288 research outputs found
Group work and the change of obstacles over time: The influence of learning style and group composition
It is through working in groups that students develop cooperative learning skills and experience. However, group work activity often leads students into a difficult experience, especially for first-year students who are not familiar with group work activities at university. This study explores obstacles faced by first-year students during their group work activities. It investigates whether a group of students with a similar learning style (homogeneous group) experience different obstacles compared to a group of students with a diverse learning style (heterogeneous group). In addition, to identify the difference, if any, between a group formed by a tutor and one where the students form the group themselves, tutor and self-allocated group allocations are explored. This study focuses on obstacles experienced by these students during group work activities. Using a sample of more than 200 students over a period of 3 years, the types and the changes of obstacles in different stages of group life are explored. The findings show that students experience obstacles which can be classified into personal and social, leadership and management, and task-related obstacles. Those obstacles were not static but increased over time. The study also investigates the impact of different methods of forming groups and whether this impacted on obstacles experienced. Overall, different interventions prompted different patterns of obstacle development
GC/MSn analysis of the crude reaction mixtures from FriedelâCrafts acylation: Unambiguous identification and differentiation of 3-aroylbenzofurans from their 4- and 6-regioisomers
Rationale:
3-Aroylbenzofurans and their 2-nitrophenyl derivatives constitute fundamental intermediates for the synthesis of target compounds with pharmaceutical properties. However, their preparation via the FriedelâCrafts acylation of 2-phenylbenzofurans, using Lewis acid as catalyst, often leads to mixtures of regioisomeric aroylbenzofurans that can be challenging to distinguish, thus preventing the reaction characterization.
Method:
We report a method for the unambiguous identification and differentiation of the desired 3-benzoyl isomers from their 4- and 6-regioisomers in a crude reaction mixture using gas chromatography coupled to multiple-stage mass spectrometric (GC/MSn) analysis performed in collision-induced dissociation (CID) mode.
Results:
Upon electron ionization, each set of isomers displayed nearly identical mass spectra. MSn revealed fragmentation patterns that varied in the location of the benzoyl group on the benzofuran scaffold: CID experiments performed on the molecular ion allowed the distinction of the 3-acyl isomers from the 4- and 6-regioisomers; CID experiments on the [MâââAr]+ ion allowed the distinction of the 4-benzoyl from the 6-benzoyl regioisomer, when the nitro group is located on the 2-phenyl ring. Moreover, the unusual loss of OHâą radical allowed ascertaining the position of the nitro group in 3-acyl regioisomers bearing the NO2 group. The origin of the diagnostic OHâą loss was investigated through MSn experiments using 18O-labelled 3-benzoyl derivatives.
Conclusions:
The method allows the rapid characterization of crude reaction mixtures of benzoylbenzofurans using solely GC/MSn analysis, simplifying the workflow of extensive isolation and purification for structure elucidationThe present work was partially supported by FIR (Fondo Integrativo per la Ricerca â annualitĂ 2018 and 2019), University of CagliariS
Delivering quality along with quantity: the challenge of teaching a large and heterogeneous engineering class
The challenges faced by a lecturer teaching large multidisciplinary engineering classes are identified. These are principally related to the size of the class, the extensive mathematical knowledge that is considered as prerequisite, as well as the heterogeneity of the class due to the diversity of studentsâ academic background and interests. In order to improve studentsâ engagement and retention in class, active learning techniques are employed and their impact on the performance of the class is captured through a questionnaire designed for this purpose. The statistics demonstrate that good teaching facilities and a well-prepared lecturer do not suffice for maximising studentsâ satisfaction, attention and retention. In order to engage the students in a large class setting, it is important to involve them in the lecture process. The employed active learning methods comprising quizzes, in class demonstration and muddiest-point cards induce a remarkably positive impact at almost no additional teaching resources
Audio versus written feedback: exploring learnersâ preference and the impact of feedback format on studentsâ academic performance
Very little is known about the impact of the different types of feedback on studentsâ academic performance. This paper explores studentsâ preference in the use of audio and written feedback and how each type of feedback received by students impact on their academic performance in subsequent assignments. The study involved 68 students who were divided into two groups that received either audio or written feedback in their first assignment which was then recalled and applied into the second assignment. An analysis of results obtained in the second assignment was conducted and comparisons made between students in the audio and written feedback group. Students were also surveyed using an online questionnaire to ascertain their perceptions about the type of feedback they had received. The study established that the type of feedback received did not impact on studentsâ grades in the subsequent assignment. In addition, while students were broadly positive about audio feedback, they indicated a strong preference for written feedback in future assignments. The study recommends, among other things, further investigation into the link between studentsâ learning styles and their preferences for different types of feedback
ULEARN: Personalised Learnerâs Profile Based On Dynamic Learning Style Questionnaire
The file attached to this record is the author's final peer reviewed version.E-Learning recommender system effectiveness re- lies upon their ability to recommend appropriate learning con- tents according to the learner learning style and preferences. An effective approach to handle the learner preferences is to build an efficient learner profile in order to gain adaptation and individualisation of the learning environment. It is usually necessary to know learning style and preferences of the learner on a domain before adapting the learning process and course content. This study focuses on identifying the learning styles of students in order to adapt the learning process and course content. ULEARN is an adaptive recommender learning system designed to provide learners with personalised learning environment such as course learning objects that match their adaptive profile. This paper presents the algorithm used in ULEARN to reduce dynamically the number of questions in Felder-Silverman learning style ques- tionnaire used to initialise the adaptive learner profile. Firstly, the questionnaire is restructured into four groups, one for each learning style dimension; and a study is carried out to determine the order in which questions will be asked in each dimension. Then an algorithm is built upon this ranking of questions to calculate dynamically the initial learning style of the user as they go through the questionnaire
The M3 muscarinic receptor Is required for optimal adaptive immunity to Helminth and bacterial infection
Innate immunity is regulated by cholinergic signalling through nicotinic acetylcholine receptors. We show here that signalling through the M3 muscarinic acetylcholine receptor (M3R) plays an important role in adaptive immunity to both Nippostrongylus brasiliensis and Salmonella enterica serovar Typhimurium, as M3R-/- mice were impaired in their ability to resolve infection with either pathogen. CD4 T cell activation and cytokine production were reduced in M3R-/- mice. Immunity to secondary infection with N. brasiliensis was severely impaired, with reduced cytokine responses in M3R-/- mice accompanied by lower numbers of mucus-producing goblet cells and alternatively activated macrophages in the lungs. Ex vivo lymphocyte stimulation of cells from intact BALB/c mice infected with N. brasiliensis and S. typhimurium with muscarinic agonists resulted in enhanced production of IL-13 and IFN-Îł respectively, which was blocked by an M3R-selective antagonist. Our data therefore indicate that cholinergic signalling via the M3R is essential for optimal Th1 and Th2 adaptive immunity to infection
Predicting mental imagery based BCI performance from personality, cognitive profile and neurophysiological patterns
Mental-Imagery based Brain-Computer Interfaces (MI-BCIs) allow their users to send commands
to a computer using their brain-activity alone (typically measured by ElectroEncephaloGraphyâ
EEG), which is processed while they perform specific mental tasks. While very
promising, MI-BCIs remain barely used outside laboratories because of the difficulty
encountered by users to control them. Indeed, although some users obtain good control
performances after training, a substantial proportion remains unable to reliably control an
MI-BCI. This huge variability in user-performance led the community to look for predictors of
MI-BCI control ability. However, these predictors were only explored for motor-imagery
based BCIs, and mostly for a single training session per subject. In this study, 18 participants
were instructed to learn to control an EEG-based MI-BCI by performing 3 MI-tasks, 2
of which were non-motor tasks, across 6 training sessions, on 6 different days. Relationships
between the participantsâ BCI control performances and their personality, cognitive
profile and neurophysiological markers were explored. While no relevant relationships with
neurophysiological markers were found, strong correlations between MI-BCI performances
and mental-rotation scores (reflecting spatial abilities) were revealed. Also, a predictive
model of MI-BCI performance based on psychometric questionnaire scores was proposed.
A leave-one-subject-out cross validation process revealed the stability and reliability of this
model: it enabled to predict participantsâ performance with a mean error of less than 3
points. This study determined how usersâ profiles impact their MI-BCI control ability and
thus clears the way for designing novel MI-BCI training protocols, adapted to the profile of
each user
CENGO: a web-based serious game to increase the programming knowledge levels of computer engineering students
In recent years, games are used to increase the level of knowledge and experience of individuals working in different domains. Especially in the education field, there are several different serious games
to teach the subjects of the lectures or other educational materials to
students in an enjoyable way. Hence, this study proposes a quantitative
research approach to increase the programming knowledge levels of the
first-year undergraduate students at computer engineering departments.
For this aim, a responsive web platform was developed to teach the syntax and logic of C programming language by using some game elements.
Therefore, the students have a chance to repeat the topics related to C
programming language continuously since the platform is always accessible. To figure out the efficiency of the designed environment, 10 first-year
computer engineering students were selected. According to the results obtained from the user tests, this game can be used as an educational tool,
which supports the traditional training methods, to increase the knowledge levels of students about the syntax and logic of C programming
language
Adaptive hypermedia driven serious game design and cognitive style in school settings: an exploratory study
The potential value of adaptive hypermedia and game based learning to education and training has long been recognised, numerous studies have been undertaken in both those areas investigating its potential to improve learner performance. In particular research has indicated that tailoring content to match the prior knowledge of the user has the power to increase the effectiveness of learning systems. Recent studies have begun to indicate that Adaptive Hypermedia Learning Systems (AHLS) based on cognitive styles have the power to improve learner performance. Recent examples of research exploring avenues for effectively incorporating serious games into AHLS indicated that integrating serious games into a personalized learning environment has the potential educational benefits of combining a personalized delivery with increased learner motivation. The exploratory study presented in this paper here developed an Adaptive Hypermedia Driven Serious Game (AHDSG) based around Paskâs Holist-Serialist dimension of cognitive style. A prototype AHDSG was designed and developed to teach students about Sutton Hoo and archaeological methods. Sixty-six secondary school students participated in this study. Overall the findings of this study show that there was an improvement in performance among all participants. Although the participants that used the system which adapted to their preferred cognitive style achieved a higher mean gain score, the difference was not significant
Environmental Factors in the Relapse and Recurrence of Inflammatory Bowel Disease:A Review of the Literature
The causes of relapse in patients with Crohn's disease (CD) and ulcerative colitis (UC) are largely unknown. This paper reviews the epidemiological and clinical data on how medications (non-steroidal anti-inflammatory drugs, estrogens and antibiotics), lifestyle factors (smoking, psychological stress, diet and air pollution) may precipitate clinical relapses and recurrence. Potential biological mechanisms include: increasing thrombotic tendency, imbalances in prostaglandin synthesis, alterations in the composition of gut microbiota, and mucosal damage causing increased permeability
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