3,687 research outputs found
Human peritoneal mesothelial cell death induced by high-glucose hypertonic solution involves Ca2+ and Na+ ions and oxidative stress with the participation of PKC/NOX2 and PI3K/Akt pathways
Indexación: Web of Science; Scopus.Chronic peritoneal dialysis (PD) therapy is equally efficient as hemodialysis while providing greater patient comfort and mobility. Therefore, PD is the treatment of choice for several types of renal patients. During PD, a high-glucose hyperosmotic (HGH) solution is administered into the peritoneal cavity to generate an osmotic gradient that promotes water and solutes transport from peritoneal blood to the dialysis solution. Unfortunately, PD has been associated with a loss of peritoneal viability and function through the generation of a severe inflammatory state that induces human peritoneal mesothelial cell (HPMC) death. Despite this deleterious effect, the precise molecular mechanism of HPMC death as induced by HGH solutions is far from being understood. Therefore, the aim of this study was to explore the pathways involved in HGH solution-induced HPMC death. HGH-induced HPMC death included influxes of intracellular Ca2+ and Na+. Furthermore, HGH-induced HPMC death was inhibited by antioxidant and reducing agents. In line with this, HPMC death was induced solely by increased oxidative stress. In addition to this, the cPKC/NOX2 and PI3K/Akt intracellular signaling pathways also participated in HGH-induced HPMC death. The participation of PI3K/Akt intracellular is in agreement with previously shown in rat PMC apoptosis. These findings contribute toward fully elucidating the underlying molecular mechanism mediating peritoneal mesothelial cell death induced by high-glucose solutions during peritoneal dialysis.https://www.frontiersin.org/articles/10.3389/fphys.2017.00379/ful
A Grammar Compression Algorithm based on Induced Suffix Sorting
We introduce GCIS, a grammar compression algorithm based on the induced
suffix sorting algorithm SAIS, introduced by Nong et al. in 2009. Our solution
builds on the factorization performed by SAIS during suffix sorting. We
construct a context-free grammar on the input string which can be further
reduced into a shorter string by substituting each substring by its
correspondent factor. The resulting grammar is encoded by exploring some
redundancies, such as common prefixes between suffix rules, which are sorted
according to SAIS framework. When compared to well-known compression tools such
as Re-Pair and 7-zip, our algorithm is competitive and very effective at
handling repetitive string regarding compression ratio, compression and
decompression running time
Runaway Futures, Technology, and the Collapse of Understanding in Times of Unprecedented Change: An Interview with Zoltán Boldizsár Simon
Simon ZB, Narita FZ. Runaway Futures, Technology, and the Collapse of Understanding in Times of Unprecedented Change: An Interview with Zoltán Boldizsár Simon. Transições. 2020;1(1):26-38
Re-designing Dynamic Content Delivery in the Light of a Virtualized Infrastructure
We explore the opportunities and design options enabled by novel SDN and NFV
technologies, by re-designing a dynamic Content Delivery Network (CDN) service.
Our system, named MOSTO, provides performance levels comparable to that of a
regular CDN, but does not require the deployment of a large distributed
infrastructure. In the process of designing the system, we identify relevant
functions that could be integrated in the future Internet infrastructure. Such
functions greatly simplify the design and effectiveness of services such as
MOSTO. We demonstrate our system using a mixture of simulation, emulation,
testbed experiments and by realizing a proof-of-concept deployment in a
planet-wide commercial cloud system.Comment: Extended version of the paper accepted for publication in JSAC
special issue on Emerging Technologies in Software-Driven Communication -
November 201
Desarrollo de un sistema de informacion y control para los accesos del
96 p.La presente investigación aborda los resultados del desarrollo de un proyecto informático con el fin de crear un sistema de información y control del acceso de público de un club deportivo profesional. Con tal fin se plantea una solución informática a un problema de gestión de los asistentes a un espectáculo deportivo y también se identifica la inversión requerida y los posibles beneficios, asà como su contribución a la mejora del manejo del volumen de socios y la situación económica de la institución
Multiplicity in Early Stellar Evolution
Observations from optical to centimeter wavelengths have demonstrated that
multiple systems of two or more bodies is the norm at all stellar evolutionary
stages. Multiple systems are widely agreed to result from the collapse and
fragmentation of cloud cores, despite the inhibiting influence of magnetic
fields. Surveys of Class 0 protostars with mm interferometers have revealed a
very high multiplicity frequency of about 2/3, even though there are
observational difficulties in resolving close protobinaries, thus supporting
the possibility that all stars could be born in multiple systems. Near-infrared
adaptive optics observations of Class I protostars show a lower binary
frequency relative to the Class 0 phase, a declining trend that continues
through the Class II/III stages to the field population. This loss of
companions is a natural consequence of dynamical interplay in small multiple
systems, leading to ejection of members. We discuss observational consequences
of this dynamical evolution, and its influence on circumstellar disks, and we
review the evolution of circumbinary disks and their role in defining binary
mass ratios. Special attention is paid to eclipsing PMS binaries, which allow
for observational tests of evolutionary models of early stellar evolution. Many
stars are born in clusters and small groups, and we discuss how interactions in
dense stellar environments can significantly alter the distribution of binary
separations through dissolution of wider binaries. The binaries and multiples
we find in the field are the survivors of these internal and external
destructive processes, and we provide a detailed overview of the multiplicity
statistics of the field, which form a boundary condition for all models of
binary evolution. Finally we discuss various formation mechanisms for massive
binaries, and the properties of massive trapezia.Comment: Accepted for publication as a chapter in Protostars and Planets VI,
University of Arizona Press (2014), eds. H. Beuther, R. Klessen, C.
Dullemond, Th. Hennin
Effect of dipolar interactions on the phase behavior of the Gay–Berne liquid crystal model
A computer simulation study of the phase behavior of the dipolar Gay–Berne liquid crystal model
is presented. The phase transitions are determined with isothermal–isobaric ~NPT! Monte Carlo
simulations, utilizing the reaction field method. The electrostatic forces are found to have a
considerable effect on the nature of the observed phases, but the density at which the isotropic fluid
becomes unstable with respect to partially ordered phases is seen to be remarkably insensitive to the
strength of the dipole. We pay particular attention to the structure of the mesophases, combining
information from several singlet and pair distribution functions to build up an accurate picture of the
molecular arrangement of the systems
Oxidative Stress in Disease and Aging: Mechanisms and Therapies 2016
International audienceOxidative stress (OS) is an imbalance between the formation of reactive oxygen species (ROS) and antioxidant defense mechanisms. This phenomenon increases with age and affects the normal functioning of several tissues. Furthermore, numerous chronic diseases associated with older age, such as diabetes and cardiovascular, renal, pulmonary, and skeletal muscle disorders, are also directly related to OS. Considering this relationship, the aim of many ongoing studies is to elucidate the underlying mechanisms and role of OS in disease onset and development. In particular, there is considerable emphasis on finding new therapeutic strategies for decreasing OS
Dust Traps in the Protoplanetary Disk MWC 758: Two Vortices Produced by Two Giant Planets?
Resolved ALMA and VLA observations indicate the existence of two dust traps in the protoplanetary disc MWC 758. By means of two-dimensional gas+dust hydrodynamical simulations post-processed with three-dimensional dust radiative transfer calculations, we show that the spirals in scattered light, the eccentric, asymmetric ring and the crescent-shaped structure in the (sub)millimetre can all be caused by two giant planets: a 1.5-Jupiter mass planet at 35 au (inside the spirals) and a 5-Jupiter mass planet at 140 au (outside the spirals). The outer planet forms a dust-trapping vortex at the inner edge of its gap (at ∼85 au), and the continuum emission of this dust trap reproduces the ALMA and VLA observations well. The outer planet triggers several spiral arms that are similar to those observed in polarized scattered light. The inner planet also forms a vortex at the outer edge of its gap (at ∼50 au), but it decays faster than the vortex induced by the outer planet, as a result of the disc’s turbulent viscosity. The vortex decay can explain the eccentric inner ring seen with ALMA as well as the low signal and larger azimuthal spread of this dust trap in VLA observations. Finding the thermal and kinematic signatures of both giant planets could verify the proposed scenario
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