Aplikasi Pencarian Rute Terpendek Tempat Wisata Di Kota Pekanbaru Menggunakan Floyd Warshall

Dinas Kebudayaan dan Pariwisata Kota Pekanbaru (2017) menyatakan Pekanbaru merupakan kota yang berpotensi untuk dikembangkan menjadi daerah tujuan wisata. Wisatawan yang datang berkunjung membutuhkan informasi rute terpendek tempat wisata, masih terbatasnya sistem informasi tentang rute tempat wisata di Kota Pekanbaru dan kurangnya penerapan teknologi informasi dibidang pariwisata untuk meningkatkan promosi dan potensi - potensi tempat wisata di Kota Pekanbaru, dapat disolusikan dengan menerapkan algoritma seperti Floyd Warshall. Algoritma tersebut akan menampilkan jalur terpendek menuju lokasi tempat wisata terdekat dengan pengguna. Hal tersebut didukung oleh GPS (Global Positioning System) untuk mengetahui keberadaan pengguna. Berdasarkan hasil penelitian ini dapat membantu wisatawan serta masyarakat memberikan informasi tentang lokasi tempat wisata dan dapat meningkatkan potensi pariwisata khususnya Kota Pekanbaru

Fit to practise? Processes for dealing with misconduct among pharmacists in Australia, Canada, the UK and US

© 2018 Elsevier Inc.In many countries with legal systems based on English common law, pharmacy regulators have a responsibility to protect, promote and maintain the health and safety of patients. Where there is a potential risk to patient safety, or where the public's confidence in pharmacy could be adversely affected by the actions of a pharmacist, these regulators have a statutory duty to investigate concerns. The legal provisions underpinning each jurisdiction's disciplinary processes depict distinctive outlooks from the different authorities, as each works towards the same goal. Legal statues, regulations, rules, and guidance affecting the disciplinary process in Great Britain, Australia, New York and New Brunswick were collated, and the processes they describe were attached to a common process flow diagram for step-by-step evaluation of their respective legal provisions. The initial stages of the respective investigation process are broadly similar in all the jurisdictions examined; however, each process has subtle differences that afford some level of advantage or disadvantage over its comparators. Factors including: how matters of discipline are framed; the existence of a separate process for minor and uncontested violations; the ability to effect an interim suspension of a practitioner's license; threshold criteria for escalation of complaints; the membership of disciplinary panels; and the perceived independence of these panels all philosophically affect the public safety remit of each regulator. This work constitutes the first comparison of international regulatory frameworks for the profession of pharmacy. Of the four jurisdictions examined, Great Britain most clearly acts in the interest of the public and the profession – rather than the respondent pharmacist – at every step of its process.Peer reviewe

IMPLEMENTASI STEGANOGRAFI PADA TEKS TERENKRIPSI DENGAN ALGORITMA RSA MENGGUNAKAN METODE BPCS

The internet network is growing rapidly and has a great impact on human life. The development of the internet network has enabled many people to exchange information or messages,one of tham by using email media. Apparently the internet is a path that in ni not too safe because it is a common communication media that can be used by everyone so prone to tapping information or messages. Therefore, security and confidentiality are needed in data communications. One may to keep messages safe is to use steganography technique. The steganography method used is the method of message insertion using BPCS (Bit Plane Complexity Segmentation). Before the message is inserted, the message is first encrypted using cryptography techniques. The cryptographic algorithm used is RSA algorithm. RSA algorithm consists of encryption algorithm and decryption algorithm. The confidential message is encrypted using RSA encryption algorithm and inserted using the insertion method of BPCS. With the technique of steganography on the image media then the delivery of a secret message will have a good level of security because it can not be detected directly by the senses of human vision. Keywords: cryptography, steganography, RSA, method BPCS   Abstrak Jaringan internet berkembang dengan pesat dan memberikan pengaruh besar bagi kehidupan manusia. Perkembangan jaringan Internet telah memungkinkan banyak orang untuk saling bertukar informasi atau pesan salah satunya dengan media email. Ternyata, internet merupakan jalur yang tidak terlalu aman karna merupakan media komunikasi umum yang dapat digunakan semua orang sehingga rawan penyadapan informasi atau pesan. Oleh karena itu, keamanan dan kerahasiaan sangat dibutuhkan dalam komunikasi data. Salah satu cara untuk menjaga keamanan pesan adalah menggunakan teknik steganografi. Metode steganografi yang digunakan adalah metode penyisipan pesan, dengan menggunakan metode BPCS (Bit Plane Complexity Segmentation). Sebelum pesan disisipkan terlebih dahulu pesan tersebut dienkripsi dengan menggunakan teknik kriptografi. Algoritma kriptografi yang digunakan adalah algoritma RSA. Algoritma RSA terdiri dari algoritma enkripsi dan algoritma dekripsi. Pesan rahasia disandikan menggunakan algoritma enkripsi RSA dan disisipkan menggunakan metode penyisipan BPCS. Dengan adanya teknik steganografi pada media citra maka pengiriman suatu pesan yang bersifat rahasia akan memiliki tingkat keamanan yang baik karena tidak dapat dideteksi langsung oleh indera penglihatan manusia. Keywords: Kriptografi, Steganogari, RSA, Metode BPC

PENGENALAN MONUMEN-MONUMEN BERSEJARAH DI KOTA PEKANBARU MENGGUNAKAN AUGMENTED REALITY (AR) BERBASIS ANDROID

Membangun sebuah media informasi menggunakan teknologi Augmented Readily (AR) berbasis Android. Kurangnya media informasi untuk masyarakat dalam mengenal monumen-monumen bersejarah di Kota Pekanbaru membuat masyarakat kurang memahami maksud dibagunnya atau  sejarah berdirinya monumen-monumen yang banyak djumpai di wilayah Kota Pekanbaru sehingga terkadang dianggap sebagai objek hiasan atau objek foto. Maka dari itu perlu dibangun sebuah media informasi untuk masyarakat dalam bentuk aplikasi salah satunya dengan memanfaatkan teknologi yang berkembang saat ini yaitu teknologi Augmented Readily (AR) berbasis Android pada monumen bersejarah di kota Pekanbaru. Dengan menggunakan metode pengumpulan data, analisis, desain, implementasi, dan pengujian. Dengan adanya aplikasi ini dapat memberikan informasi kepada masyarakat mengenai sejarah dan maksud dibangunya monumen-monumen yang ada di Kota Pekanbaru.   Kata Kunci : monumen, augmented reality, sejarah, android, pekanbaru

Analisa Dan Implementasi Security Mail Server

Mail server is one of the most widely used server functions in the company. This discusses e-mail itself which can reduce mailing costs, is more efficient than manual communication and can be used as attachments that are useful as a supplement and additional documents related to the contents of e-mail. Zimbra is a mail server application that provides complete features and also makes it easy to install mail server management, also mail server security issues are a factor that must be considered by the system administrator. The security design for e-mail servers addresses the importance of being able to prevent spam e-mail attacks that can fill e-mail servers and make mail server performance faster. Because a good mail server security can optimize the performance of the mail server itself. In this final project, the work and implementation of the zimbra mail server security will be carried out specifically for handling email spam. The zimbra email server will analyze its security against spam email attacks, so that it can function as an email server on the company

PENINGKATAN KUALITAS PUBLIKASI ILMIAH DAN PENELITIAN BAGI GURU SLTA DENGAN PEMANFAATAN SOFTWARE REFERENSI

Republic of Indonesia Law No. 14 of 2005 describes teachers as professional educators with the main task of educating, teaching, guiding, directing, training, evaluating, and evaluating students in the formal education listed. The teacher has an important role in planning and implementing the learning process, so as to obtain opportunities to improve competence. One of the activities that must be carried out by teachers in developing their competence as teachers is scientific publications, which are listed in Article 11 of the Minister of PAN & RB Regulation No.16 of 2009 concerning teacher functional positions. In designing scientific publications there are stages and methods that are different from other papers. The research work comes from the research activities carried out so that it can be a reference in the follow-up of educational activities. The existence of information technology devices makes it easy for teachers to carry out research activities to publish them. The more research carried out at this time is not necessarily comparable with the quality of research. The demand to fulfill good and correct reference criteria is a challenge for teachers in the stages of reviewing and following up on publications. This service activity provides other insights into better article writing and reference techniques using computer-assisted devices. Problems with the obstacles faced so far by the teacher in writing are expected to be solved so that joint efforts in creating an environment of professionalism in education can be realized

Acute oral toxicity study of root methanol extract of Goniothalamus lanceolatus miq. and its isolated bioactive compound (parvistone D) in murine model

Goniothalamus lanceolatus Miq. is widely used by the indigenous people of Sarawak, Malaysia as a folk remedy to treat various ailments including skin diseases, cold, and fever. A previous study reported that the root methanol extract, and parvistone D, an active compound of the plant, showed promising in vitro antiplasmodial activity against Plasmodium parasites. However, there is limited data reporting on its toxicological profile. Thus, this study aims to evaluate the potential toxicity of root methanol extract and parvistone D of G. lanceolatus in mice. The acute oral toxicity of the extract and compound was assessed at a single dose of 2000 and 500 mg/kg body weight, respectively. The animals were observed for any mortality, behavioral, motor-neuronal abnormalities, and body weight changes for 14 days. At the end of the experiment, relative organ weights were measured, and gross examination, as well as histopathological analysis, were performed. There was no sign of toxicity, and mortality seen in mice treated with G. lanceolatus root methanol extract, and parvistone D at the administered doses. In addition, no significant differences were observed in the body and relative organ weights between the control and treated groups. Gross and histopathological examinations showed normal appearance of the liver, spleen, kidneys, heart, and lungs as compared to their respective control groups. In conclusion, oral administration of root methanol extract, and parvistone D of G. lanceolatus are safe at the studied dosage levels and cause no acute toxicity in mice

Leishmania Genome Dynamics during Environmental Adaptation Reveal Strain-Specific Differences in Gene Copy Number Variation, Karyotype Instability, and Telomeric Amplification.

Protozoan parasites of the genus Leishmania adapt to environmental change through chromosome and gene copy number variations. Only little is known about external or intrinsic factors that govern Leishmania genomic adaptation. Here, by conducting longitudinal genome analyses of 10 new Leishmania clinical isolates, we uncovered important differences in gene copy number among genetically highly related strains and revealed gain and loss of gene copies as potential drivers of long-term environmental adaptation in the field. In contrast, chromosome rather than gene amplification was associated with short-term environmental adaptation to in vitro culture. Karyotypic solutions were highly reproducible but unique for a given strain, suggesting that chromosome amplification is under positive selection and dependent on species- and strain-specific intrinsic factors. We revealed a progressive increase in read depth towards the chromosome ends for various Leishmania isolates, which may represent a nonclassical mechanism of telomere maintenance that can preserve integrity of chromosome ends during selection for fast in vitro growth. Together our data draw a complex picture of Leishmania genomic adaptation in the field and in culture, which is driven by a combination of intrinsic genetic factors that generate strain-specific phenotypic variations, which are under environmental selection and allow for fitness gain.IMPORTANCE Protozoan parasites of the genus Leishmania cause severe human and veterinary diseases worldwide, termed leishmaniases. A hallmark of Leishmania biology is its capacity to adapt to a variety of unpredictable fluctuations inside its human host, notably pharmacological interventions, thus, causing drug resistance. Here we investigated mechanisms of environmental adaptation using a comparative genomics approach by sequencing 10 new clinical isolates of the L. donovani, L. major, and L. tropica complexes that were sampled across eight distinct geographical regions. Our data provide new evidence that parasites adapt to environmental change in the field and in culture through a combination of chromosome and gene amplification that likely causes phenotypic variation and drives parasite fitness gains in response to environmental constraints. This novel form of gene expression regulation through genomic change compensates for the absence of classical transcriptional control in these early-branching eukaryotes and opens new venues for biomarker discovery

Impact of opioid-free analgesia on pain severity and patient satisfaction after discharge from surgery: multispecialty, prospective cohort study in 25 countries

Background: Balancing opioid stewardship and the need for adequate analgesia following discharge after surgery is challenging. This study aimed to compare the outcomes for patients discharged with opioid versus opioid-free analgesia after common surgical procedures.Methods: This international, multicentre, prospective cohort study collected data from patients undergoing common acute and elective general surgical, urological, gynaecological, and orthopaedic procedures. The primary outcomes were patient-reported time in severe pain measured on a numerical analogue scale from 0 to 100% and patient-reported satisfaction with pain relief during the first week following discharge. Data were collected by in-hospital chart review and patient telephone interview 1 week after discharge.Results: The study recruited 4273 patients from 144 centres in 25 countries; 1311 patients (30.7%) were prescribed opioid analgesia at discharge. Patients reported being in severe pain for 10 (i.q.r. 1-30)% of the first week after discharge and rated satisfaction with analgesia as 90 (i.q.r. 80-100) of 100. After adjustment for confounders, opioid analgesia on discharge was independently associated with increased pain severity (risk ratio 1.52, 95% c.i. 1.31 to 1.76; P < 0.001) and re-presentation to healthcare providers owing to side-effects of medication (OR 2.38, 95% c.i. 1.36 to 4.17; P = 0.004), but not with satisfaction with analgesia (beta coefficient 0.92, 95% c.i. -1.52 to 3.36; P = 0.468) compared with opioid-free analgesia. Although opioid prescribing varied greatly between high-income and low- and middle-income countries, patient-reported outcomes did not.Conclusion: Opioid analgesia prescription on surgical discharge is associated with a higher risk of re-presentation owing to side-effects of medication and increased patient-reported pain, but not with changes in patient-reported satisfaction. Opioid-free discharge analgesia should be adopted routinely

Mortality from gastrointestinal congenital anomalies at 264 hospitals in 74 low-income, middle-income, and high-income countries: a multicentre, international, prospective cohort study

Summary Background Congenital anomalies are the fifth leading cause of mortality in children younger than 5 years globally. Many gastrointestinal congenital anomalies are fatal without timely access to neonatal surgical care, but few studies have been done on these conditions in low-income and middle-income countries (LMICs). We compared outcomes of the seven most common gastrointestinal congenital anomalies in low-income, middle-income, and high-income countries globally, and identified factors associated with mortality. Methods We did a multicentre, international prospective cohort study of patients younger than 16 years, presenting to hospital for the first time with oesophageal atresia, congenital diaphragmatic hernia, intestinal atresia, gastroschisis, exomphalos, anorectal malformation, and Hirschsprung’s disease. Recruitment was of consecutive patients for a minimum of 1 month between October, 2018, and April, 2019. We collected data on patient demographics, clinical status, interventions, and outcomes using the REDCap platform. Patients were followed up for 30 days after primary intervention, or 30 days after admission if they did not receive an intervention. The primary outcome was all-cause, in-hospital mortality for all conditions combined and each condition individually, stratified by country income status. We did a complete case analysis. Findings We included 3849 patients with 3975 study conditions (560 with oesophageal atresia, 448 with congenital diaphragmatic hernia, 681 with intestinal atresia, 453 with gastroschisis, 325 with exomphalos, 991 with anorectal malformation, and 517 with Hirschsprung’s disease) from 264 hospitals (89 in high-income countries, 166 in middleincome countries, and nine in low-income countries) in 74 countries. Of the 3849 patients, 2231 (58·0%) were male. Median gestational age at birth was 38 weeks (IQR 36–39) and median bodyweight at presentation was 2·8 kg (2·3–3·3). Mortality among all patients was 37 (39·8%) of 93 in low-income countries, 583 (20·4%) of 2860 in middle-income countries, and 50 (5·6%) of 896 in high-income countries (p<0·0001 between all country income groups). Gastroschisis had the greatest difference in mortality between country income strata (nine [90·0%] of ten in lowincome countries, 97 [31·9%] of 304 in middle-income countries, and two [1·4%] of 139 in high-income countries; p≤0·0001 between all country income groups). Factors significantly associated with higher mortality for all patients combined included country income status (low-income vs high-income countries, risk ratio 2·78 [95% CI 1·88–4·11], p<0·0001; middle-income vs high-income countries, 2·11 [1·59–2·79], p<0·0001), sepsis at presentation (1·20 [1·04–1·40], p=0·016), higher American Society of Anesthesiologists (ASA) score at primary intervention (ASA 4–5 vs ASA 1–2, 1·82 [1·40–2·35], p<0·0001; ASA 3 vs ASA 1–2, 1·58, [1·30–1·92], p<0·0001]), surgical safety checklist not used (1·39 [1·02–1·90], p=0·035), and ventilation or parenteral nutrition unavailable when needed (ventilation 1·96, [1·41–2·71], p=0·0001; parenteral nutrition 1·35, [1·05–1·74], p=0·018). Administration of parenteral nutrition (0·61, [0·47–0·79], p=0·0002) and use of a peripherally inserted central catheter (0·65 [0·50–0·86], p=0·0024) or percutaneous central line (0·69 [0·48–1·00], p=0·049) were associated with lower mortality. Interpretation Unacceptable differences in mortality exist for gastrointestinal congenital anomalies between lowincome, middle-income, and high-income countries. Improving access to quality neonatal surgical care in LMICs will be vital to achieve Sustainable Development Goal 3.2 of ending preventable deaths in neonates and children younger than 5 years by 2030