6 research outputs found
Should patients with hip joint prosthesis receive antibiotic prophylaxis before dental treatment?
- Author
- Abraham-Inpijn L
- American Dental Association
- American Dental Association
- Assael LA
- Bagg J
- Bahrani-Mougeot FK
- Bartzokas CA
- Bauer T
- Berbari EF
- Berbari EF
- Berendt AR
- Bignardi GE
- Blomgren J
- Blomgren J
- Crasta K
- Dahlén G
- Daniluk T
- Deacon JM
- Egil Lingaas
- Esposito S
- Fe Marqués A
- Finnur Snorrason
- Friedlander AH
- Geipel U
- Gibson J
- Guntheroth WG
- Honda E
- Honma K
- Iatrou IA
- Ingar Olsen
- Ishikawa A
- Jackson MS
- Jackson MS
- Jacobsen PL
- Jacobson JJ
- Jacobson JJ
- Jaspers MT
- Jenny J-Y
- Jobbins J
- Kaar TK
- Kennedy HF
- Kurtz S
- Kurtz SM
- Labriola JD
- LaPorte DM
- Lewis MA
- Little JW
- Lockhart PB
- MacFarlane TW
- Maderazo EG
- Marek CL
- Marsh PD
- Martinez-Martinez RE
- Matsuura T
- McGowan DA
- Mechan J
- Mertz D
- Miyake Y
- Moen K
- Moen K
- Moore WEC
- Morris AM
- Murdoch FE
- Napeñas JJ
- Nicolasora NP
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- Norden CW
- Ohara-Nemoto Y
- Olsen I
- Oswald TF
- Pallasch TJ
- Parvizi J
- Percival RS
- Peterson DE
- Podbielski A
- Portnof JE
- Rams TE
- Rams TE
- Rautemaa R
- Rega AJ
- Rossi M
- Rossi T
- Rossi T
- Rousseau P
- Sandhu SS
- Scott JF
- Seymour RA
- Simmons NA
- Skiest DJ
- Small H
- Smith AJ
- Smith AJ
- Storoe W
- Sulco TP
- SzymaĆska J
- SĂĄnchez-Codero S
- Tawara Y
- Theilade E
- Thyne GM
- TomĂĄs L
- Tsang PCS
- Uçkay I
- van der Bruggen JT
- Waldman BJ
- Wijngaarden S
- Williams BL
- Zimmerli W
- Ăhman SC
- Publication venue
- CoAction Publishing
- Publication date
- 01/08/2010
- Field of study
The safety committee of the American Academy of Orthopedic Surgeons (AAOS) recommended in 2009 that clinicians should consider antibiotic prophylaxis for all patients with total joint replacement before any invasive procedure that may cause bacteremia. This has aroused confusion and anger among dentists asking for the evidence. The present review deals with different aspects of the rationale for this recommendation giving attention to views both in favor of and against it
Outcomes from elective colorectal cancer surgery during the SARS-CoV-2 pandemic
- Author
- 14 | COVIDSurg COllabOratIVe Tzovaras G. (General University Hospital of Larissa)
- Aawsaj Y.
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- COVIDSurg COllabOratIVe | 15 Violante T. (IRCCS Azienda Ospedaliero â Universitaria di Bologna
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- Thulasiraman S. V.
- Timbrell S.
- Tirloni L.
- Titu S. (Prof. Dr. Ion Chiricuta Institute of Oncology). Russia: Garmanova T.
- Tonini V. (S. Orsola-Malpighi Hospital)
- Torres A. (Hospital ClĂnico de Madrid)
- Torres Arcos C.
- Townson A.
- Trabulsi N. (King Abdulaziz University Hospital)
- Travaglio E. (Regina Montis Regalis Hospital
- Tribillon E. (Institut Mutualiste Montsouris)
- Troncoso Pereira P. (Hospital Mateu Orfila)
- Tropeano F. P. (Federico II University Hospital)
- Trujillo DĂaz J.
- Tsai L.
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- Tsiamalou I.
- Tsiaoussis I.
- TU Dresden)
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- Tuncer K.
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- Tweedle E. (Addenbrookeâs Hospital)
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- UludaÄ S. S.
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- Universiti Sains Malaysia)
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- Uslu G.
- Utkan N. Z.
- Uyanik M. S. (Samsun Training and Research Hospital)
- Uzunoglu F. G. (University Medical Center HamburgâEppendorf). Greece: Antonakis P.
- Vaccarella G. (Azienda Ospedaliera Ospedali Riuniti Villa Sofia-Cervello)
- Valbuena Jabares V. (Marqués de Valdecilla University Hospital)
- Valdes- Hernandez J. (Hospital Universitario Virgen Macarena)
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- Valle Rubio A. (Getafe University Hospital)
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- Van den Eynde J.
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- Vassiliu P. (Attikon University General Hospital)
- Vaz Pereira R.
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- Velchuru V.
- Velickovic D. (Clinic for Digestive Surgery
- Velidedeoglu M.
- Venn M. (Royal London Hospital)
- Venskutonis D. (Lithuanian University of Health Sciences Kaunas Clinical Hospital). Madagascar: Rasoaherinomenjanahary F.
- Vera Mansilla C. (Hospital Universitario Principe de Asturias)
- Verberne C. (John Radcliffe Hospital)
- Vergari R. (Ospedali Riuniti di Ancona)
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- Vervoort D.
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- Vieira Caroço T. (IPO Coimbra)
- Vieira Paiva Lopes A. C. (Hospital de Torres Vedras â Centro Hospitalar do Oeste)
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- Vigorita V. (Ălvaro Cunqueiro Hospital)
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- Wani R. (Sher-I-Kashmir Institute of Medical Sciences)
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- Warren O. (Chelsea and Westminster Hospital)
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- Westwood E. (James Paget University NHS Foundation Trust Hospital)
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- Williams G. (Royal Gwent Hospital)
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- Xavier R. G.
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- Yıldırım A.
- Yildiz A. (Yildirim Beyazit University Yenimahalle Training and Research Hospital). Uganda: Lule H.
- Young R. (York Teaching Hospitals NHS Trust)
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- Youssef M. (Norfolk and Norwich University Hospital)
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- YĂŒksel E. (Kocaeli University Teaching Hospital)
- Zafar S. N. (University of Wisconsin)
- Zakaria A. D.
- Zakaria Z. (School of Medical Sciences and Hospital
- Zambon M. (Policlinico Umberto I Sapienza University of Rome)
- Zanus G. (Caâ Foncello Treviso â DISCOG â UniversitĂ di Padova)
- Zegarac M. (Institute for Oncology and Radiology of Serbia)
- ZeliÄ M. (University Hospital Center Rijeka)
- Zengin A. K. (Istanbul Universty â CerrahpaĆa Medical Faculty)
- Zerbib P. (CHU Lille)
- Zervas K.
- Zese M. (Santa Maria degli Angeli Hospital ULSS 5 â Adria)
- Zhang H. (Concord Repatriation General Hospital)
- Zizzo M. (Azienda UnitĂ Sanitaria Locale â IRCCS di Reggio Emilia)
- Zografos C. (Laiko University Hospital)
- Zorrilla OrtĂșzar J. (Hospital General Universitario Gregorio Marañón)
- Zourntou S. (General Hospital of Larissa âKoutlimpaneio and Triantafylleioâ)
- Zubaidi A. M. (King Saud University). Serbia: AleksiÄ L.
- Ăngelo M.
- Ăelebi F.
- Ăolak E.
- Ăfner D. (Medical University of Innsbruck)
- Ăhlberger L.
- Ăzçelık M. F.
- ĂÄĂŒcĂŒ H.
- ĂberrĂŒck L.
- Äoza I.
- Publication venue
- 'Wiley'
- Publication date
- 01/01/2020
- Field of study
This study aimed to describe the change in surgical practice and the impact of SARS-CoV-2 on mortality after surgical resection of colorectal cancer during the initial phases of the SARS-CoV-2 pandemic
Organocatalytic Transfer Hydrogenation and Hydrosilylation Reactions
- Author
- A Aillerie
- A Berkessel
- A Dondoni
- A Genoni
- A Hantzsch
- A Hantzsch
- A Kamal
- A Weickgenannt
- AG Doyle
- AR Katritzky
- AV Malkov
- AV Malkov
- AV Malkov
- AV Malkov
- AV Malkov
- AV Malkov
- AV Malkov
- AV Malkov
- AV Malkov
- AV Malkov
- AV Malkov
- B Weiner
- BE Sleebs
- BM Paz
- BT Cho
- C Wang
- C Wang
- C Wang
- C Zheng
- C Zhu
- C Zhu
- C-C Hsiao
- CH Senanayake
- D AlmaĆi
- D Enders
- D Kampen
- D Morton
- D Parmar
- D Pei
- D Pei
- D Pini
- D Seiyaku
- DL Steer
- E Juaristi
- E Marqués-López
- E Marqués-López
- E Marqués-López
- E Martinelli
- E Massolo
- E Sugiono
- F Bohlmann
- F Cozzi
- F Iwasaki
- F Iwasaki
- F Kortmann
- F Shi
- F Shi
- FE Held
- FJ LaRonde
- G Adair
- G Guillena
- G Jakab
- G Li
- G Li
- G Li
- H Adolfsson
- H Pellissier
- H Zheng
- H-H Liao
- H-J Zheng
- H-U Blaser
- HC Brown
- HM Sklenicka
- I Fernandez
- I Hayakawa
- I Jacquemond-Collet
- I ÄoriÄ
- ID Jurberg
- J Marco-Contelles
- J Seayed
- J Yu
- J-F Carpentier
- JA Ellman
- JA Ellman
- JAJ Breuzard
- JB Steevens
- JB Tuttle
- JF Schneider
- JH Rakotoson
- JSM Samec
- JW Hilborn
- JW Yang
- JW Yang
- K Akagawa
- K Akagawa
- L Bernardi
- L Ren
- L SimĂłn
- M Benaglia
- M Benaglia
- M Chrzanowska
- M Fantin
- M Figlus
- M Fujii
- M Gruttadauria
- M Kotke
- M Nielsen
- M Nielsen
- M Patel
- M Rueping
- M Rueping
- M Rueping
- M Rueping
- M Rueping
- M Rueping
- M Rueping
- M Rueping
- M Rueping
- M Rueping
- M Rueping
- M Rueping
- M Rueping
- M Terada
- M Terada
- M Ueda
- M-W Chen
- MC Bagley
- MJ Palmer
- MS Taylor
- NJA Martin
- NJA Martin
- NJA Martin
- O Onomura
- OV Serdyuk
- P FriedlÀnder
- P KoÄovskĂœ
- P KoÄovskĂœ
- P Melchiorre
- P Wu
- P Zhou
- PI Dalko
- PJ Houghton
- PR Schreiner
- Q Dai
- Q Kang
- Q Kang
- Q-S Guo
- R-N Guo
- RE TenBrink
- RI Storer
- RP Tripathi
- S Bertelsen
- S Guizzetti
- S Hoffmann
- S Jones
- S Kobayashi
- S Li
- S Mayer
- S Narayanaperumal
- S Rossi
- S Singh
- S Torssell
- S-L You
- S-L You
- SE Denmark
- SE Denmark
- SG Ouellet
- SG Ouellet
- SJ Connon
- SJ Connon
- ST-C Eey
- T Akiyama
- T Itoh
- T Itoh
- T Kanemitsu
- T Marcelli
- T Marcelli
- T Sakamoto
- TE Kristensen
- TJ Hoffman
- W Tang
- X Chen
- X Ge
- X Ge
- X Wu
- X-F Tu
- X-W Liu
- X-W Liu
- Y Hsiao
- Y Huang
- Y Jiang
- Y Matsumura
- Y Takemoto
- Y-C Xiao
- Y-C Xiao
- Z Wang
- Z Wang
- Z Wang
- Z Wang
- Z Zhang
- Z-Y Han
- Z-Y Xue
- ZY Wang
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Die Vererbung von Augenleiden
- Author
- A Alt
- A Baekan
- A Betsch
- A Bostroem
- A Bostroem
- A Boulanger
- A Bronner
- A Bruckner
- A BrĂŒckner
- A BrĂŒcxner
- A Busacca
- A Cantonnet
- A Darter
- A Darter
- A Dollinger
- A Dutort
- A Franceschetti
- A Franceschetti
- A Francescjetti
- A Francesohetti
- A Gillivray
- A Gloor
- A Graefe
- A Graefe
- A Graefe
- A Groenouw
- A Gxoenouw
- A Gxoenouw
- A Hubbel
- A Hudson
- A Jess
- A Kaznelson
- A Kestenbaum
- A Klopstock
- A Knapp
- A Knapp
- A Knapp
- A Lang
- A Lint
- A Lint
- A MaĂźtre-Jan
- A Nieden
- A Pagenstecher
- A Patry
- A Patry
- A Peiper
- A Peiper
- A Peters
- A Peters
- A Peters
- A Peters
- A Peters
- A Peters
- A Pflegst
- A Pillat
- A Radloff
- A Robertson
- A Romer
- A Rumpel
- A Rumpel
- A Röttx
- A Röttx
- A Sachsalber
- A Scily
- A Shuback
- A Simmonds
- A Sziny
- A Thier
- A Tine
- A Trousseau
- A Varelmann
- A Voegeli
- A Voegeli
- A Vogt
- A Vogt
- A Vogt
- A Vogt
- A Vogt
- A Vogt
- A Vogt
- A Vogt
- A Vogt
- A Vogt
- A Vossius
- A Vossius
- A Vossius
- A Weil
- A Westphal
- A Wider
- A. Szily
- AA Bradburne
- AA Bradburne
- AD Williams
- ADE Candolle
- Adert
- AE Burroughs
- AE Burroughs
- AE Goldfeder
- AE Taft
- AH Griffith
- AH Griffith
- AH Levy
- AH Thompson
- AH Thompson
- AJ Liai
- AJ Schnee
- allgemeinen Bemerkungen ĂŒber die Vererbung bei Augenleiden
- AM Gossage
- Ammons
- AO Pfingst
- Apert
- Apert et Dubuse
- AR Baker
- AR Guxx
- Asayama
- Aubineau
- Augstein
- Aurand
- Aurand
- AW Ormond
- AW Ormond
- AW Ormond
- AW Stirling
- B Chance
- B Chance
- B DĂŒrken
- B Fleischer
- B Fleischer
- B Fleischer
- B Fleischer
- B Fleischer
- B Fleischer
- B Fleischer
- B Fleischer
- B Fleischer
- B Fleischer
- B Fleischer
- B Garfunkel
- B GlĂŒg
- B Jeffries
- B Kayser
- B Kolbe
- B Meyer-Riemsloh
- B Meyer-Riemsloh
- B Meyer-Riemsloh
- B Moniervinard
- B Pellathy
- B Pusey
- B Sachs
- B Wicherkiewicz
- BA Berry
- Bach
- Bach
- Badal
- Badal
- Bauer
- Baumgarten
- Beauvieux
- Beck D
- Becker
- Beckershaus
- Behr
- Belivier
- Bell
- Berneaui
- Besson-Net
- Bettmann
- Biber
- Bielschowsky
- Bocx
- Bolten
- Bolten
- Breitbarth
- Brodmanr
- Brodmanr
- Browxrxg
- Bruns
- Brushfield and Wyatt
- Brusxflel3 and Wyatt
- Bryn
- Buchanan
- Bucklers
- Buisso
- Buisson
- Bullocx
- Bullooii
- Bullooii
- Böhm
- C Behr
- C Behr
- C BĂ€r
- C Colden
- C Correns
- C Cutler
- C Danforth
- C Feli
- C Fromaget
- C Gredrg
- C Hess
- C Hess
- C Ivioeves
- C Ivioeves
- C Koller
- C Lafond
- C Noorden
- C Papastratigaxis
- C Pascheff
- C Posey
- C Posey
- C Scarömz
- C Schmid
- C Seyfarth
- C Usher
- C Worsterdrought
- C Worsterdrought
- C Worth
- CA Adair-Dighton
- CA Hegner
- CA Hegner
- Cahuzac
- Caillaud
- Cameron
- Cameron
- Cassirer
- Cassirer
- Caussade
- CB Bridges
- CB Davenport
- CC Rush
- CGR Wool
- CGR Wool
- CGT Ruete
- CH Blair
- CH Usher
- CH Usher
- CH Usher
- CHA Westhoff
- CHA Westhoff
- ChenneviĂšre
- ChenneviĂšre
- CHR Thomsen
- CL Herrlinger
- Clark C. F.
- Clarke
- Classen
- Classen
- Clausen
- Clausen
- Clausen
- Clausen
- Collins
- Conlon
- Cooper
- Cordiale
- Crocco
- Crouzox O. u. P
- Crzellitzer
- CS Jeaffeeson
- Cunier
- Cunningham J. F.
- Cunter
- Cusa.ING H.
- CW Cutler
- D Coover
- D Cyon
- D Davidsohn
- D Gunn
- D Marinesco
- DA Mendes
- Dalén
- Davis
- Davis
- DCL Owen
- Degeer
- Delord
- Derby
- DF Jones
- Dreyer-Dufer
- Dreyer-Dufer
- Duddel
- Dudley
- Dujardin
- Duscunitz
- Dutil
- Duyse van G.-M.
- DĂŒrr u. Schlegtendal
- E Ackermann
- E Adrogué
- E Ammann
- E Bachstez
- E Bartok
- E Baur
- E Baur
- E Bronson
- E Cecchetto
- E Clarke
- E Collins
- E Collins
- E Derzler
- E Engelking
- E Engelking
- E Fuchs
- E Fuchs
- E Fucus
- E Fucus
- E Fucxs
- E Gimplinger
- E Grönblad
- E Guzmann
- E Guzmann
- E Hanhart
- E Hanhart
- E Hertel
- E Himly
- E Hippel
- E Hippel
- E Hippel
- E Hirpel
- E Hocqiard
- E Holm
- E Holm
- E Holm
- E Houe
- E Illing
- E Illing
- E Jackson
- E Jacobsohn
- E Jakobsohn
- E Jakobsohn
- E Jendrassik
- E Jendrassik
- E Jendrassik
- E JuxĂšs
- E Kibort
- E Landolt
- E Leblond
- E Lenoble
- E Lenoble
- E Moucnot
- E Nettleshif
- E Nettleship
- E Nettleship
- E Nettleship
- E Nettleship
- E Nettleshir
- E Nettleshir
- E Nettlesiiip
- E RarnenfĂŒhrer
- E Remky
- E Rubel
- E Savini-Castano
- E Schall
- E Schmidt
- E Spengler
- E Spengler
- E Thomsox
- E Tron
- E Tönöx
- E Velardi
- E Wiechmann
- E Wolfflin
- E Wölfflin
- E Zirm
- EA Cockayne
- EA Cockayne
- EB Wilson
- ED Jensen
- ED Jensen
- ED Stieren
- Eddowes
- EG Shannon
- EH Houlthouse
- Eha
- EL Metzger
- EL Oatman
- Elscxnig
- EM Barrot
- EM Peterdy
- EM Selter
- Ennelma
- Enslin
- Enslin
- EP Cameron
- Epinatzew
- EV Frxsuxowa
- EVON Eiffel
- Exgelxnxg
- F Arlt
- F Becker
- F Beckershaus
- F Berg
- F Bernstein
- F Bernstein
- F Best
- F Best
- F Cunier
- F Dimmer
- F Gaisböck
- F Gaisböck
- F GĂŒnsburg
- F GĂŒnsburg
- F Herrenscuwand
- F Hxrbitz
- F Kauffmann
- F Kennedy
- F Koby
- F Kouv
- F Krusius
- F Lennmalm
- F Lennmalm
- F Lenz
- F Lenz
- F Lenz
- F Nolte
- F Poos
- F Rozabal
- F Rössler
- F Saeger
- F Santos
- F SchlĂŒter
- F SchlĂŒter
- F SchmidhÀuser
- F Schob
- F Schönenberger
- F Schönenberger
- F Terrien
- F Terrien
- F Thaden
- F Weyert
- F WĂŒstefeld
- F. W. Marlow
- FA Juler
- FA Kehrer
- FA Kehrer
- FA Kehrer
- Falkenheim
- FB Tiffany
- FC Donders
- FC Donners
- FE Batten
- FE Batten
- FE Batten
- FE Koby
- Fecht W
- Feingold
- Fetsciner
- Fetsciner
- Fietta
- Fischer
- FK Walter
- Fleischer
- Fleischer
- Fleischer
- FM Boehm
- FM Ogilvie
- FM Ogilvie
- FN Knapp
- FP Calhoun
- FP Weber
- FPH Calhoun
- FPH Calhoun
- FR Börger
- FR Cross
- FR Horner
- FR Martin
- FR Martin
- FR Pelizaeus
- FR Pelizaeus
- FR Peterson
- Frickhöffer
- Friede
- Fritsch
- Fromaget
- Fuchs
- Fucus
- FW Bremer
- FW Burton
- FW Marlow
- G Arcoleo
- G Bardet
- G Bolten
- G Braun
- G Braun
- G Coats
- G Coats
- G Combe
- G Couturier
- G Crampton
- G Derigs
- G Die
- G Doederlein
- G Fischer
- G Freytag
- G Göthlin
- G Hemmes
- G Heuck
- G Hoekstra
- G Just
- G Just
- G Klopfer
- G Klopfer
- G Levinsorrn
- G Mariiesco
- G Marx
- G Mayerhausen
- G Norrie
- G Oliver
- G Pisenti
- G Purtscher
- G Riddoch
- G Rindfleisch
- G Rouffinet
- G Rouffinet
- G Weill
- G Weisel
- G Wildi
- Galezowsiu
- Galezowski
- Gallemaerts
- Gallenga
- Gallenga
- Gazjipy
- GB Savellt
- GC Harlan
- GC Harlan
- GC Harlan
- GD Hemmes
- GDE Rosa
- GDE Rosa
- Gehrung
- Gelpke
- GeĂČsz
- GFR Rochat
- GH Waaler
- Gifford
- Ginestous et Lame
- GM Gould
- GM Gould
- Goldschmidt
- Gonzalez
- Gourfein
- Gowers
- Gowers
- GP Frets
- Grob
- Groenouw
- Grossmann. E.
- Grönholm
- GS Mariiesco
- GT Mould
- Guerin
- Gutierrez-PONCE
- Guyer
- GW Roll
- GĂ€nsslen
- GĂ€nsslen
- GĂ€nsslen u. FRrrz
- GĂ€nsslen u. Frrrz
- H Armaignac
- H Audeoud
- H Bahrdt
- H Bahrdt
- H Bolten
- H Bresgen
- H Bruns
- H Burrows
- H Butler
- H Cockayne
- H Cohn
- H Curschmann
- H Cushing
- H Don
- H Don
- H Fees
- H Frenkel
- H Frenkel
- H Frenxel
- H Frenzel
- H Freund
- H Gebb
- H Gifford
- H Harlan
- H Hartung
- H Higier
- H Higier
- H Higier
- H Hoffmann
- H Juler
- H Juler
- H Kast
- H Killian
- H Knapp
- H Koenig
- H Kufs
- H Langdon
- H Larsen
- H Larsen
- H Lauber
- H Lauber
- H Lauber
- H Lembeck
- H Lundborg
- H Magnus
- H Magnus
- H Mauksch
- H Mauksch
- H Nonop
- H Osterroht
- H Paal
- H Page
- H Pagenstecher
- H Rieger
- H SchlĂŒter
- H Schmalfuss
- H Schmidt
- H Schmidt-Rimpler
- H Schmidtrimpler
- H Schmidtrimpler
- H Schneider
- H Schneider
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- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/1930
- Field of study
Treatment with tocilizumab or corticosteroids for COVID-19 patients with hyperinflammatory state: a multicentre cohort study (SAM-COVID-19).
- Author
- Arribas José Ramón
- Berenguer Juan
- CarratalĂ Jordi
- Complejo Asistencial de Ăvila
- Complejo Hospitalario Universitario A Coruña
- Complejo Hospitalario Universitario de Ferrol
- Complejo Hospitalario Universitario Santa LucĂa
- Complejo Hospitalario Virgen de la Salud
- FundaciĂłn Hospital de Calahorra
- FundaciĂłn SEIMC-GESIDA
- Hospital Alto Deba
- Hospital CIMA-Sanitas
- Hospital ClĂnico San Cecilio
- Hospital ClĂnico Universitario de Valencia
- Hospital ClĂnico Universitario de Valladolid
- Hospital ClĂnico Universitario Lozano Blesa
- Hospital Comarcal de Blanes
- Hospital Costa del Sol
- Hospital de Barcelona SCIAS
- Hospital de Donostia
- Hospital de Guadalajara
- Hospital de Melilla
- Hospital de PalamĂłs
- Hospital de Sabadell (Parc Tauli)
- Hospital del Mar
- Hospital do Salnés
- Hospital Dos De Maig - Consorci Sanitari Integral
- Hospital FundaciĂłn JimĂ©nez DĂaz
- Hospital General de la Palma
- Hospital General Universitario Reina SofĂa
- Hospital Infanta Leonor
- Hospital Josep Trueta
- Hospital Juan Ramón Jiménez
- Hospital La Inmaculada
- Hospital Mutua de Terrassa
- Hospital Puerta de Hierro
- Hospital Regional de MĂĄlaga
- Hospital San Eloy de Barakaldo
- Hospital Son Espases
- Hospital Son Llatzer
- Hospital Universitari de Bellvitge
- Hospital Universitario Central de Asturias
- Hospital Universitario de Cruces
- Hospital Universitario de Getafe
- Hospital Universitario de Gran Canaria Dr NegrĂn
- Hospital Universitario de Jaén
- Hospital Universitario de Jerez
- Hospital Universitario de Valme
- Hospital Universitario de Ălava
- Hospital Universitario Gregorio Marañón
- Hospital Universitario Infanta Sofia
- Hospital Universitario La Paz
- Hospital Universitario los Arcos del Mar Menor
- Hospital Universitario Marqués de Valdecilla
- Hospital Universitario Puerto Real
- Hospital Universitario Rafael MĂ©ndez
- Hospital Universitario RamĂłn y Cajal
- Hospital Universitario San Pedro
- Hospital Universitario Severo Ochoa
- Hospital Universitario Virgen del RocĂo
- Hospital Universitario Virgen Macarena
- Hospital Universitario y Politécnico La Fe
- Hospital Vega Baja
- Hospital Virgen de la Arrixaca
- Hospital Ălvaro Cunqueiro
- JarrĂn Inmaculada
- PachĂłn JerĂłnimo
- Parc Sanitari Sant Joan de DĂ©u
- RodrĂguez-Baño JesĂșs
- Ryan Pablo
- SAM-COVID Study Group
- Yllescas MarĂa
- Publication venue
- 'Elsevier BV'
- Publication date
- 27/08/2020
- Field of study
The objective of this study was to estimate the association between tocilizumab or corticosteroids and the risk of intubation or death in patients with coronavirus disease 19 (COVID-19) with a hyperinflammatory state according to clinical and laboratory parameters. A cohort study was performed in 60 Spanish hospitals including 778 patients with COVID-19 and clinical and laboratory data indicative of a hyperinflammatory state. Treatment was mainly with tocilizumab, an intermediate-high dose of corticosteroids (IHDC), a pulse dose of corticosteroids (PDC), combination therapy, or no treatment. Primary outcome was intubation or death; follow-up was 21 days. Propensity score-adjusted estimations using Cox regression (logistic regression if needed) were calculated. Propensity scores were used as confounders, matching variables and for the inverse probability of treatment weights (IPTWs). In all, 88, 117, 78 and 151 patients treated with tocilizumab, IHDC, PDC, and combination therapy, respectively, were compared with 344 untreated patients. The primary endpoint occurred in 10 (11.4%), 27 (23.1%), 12 (15.4%), 40 (25.6%) and 69 (21.1%), respectively. The IPTW-based hazard ratios (odds ratio for combination therapy) for the primary endpoint were 0.32 (95%CI 0.22-0.47; p Tocilizumab might be useful in COVID-19 patients with a hyperinflammatory state and should be prioritized for randomized trials in this situation
Characteristics and predictors of death among 4035 consecutively hospitalized patients with COVID-19 in Spain.
- Author
- Arriba José Ramón
- Berenguer Juan
- CarratalĂ Jordi
- Centro Nacional de EpidemiologĂa
- ClĂnica Universitaria de NavarraâCampus Madrid
- ClĂnica Universitaria de NavarraâCampus Navarra
- Complejo Asistencial de Ăvila
- Complejo Asistencial Universitario de Salamanca
- Complejo Hospitalario Universitario A Coruña
- Complejo Hospitalario Universitario de Ferrol
- Complejo Hospitalario Universitario Insular Materno-Infantil
- Complejo Hospitalario Universitario Nuestra Señora de La Candelaria
- Complejo Hospitalario Universitario Santa LucĂa
- Complejo Hospitalario Virgen de la Salud
- COVID-19@Spain Study Group
- EOXI Pontevedra e Salnés
- FundaciĂłn Hospital de Calahorra
- FundaciĂłn Hospital Universitario AlcorcĂłn
- FundaciĂłn JimĂ©nez DĂaz
- FundaciĂłn SEIMC-GESIDA
- HC Marbella Internacional Hospital
- HM Sanchinarro
- Hospital Alto Deba
- Hospital Arnau de Vilanova-Lliria
- Hospital CIMA-Sanitas
- Hospital Clinic de Barcelona
- Hospital ClĂnica Benidorm
- Hospital ClĂnico San Carlos
- Hospital ClĂnico San Cecilio
- Hospital ClĂnico Universitario de Santiago de Compostela
- Hospital ClĂnico Universitario de Valencia
- Hospital ClĂnico Universitario de Valladolid
- Hospital ClĂnico Universitario Lozano Blesa
- Hospital Comarcal de Alcañiz
- Hospital Comarcal de Blanes
- Hospital Costa del Sol
- Hospital de Can Misses
- Hospital de Donostia
- Hospital de Figueres
- Hospital de Guadalajara
- Hospital de Guadarrama
- Hospital de l'Esperit Sant
- Hospital de la Marina Baixa
- Hospital de la Plana
- Hospital de MatarĂł
- Hospital de Melilla
- Hospital de Mendaro
- Hospital de PalamĂłs
- Hospital de Sabadell (Parc Tauli)
- Hospital de Sagunto
- Hospital de Tortosa Virgen de la Cinta
- Hospital de Urduliz Alfredo Espinosa
- Hospital de Viladecans
- Hospital del Mar
- Hospital Doce de Octubre
- Hospital Don Benito-Villanueva de la Serena
- Hospital Dos de Maig
- Hospital Dr José Molina Orosa
- Hospital El Bierzo
- Hospital Francesc de Borja
- Hospital General de la Defensa GĂłmez Ulla
- Hospital General de la Palma
- Hospital General Universitario de Alicante
- Hospital General Universitario de Elche
- Hospital General Universitario Gregorio Marañón
- Hospital HLA Inmaculada
- Hospital HLA Universitario Moncloa
- Hospital Infanta Leonor
- Hospital Josep Trueta
- Hospital Juan Ramón Jiménez
- Hospital La Princesa
- Hospital Marina Salud de DĂ©nia
- Hospital Mutua de Terrassa
- Hospital Nuestra Señora de Gracia
- Hospital Puerta de Hierro
- Hospital Quiron-Salud de Torrevieja
- Hospital Quirón A Coruña
- Hospital Reina SofĂa de Tudela
- Hospital Riotinto
- Hospital San Eloy de Barakaldo
- Hospital Sant Jaume de Calella
- Hospital Santa BĂĄrbara
- Hospital Santa Creu i Sant Pau
- Hospital Santos Reyes
- Hospital Son Espases
- Hospital Son Llatzer
- Hospital Universitari de Bellvitge
- Hospital Universitari de Tarragona Joan XXIII
- Hospital Universitario Basurto
- Hospital Universitario Central de Asturias
- Hospital Universitario de Canarias
- Hospital Universitario de Cruces
- Hospital Universitario de Getafe
- Hospital Universitario de Gran Canaria Dr NegrĂn
- Hospital Universitario de Jaén
- Hospital Universitario de Jerez
- Hospital Universitario de la Ribera
- Hospital Universitario de MĂłstoles
- Hospital Universitario de Valme
- Hospital Universitario de Ălava
- Hospital Universitario del Henares
- Hospital Universitario del VinalopĂł
- Hospital Universitario HM Madrid
- Hospital Universitario HM MonteprĂncipe
- Hospital Universitario HM Puerta del Sur
- Hospital Universitario HM Torrelodones
- Hospital Universitario Infanta SofĂa
- Hospital Universitario La Paz
- Hospital Universitario los Arcos del Mar Menor
- Hospital Universitario Lucus Augusti
- Hospital Universitario Marqués de Valdecilla
- Hospital Universitario Miguel Servet
- Hospital Universitario PrĂncipe de Asturias
- Hospital Universitario Puerto Real
- Hospital Universitario Rafael MĂ©ndez
- Hospital Universitario RamĂłn y Cajal
- Hospital Universitario Rey Juan Carlos
- Hospital Universitario Rio Hortega
- Hospital Universitario San Juan de Alicante
- Hospital Universitario San Pedro
- Hospital Universitario Severo Ochoa
- Hospital Universitario Virgen del RocĂo
- Hospital Universitario Virgen Macarena
- Hospital Universitario y Politécnico la Fe
- Hospital Vall dâHebrĂłn
- Hospital Vega Baja
- Hospital Virgen de la Arrixaca
- Hospital Virgen de la ConchaâComplejo Asistencial de Zamora
- Hospital Virgen de la Victoria
- Hospital Virgen del Puerto
- Hospital Ălvaro Cunqueiro
- JarrĂn Inmaculada
- PachĂłn JerĂłnimo
- Parc Sanitari Sant Joan de DĂ©u
- RodrĂguez-Baño JesĂșs
- Ryan Pablo
- SCIAS Hospital de Barcelona
- Yllescas MarĂa
- Publication venue
- 'Elsevier BV'
- Publication date
- 04/08/2020
- Field of study
To analyse the characteristics and predictors of death in hospitalized patients with coronavirus disease 2019 (COVID-19) in Spain. A retrospective observational study was performed of the first consecutive patients hospitalized with COVID-19 confirmed by real-time PCR assay in 127 Spanish centres until 17 March 2020. The follow-up censoring date was 17 April 2020. We collected demographic, clinical, laboratory, treatment and complications data. The primary endpoint was all-cause mortality. Univariable and multivariable Cox regression analyses were performed to identify factors associated with death. Of the 4035 patients, male subjects accounted for 2433 (61.0%) of 3987, the median age was 70Â years and 2539 (73.8%) of 3439 had one or more comorbidity. The most common symptoms were a history of fever, cough, malaise and dyspnoea. During hospitalization, 1255 (31.5%) of 3979 patients developed acute respiratory distress syndrome, 736 (18.5%) of 3988 were admitted to intensive care units and 619 (15.5%) of 3992 underwent mechanical ventilation. Virus- or host-targeted medications included lopinavir/ritonavir (2820/4005, 70.4%), hydroxychloroquine (2618/3995, 65.5%), interferon beta (1153/3950, 29.2%), corticosteroids (1109/3965, 28.0%) and tocilizumab (373/3951, 9.4%). Overall, 1131 (28%) of 4035 patients died. Mortality increased with age (85.6% occurring in older than 65Â years). Seventeen factors were independently associated with an increased hazard of death, the strongest among them including advanced age, liver cirrhosis, low age-adjusted oxygen saturation, higher concentrations of C-reactive protein and lower estimated glomerular filtration rate. Our findings provide comprehensive information about characteristics and complications of severe COVID-19, and may help clinicians identify patients at a higher risk of death