz Cecilia
- Cardonnet Luis P.
- Careless Jon P.
- Carpentier Dorothée
- Carreño Nicolás G.
- Carteaux Guillaume
- Casalena Paolo
- Casement Jonathan
- Castro Alejandro G.
- Castro Silvia
- Catorze Nuno T.
- Cazorla-Barranquero Francisca G.
- Ceniceros-Barros Alexandra
- Cereijo Enrique
- Cerny Vladimir
- Cerrato Valeria I.
- Cervantes Mavy Ramirez
- Cesar Palazon Sanchez
- Ceunen Helga
- Ceylan Ilkay
- Chabanne Russell
- Chapman Rhiannon
- Chau Simon K.
- Chelly Jonathan
- Chen Kai
- Chena Ariel
- Cheng Meisy Perez
- Chiche Jean-Daniel
- Chouchene Imed
- Choudry Shazia
- Christiansen Aage
- Cimic Nedim
- Cinnella Gilda
- Cirone Rob
- Citalán Johanna E.
- Claraco-Vega Luis M.
- Clarkson Kevin
- Clarkson Kevin P.
- Claverias Laura
- Cohen Jason E.
- Cole Jade M.
- Collins Daniel V.
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- Combaux Daniele M.
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- Corneci Dan E.
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- Coxo Cristina M.
- Cracchiolo Andrea N.
- Cranshaw Julius H.
- Crapelli Giulia
- Crouch Daniel R.
- Crova Philippe J.
- Csabi Peter
- Curley Gerard
- Curto Elena Gallego
- Daldin Julio
- Dangers Laurence
- Danin Pierre-Eric
- Daubin C. dric
- Daviaud Fabrice
- Davies Kyle G.
- Dawson Heidi
- de Cima-Iglesias Sara
- de Gordoa Laura Ortiz-Ruiz
- de Haro Candelaria
- de Pablo Raul
- de Prost Nicolas
- Dean Michael N.
- Declercq Pierre-Louis M.
- Dector Dulce
- Dector Dulce M.
- Deicas Alberto
- del Carmen Lorente Maria
- Dellamonica Jean
- Dellera Christian
- Delsing Angela
- Demirkiran Oktay
- Demoule Alexandre
- Dempsey Ged
- Dendane Tarek
- Depuydt P.
- Depuydt Pieter
- Derman Suleyman S.
- di Tomasso Nora N.
- di Yu D.
- Diaz-Rodriguez Esther
- Dive Alain M.
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- Fan Eddy
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- Farías Pamela A.
- Fawkes Danielle A.
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- Fernandez Adriana M.
- Fernandez Ruben O.
- Fierro Jonathan M.
- Floris Leda
- Follin Arnaud
- Fontenele Danielle C.
- Formenti Paolo
- Forteza Catalina
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- Frigyik Aniko D.
- Fusari Maurizio
- Futami Satoru
- Gally Josette
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- Gao Yan
- Gao Yuan N.
- Garcia Patricio H.
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- Gazenkampf Andrey A.
- Gelée Bruno
- George Fernando G.
- Ghazi Mohammed
- Gianinetto Hernan
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- Girgin Nermin Kelebek
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- Gonz Á Lez Raquel Montiel
- Gonzalez Daniel R.
- Gonzalez Marcos
- González Rojas Manuel A.
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- Gonçalves Claudio H.
- Goodson Jennifer C.
- Gordo Federico
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- Gritsan Alexey I.
- Grubissich Nicolas
- Gueret Renaud M.
- Gurjar Mohan
- Guttormsen Anne B.
- Guérin Claude
- Gómez Pilar Ricart Aroa
- Hacking Danielle J.
- Haddad Youssef
- Hadfield Dan
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- Han Yi
- Hang Ai Y.
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- Harasawa Tomofumi
- Harrois Anatole
- Hashemian S. M.
- Hashemian Seyed Mohammadreza
- Hashida Tomoaki
- He Zhenyang
- Hedlund Lars
- Heidari Farshad
- Heines Serge J.
- Helleberg Johan
- Henderson Galen
- Herbrecht Jean-Etienne
- Hermosa Cecilia
- Hessell Robert J.
- Heunks Leo M.
- Higashijima Ushio
- Hirata Akira
- Holzgraefe Bernhard
- Honda Hiroyuki
- Honrubia Teresa
- Hopf Hans-Bernd F.
- Hopkins Phil
- Hormis Anil P.
- Hou Peter C.
- Hou Sen-Kuang
- Hraiech Sami
- Hua Ma X.
- Huang Qing Q.
- Huang Xiao B.
- Huerta Francisco P.
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- Humphreys Sally K.
- Hunt Anna
- Hurtado Javier
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- Ibañez-Santacruz Marcos
- Ichikado Kazuya
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- Imai Hiroshi
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- Ioannou Nicholas
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- Ismail Mehvish
- Ito Fumihito
- Izawa Masayo
- Jaafar Rola F.
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- Jamaati Hamidreza
- Jarquin-Badiola Yves D.
- Jassal Mandeep
- Javeed Areej
- Javier-Blanco
- Jhamatthew Thomas Rajeev R.
- Jiang Liangyan
- Jibaja Manuel
- Jimenez Antonio G.
- Jochmans S. bastien
- Jog Sameer A.
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- Judy Claine
- Jurado M. . Teresa
- Kadaba Varsha
- Kajtor Istvan
- Kakar Vivek
- Kalaitzis Evangelos
- Kalkoff Michael
- Kamel Ghassan
- Kameyama Yoshinobu
- Kamoun Salma
- Kander Thomas
- Kannan Santhana G.
- Kansuke-Koyama
- Kashiwa Yozo
- Kedelv Hans
- Kennedy Barry
- Khebbeb Samy
- Kheir Fayez
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- Kitch Barrett T.
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- Kraßler Jens
- Krstevski Amanda
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- Labarca Eduardo F.
- Laffey John
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- Larsson Anders
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- le Moal Charlene
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- Li Bin
- Li Qingdong
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- Li Wenwen
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- Li Xinyu
- Li Yimin
- Li Yuan Y.
- Li-Xin Zhou
- Liew Kong Y.
- Ling Long L.
- Liu Haitao
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- Lovazzano Pablo
- Lu Weihua
- Lu Yuanhua
- Luis Palazon Sanchez Eugenio
- Luo Xiaoming
- Lynch Joan M.
- López-Messa Juan B.
- Maazouzi Wajdi
- MacFadyen Rosaleen
- MacFie Caroline C.
- Madotto Fabiana
- Maeyama Hiroki N.
- Maghrabi Khalid A.
- Magret Monica
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- Marin Maria C.
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- Martinho Aurelia M.
- Marum Susan M.
- Massa Eleni V.
- Mataloun Sergio
- Matamis Dimitrios
- Matsumoto Shuhei
- Mattei Alessia
- May Martin M.
- McArthur Colin
- McAuley Daniel F.
- McAuley Daniel F.
- McAuley Danny
- McCalman Katie H.
- McKechnie Stuart
- McKee Raymond
- McKenna Toni E.
- McLeod Alex
- McNamee Lia
- McNicholas Bairbre
- Meaney Edel A.
- Meco Basak Ceyda
- Meersseman Philippe
- Mehta Sangeeta
- Mejia Francisco Javier Flores
- Mellis Clare
- Memon Mohammedfaruk
- Mercat Alain
- Mesar Tomaz
- Messias António M.
- Messika Jonathan
- Meybohm Patrick
- Michel Philippe
- Millar Rebecca T.
- Miller Jennene J.
- Miller Russel R.
- Mirabella Lucia
- Miryam-Prieto-González
- Mizuguchi Ichiko
- Mochizuki Katsunori
- Mohr Nicholas M.
- Mojoli Francesco
- Moles Silvia Iglesias
- Molin Alexandre
- Montanha Gustavo M.
- Monteiro Jorge M.
- Montero Laura Alvarez
- Montes Oscanoa Fredy A.
- Monti Giacomo
- Montini Luca M.
- Moock Marcelo
- Morin Anna-Karin
- Mortaza Satar
- Morton Alex
- Mouloudi Eleni K.
- Mukkera Satyanarayana Reddy
- Mustafa Ghanem M.
- Muthuchellappan Radhakrishnan
- Myra-Rinia
- Máca Jan
- Nagy Eva O.
- Nakamura Tomoyuki
- Namih Miriam
- Nassar Antonio P.
- Nasu Michitaka
- Navalpotro Miguel Angel Blasco
- Navarra Leanlove
- Navarro Gonzalo
- Neal John
- Negoita Silvius Ioan
- Newby Lynette
- Nichol Alistair
- Nielsen Jonas
- Niimi Daisuke
- Nin Nicolas
- Nin Nicolás
- Nishikawa Erin
- Nitta Kenichi
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- Olga Moreno F.
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- Ortiz Claudia A.
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- Palmese Salvatore
- Palo Jose Emmanuel
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- Papanikolaou Metaxia N.
- Papavasilopoulou Theonymfi G.
- Papazian Laurent
- Papurica Marius
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- Parhar Ken
- Parotto Matteo
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- Pham Tai
- Phan Nga T.
- Piacentini Enrique A.
- Pillai Suresh
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- Poli Michela M.
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- Qin Tie H.
- Qiu Haibo
- Raaijmakers Monique
- Rafael S. nchez I.
- Raimondi Ferdinando
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- Reske Andreas W.
- Reuter Danielle
- Reynolds Claire
- Rezoagli Emanuele
- Rhayakar Rachana V.
- Rialp Gemma
- Richecoeur Jack R.
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- Wang Hua X.
- Wang Shou H.
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- Watanabe Eizo
- Watt Philip
- Welters Ingeborg D.
- Wenham Tim
- Wessbergh Joanna
- Whitehead Christina
- Willett Emma L.
- Williams Alexandra J.
- Williams Karen E.
- Wise Matt P.
- Wittebole Xavier
- Wong Helen S.
- Woods Paul W.
- Wrathall David W.
- Wrigge Hermann
- Wu Ya Q.
- Xin-Hua Qiang
- Xu Yonghao
- Yamaguchi Osamu
- Yamaji Yoshihiro
- Yao Qingchun
- Ye Zheng L.
- Yeatts Dale J.
- Yu Rongguo
- Yu Tao
- Yu Wenkui
- Yumha Jacob S.
- Yuste Luis J.
- Zacharas Giannis A.
- Zacharowski Kai D.
- Zani Gianluca
- Zantua Kim S.
- Zazu Alan
- Zeggwagh Amine Ali
- Zein Salem Ould
- Zender Hervé O.
- Zhai Zhe
- Zhang Fan
- Zhang Xing Y.
- Zhao Huiying
- Zhao Jun
- Zhao Xian Y.
- Zheng Ruiqiang
- Zhou Fa C.
- Zhou Suming
- Zhu Bao H.
- Zhu Wei H.
- Zogheib Elie H.
- Ñamendys-Silva Silvio A.
- Ünal Necmettin
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2020
- Field of study
Publisher Copyright: © 2020 The Author(s). Copyright: Copyright 2020 Elsevier B.V., All rights reserved.Background: Concerns exist regarding the prevalence and impact of unnecessary oxygen use in patients with acute respiratory distress syndrome (ARDS). We examined this issue in patients with ARDS enrolled in the Large observational study to UNderstand the Global impact of Severe Acute respiratory FailurE (LUNG SAFE) study. Methods: In this secondary analysis of the LUNG SAFE study, we wished to determine the prevalence and the outcomes associated with hyperoxemia on day 1, sustained hyperoxemia, and excessive oxygen use in patients with early ARDS. Patients who fulfilled criteria of ARDS on day 1 and day 2 of acute hypoxemic respiratory failure were categorized based on the presence of hyperoxemia (PaO2 > 100 mmHg) on day 1, sustained (i.e., present on day 1 and day 2) hyperoxemia, or excessive oxygen use (FIO2 ≥ 0.60 during hyperoxemia). Results: Of 2005 patients that met the inclusion criteria, 131 (6.5%) were hypoxemic (PaO2 < 55 mmHg), 607 (30%) had hyperoxemia on day 1, and 250 (12%) had sustained hyperoxemia. Excess FIO2 use occurred in 400 (66%) out of 607 patients with hyperoxemia. Excess FIO2 use decreased from day 1 to day 2 of ARDS, with most hyperoxemic patients on day 2 receiving relatively low FIO2. Multivariate analyses found no independent relationship between day 1 hyperoxemia, sustained hyperoxemia, or excess FIO2 use and adverse clinical outcomes. Mortality was 42% in patients with excess FIO2 use, compared to 39% in a propensity-matched sample of normoxemic (PaO2 55-100 mmHg) patients (P = 0.47). Conclusions: Hyperoxemia and excess oxygen use are both prevalent in early ARDS but are most often non-sustained. No relationship was found between hyperoxemia or excessive oxygen use and patient outcome in this cohort. Trial registration: LUNG-SAFE is registered with ClinicalTrials.gov, NCT02010073publishersversionPeer reviewe
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- Ainscough Kate
- Al Qasim Eman
- Al Swaidan Lolowa
- Al-Bassam Wisam
- Al-Beidh Farah
- Al-Beidh Farah
- Albert Martin
- Alegria Ana
- Alexander Brian
- Alexander Peter
- Allan Angela
- Allan Elizabeth
- Allen Louise
- Allibone Suzanne
- Amaro dos Santos Catorze Teodoro
- Anderson Tom
- Andric Zdravko
- Angus Derek
- Angus Derek C
- Anjum Aisha
- Ankert Juliane
- Annane Djillali
- Annane Djillali
- Anstey Matthew
- Antcliffe David
- Aparicio Christelle
- Appelt Peter
- Arabi Yaseen
- Arabi Yaseen
- Arbane Gill
- Archer Simon
- Aref Noah
- Arias Ana-Marie
- Arishi Hatim
- Arnold Donald
- Asghar Adeeba
- Ashelford Angela
- Attwood Ben
- Austin Karen
- Aysel Florescu Simin
- Azaiz Amine
- Babel Jakša
- Babio-Galan Maite
- Badie Julio
- Bagshaw Sean
- Baillie Kenneth
- Baker Evelyn
- Bakthavatsalam Dhanalakshmi
- Bamford Peter
- Banach Dorota
- Bannard-Smith Jonathan
- Barbazza Leanne
- Barber Russell
- Barge Deborah
- Barnes Nicky
- Baršić Bruno
- Bashyal Archana
- Basile Kim
- Bass Frances
- Bates Michelle
- Bauchmuller Kris
- Bean Sarah
- Beane Abigail
- Beane Abigail
- Beasley Richard
- Begin Phillipe
- Bellemare David
- Benettaib Fatna
- Benzekri Dalila
- Berdaguer Fernando Daniel
- Bergin Colin
- Berry Lindsay
- Berry Lindsay
- Berry Scott
- Berry Scott
- Bhimani Zahra
- Bhimani Zahra
- Bihari Shailesh
- Bihari Shilesh
- Binnie Alexandra
- Bion Julian
- Biradar Vishwanath
- Birch Janine
- Birch Jenny
- Birchall Katie
- Birkinshaw Isobel
- Black Ethel
- Bloos Frank
- Board Jasmin
- Bone Allsion
- Bonner Stephen
- Bonten Marc
- Bonten Marc
- Borgatta Barbara
- Borrill Zoe
- Bosch Ziekenhuis Jeroen
- Boschert Catherine
- Bossard Isabelle
- Boumahni Dounia
- Bourgoin Charlotte
- Bourne Michelle
- Bourne Richard
- Bouwman Wietske
- Bowler Helen
- Boyd Craig
- Bracke Stephanie
- Bradbury Charlotte
- Bradbury Charlotte
- Bradley-Potts Joanne
- Brailsford Jane
- Brain Matthew
- Brant Emily
- Breen Patrick
- Brett Stephen
- Brewer Chris
- Brickell Kathy
- Brightling Chris
- Brillinger Nicole
- Brimfield Lutece
- Brinkerhoff Gail
- Brochard Laurent
- Brohi Farooq
- Browne Troy
- Brunkhorst Frank
- Brunkhorst Frank
- Budd Joanna
- Buehner Ulrike
- Buhr Heidi
- Bullman Laetitia
- Burns Karen
- Burt Karen
- Buscher Hergen
- Butler Amelia
- Butler M
- Buxton Meredith
- Buxton Meredith
- Buzgau Adrian
- Byrne Deborah
- Byrne Kathleen
- Bélteczki János
- Cabreros Leilani
- Calfee Carolyn
- Callender Owen
- Campbell Andy
- Campbell Hilary
- Campbell Lewis
- Camsooksai Julie
- Caplin Cecile
- Carbonneau Elaine
- Carmona Flores Rosario
- Carr-Knott Lisa
- Carrier François Martin
- Carrier Marc
- Cartner Brittney
- Casey Ruth
- Casey Siobhan
- Castro Ferreira Ricardo Manuel
- Cate Heidi
- Cathcart Susanne
- Cavayas Alexandros
- Cawley Kathryn
- Cazzola Federica
- Centofanti John
- Chablani Manish
- Chamara Warnapura Loku
- Chan Carmen
- Chan Charles
- Chan Peter
- Charlewood Richard
- Charron Cyril
- Chartier Delphine
- Chasse Michael
- Chassé Michaël
- Chen Yan
- Cheng Allen
- Cheng Allen C
- Cherian Shiney
- Cheung Winston
- Chhablani Manish
- Chudeau Nicolas
- Cirstea Emanuel
- Clarey Emma
- Claridge Helen
- Clark Michele
- Clark Sarah
- Claxton Andrew
- Clermont Giles
- Cloutier Ève
- Coburn Susan
- Codreanu Daniel
- Coghlan Phoebe
- Cole Jade
- Coles Holly
- Coles Jennifer
- Colin Gwenhael
- Collier Dawn
- Collins Daniel
- Collins Emma
- Collins Joanne
- Connor Jason
- Cooke Jill
- Cooper Jamie
- Cooper Melanie
- Cornell Sarah
- Cort Jon
- Courtin Laura
- Cowdrey Keri-Anne
- Cowley Nicholas
- Cowton Amanda
- Coyne Mark
- Craner Michelle
- Craven Thomas
- Creagh-Brown Ben
- Crisp Nikki
- Croft Maria
- Cusack Rebecca
- Cutler Sean
- Cviljevic Sabina
- Cárcel Fernández Sheila
- Daly James
- Daly Zoe
- Daneman Nick
- Dark Paul
- Darreau Cédric
- Dasgin Joanne
- Davey Miriam
- Davidson Neil
- Davies Gwyneth
- Davies Louisa
- Davies Michelle
- Dawda Ashlish
- Day Christopher
- De Beaux Fiona
- De Bus Liesbet
- de Courcy-Golder Kim
- de Jager P
- de Jong Menno
- De Jong Menno
- de Jonge E
- de la Fuente Martos Carmen
- de Lima Pereira Tiago Nuno Alfaro
- de Man Angelique
- De Waele Jan
- Dearden Joy
- Dechert William
- Deelchand Vashish
- Dela Rosa Arnold
- Dell Amanda
- Demetriou Carrie
- Depante Maria Theresa
- Depuydt Pieter
- Dequin PierreFrançois
- Derde Lennie
- Derde Lennie
- Detry Michelle
- Detry Michelle
- Deye Nicolas
- Digby Stephen
- Distler Michael
- Doble Patricia
- Donnelly Adrian
- Donnison Phil
- Doran Peter
- Dragija Lidija
- Driscoll Alana
- Drummond Andrew
- Duan Erick
- Duffy Eamon
- Duke Graeme
- Duncan Tracey
- Duplaix Mathilde
- Dushianthan Ahilanandan
- Dyas Sarah
- D’Aragon Frédérick
- D’Souza Ramsy
- Effelaar Evelien
- Elhassan Munzir
- Elin Hall Rebecca
- Ellis Christine
- Elmahi Einas
- Elsefi Tarek
- English Shane
- Estcourt Lise
- Estcourt Lise
- Estensen Kristen
- Everitt Robert
- Evers Mirjam
- Farahi Neda
- Fartoukh Muriel
- Faulkner Beverley
- Faulkner Maria
- Fazekas Ágnes
- Felton Tim
- Ferguson Niall
- Ferguson Susan
- Fergusson Dean
- Fernández de Pinedo Artaraz Ziortza
- Ferrier Janet
- Fierens Jan
- Finn André
- Finn Stephanie
- Fischer Roy
- Fitzgerald Mark
- Fitzgerald Mark
- Fletcher Simon
- Flint Neil
- Forbes Andrew
- Forbes Loretta
- Forton Daniel
- Fortune Louise
- Fottrell-Gould Deirdre
- Fowler Rob
- Fowler Robert
- Fox Claire
- Francia Federica
- Francoeur Charles
- Frey Anna
- Friedrich Hinrichs Carl
- Frohlich Stephen
- Fysh Ed
- Gallagher Linda Jude
- Ganguly Saibal
- Ganpat Radhika
- Garcia Rebecca
- Gardiner-Hill Caroline
- Garrard Hywel
- Garrard William
- Gates Simon
- Gattas David
- Gellamucho Minerva
- Gendall Emma
- Genetu Roman Mary
- Geng Wenli
- Geri Guillaume
- Ghamraoui Ali
- Ghosh Alison
- Gibson Charly
- Girard Timothy
- Girijadevi Dinu
- Gledhill Lisa
- Godement Mathieu
- Golden David
- Goligher Ewan
- Gomm Linda
- Goodson Jennifer
- Goodwin Jayne
- Goossens Herman
- Goossens Herman
- Gopal Shameer
- Gopinath Amitha
- Gordon Anthony
- Gordon Anthony C
- Gordon Elizabeth
- Gosbell Iain
- Gould Richard
- Grecu Irina
- Green Cameron
- Green Cameron
- Gregory Jane
- Gresha Rebecca
- Grimmer Lisa
- Grimwade Kate
- Guilder E
- Guitton Christophe
- Hacking Danielle
- Hadebe Bernard
- Hagel Stefan
- Haidar Ghady
- Hall Andrew
- Hall Kathryn
- Hamilton David Oliver
- Hamilton-Davies Colin
- Hamlyn Vincent
- Hammond Naomi
- Haniffa Rashan
- Haniffa Rashan
- Hanson Jane
- Harford Rachel
- Harland Cain
- Harrington Kate
- Harris Nichola
- Harrison Susie
- Hart Ciaran
- Harvala-Simmonds Heli
- Harvey Daniel
- Harward Meg
- Hawcutt Daniel
- Hawkins Nancy
- Hay Sophie Kennedy
- Hayes Kati
- Hayes Leanne
- Hays Carole
- Health Monash
- Heinonen Jonna
- Heming Nicholas
- Henderson Seton
- Henderson Steven
- Henning Jeremy
- Henry Joanne
- Heritier Stephane
- Hickey Naomi
- Higgins Alisa M
- Higgins Lisa
- Hill Helen
- Hills Thomas
- Hills Tom
- Hird Clare
- Hodgson Carol
- Hoff Uwe
- Hoiting Oscar
- Holland Nicky
- Hollos Laszlo
- Homes Jennifer
- Hope David
- Hopkins Phil
- Hormis Anil
- Horton Michelle
- Horton Sarah
- Horvat Christopher
- Horvat Christopher
- Howcroft Clare
- Howle Ryan
- Huang David
- Huckle Abby
- Hughes Emma
- Hugill Keith
- Hullegie Sebastiaan
- Hullegie Sebastiaan J
- Hulley Amanda
- Hulme Jonathan
- Hunt Beverley
- Hunter Stephanie
- Hutter Joanne
- Hutton Paula
- Innes Richard
- Ireland Jane
- Isgro Graziella
- Ivatt Helen
- Jackson Matthew
- Jackson Shane
- Jackson Susan
- Jacques Nicola
- Jacquier Sophie
- Jagannathan Vijay
- Janin Pierre
- Jarczak Dominik
- Jeblaoui Asma
- Jeffrey Helen
- Jenkins Sarah
- Jha Rajeev
- Jhanji Shaman
- Johns Maggie
- Johnson David
- Johnson Rebekah
- Johnston Paul
- Jones Andrea
- Jones Jo
- Joseph Sibet
- José Nuno
- Juhaz Vera
- Kalchthaler Kyle
- Kalogirou Michael
- Kamel Toufik
- Karachi Tim
- Karlikowski Michal
- Karlsson Sari
- Kasipandian Vidya
- Kayani Abdul
- Kazemi Alex
- Keen Alexandra
- Keenan Samantha
- Keet Owen
- Kell Kay
- Kelly Martin
- Kelsall Olivia
- Kernan Maeve
- Kersiake Ian
- Khalid Imrana
- Khare Divya
- Kiiski Heikki
- Kimpton Sarah
- King Andrew
- Kinney Fiona
- Kirkby Amy
- Klinikum Neukölln Vivantes
- Kluge Stefan
- Knott Cameron
- Kol Mark
- Kolanos Steffi
- Koppen Cassandra
- Kosa Alma Gabriela
- Kotarski Viktor
- Kovács Sándor
- Kreß Gabriele
- Krishnamurthy Vinodh
- Kruger Peter
- Kruger Peter
- Kuitunen Anne
- Kumar Anand
- Kumar Nikhil
- Kunz Kevin
- Kurenda Catherine
- Kutleša Marko
- Kušan Ira
- KyereDiabour Thyra
- Kyeremeh Lynsey
- Labbe Vincent
- Laffan Mike
- Laffey John
- Laha Shondipon
- Lai Vivian
- Lamb Thomas
- Lamonagne Francois
- Lamontagne Francois
- Lamontagne Francois
- Lamontagne François
- Landais Mickaël
- Lane Janis-Best
- Lankester Liana
- Laver Russell
- Lawler Patrick
- Lawler Patrick R
- Lawless Patrick
- Lazaro Juan Martin
- Leaver Susannah
- Leblond Julie
- Lee Kelvin
- Lee Stephanie
- Leparco Cécile
- Lesona Eden
- Leszkoven János
- Lewis Roger
- Lewis Roger J
- Lewis Sarah
- León López Rafael
- Limb James
- Linstrum Kelsey
- Linstrum Kelsey
- Litton Ed
- Litton Edward
- Litton Edward
- Lomme Kaatje
- London Emily
- Lorenzi Elizabeth
- Lorenzi Elizabeth
- Lother Sylvain
- Lowe Benjamin
- Lowrey Julie
- Luis David
- Luk Tracy
- L’Hotellier Sylvie
- Mackay Callum
- Mackay Euan
- MacLennan Sheila
- Maguire Teena
- Magyar István
- Maiden Matthew
- Makowski Arystarch
- Malakoutis Salim
- Malfroy Sylvain
- Malissin Isabelle
- Maloney Carolyn
- Manax Victoria
- Mandadapu Vineela
- Mangindaan Yara
- Maquigneau Natacham
- Marabi Yaseen
- Mariappa Vasanth
- Marin-Corral Judith
- Markgraf Rene
- Marroquin Oscar
- Marshall John
- Marshall John
- Marshall Nicola
- Mart Emma
- Marten Nicole
- Martin Jane
- Martin Timothy
- Martynoga Robert
- Maselli Astrid
- Masse Marie-Helene
- Mateo López Maria Isabel
- Matsa Ramprasad
- Mattocks Lehentha
- Maxime Virginie
- Mc Goldrick Clare
- Mc Master Moyra
- McArthur Colin
- McArthur Colin
- McAuley Daniel
- McAuley Daniel
- McAuley Danny
- McCallum Peter
- McClintock Declan
- McConnochie Rachael
- McCracken Phobe
- McCue Claire
- McCullagh Iain
- McCullough James
- McDyer John
- McGhee Christopher
- McGlothin Anna
- McGlothlin Anna
- McGloughlin Steve
- McGlynn Deborah
- McGuigan Peter
- McGuinness Shay
- McGuinness Shay
- McIntyre Lauralyn
- McLachlan Danielle
- McMillan Alexandra
- McNamara Robert
- McNicholas Bairbre
- McQuilten Zoe
- McVerry Bryan
- McVerry Bryan
- McWilliam Stephen
- Megarbane Bruno
- Mehrtens Jan
- Menon David
- Menzies Daniel
- Mercier Emmanuelle
- Mercier Romain
- Meredith Megan
- Metherell Stella
- Mevavala Bhaumik
- Mew Louise
- Meyer Jason
- Mezher Chaouki
- Mfuko Celina
- Mguni Nhlanhla
- Middeldopr Saskia
- Miezitis Sydney
- Millen Tina
- Miller Eliza
- Mills Gary
- Miln Rebecca
- Mineall Sarah
- Mirković Gordan
- Misak Cheryl
- Misztal Beata
- Mitchard Sarah
- Moine Pierre
- Monchi Mehran
- Moneer Hagazy Mohamned
- Montague Laura
- Montgomery Stephanie
- Montgomery Stephanie
- Moore Lorraine
- Morel Guillaume
- Moreno Cuesta Jeronimo
- Morgan Matt
- Morpeth Susan
- Morris Sheila
- Morrison Lynette
- Mouncey Paul
- Mouncey Paul
- Moviat M
- Mullan Dee
- Muller Grégoire
- Munt Sheila
- Murphy Sheenagh
- Murray Lauren
- Murthy Srinivas
- Murthy Srinivas
- Music Edvin
- Muñoz-Bermúdez Rosana
- Mwaura Esther
- Myers Erina
- Naiker Kevin
- Nair Priya
- Nay Mai-Anh
- Neal Matthew
- Nee Jens
- Netea Mihai
- Netherton Kimberley
- Neto Ary
- Neves Pessoa Lucilia Maria
- Newby Lynette
- Newman Tabitha
- Nichol Alistair
- Nichol Alistair
- Nicholier Tiphaine Barbarin
- Nichols Lesley
- Nicholson Andrew
- Nicholson Sarah
- Nierhaus Axel
- Nikitas Nikitas
- Noble Harriet
- North Julie
- Nortje Jurgens
- Oakley Susan
- Oborska Aneta
- Oczkowski Simon
- Olatunji Shaanti
- Orath Prabakaran Rajalakshmi
- Orford Neil
- Oritz-Ruiz de Gordoa Laura
- Orr Katrina
- Oza Deepali
- O’Brien Julie
- O’Dywer Michael
- O’Kane Cecilia
- O’Kane Sinéad
- O’Malley Laura
- O’Neill Aisling
- Page Valerie
- Paling A
- Panwar Rakshit
- Paramasivam Elankumaran
- Parekh Dhruv
- Parke Rachael
- Parke Rachael
- Parker Jane
- Parker Lorraine
- Parrilla Gómez Francisco
- Parsons Penny
- Pasi John
- Pasieka Bastian
- Patanwala Asad
- Patch Sarah
- Patel Amit
- Patel Kamal
- Pateman Kelsey
- Paterson David
- Patterson Lisa
- Peake Sandra
- Pearson Karen
- Pegler Suzannah
- Pellicano Annamaria
- Pereira Sousa Bastos Joana Margarida
- Pereira Rita
- Peters Anna Linda
- Peters Marco
- Peters Svenja
- Petros Sirak
- Pettilä Leena
- Phalod Gunjan
- Philbin Jennifer
- Phillips Barbara
- Phull Mandeep-Kaur
- Pillai Suresh
- Pinder Meredith
- Pinnell Jez
- Pitts Sally
- Pletz Mathias
- Pletz Mathias
- Plumb Benjamin
- Pogreban Tatiana
- Pogson David
- Polderman F
- Polgarova Petra
- Pomeroy Fiona
- Porteous Rebecca
- Porter David
- Potter Alison
- Pourcine Franck
- Powell Elizabeth
- Powell Matthew
- Presneill Jeffrey
- Pridee Nicole
- Prinssen Anton
- Prout Rachel
- Pugh Richard
- Pulletz Mark
- Purandare Laura
- Purohit Dharam
- Purvis Sarah
- Puthucheary Zudin
- Puxty Kathryn
- Quayle Rachael
- Quinn Kevin
- Qureshi Hafiz
- Rad Laura
- Rademaker Emma
- Rae Nicola
- Raithatha Ajay
- Ramali Mohamed
- Ramanan Mahesh
- Ramos Lidia
- Randell Georgina
- Rauniyar Rashmi
- Raymakers Kik
- Reddy Amie
- Reddy Harsha
- Rees Tabitha
- Reeve Brenda
- Regli Adrian
- Reill Lorenz
- Rengers Els
- Reschreiter Henrik
- Reynolds Claire
- Reynolds John
- Rhodes Jonathan
- Richards-Belle Alvin
- Ricketts Daniel
- Rietveld Ilse
- Ristimäki Sanna
- Ritzema Carter Jay
- Robert Alain
- Roberts David
- Robertson Yvonne
- Robinson Matt
- Robinson Philip
- Rochwerg Bram
- Rodden Natalie
- Rodriguez Fernandez Jorge
- Roedl Kevin
- Rohde Gernot
- Rojo Roceld
- Rook Clare
- Rooney Kevin
- Rosaroso Lace Paulyn
- Rose Steve
- Rostron Anthony
- Rowan Kathryn
- Rowan Kathryn
- Rowan Kathy
- Rowland Matthew
- Roy Alistair
- Roynon-Reed Anna
- Rozendaal Wim
- Russell Robert
- Ryalls Kim
- Ryan Lucy
- Sagnier Anne
- Salazar Degracia Anna
- Salerno Tania
- Salet A
- Salisbury Sarah
- Sall Jas
- Salmon Charlotte
- Sandhu Gyan
- Sanil Ashish
- Sanil Ashish
- Santamaria John
- Santos Filipa
- Santos Marlene
- Santos Marlene
- Saull Michelle
- Saunders Christina
- Saunders Christina
- Schischka Livia
- Schneider Francis
- Schotsman Joost
- Schuster-Bruce Martin
- Schutgens Roger
- Schweikert Sacha
- Schütze Bianka
- Scully Michael
- Sellers Katharine
- Selvamoni Selvin
- Senya Ho Jan
- Seppelt Ian
- Serri Karim
- Sever Helena
- Seymour Christopher
- Seymour Christopher
- Shah Asim
- Shakih Arif
- Shankar-Hari Manu
- Shaw David
- Shaw Joanne
- Shearer Audrey
- Sheffield Jonathan
- Shehabi Yahya
- Shovelton Charmaine
- Shrestha Tapaswi
- Shyamsundar Murali
- Siami Shidasp
- Silversides Jon
- Sim Malcolm
- Simmonds Catherine
- Simons Koen
- Simpson Joanne
- Simpson Scott
- Singh Vanessa
- Singleton Jo
- Sinha Pratik
- Slevin Kathryn
- Small Charlotte
- Smallwood Andrew
- Smee Joanna
- Smith Joanne
- Smith John
- Smith Judith
- Smith Julie
- Smith Kirsy
- Smith Margaret
- Smith Roger
- Smith Simon
- Smith Tim
- Smuts Sara
- Smyth Michelle
- Soar Natalie
- Somerville Alastair
- Song Rima
- Sousa Arias Sonia
- Southern David
- Southin Sara
- Spencer Thomas
- Spittle Nick
- Spivey Michael
- Stanciu Delia
- Stanworth Simon
- Sterba Martin
- Stevenson Hannah
- Stewart Richard
- Strzelecka Anna
- Sundara Raman Ajay
- Sundaran Dhinesh
- Sutherland Helen
- Sutterlin Laetitia
- Sutu Mihaela
- Sweet Katie
- Szakmany Tamas
- Szigligeti Gábor
- Szőke Viktória
- Tallott Mandy
- Tatham Kate Colette
- Templeton Maie
- Thomas Amy
- Thomas Helen
- Thomas Matt
- Thomas Matthew
- Thompson Taylor
- Thomson Nicola
- Thrush Jessica
- Tilney Emma
- Tinmouth Alan
- Tong Steve
- Tooley Joe
- Touma Omar
- Trapani Tony
- Trask Kara
- Triulzi Darrell
- Trodd Dawn
- Tsang Jennifer
- Tully Redmond
- Turgeon Alexis
- Turki Salah
- Turner Anne
- Turner Anne
- Turner-Bone Ian
- Turns Margaret
- Uddin Ruzena
- Udy Andrew
- Uyeki Tim
- Vaara Suvi
- Vahtera Annukka
- Vamplew Luke
- van Bentum Puijk Wilma
- van Bentum-Puijk Wilma
- van Bentum-Puijk Wilma
- van Beurden Marloes
- van de Veerdonk Frank
- van de Veerdonk Frank
- Van Der Heyden Kym
- van der Poll Tom
- van’t Hoff Willian
- Vates Jennifer
- Vautier Sarah
- Vazquez-Grande Gloria
- Venkatesh Bala
- Venkatesh Balasubramanian
- Venz Ellen
- Verlander Mark
- Verrier Nathalie
- Victor Saji
- Vieillard-Baron Antoine
- Voicu Sebastian
- Vowell Emma
- Vujaklija Brajković Ana
- Vuylsteke Alain
- Wagh Atul
- Walden Andrew
- Walker Rachel
- Walsh Joanne
- Walsh Tim
- Walsham James
- Ward Kathryn
- Warnock Majella
- Waterson Sharon
- Watkins Claire
- Watpool Irene
- Watters Malcolm
- Waugh Victoria
- Webb Steve
- Webb Steven A
- Wedd Steve
- Weismann Dirk
- Weissman Alexandra
- Wells Colin
- Welters Ingeborg
- Wetherill Bill
- Whelan Ruth
- Whileman Amanda
- Whitbread Jennifer
- White Hayden
- White Ian
- White Katie
- Whitehead Christina
- Wibrow Bradley
- Wigbers J
- Wilby Elizabeth
- Wild Laura
- Wild Laura
- Wilding Laura
- Wiley Daisy
- Wilhelmsen Elva
- Wilkinson Dean
- Willams Felicity
- Williams Alexandra
- Williams Erin
- Williams Hannah
- Williams Karen
- Williams Patricia
- Williams Patricia
- Williams Penny
- Williams Tony
- Williams Virginie
- Williamson Dawn
- Williamson James
- Wilson Karen
- Wilson Maggie
- Wiseman Sophie
- Wong Helen
- Wood Erica
- Wood Hannah
- Wood Tracy
- Woods Jane
- Woods Lindsey
- Worner Ruth
- Wren Jess
- Wren Lynn
- Wrey Brown Caroline
- Writing Committee for the REMAP-CAP Investigators
- Xavier Kugan
- Xia Le Tai Charlotte
- Yarad Elizabeth
- Yates David
- Young Chelsea
- Young Ian
- Young Meredith
- Young Paul
- Yusuff Hakeem
- Zaharia Miahela Florentina
- Zaidi Abbas
- Zaki Ahmed
- Zaman Mohsin
- Zammit Claire
- Zapalac Marija
- Zarychanski Ryan
- Zarychanski Ryan
- Zhao Xiao Bei
- Zinzoni Vanessa
- Zitter Letizia
- Đimoti Renata
- Publication venue
- JAMA: Journal of the American Medical Association
- Publication date
- 06/10/2020
- Field of study
Importance: Evidence regarding corticosteroid use for severe coronavirus disease 2019 (COVID-19) is limited. Objective: To determine whether hydrocortisone improves outcome for patients with severe COVID-19. Design, Setting, and Participants: An ongoing adaptive platform trial testing multiple interventions within multiple therapeutic domains, for example, antiviral agents, corticosteroids, or immunoglobulin. Between March 9 and June 17, 2020, 614 adult patients with suspected or confirmed COVID-19 were enrolled and randomized within at least 1 domain following admission to an intensive care unit (ICU) for respiratory or cardiovascular organ support at 121 sites in 8 countries. Of these, 403 were randomized to open-label interventions within the corticosteroid domain. The domain was halted after results from another trial were released. Follow-up ended August 12, 2020. Interventions: The corticosteroid domain randomized participants to a fixed 7-day course of intravenous hydrocortisone (50 mg or 100 mg every 6 hours) (n = 143), a shock-dependent course (50 mg every 6 hours when shock was clinically evident) (n = 152), or no hydrocortisone (n = 108). Main Outcomes and Measures: The primary end point was organ support-free days (days alive and free of ICU-based respiratory or cardiovascular support) within 21 days, where patients who died were assigned -1 day. The primary analysis was a bayesian cumulative logistic model that included all patients enrolled with severe COVID-19, adjusting for age, sex, site, region, time, assignment to interventions within other domains, and domain and intervention eligibility. Superiority was defined as the posterior probability of an odds ratio greater than 1 (threshold for trial conclusion of superiority >99%). Results: After excluding 19 participants who withdrew consent, there were 384 patients (mean age, 60 years; 29% female) randomized to the fixed-dose (n = 137), shock-dependent (n = 146), and no (n = 101) hydrocortisone groups; 379 (99%) completed the study and were included in the analysis. The mean age for the 3 groups ranged between 59.5 and 60.4 years; most patients were male (range, 70.6%-71.5%); mean body mass index ranged between 29.7 and 30.9; and patients receiving mechanical ventilation ranged between 50.0% and 63.5%. For the fixed-dose, shock-dependent, and no hydrocortisone groups, respectively, the median organ support-free days were 0 (IQR, -1 to 15), 0 (IQR, -1 to 13), and 0 (-1 to 11) days (composed of 30%, 26%, and 33% mortality rates and 11.5, 9.5, and 6 median organ support-free days among survivors). The median adjusted odds ratio and bayesian probability of superiority were 1.43 (95% credible interval, 0.91-2.27) and 93% for fixed-dose hydrocortisone, respectively, and were 1.22 (95% credible interval, 0.76-1.94) and 80% for shock-dependent hydrocortisone compared with no hydrocortisone. Serious adverse events were reported in 4 (3%), 5 (3%), and 1 (1%) patients in the fixed-dose, shock-dependent, and no hydrocortisone groups, respectively. Conclusions and Relevance: Among patients with severe COVID-19, treatment with a 7-day fixed-dose course of hydrocortisone or shock-dependent dosing of hydrocortisone, compared with no hydrocortisone, resulted in 93% and 80% probabilities of superiority with regard to the odds of improvement in organ support-free days within 21 days. However, the trial was stopped early and no treatment strategy met prespecified criteria for statistical superiority, precluding definitive conclusions. Trial Registration: ClinicalTrials.gov Identifier: NCT02735707
Finishing the euchromatic sequence of the human genome
- Author
- . Haifeng
- . Magner
- . Yin
- Abbott Scott
- Abbott-Ozersky Amanda
- Abdellah Zahra
- Abouelleil Amr
- Abrajano Anne
- Adachi Tamami
- Adam Catherine
- Adams Charles Q.
- Adamson Aaron
- Adekoya Emmanuel
- Adio-Oduola Babajide
- Aerts Andrea
- Aggarwal Arun
- Ahmadi Alireza
- Ahmed Shahana
- Aimable Matthew
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- Ait-Zahra Mostafa
- Aizu Tomoyuki
- Alcivare Dana
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- Jassal Bijay
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- Jekosch Kerstin
- Jenkins Lee
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- Jewett Phillip E.
- Jia Jia
- Jia Jia
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- Jiang Lu
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- Jimenez Alberto
- Jin Jian
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- Jones Myrna D.
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- Kershaw Joanna
- Kettleborough Ross
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- Khan Umer F.
- Khan Ziad Mohid
- Khine Susu
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- Kovar Christie L.
- Krawczyk Marie-Claude
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- Kruchowski Scott S.
- Kube Michael
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- Lorensuhewa Lorna M.
- Lou Yunian
- Loulseged Hermela
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- Lovett Demetria A.
- Lowenstein Michael G.
- Lowry Stephen
- Lozado Ryan J.
- Lu Lingfeng
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- Lu Yongxiang
- Lu Yontao T.
- Lu Yue
- Lucas Robert
- Lucas Susan
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- Lucier Raymond L.
- Ludeman Thom
- Lui Annie
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- Machrus Migdad
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- Macken Catherine A.
- MacLean Christine
- Madabhushi Ramki
- Madu Renita C.
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- Maheshwari Manjula
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- Maltbie Mary I.
- Mangum Brian
- Manning Jonathan
- Manohar Chitra
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- Marabella Dick
- Mardis Elaine R.
- Mareth David
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- Marinelli Lisa
- Mark Graham A.
- Marquis-Homeyer Catherine
- Marr Thomas G.
- Marra Marco
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- Matthews Sterling D.
- Mauceli Evan
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- McMurray Des
- McMurray Kimberly
- McMurray Kimberly L.
- McNinch Jenny
- McPherson John
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- Mehta Nalini
- Meidi Patrick
- Meier Elke
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- Mercado Iracema C.
- Mercer Simon
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- Mesirov Jill P.
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- Mungall Andy
- Munidasa Mala
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- Murayama Yuji
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- Nagao Syunsuke
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- Nair Latha
- Nair Seema R.
- Naka Maho
- Nakagawa Masayo
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- Nazareth Lynne V.
- Neal Dearl D.
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- Nelson Deborah A.
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- Nowlin Larry
- Nusbaum Chad
- Nwaokelemeh Ogechi O.
- Nwokenkwo Stanley
- O\u27Donnell Paula
- O\u27Donovan Daniel
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- O\u27Loughlin Jennifer
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- Okui Michiyo
- Okumura Reina
- Okwuonu Geoffrey O.
- Okwuonu Kenneth C.
- Olarnpunsagoon Alisa
- Olivas Jason
- Oliver Hayley
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- Olson Maynard V.
- Omotosho Bamidele
- Onoda Junko
- Oomori Nobuhiro
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- Oragunye Njideka
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- Ovcharenko Ivan
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- Oviedo Rodolfo J.
- Ow David
- Ozawa Ritsuko
- Ozersky Philip
- Pace Araceli C.
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- Parkin Kim
- Parks Kenya L.
- Parry-Brown Ginny
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- Pasternak Shiran
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- Patel Vishal V.
- Patrick James
- Paul Heidie A.
- Paul Shelia
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- Payton Brett A.
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- Pearman Charlene
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- Peng Vivian
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- Peng Yi
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- Pennacchio Len A.
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- Perez Agapito
- Perez Lesette M.
- Perito Andrew
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- Porter Keith
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- Poundstone Pat
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- Powell Don
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- Prathalingham Radhika
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- Qiang Boqin
- Qiao Zhenyong
- Qin Xiang
- Quail Michael
- Quan Glenda
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- Quiles Miyo M.
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- Quiroz Juana B.
- Qureshi Matloob
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- Rachlin Eric K.
- Rachupka Anthony
- Radionenko Maxim
- Rajagopal Mohan
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- Reily Amy D.
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- Ridler Kerry
- Riethman Harold
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- Rise Cecil
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- Robert Catherine
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- Robinson Donna L.
- Robinson Melanie
- Rochford Rebecca
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- Sasaki Takashi
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- Saurin William
- Savery Glenford G.
- Sawada Nori
- Sawhill William W.
- Saxman Eric
- Scarpelli Claude
- Scharfe Maren
- Schatzkamer Kyriena L.
- Scherer Steven Edward
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- Siddiqui Roman
- Siepel Adam C.
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- Silk Richard
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- Solovyev Victor
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- Sonaike Titilola
- Song Liping
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- Song Xing-Zhi
- Sonnhammer Erik
- Sonnhammer Erik
- Sorelle Richard P.
- Sotheran Elizabeth
- Sougnez Carrie
- Spainhower Corey
- Sparks Anastasia L.
- Spencer Brian
- Spieth John
- Spooner William
- Spraggon Lee
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- Stabenau Arne
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- Stallings Raymond I.
- Stalvey Malinda
- Stamford Steve
- Stammers Melanie
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- Steffen David
- Stege Justin T.
- Steingruber Helen
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- Su Xiaohu
- Subramanian Sandhya
- Subramanian Sandhya
- Sudbrak Ralf
- Sugnet Charles W.
- Sulston John
- Summers Leslie J.
- Sun Hui
- Sun Jiajia
- Sun Jiandong
- Sun Jiu Qin
- Sun Min
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- Sun Wei
- Sun Yongqiao
- Sun Yu
- Sun Yue
- Sutherland Grant R.
- Sutherland Robert D.
- Sutton Angelica E.
- Svatek Amanda F.
- Svetz Jessica
- Svetz Leah Anne
- Swainson Chris
- Swann Mark
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- Swearengen-Shahid Sharhonda
- Sycamore Neil
- Ségurens Béatrice
- Tabor Paul E.
- Tacey Kristina
- Tagett Beckie
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- Takaoka Tori
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- Tam Serena
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- Tan Olivia
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- Tan Xinyu
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- Tansey Jennifer
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- Tapia Roxanne
- Taring Elizabeth
- Tatsuyama Miho
- Tatum Owatha I.
- Taudien Stefan
- Taylor Amy
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- Taylor Tineace R.
- Taylor Todd Duane
- Tchuinga Pierre
- Tee Louise
- Telford Ethan Brett
- Tenzin Pema
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- Tesfaye Senait
- Tesmer Judith G.
- Tester Julieanne
- Thayer Nina
- Theaker Andrew
- Theil James
- Theodore Joumathe
- Thexton David
- Thies Stephanie
- Thomas Craig
- Thomas Daniel
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- Zhen Zhicheng
- Zheng Haibo
- Zhong Ming
- Zhou Carol
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- Zhou Jianling
- Zhou Nannan
- Zhou Xinfeng
- Zhou Yan
- Zhou Yang
- Zhou Yi
- Zhu Bingying
- Zhu Bofeng
- Zhu Fenghua
- Zhu Genfeng
- Zhu Genfeng
- Zhu Miao
- Zhu Ning
- Zhu Yongge
- Zhu Zhen
- Zhuang Shitao
- Zierten Deborah
- Zimmer Andrew
- Zody Michael C.
- Zollo Massimo
- Zorrilla Sara E.
- Zuo Lin
- Publication venue
- LSU Digital Commons
- Publication date
- 21/10/2004
- Field of study
The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead
Impact of opioid-free analgesia on pain severity and patient satisfaction after discharge from surgery: multispecialty, prospective cohort study in 25 countries
- Author
- Aamir Faiqa Binte
- Aamir Syed Roohan
- Ababneh Adnan
- Abbal Muhammad Anas
- Abbas Ahmed M
- Abbas Mostafa
- Abd-Albain Montasir A
- Abdalei Abdulwahab
- Abdalla Ahmed
- Abdalla Ahmed Yassir
- Abdalla Mohamed Galal Ali
- Abdalla Zainab
- Abdallah Mohamed M
- Abdalmahmoud Noon Ezzeldien
- Abdalsadeg Rowa
- Abdelaal Ahmed M
- Abdelbagi Alnazeer Y
- Abdelbaky Mostafa
- Abdelbaset Doaa
- AbdElbaset Esraa
- Abdelbast Menhag
- Abdelfatah Mohammed Abdelnasser
- Abdelgawad Samia
- Abdelhamid Mohamed M
- Abdeljaber Mahmoud
- Abdelkhalig Mubarak
- Abdelmaksoud Mohamed
- Abdelmeguid Rana
- Abdelmelek Dhia Errahmane
- Abdelnaeam Samah
- Abdelnasser Mohammad K
- Abdelrahim Najwa
- Abdelrahman Amira
- Abdelrahman Ayman
- Abdelsalam Hebatalla
- Abdelsamed Enas Abdelbaset
- Abdelwahab Khaled
- Abdoun Meriem
- Abdulali Fatima
- Abdulaziz Mohamed
- Abdulla Dheba Almukhtar
- Abdullah Bahiyah
- Abdullah Bahiyah
- Abdullah Walaa
- Abdullahi Habiba Ibrahim
- Abdulrahman Ahmed
- Abdulrasheed Lubabatu
- Abdulwahed Eman
- Abdulwahed Eman
- Abeysirigunawardana Dewmi
- Abidin Muhammad Fihmi Zainal
- Abiola Olukayode
- Abiyere Henry
- Abodina Ahmed Mohammed
- Aboelela Reham
- AboElfarh Hadeer Elsaeed
- Aboudlal Husein
- AbouHiekal Osama
- Aboulfotouh Ahmed
- Abozid Anwaar
- Abubaker Noora
- Abubaker Noora
- Abufanas Asma
- Abughanima Mahmoud
- Abuhashem Shehab
- Abulafia Daniel
- Abushaala Fatima
- Abushanab Khaled
- AbuShawareb Issa
- Abuuqteish Hamza
- Abuzaho Amany
- Achem Arome
- Adam Eithar
- Adam Mohammed
- Adam Mohammed A
- Addalla Mohamed
- Addley Jordan
- Adeleye Gbadebo
- Adeniyi Adebayo
- Adewole Nathaniel
- Adeyemo Olabisi
- Adeyeye Ademola
- Adeyeye Ademola
- Adly Michael
- Adnan Siti Nasyirah Nisya
- Ads Adel Mohamed
- Ads Alaa Mohamed
- Adze Joel Amwe
- Afeikhena Ehis
- Agida Teddy
- Agilla Hamza
- Agnew Emilie
- Agu Joy Onyekachi
- Ahmad Zatul Akmar
- Ahmed Abdalla
- Ahmed Ahmed
- Ahmed Ahmed
- Ahmed Alaaaldeen
- Ahmed Entisar
- Ahmed Habeeba
- Ahmed Hatem
- Ahmed Reem
- Ahmed Rehab
- Ahmed Rihab
- Ahmed Rogia Ahmed Abdalla
- Ahmed Ruaa
- Ahmed Sharwany
- Ahmed Uzair
- Ahmed Wahiba
- Ahmeed Sultan
- Airede Lydia Regina
- Aitchison Lori
- Ajredini Mirac
- Ajulo Adeshina A
- Akaba Godwin
- Akasha Mazin
- Akbar Maha Ghulam
- Akbuz Seyma Orcan
- Akdere Hakan
- Akın Bilge
- Akkaya Ege Nur
- Akpamgbo Chukwunonso Nnamdi
- Akwaisah Ayoub
- Al Hammoud Amr
- Al Rawashdeh Toka
- Al-Baw Mahmoud
- Al-Dahdouh Mosheer
- Al-Haek Safa’
- Al-Hazaimeh Mo'ath
- Al-issawi Dima
- Al-Issawi Subhi
- Al-jammal Maryam
- Al-Juaifari Maytham A
- Al-Mwajeh Tesneem
- Al-Omary Sohaib
- Al-Quossi Mohammed
- Al-Shambaty Yasir Babkir Ali
- Al-Shami Qotadah
- Al-Smirat Heba
- Al-Tahayneh Sief-Addeen
- Al-Touny Aiman
- Al-Touny Shimaa
- Al-zawaydeh Alia
- Alaa Ali
- Alabed Ebtihal
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- Alagoz Ahmet Can
- Alameen Hind
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- Alamlih Laith
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- Alarabi Rehab
- Alariby Fatima
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- Alathameen Nassar
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- Albarhomy Osama
- Albarki Aisha
- Albashaireh Alaa
- Albatni Safa Sasi
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- Alboon Mosab
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- Alboueishi Asraa Ali
- Aldeges Marwan
- Aldreawi Mohammed
- Alflite Asil Omar Saleh
- Alfrijat Tamam
- Alfrjani Tariq
- Algabbasi Salima
- Algatanesh Nassib
- Alhadad Qamrah
- Alhaddad Hoda Salem
- Alhaleem Ayah
- Alhaleeq Saif
- Alharam Abtisam
- Alhashimi Abdulhadi Mohammed Alhadi
- Alhassan Monzer
- Alhudhairy Sara
- Ali Ahmed
- Ali Aml
- Ali Doua
- Ali Eithar M
- Ali Iqra Fatima Munawar
- Ali Maab
- Ali Manal
- Ali Muhammad
- Ali Radwa
- Ali Rawan Alsheikh
- Ali Rzan Ali Hamedelneel
- Ali Shehroz
- Aliosin Oleg
- Aljamal Mohammad
- Aljamal Sarah
- Alkaraja Layth
- Alkaseek Akram
- Alkazali Mustafa
- Alkchr Hayat Ben Hasan Mohamed A A
- Alkhatib Abed Alazeez
- Allam Shereen
- Almahroush Marin
- Almakki Doha Mohammed Ahmed
- Alnajjar Lara
- Alnajjar Majjd
- Alnatsheh Wesam
- Alnour Ammar
- Alomar Rabiaa
- Alomari Yazan
- Alqaarh Aya
- Alragig Zahra
- Alrifae Ghaliya Mohamed H
- Alrosan Risan
- Alsagoff Sharifah Nor Amirah Syed Abdul Latiff
- Alsaid Hamza
- Alsaify Esmat
- Alsaih Sawsan
- Alsari Najah
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- Alshawadfy Abdelrhman
- Alshawesh Aisha
- Alsheik Ahmad
- Alsori Mohamed
- Alsoudani Ali
- Altabbaa Hashem
- Altahir Mohamed
- Altair Mawadda
- Altaweel Ahmad
- Altughar Bushra
- Alvarez Matias
- Alvarez-Lozada Luis Adrian
- Alvarez-Lozada Luis Adrian
- Alwahaib Anas
- Alwash Mohammed
- Alzarga Ali
- Alzarouq Ebtisam
- Alzarroug Amal
- Alzghoul Bader
- Alzyoud Osama
- Amarasekara Mishka
- Amary Marwa
- Ametov Amet
- Amin Mostafa K
- Aminu Bashiru
- Aminu Muhammad Baffah
- Ammar Ahmed Siddique
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- Ananthapadmanabhan Shravankrishna
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- Teema Eman
- Telci Hatice
- Temerik Abdallah Rashad
- Teng Cherilyn
- Tepe Mustafa Deniz
- Tepe Mustafa Deniz
- Terrosu Giovanni
- Theophilus Mary
- Thompson Nasya
- Thornton-Hume David
- Tiffany Lea
- Ting Clarissa
- Tiras Hale Nur
- Titan Ashley
- Toft Alexandra
- Traina Francesco
- Tran Anthony
- Tran Quang
- Tran Tam
- Tran Will
- Trotta Georgina
- Tsakiridis Ioannis
- Tsakiridis Nikolaos
- Tsourouflis Gerasimos
- Tsui Sonia Ching Ting
- Tu Hien
- Tun Than
- Tung Melody
- Tuzuner Filiz
- Tynan Dominic
- Ugool Mahmoud
- Uğurlu Mustafa Ümit
- Ukrani Ronika Devi
- Ukwuoma Ohia Ernest
- Ulkucu Attila
- Uludag Server Sezgin
- Ulusahin Mehmet
- umar Abubakar
- Umar Gabi Ibrahim
- Uprak Tevfik Kıvılcım
- Ureña Violeta
- Usman Liman Haruna
- Uyanık Mustafa Safa
- Uzair Ahmad
- Uzel Kadir
- Vadioaloo Dinesh Kumar
- Valaroutsou Olga Maria
- Valverde-Vazquez Rocio
- Vance Lucille
- Vanguardia Kristina
- Vanguardia Maria Kristina
- Vanzuylekom Katie
- Varesano Marco
- Varghese Chris
- Varghese Chris
- Velenciuc Natalia
- Vermeulen Wikus
- Vidanagama Sasini
- Vimalan Vineeth
- Virani Sehar Salim
- Vollenhoven Beverley
- Vong Crystal
- Vrakopoulou Gavriella Zoi
- Vu Jennifer
- Vu Jennifer
- Waaka Nicholas
- Wadhwa Sanya
- Wagaarachchi Prabhath
- Waheed Ayesha Akbar
- Waldin Lucy
- Walsh Eamon
- Walters Chris
- Wang Bill
- Wang Christine
- Wang Erica
- Wang Grace
- Wang Katie
- Wang Nicole Qiwen
- Wang Pengnan
- Wang Qiwen
- Wang Shelley
- Wang Yantong
- Wang Zixuan
- Waqar Usama
- Waraich Abdullah
- Ward Jack
- Wardeh Salah Abu
- Wasim Tayyiba
- Watson David
- Watson David
- Wedatalla Mansour
- Weeda Lewis
- Wells Cameron
- Wells Cameron
- Wells Cameron
- Wells Oliver
- Werenski Hope
- Wijayaratne Rivindu
- Wijetunga Asanka
- Williams Brittany
- Williams Peter
- Wilson Thomas
- Windsor John
- Windsor John
- Winthrop Lily
- Withanage Indrajith
- Wong James
- Wong Jason
- Wong Kenneth
- Wong King Ho
- Wong Patrick
- Wong Samantha
- Woodbridge Christian
- Wright Deborah
- Wright Deborah
- Wright Deborah
- Wu Alan
- Wu Alan
- Wu Chun-Yen
- Wu Hongyi
- Wycliff Daniel
- Xiao Haotian
- Xie Maria
- Xu Cindy
- Xu William
- Xu William
- Xu William
- Yaghmour Jamal
- Yahya Bilal Shuaibu
- Yahya Rawad
- Yang Wah
- Yao Michelle
- Yao Sunny
- Yao Sunny
- Yasar Meltem
- Yasir Ruaa
- Yassin Mohamed
- Yavuz Dogancan
- Yavuz Ikranur
- Yaytokgil Muhammet
- Yazgan Yasemin
- Yee Su-Ann
- Yeung Justin
- Yeung Kar Long
- Yew Anthea
- Yi Kevin
- Yiannakopoulos Christos
- Yildirim Yasemin
- Yildiz Ahmet
- Yıldız Berkay
- Yilmaz Hakan
- Yin Chonghao
- Ying Geoffrey
- Yodkitydomying Chatnapa
- Yong Nathania
- Yoon Si Woo
- You Ha Seong
- Young Simon
- Young Stevie
- Younus Khadijah
- Yousif Fatima Imad
- Yousri Mohamed
- Youssef Ahmed A
- Youssef Arkan
- Yu Hoi Hang
- Yu Victor
- Yuan Grace
- Yue Bosco
- Yue Tiffany
- Yunos Mohamed Haseef Mohamed
- Yusuf Stephen
- Yuzgec Ayse Nilufer
- Zachomitros Fotios
- Zaed Moahmed
- Zafar Fatima
- Zaghloul Ahmed
- Zaheer Adil
- Zaidi Faseeh
- Zain Ahmad
- Zakaria Ahmed
- Zakaria Andee Dzulkarnaen
- Zakaria Mohd Zaim
- Zalloum Jihad
- Zamanbandhon Bushra
- Zambon Mattia
- Zapsalis Konstantinos
- Zargar Kamran
- Zarzour Mohamed A
- Zeng Raymond
- Zeng Raymond
- Zengin Kagan
- Zertuche Juventino Tadeo Guerrero
- Zhang Caitlin
- Zhang Edward
- Zhang Shane
- Zhang Yichi
- Zhao Hailin
- Zheng Helen
- Zhou Karen
- Zhou Yida
- Ziergiebel Felix
- Zou Peishan
- Zuylekom Kate Van
- Zuylekom Katie Van
- Zwain Yasir Adnan
- Zyul'korneeva Sof'ya
- Aladna Abdallah
- Aljoumaa Abdullah
- Nawfal Hamdi
- Niazi Ammar
- Publication venue
- Publication date
- 01/01/2024
- Field of study
Background: Balancing opioid stewardship and the need for adequate analgesia following discharge after surgery is challenging. This study aimed to compare the outcomes for patients discharged with opioid versus opioid-free analgesia after common surgical procedures.Methods: This international, multicentre, prospective cohort study collected data from patients undergoing common acute and elective general surgical, urological, gynaecological, and orthopaedic procedures. The primary outcomes were patient-reported time in severe pain measured on a numerical analogue scale from 0 to 100% and patient-reported satisfaction with pain relief during the first week following discharge. Data were collected by in-hospital chart review and patient telephone interview 1 week after discharge.Results: The study recruited 4273 patients from 144 centres in 25 countries; 1311 patients (30.7%) were prescribed opioid analgesia at discharge. Patients reported being in severe pain for 10 (i.q.r. 1-30)% of the first week after discharge and rated satisfaction with analgesia as 90 (i.q.r. 80-100) of 100. After adjustment for confounders, opioid analgesia on discharge was independently associated with increased pain severity (risk ratio 1.52, 95% c.i. 1.31 to 1.76; P < 0.001) and re-presentation to healthcare providers owing to side-effects of medication (OR 2.38, 95% c.i. 1.36 to 4.17; P = 0.004), but not with satisfaction with analgesia (beta coefficient 0.92, 95% c.i. -1.52 to 3.36; P = 0.468) compared with opioid-free analgesia. Although opioid prescribing varied greatly between high-income and low- and middle-income countries, patient-reported outcomes did not.Conclusion: Opioid analgesia prescription on surgical discharge is associated with a higher risk of re-presentation owing to side-effects of medication and increased patient-reported pain, but not with changes in patient-reported satisfaction. Opioid-free discharge analgesia should be adopted routinely
Phase 3, Randomized, 20-Month Study of the Efficacy and Safety of Bimatoprost Implant in Patients with Open-Angle Glaucoma and Ocular Hypertension (ARTEMIS 2)
- Author
- Alezzandrini Arturo
- Amir Ahmad
- Arango Santiago
- Bacharach Jason
- Bacharach Jason
- Bandello Francesco
- Barnebey Howard
- Beck Allen
- Bejanian Marina
- Belalcázar Sandra
- Belalcázar Sandra
- Bell Katharina
- Bercovich Gabriel
- Bergstrom Lance
- Birt Catherine
- Borisuth Navaneet
- Bourne Rupert R. A.
- Branch James D.
- Briggs Jonathan
- Bylsma Stephen
- Cagini Carlos
- Chang Peter
- Chen Michelle Y.
- Choudhary Anshoo
- Christie William
- Cordeiro Francesca
- Cotter Frank
- Crichton Andrew
- Depenbusch Michael
- Deromedis Pablo
- Dubois Vincent
- El Ibiary Hani
- El Sanabary Zeinab
- Eraslan Muhsin
- Ferguson Gloria
- Figus Michele
- Furno Sola Federico
- Gagne Sebastien
- Gentile Carolina
- Giunta Michael
- Goldberg Damien F.
- Goodkin Margot L.
- Gous Petrus
- Greiner Jack
- Greslechner Roman
- Guo Qiang
- Gupta Shailesh
- Gutmark Ron
- Han Ying
- Harasymowycz Paul
- Heersink Sebastian
- Husain Rahat
- Jinapriya Delan
- Kadlecova Jana
- Kahook Malik
- Kayikcioglu Ozcan
- Kee Changwon
- Khairy Hany
- Khouri Albert
- Kim Joshua
- Kirwan James
- Koch Jöerg
- Koh Victor
- Kook Michael
- Korda Vladimir
- Kushnick Howard
- Lerner Simon
- Lim Dawn
- Lim Sheng
- Lin Christopher
- Liu Jeen
- Lorenz Katrin
- Luchs Jodi
- Lupinacci Anahi
- Maharaj Arindel
- Mansberger Steven L.
- Mares Frank
- Martin Keith
- Martinez Alexander
- Mastropasqua Leonardo
- Miller-Ellis Eydie
- Modi Satish
- Nicolela Marcelo
- Nithy Antony
- Nixon Donald
- Oberacher-Velten Isabel
- Park Ki-Ho
- Parra Restrepo Juan C.
- Paul Matthew
- Pitha Ian
- Prabhu Avinash
- Robinson Michael R.
- Rossetti Luca
- Saltzmann Robert
- Sato Michelle
- Saurel Patrick
- Savestsky Michael
- Schmickler Stefanie
- Schuart Claudie
- Segal Bruce
- Segal Zachary
- Serle Janet
- Sherwood Mark
- Singh Inder
- Smith Stephen E.
- Song Julia
- Sorenson Robert
- Svacinova Jitka
- Tatham Andrew
- Tatham Andrew
- Tekwani Navin
- Tenkman Lawrence
- Thayanithi Sandragasu
- Thieme Hagen
- Thieme Hagen
- Tin Aung
- Tubbs Carl
- Tyson Farrell
- Uva Maurizio G.
- Venter Lynette
- Vizzeri Gianmarco
- Vold Steven
- Vu Qui
- Warren Kimberly S.
- Wells Anthony
- Wirta David
- Wirta David L.
- Yan David
- Yildirim Nilgun
- Yuen Darana
- Zeolite Carlos
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/11/2021
- Field of study
Objective-
To evaluate the intraocular pressure (IOP)-lowering efficacy and safety of 10 and 15 µg bimatoprost implant in patients with open-angle glaucoma (OAG) or ocular hypertension (OHT).
Methods-
This randomized, 20-month, multicenter, masked, parallel-group, phase 3 trial enrolled 528 patients with OAG or OHT and an open iridocorneal angle inferiorly in the study eye. Study eyes were administered 10 or 15 µg bimatoprost implant on day 1, week 16, and week 32, or twice-daily topical timolol maleate 0.5%. Primary endpoints were IOP and IOP change from baseline through week 12. Safety measures included treatment-emergent adverse events (TEAEs) and corneal endothelial cell density (CECD).
Results-
Both 10 and 15 µg bimatoprost implant met the primary endpoint of noninferiority to timolol in IOP lowering through 12 weeks. Mean IOP reductions from baseline ranged from 6.2–7.4, 6.5–7.8, and 6.1–6.7 mmHg through week 12 in the 10 µg implant, 15 µg implant, and timolol groups, respectively. IOP lowering was similar after the second and third implant administrations. Probabilities of requiring no IOP-lowering treatment for 1 year after the third administration were 77.5% (10 µg implant) and 79.0% (15 µg implant). The most common TEAE was conjunctival hyperemia, typically temporally associated with the administration procedure. Corneal TEAEs of interest (primarily corneal endothelial cell loss, corneal edema, and corneal touch) were more frequent with the 15 than the 10 µg implant and generally were reported after repeated administrations. Loss in mean CECD from baseline to month 20 was ~ 5% in 10 µg implant-treated eyes and ~ 1% in topical timolol-treated eyes. Visual field progression (change in the mean deviation from baseline) was reduced in the 10 µg implant group compared with the timolol group.
Conclusions-
The results corroborated the previous phase 3 study of the bimatoprost implant. The bimatoprost implant met the primary endpoint and effectively lowered IOP. The majority of patients required no additional treatment for 12 months after the third administration. The benefit-risk assessment favored the 10 over the 15 µg implant. Studies evaluating other administration regimens with reduced risk of corneal events are ongoing. The bimatoprost implant has the potential to improve adherence and reduce treatment burden in glaucoma
GWAS meta-analysis of over 29,000 people with epilepsy identifies 26 risk loci and subtype-specific genetic architecture
- Author
- Abou-Khalil Bassel
- Adesoji Oluyomi M.
- Afawi Zaid
- Amadori Elisabetta
- Anderson Alison
- Anderson Joseph
- Andrade Danielle M.
- Annesi Grazia
- Auce Pauls
- Avbersek Andreja
- Bahlo Melanie
- Baker Mark D.
- Balagura Ganna
- Balestrini Simona
- Barba Carmen
- Barboza Karen
- Bartolomei Fabrice
- Bast Thomas
- Baum Larry
- Baumgartner Tobias
- Baykan Betül
- Bebek Nerses
- Becker Albert J.
- Becker Felicitas
- Bennett Caitlin A.
- Berghuis Bianca
- Berkovic Samuel F.
- Beydoun Ahmad
- Bianchini Claudia
- Bisulli Francesca
- Blatt Ilan
- Bobbili Dheeraj R.
- Borggraefe Ingo
- Bosselmann Christian
- Braatz Vera
- Bradfield Jonathan P.
- Brockmann Knut
- Brody Lawrence C.
- Buono Russell J.
- Busch Robyn M.
- Caglayan Hande
- Campbell Ciarán
- Campbell Ellen
- Canafoglia Laura
- Canavati Christina
- Cascino Gregory D.
- Castellotti Barbara
- Catarino Claudia B.
- Cavalleri Gianpiero L.
- Cerrato Felecia
- Chassoux Francine
- Chen Siwei
- Cherny Stacey S.
- Cheung Ching-Lung
- Chinthapalli Krishna
- Chou I-Jun
- Chung Seo-Kyung
- Churchhouse Claire
- Clark Peggy O.
- Cole Andrew J.
- Compston Alastair
- Coppola Antonietta
- Cosico Mahgenn
- Cossette Patrick
- Craig John J.
- Cusick Caroline
- Daly Mark J.
- Davis Lea K.
- de Haan Gerrit-Jan
- Delanty Norman
- Depondt Chantal
- Derambure Philippe
- Devinsky Orrin
- Di Vito Lidia
- Dlugos Dennis J.
- Doccini Viola
- Doherty Colin P.
- El-Naggar Hany
- Elger Christian E.
- Ellis Colin A.
- Eriksson Johan G.
- Faucon Annika
- Feng Yen-Chen A.
- Ferguson Lisa
- Ferraro Thomas N.
- Ferri Lorenzo
- Feucht Martha
- Fitzgerald Mark
- Fonferko-Shadrach Beata
- Fortunato Francesco
- Franceschetti Silvana
- Franke Andre
- French Jacqueline A.
- Freri Elena
- Gagliardi Monica
- Gambardella Antonio
- Geller Eric B.
- Giangregorio Tania
- Gjerstad Leif
- Glauser Tracy
- Goldberg Ethan
- Goldman Alicia
- Granata Tiziana
- Greenberg David A.
- Guerrini Renzo
- Gupta Namrata
- Haas Kevin F.
- Hakonarson Hakon
- Hallmann Kerstin
- Hassanin Emadeldin
- Hegde Manu
- Heinzen Erin L.
- Helbig Ingo
- Hengsbach Christian
- Heyne Henrike O.
- Hirose Shinichi
- Hirsch Edouard
- Hjalgrim Helle
- Howrigan Daniel P.
- Hucks Donald
- Hung Po-Cheng
- Iacomino Michele
- Imbach Lukas L.
- Inoue Yushi
- Ishii Atsushi
- Jamnadas-Khoda Jennifer
- Jehi Lara
- Johnson Michael R.
- Kamatani Yoichiro
- Kanaan Moien
- Kanai Masahiro
- Kantanen Anne-Mari
- Kara Bülent
- Kariuki Symon M.
- Kasperavičiūte Dalia
- Kasteleijn-Nolst Trenite Dorothee
- Kato Mitsuhiro
- Kegele Josua
- Kesim Yeşim
- Khoueiry-Zgheib Nathalie
- King Chontelle
- Kirsch Heidi E.
- Klein Karl M.
- Kluger Gerhard
- Knake Susanne
- Knowlton Robert C.
- Koeleman Bobby P. C.
- Korczyn Amos D.
- Koupparis Andreas
- Kousiappa Ioanna
- Krause Roland
- Krenn Martin
- Krestel Heinz
- Krey Ilona
- Kunz Wolfram S.
- Kurki Mitja I.
- Kurlemann Gerhard
- Kuzniecky Ruben
- Kwan Patrick
- Kälviäinen Reetta
- Labate Angelo
- Lacey Austin
- Lal Dennis
- Landoulsi Zied
- Lau Yu-Lung
- Lauxmann Stephen
- Leech Stephanie L.
- Lehesjoki Anna-Elina
- Lemke Johannes R.
- Lerche Holger
- Lesca Gaetan
- Leu Costin
- Lewin Naomi
- Lewis-Smith David
- Li Gloria H.-Y.
- Li Qingqin S.
- Licchetta Laura
- Lin Kuang-Lin
- Lindhout Dick
- Linnankivi Tarja
- Lopes-Cendes Iscia
- Lowenstein Daniel H.
- Lui Colin H. T.
- Madia Francesca
- Magnusson Sigurdur
- Marson Anthony G.
- May Patrick
- McGraw Christopher M.
- Mei Davide
- Mills James L.
- Minardi Raffaella
- Mirza Nasir
- Molloy Anne M.
- Montomoli Martino
- Mostacci Barbara
- Muccioli Lorenzo
- Muhle Hiltrud
- Møller Rikke S.
- Müller-Schlüter Karen
- Najm Imad M.
- Nasreddine Wassim
- Neale Benjamin M.
- Neubauer Bernd
- Newton Charles R. J. C.
- Nothnagel Michael
- Nöthen Markus M.
- Nürnberg Peter
- Okada Yukinori
- Oliver Karen L.
- O’Brien Terence J.
- Palotie Aarno
- Pangilinan Faith
- Papacostas Savvas S.
- Parrini Elena
- Pato Carlos N.
- Pato Michele T.
- Pendziwiat Manuela
- Petrovski Slavé
- Pickrell William O.
- Pinsky Rebecca
- Pippucci Tommaso
- Poduri Annapurna
- Pondrelli Federica
- Powell Rob H. W.
- Privitera Michael
- Rademacher Annika
- Radtke Rodney
- Ragona Francesca
- Rau Sarah
- Rees Mark I.
- Regan Brigid M.
- Reif Philipp S.
- Rhelms Sylvain
- Riva Antonella
- Rosenow Felix
- Ryvlin Philippe
- Saarela Anni
- Sadleir Lynette G.
- Sander Josemir W.
- Sander Thomas
- Scala Marcello
- Scattergood Theresa
- Schachter Steven C.
- Schankin Christoph J.
- Scheffer Ingrid E.
- Schmitz Bettina
- Schoch Susanne
- Schubert-Bast Susanne
- Schulze-Bonhage Andreas
- Scudieri Paolo
- Sham Pak
- Sheidley Beth R.
- Shih Jerry J.
- Sills Graeme J.
- Sisodiya Sanjay M.
- Smith Michael C.
- Smith Philip E.
- Sonsma Anja C. M.
- Speed Doug
- Sperling Michael R.
- Stefansson Hreinn
- Stefansson Kári
- Steinhoff Bernhard J.
- Stephani Ulrich
- Stevelink Remi
- Stewart William C.
- Stipa Carlotta
- Striano Pasquale
- Stroink Hans
- Strzelczyk Adam
- Surges Rainer
- Suzuki Toshimitsu
- Tan K. Meng
- Taneja R. S.
- Tanteles George A.
- Taubøll Erik
- Thio Liu Lin
- Thomas G. Neil
- Thomas Rhys H.
- Timonen Oskari
- Tinuper Paolo
- Todaro Marian
- Topaloğlu Pınar
- Tozzi Rossana
- Tsai Meng-Han
- Tumiene Birute
- Turkdogan Dilsad
- Unnsteinsdóttir Unnur
- Utkus Algirdas
- Vaidiswaran Priya
- Valton Luc
- van Baalen Andreas
- Vetro Annalisa
- Vining Eileen P. G.
- Visscher Frank
- von Brauchitsch Sophie
- von Wrede Randi
- Wagner Ryan G.
- Weber Yvonne G.
- Weckhuysen Sarah
- Weisenberg Judith
- Weller Michael
- Widdess-Walsh Peter
- Wolff Markus
- Wolking Stefan
- Wu David
- Yamakawa Kazuhiro
- Yang Wanling
- Yapıcı Zuhal
- Yücesan Emrah
- Zagaglia Sara
- Zahnert Felix
- Zara Federico
- Zhou Wei
- Zimprich Fritz
- Zsurka Gábor
- Zulfiqar Ali Quratulain
- Ólafsson Elías
- Özkara Çiğdem
- Publication venue
- Nature Research
- Publication date
- 01/01/2023
- Field of study
Epilepsy is a highly heritable disorder affecting over 50 million people worldwide, of which about one-third are resistant to current treatments. Here we report a multi-ancestry genome-wide association study including 29,944 cases, stratified into three broad categories and seven subtypes of epilepsy, and 52,538 controls. We identify 26 genome-wide significant loci, 19 of which are specific to genetic generalized epilepsy (GGE). We implicate 29 likely causal genes underlying these 26 loci. SNP-based heritability analyses show that common variants explain between 39.6% and 90% of genetic risk for GGE and its subtypes. Subtype analysis revealed markedly different genetic architectures between focal and generalized epilepsies. Gene-set analyses of GGE signals implicate synaptic processes in both excitatory and inhibitory neurons in the brain. Prioritized candidate genes overlap with monogenic epilepsy genes and with targets of current antiseizure medications. Finally, we leverage our results to identify alternate drugs with predicted efficacy if repurposed for epilepsy treatment
Genome-wide identification and phenotypic characterization of seizure-associated copy number variations in 741,075 individuals
- Author
- Abbott Liam E
- Abou-Khalil Bassel W
- Afawi Zaid
- Ali Quratulain Zulfiqar
- Allen Andrew S
- Amadori Elisa
- Anderson Joe
- Andrade Danielle M
- Annesi Grazia
- Arslan Mutluay
- Auce Pauls
- Baker Mark D
- Balestrini Simona
- Barba Carmen
- Barisic Nina
- Bartolomei Fabrice
- Baum Larry W
- Baumgartner Tobias H
- Baykan Betul
- Bebek Nerses
- Becker Felicitas
- Bennett Caitlin A
- Bennett Caitlin A
- Berkovic Samuel F
- Berkovic Samuel F
- Berkovic Samuel F
- Beydoun Ahmad
- Bianchini Claudia
- Bisulli Francesca
- Blatt Ilan
- Borggrafe Ingo
- Bosselmann Christian
- Braatz Vera
- Brockmann Knut
- Bruenger Tobias
- Buono Russell J
- Busch Robyn M
- Byrnes Andrea E
- Caglayan S Hande
- Canafoglia Laura
- Canavati Christina
- Castellotti Barbara
- Cavalleri Gianpiero L
- Cavalleri Gianpiero L
- Cerrato Felecia
- Chassoux Francine
- Cherny Stacey S
- Chou I-Jun
- Chung Seo-Kyung
- Churchhouse Claire
- Clark Peggy O
- Cole Andrew J
- Collins Ryan L
- Cosico Mahgenn
- Cossette Patrick
- Cossette Patrick
- Cotsapas Chris
- Cusick Caroline
- Davis Lea
- De Jonghe Peter
- De Jonghe Peter
- Delanty Norman
- Dennig Dieter
- Depondt Chantal
- Depondti Chantal
- Derambure Philippe
- Devinsky Orrin
- Dhindsa Ryan S
- Dhindsa Ryan S
- Dixon-Salazar Tracy
- Dlugos Dennis J
- Dlugos Dennis J
- Dlugos Dennis J
- Doccini Viola
- Doherty Colin P
- El-Naggar Hany
- Ellis Colin A
- Faucon Annika
- Feng Yen-Chen Anne
- Ferguson Lisa
- Ferraro Thomas N
- Feucht Martha
- Fitch Eryn
- Fonferko-Shadrach Beata
- Franceschetti Silvana
- French Jacqueline A
- French Jacqueline A
- Freyer Catharine
- Gagliardi Monica
- Gambardella Antonio
- Ganesan Shiva
- Giacomini Thea
- Glauser Tracy A
- Goldberg Ethan
- Goldman Alicia
- Goldstein David B
- Goldstein David B
- Goldstein David B
- Granata Tiziana
- Greenberg David A
- Guerrini Renzo
- Guerrini Renzo
- Gundogdu-Eken Asli
- Gupta Namrata
- Haas Kevin
- Haeusler Martin
- Hakonarson Hakon
- Hakonarson Hakon
- Haryanyan Garen
- Hegde Manu
- Heinzen Erin L
- Helbig Ingo
- Helbig Ingo
- Helbig Ingo
- Helbig Ingo
- Helbig Katherine L
- Hengsbach Christian
- Heyne Henrike
- Hirose Shinichi
- Hirsch Edouard
- Ho Chen-Jui
- Howrigan Daniel P
- Hucks Donald
- Iacomino Michele
- Inoue Yushi
- Ishii Atsushi
- Jehi Lara
- Johnson Michael R
- Kalviainen Reetta
- Kamalakaran Sitharthan
- Kanaan Moien
- Kara Bulent
- Kariuki SymonM
- Kegele Josua
- Kegele Josua
- Kesim Yesim
- Khoueiry-Zgheib Nathalie
- Khoury Jean
- King Chontelle
- Klein Karl Martin
- Klein Karl Martin
- Kluger Gerhard
- Knake Susanne
- Korczyn Amos D
- Korinthenberg Rudolf
- Kousiappa Ioanna
- Krause Roland
- Krestel Heinz
- Krey Ilona
- Kunz Wolfram S
- Kurlemann Gerhard
- Kurlemann Gerhard
- Kuzniecky Ruben I
- Kuzniecky Ruben I
- Kwan Patrick
- Kwan Patrick
- Kwan Patrick
- Labate Angelo
- Lal Dennis
- Lal Dennis
- Lal Dennis
- Lassuthova Petra
- Lauxmann Stephan
- Lawthom Charlotte
- Leech Stephanie L
- Leech Stephanie L
- Lehesjoki Anna-Elina
- Lemke Johannes R
- Lerche Holger
- Lerche Holger
- Lerche Holger
- Lesca Gaetan
- Leu Costin
- Leu Costin
- Lewis-Smith David
- Lewis-Smith David
- Lewis-Smith David
- Licchetta Laura
- Lin Chih-Hsiang
- Lin Kuang-Lin
- Linnankivi Tarja
- Lino Nobili
- Lo Warren
- Lowenstein Daniel H
- Lowenstein Daniel H
- Lowenstein Daniel H
- Lowenstein Daniel H
- Lui Colin HT
- Macnee Marie
- Madeleyn Rene
- Madia Francesca
- Maillard Louis
- Mancardi Maria Margherita
- Manna Lorella
- Marson Anthony G
- Marson Anthony G
- May Patrick
- Mayer Thomas
- McGraw ChristopherM
- McKenna Kevin
- Mei Davide
- Michel Veronique
- Minardi Raffaella
- Montanucci Ludovica
- Montomoli Martino
- Mostacci Barbara
- Motelow Joshua E
- Muccioli Lorenzo
- Mueller-Schlueter Karen
- Muhle Hiltrud
- Najm Imad M
- Nasreddine Wassim
- Neale Benjamin M
- Neubauer Bernd A
- Newton Charles RJC
- Niestroj Lisa-Marie
- Noebels Jeffrey L
- O'Brien Terence J
- Owusu-Agyei Seth
- Ozkara Cigdem
- Papacostas Savvas S
- Parrini Elena
- Parthasarathy Shridhar
- Pendziwiat Manuela
- Petrovski Slave
- Petrovski Slave
- Pickrell William O
- Pippucci Tommaso
- Poduri Annapurna
- Povysil Gundula
- Powell Robert HW
- Privitera Michael
- Rademacher Annika
- Ragona Francesca
- Rau Sarah
- Rees Mark I
- Regan Brigid M
- Regan Brigid M
- Reif Philipp S
- Reinthaler Eva
- Rheims Sylvain
- Riva Antonella
- Rosenow Felix
- Ryvlin Philippe
- Saarela Anni
- Sadleir Lynette G
- Sadoway Tara R
- Salman Baris
- Salpietro Vincenzo
- Scala Marcello
- Schachter Steven
- Schaller Andre
- Schankin Christoph J
- Scheffer Ingrid E
- Scheffer Ingrid E
- Schneider Natascha
- Schreiber Herbert
- Schubert-Bast Susanne
- Schulze-Bonhage Andreas
- Sedlackova Lucie
- Shain Catherine
- Sham Pakc
- Shiedley Beth R
- Shukralla Arif
- Siena S Anthony
- Sills Graeme J
- Singh Tarjinder
- Sisodiya Sanjay M
- Sisodiya Sanjay M
- Solomonson Matthew
- Sperling Michael R
- Stamberger Hannah
- Stanley Kate E
- Stanley Kate E
- Steinhoff Bernhard J
- Stephani Ulrich
- Sterbova Katalin
- Stewart Randy
- Striano Pasquale
- Striano Pasquale
- Surges Rainer
- Suzuki Toshimitsu
- Talkowski Michael
- Taneja Randip S
- Tanteles George A
- Tashman Katherine
- Thomas Rhys H
- Timonen Oskari
- Tinuper Paolo
- Todaro Marian
- Topaloglu Pinar
- Tsai Meng-Han
- Tumiene Birute
- Turkdogan Dilsad
- Ugur-Iseri Sibel
- Utkus Algirdas
- Vaidiswaran Priya
- Valton Luc
- van Baalen Andreas
- Vari Maria Stella
- Vetro Annalisa
- Vlckova Marketa
- von Spiczak Sarah
- von Wrede Randi
- Wagner Ryan G
- Watts Nick
- Weber Yvonne G
- Weckhuysen Sarah
- Weckhuysen Sarah
- Widdess-Walsh Peter
- Wolff Markus
- Wolking Stefan
- Wu David
- Xian Julie
- Yamakawa Kazuhiro
- Yapici Zuhal
- Yiolanda Christou
- Yis Uluc
- Yucesan Emrah
- Zagaglia Sara
- Zara Federico
- Zimprich Friedrich
- Zsurka Gabor
- Publication venue
- Nature Publishing Group
- Publication date
- 01/01/2023
- Field of study
Copy number variants (CNV) are established risk factors for neurodevelopmental disorders with seizures or epilepsy. With the hypothesis that seizure disorders share genetic risk factors, we pooled CNV data from 10,590 individuals with seizure disorders, 16,109 individuals with clinically validated epilepsy, and 492,324 population controls and identified 25 genome-wide significant loci, 22 of which are novel for seizure disorders, such as deletions at 1p36.33, 1q44, 2p21-p16.3, 3q29, 8p23.3-p23.2, 9p24.3, 10q26.3, 15q11.2, 15q12-q13.1, 16p12.2, 17q21.31, duplications at 2q13, 9q34.3, 16p13.3, 17q12, 19p13.3, 20q13.33, and reciprocal CNVs at 16p11.2, and 22q11.21. Using genetic data from additional 248,751 individuals with 23 neuropsychiatric phenotypes, we explored the pleiotropy of these 25 loci. Finally, in a subset of individuals with epilepsy and detailed clinical data available, we performed phenome-wide association analyses between individual CNVs and clinical annotations categorized through the Human Phenotype Ontology (HPO). For six CNVs, we identified 19 significant associations with specific HPO terms and generated, for all CNVs, phenotype signatures across 17 clinical categories relevant for epileptologists. This is the most comprehensive investigation of CNVs in epilepsy and related seizure disorders, with potential implications for clinical practice
Effect of angiotensin-converting enzyme inhibitor and angiotensin receptor blocker initiation on organ support-free days in patients hospitalized with COVID-19
- Author
- ?ivko Iris
- Abbass Hakam
- Abdeladim Lilia
- Abdelhady Hesham
- Abdelkharim Hussam
- Abdelrazik Marwa
- Abdi Zakee
- Abdukahil Sheryl Ann
- Abel Lynn
- Abraham Jacinta
- Abrahamson Gail
- Abusamra Yousuf
- Aceto Romina
- Adams Nick
- Adams Peter
- Adebambo Olumide
- Adhikari Neill
- Adhikari Sheetal
- Affleck Julia
- Agha Gloria
- Aghemo Alessio
- Agno Ronan
- Ahmad Norfaizan
- Ain Quratul
- Ainscough Kate
- Ainsworth James
- Aitken Lindianne
- Akamp Ceren
- Al Enezi Farhan
- Al-Bassam Wisam
- Al-Beidh Farah
- Albert Martin
- Albrett Jonathan
- Alderman Meera
- Aldo Bonizzoni Matteo
- Alegria Ana
- Alessandro Carà Gianmarco
- Alexander Brian
- Alexander Peter
- Alfonso Jordan
- Ali Maryam
- Ali Murtaza
- Allam Hayat
- Allen Barbara
- Allen Louise
- Allibone Suzanne
- Almeshhedani Hasham
- AlQahtani Samah
- Alswaidan Lolowa
- Altomy Mohammed
- Al Amri Ali
- Al Qasim Eman
- Amatya Sameena
- Ambrosino Richard
- Anderson Thomas
- Andreae Mark
- Aneman Anders
- Angus Derek C.
- Anjum Aisha
- Ankert Juliane
- Annane Djillali
- Anne-Laure Fedou
- Anstey Matthew
- Antcliffe David
- Anthony Alpha
- Antoine Marchalot
- Antoine Pierre
- Antoine Studer
- Anumakonda Vikram
- Aparicio Christelle
- Aquino Maia
- Arabi Yaseen M.
- Arachchige Malka
- Aravindan Latha
- Arbane Gill
- Archambault Patrick
- Archer Simon
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- Arias Ana-Marie
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- del Sorbo Lorenzo
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- Derde Lennie P. G.
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- de la Fuente Carmen
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- Paramasivam Elankumaran
- Parekh Dhruv
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- Ralston Maximillian
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- van Amerongen Roosmarijn
- van Bentum-Puijk Wilma
- van Bree Sjoerd
- van de Veerdonk Frank L.
- van den Berg Lettie
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- Wells Alan
- Wells Colin
- Wells Karen
- Welters Ingeborg
- West Lauren
- Westlake Samantha
- Wetherill Bill
- Wetzold Richard
- Whileman Amanda
- Whitbread Jennifer
- White Alison
- White Hayden
- White Ian
- White Katie
- Whitehead Christina
- Whitehouse Tony
- Wibrow Bradley
- Wigbers Jeanette
- Wijewardena Gayathri
- Wilby Elizabeth
- Wilcox Elizabeth
- Wilcox Louise
- Wild Helen
- Wild Laura
- Wilding Laura
- Wiles Matt
- Wiley Daisy
- Wilhelmsen Elva
- Wilkinson Dean
- Willams Felicity
- Williams Alexandra
- Williams Angharad
- Williams Anna
- Williams Erin
- Williams Gemma
- Williams Hannah
- Williams Karen
- Williams Marie
- Williams Patricia
- Williams Penny
- Williams Tony
- Williams Virginie
- Williamson Dawn
- Williamson James D
- Willis Joanna
- Willson Jayne
- Wilson Anna
- Wilson Craig
- Wilson Jean
- Wilson Maggie
- Winters James
- Winters Lauren
- Wise Matt
- Wisniewski Mary
- Wittekamp Bastiaan
- Wittenberg Wendy
- Wnuk Chris
- Woelke Amy
- Wong Jenny
- Wong Onyee
- Wood Erica
- Wood Hannah
- Wood Tracy
- Woods Jane
- Woods Lindsey
- Woodward Robert
- Woolett Melissa
- Worner Ruth
- Wren Jess
- Wren Lynn
- Wrey Brown Caroline
- Wright Chris
- Wright Kim
- Wunderley Renee
- Wyatt Rachel
- Wylie Katharine
- Xavier Kugan
- Yamagishi Yoshiaki
- Yamashita Chizuru
- Yang Yang
- Yarad Elizabeth
- Yates Bryan
- Yates David
- Yealy Donald
- Young Ian
- Young Meredith
- Young Paul
- Youngstein Taryn
- Yu Haili
- Yusuff Hakeem
- Zaharia Mihaela
- Zaidi Abbas
- Zaki Ahmed
- Zaman Mohsin
- Zarychanski Ryan
- Zdanavidiene Ausra
- Zhao Xiao
- Zinzoni Vanessa
- Zitter Letizia
- Zouita Louisa
- Publication venue
- 'American Medical Association (AMA)'
- Publication date
- 11/04/2023
- Field of study
IMPORTANCE Overactivation of the renin-angiotensin system (RAS) may contribute to poor clinical outcomes in patients with COVID-19.
Objective To determine whether angiotensin-converting enzyme (ACE) inhibitor or angiotensin receptor blocker (ARB) initiation improves outcomes in patients hospitalized for COVID-19.
DESIGN, SETTING, AND PARTICIPANTS In an ongoing, adaptive platform randomized clinical trial, 721 critically ill and 58 non–critically ill hospitalized adults were randomized to receive an RAS inhibitor or control between March 16, 2021, and February 25, 2022, at 69 sites in 7 countries (final follow-up on June 1, 2022).
INTERVENTIONS Patients were randomized to receive open-label initiation of an ACE inhibitor (n = 257), ARB (n = 248), ARB in combination with DMX-200 (a chemokine receptor-2 inhibitor; n = 10), or no RAS inhibitor (control; n = 264) for up to 10 days.
MAIN OUTCOMES AND MEASURES The primary outcome was organ support–free days, a composite of hospital survival and days alive without cardiovascular or respiratory organ support through 21 days. The primary analysis was a bayesian cumulative logistic model. Odds ratios (ORs) greater than 1 represent improved outcomes.
RESULTS On February 25, 2022, enrollment was discontinued due to safety concerns. Among 679 critically ill patients with available primary outcome data, the median age was 56 years and 239 participants (35.2%) were women. Median (IQR) organ support–free days among critically ill patients was 10 (–1 to 16) in the ACE inhibitor group (n = 231), 8 (–1 to 17) in the ARB group (n = 217), and 12 (0 to 17) in the control group (n = 231) (median adjusted odds ratios of 0.77 [95% bayesian credible interval, 0.58-1.06] for improvement for ACE inhibitor and 0.76 [95% credible interval, 0.56-1.05] for ARB compared with control). The posterior probabilities that ACE inhibitors and ARBs worsened organ support–free days compared with control were 94.9% and 95.4%, respectively. Hospital survival occurred in 166 of 231 critically ill participants (71.9%) in the ACE inhibitor group, 152 of 217 (70.0%) in the ARB group, and 182 of 231 (78.8%) in the control group (posterior probabilities that ACE inhibitor and ARB worsened hospital survival compared with control were 95.3% and 98.1%, respectively).
CONCLUSIONS AND RELEVANCE In this trial, among critically ill adults with COVID-19, initiation of an ACE inhibitor or ARB did not improve, and likely worsened, clinical outcomes.
TRIAL REGISTRATION ClinicalTrials.gov Identifier: NCT0273570