Epidemiology of pemphigus in Turkey: One-year prospective study of 220 cases

Pemphigus is a group of rare and life-threatening autoimmune blistering diseases of the skin and mucous membranes. Although they occur worldwide, their incidence shows wide geographical variation, and prospective data on the epidemiology of pemphigus are very limited. Objective of this work is to evaluate the incidence and epidemiological and clinical features of patients with pemphigus in Turkey. All patients newly diagnosed with pemphigus between June 2013 and June 2014 were prospectively enrolled in 33 dermatology departments in 20 different provinces from all seven regions of Turkey. Disease parameters including demography and clinical findings were recorded. A total of 220 patients were diagnosed with pemphigus during the 1-year period, with an annual incidence of 4.7 per million people in Turkey. Patients were predominantly women, with a male to female ratio of 1:1.41. The mean age at onset was 48.9 years. Pemphigus vulgaris (PV) was the commonest clinical subtype (n=192; 87.3%), followed by pemphigus foliaceus (n=21; 9.6%). The most common clinical subtype of PV was the mucocutaneous type (n=83; 43.2%). The mean Pemphigus Disease Area Index was 28.14±22.21 (mean ± Standard Deviation).  The incidence rate of pemphigus in Turkey is similar to the countries of South-East Europe, higher than those reported for the Central and Northern European countries and lower than the countries around the Mediterranean Sea and Iran. Pemphigus is more frequent in middle-aged people and is more common in women. The most frequent subtype was PV, with a 9-fold higher incidence than pemphigus foliaceus.   </p

How has the Pandemic Affected the Perceived Stress and Coping Behaviours of Nursing Students during Their First Clinical Experience? Impact of The Pandemic on The First Clinical Experience

AbstractIntroduction: The Covid 19 pandemic has increased the stress and fear of the society. Evaluating the reflections of the pandemic on nursing students' first clinical practices are important in terms of ensuring the adaptation to the practice. The aim of this study is to determine the stress levels and coping behaviours of nursing students during the COVID-19 pandemic.Methods: This study descriptive and correlational. The data were collected from nursing students who were started first clinical practice. This study was carried out in the nursing department of a public university, Turkey. The purposive sampling method was used in this study. The research was carried out with 203 volunteers. The Perceived Stress Scale for Nursing Students (PSSNS), the Coping Behaviours of Stress Scale for Nursing Students (CBSSNS) were used to collect the data and started first experience of clinical practice.Results: The mean age of the students was 20.79±2.29, 79.3% were afraid of having a negative experience. The mean score of PSSNS was 58.23±22.48. The maximum stress experienced by the students was observed in the subscale “stress from taking care of patients” (16.58±6.71). The most frequently used coping behaviour was “Avoidance” (13.39±4.33).Conclusions: It was determined that the nursing students had moderate level of stress during their first clinical practice during the pandemic period, they experienced the most stress while caring for the patient, and they used the avoidance approach the most

The relationship of the smoking status of students in the school of health and vocational school of health services with the dependent personality trait

The purpose of this study is to investigate the relationship between the smoking prevalence and dependent personality trait of the students receiving health education in Bitlis Eren University. The students who were enrolled in and were continuing to attend Bitlis Eren University School of Health and Vocational School of Health Services in the 2011-2012 academic year were selected in the sample. The questionnaires were applied to the students under supervision between December 2011 and January 2012. The mean age of 413 students participating in the study was 20.8, and 49.9% of them were male, and 50.1% were female. While the smoking rate was 29.8% in the sample group, this rate was 45.6% in the male students and 14% in the female students. When the smokers and those who quit smoking were assigned to a group and compared with those who never smoked, the dependent personality scores of the students who were smoking or quit smoking were lower than those who never smoked before (p [Med-Science 2019; 8(4.000): 820-6

Allium cyrilli complex (sect. Melanocrommyum) in Turkey

As a part of a revisional study of the genus Allium L. sect Melanocrommyum Webb et Berthel. in Turkey, detailed studies were conducted on 3 very closely related and taxonomically difficult species cited in the Flora of Turkey: Allium cyrilli Ten., A. atropurpureum Waldst. & Kit., and A. decipiens Fisch. ex Schult. & Schult. f., to clarify their occurrence in Turkey and their taxonomy. The results of this study show that A. atropurpureum and A. decipiens do not occur in Turkey. On the other hand, A. cyrilli is represented by 3 subspecies of which 2 are new for science: subsp. fritschii N.Ozhatay & I.Genc and subsp. asumaniae N.Ozhatay & I.Genc. The diagnostic morphological characters, distribution, conservation status, and colour photographs of the 3 subspecies as well as their chromosome numbers are presented: 2n = 16 (diploid) for subsp. fritschii, and 2n = 32 (tetraploid) for subsp. asumaniae and subsp. cyrilli

Allium efeae (Amaryllidaceae), a new species from northwest Anatolia, Turkey

Allium efeae Ozhatay & I.Genc is described as a new species from northwest Anatolia. The distribution area of this species is restricted to Kibriscik (Bolu) and Beypazan (Ankara). It resembles Allium lycaonicum Siehe, but differs in tepal shape and color, leaf length, and filament shape. A table comparing the diagnostic morphological characters of the new species and A. lycaonicum is provided. The diagnostic morphological characters, distribution, conservation status, and color photographs of the new species as well as its chromosome number (2n = 24) are presented

Allium efeae (Amaryllidaceae), a new species from northwest Anatolia, Turkey

Allium efeae Ozhatay & I.Genc is described as a new species from northwest Anatolia. The distribution area of this species is restricted to Kibriscik (Bolu) and Beypazan (Ankara). It resembles Allium lycaonicum Siehe, but differs in tepal shape and color, leaf length, and filament shape. A table comparing the diagnostic morphological characters of the new species and A. lycaonicum is provided. The diagnostic morphological characters, distribution, conservation status, and color photographs of the new species as well as its chromosome number (2n = 24) are presented

Multistep Synthesis of Phosphazene Derivative of Chenodeoxycholicacid (CDCA)

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Temporal Changes in Linezolid Minimum Inhibitory Concentration Values in Vancomycin-resistant Enterococci and Methicillin-resistant Staphylococcus aureus Strains

WOS: 000511368300006Introduction: Vancomycin-resistant enterococci (VRE) and methicillin-resistant Staphylococcus aureus (MRSA) infections are among the most common Gram-positive nosocomial infections. These isolates are resistant to most antibiotics, limiting the antibiotic options that can be used in treatment and causing treatment failure. Linezolid is an important option in the treatment of resistant Gram-positive infections, and came into use in Turkey in 2006. Linezolid-resistant Enterococci and Staphylococcus strains are rarely reported worldwide. The aim of this study was to investigate whether there was an increase in linezolid minimum inhibitory concentration (MIC) values in VRE and MRSA isolates over time. Materials and Methods: Thirteen VRE and 20 MRSA isolates from 2005-2009 (group 1), 18 VRE and 20 MRSA isolates from 2013-2014 (group 2), and seven VRE and 27 MRSA isolates from 2017-2018 (group 3) obtained from various clinical samples at Kocaeli University Medical Faculty Hospital were included in the study. The linezolid MIC values of the isolates were determined by broth microdilution method. The results were interpreted according to the European Committee on Antimicrobial Susceptibility Testing standards. Results: All of the VRE and MRSA isolates were susceptible to linezolid. Linezolid MIC50 and MIC90 values were 2 mg/l in VRE isolates in all three groups. In MRSA isolates, MIC50 was 2 mg/l in group 1, and 4 mg/l in groups 2 and 3, while MIC90 was 4 mg/l in all groups. Conclusion: Global rates of linezolid resistance has been reported to be <1% for S. aureus and VRE. There were no linezolid-resistant isolates in this study. However, we detected a significant increase in MIC50 and MIC90 values compared to most earlier studies performed in Turkey. This increase is expected due to the widespread use of linezolid over the years. The principles of rational antibiotic use should be applied to maintain the low resistance rates to linezolid, which is one of the few remaining options for the treatment of multidrug-resistant Gram-positive infections

The inhibitory effects of isolated constituents from Plantago major subsp. major L. on collagenase, elastase and hyaluronidase enzymes

Plantago major L. which is a medicinal plant with important biological activities, commonly used as traditional medicine. Potential inhibitory activities of the aqueous extract and three isolated constituents calceorioside B (1), homoplantaginin (hispidulin-7-O-glucoside) (2) and plantamajoside (3) from the aerial parts of Plantago major subsp. major L. (Plantaginaceae) have been tested against hyaluronidase, collagenase, and elastase, which play critical roles in wound pathogenesis. Even though, the extract (27.04%), and among the isolated compounds, calceorioside B (41.16%) exerted significant inhibition against hyaluronidase enzyme, homoplantaginin and plantamajoside were found to be inactive. Similar results were obtained from collagenase enzyme inhibition test. The extract (21.92%) and calceorioside B (28.34%) also caused notable inhibition in this test. However, no remarkable inhibition was observed in the presence of elastase enzyme. The experimental data revealed that P. major subsp. major displayed remarkable inhibitory activity against hyaluronidase and collagenase enzymes. In vitro enzyme activity of P. major subsp. major is reported for the first time in the current study.PubMe