On strongly lacunary summability of sequences of sets

Abstract In this paper, we introduce the concept of Wijsman strongly lacunary summability for set sequences. Then, we discus its relation with Wijsman strongly Cesàro summability. Furthermore, we also give its relation with Wijsman almost convergence

A neglected case of giant synovial chondromatosis in knee joint

Synovial chondromatosis is a rare benign condition arising from the synovial membrane of the joints, synovial sheaths or bursae around the joints. Primary synovial chondromatosis typically affects the large joints in the third to fifth decade of life. The purpose of this case report is to document this rare synovial pathology, which required open synovectomy and debridement to eradicate it. In our case, the biggest sized SOC was 20x19x6 cm, although there were many joint mice. Our case had the biggest SOC ever extracted, which to the best of my knowledge has not been reported earlier.Key words: Synovial chondromatosis, giant, loose body, knee Joint, surger

Lacunary I_2-Invariant Convergence and Some Properties

In this paper, the concept of lacunary invariant uniform density of any subset $A$ of the set $\mathbb{N}\times\mathbb{N}$ is defined. Associate with this, the concept of lacunary $\mathcal{I}_2$-invariant convergence for double sequences is given. Also, we examine relationships between this new type convergence concept and the concepts of lacunary invariant convergence and $p$-strongly lacunary invariant convergence of double sequences. Finally, introducing lacunary $\mathcal{I}_2^*$-invariant convergence concept and lacunary $\mathcal{I}_2$-invariant Cauchy concepts, we give the relationships among these concepts and relationships with lacunary $\mathcal{I}_2$-invariant convergence concept

Two four-marker haplotypes on 7q36.1 region indicate that the potassium channel gene HERG1 (KCNH2, Kv11.1) is related to schizophrenia: a case control study

<p>Abstract</p> <p>Background</p> <p>The pathobiology of schizophrenia is still unclear. Its current treatment mainly depends on antipsychotic drugs. A leading adverse effect of these medications is the acquired long QT syndrome, which results from the blockade of cardiac HERG1 channels (human ether-a-go-go-related gene potassium channels 1) by antipsychotic agents. The HERG1 channel is encoded by <it>HERG1 </it>(<it>KCNH2</it>, <it>Kv11.1</it>) gene and is most highly expressed in heart and brain. Genetic variations in <it>HERG1 </it>predispose to acquired long QT syndrome. We hypothesized that the blockade of HERG1 channels by antipsychotics might also be significant for their therapeutic mode of action, indicating a novel mechanism in the pathogenesis of schizophrenia.</p> <p>Methods</p> <p>We genotyped four single nucleotide polymorphisms (SNPs) in 7q36.1 region (two SNPs, rs1805123 and rs3800779, located on <it>HERG1</it>, and two SNPs, rs885684 and rs956642, at the 3'-downstream intergenic region) and then performed single SNP and haplotype association analyses in 84 patients with schizophrenia and 74 healthy controls after the exclusion of individuals having prolonged or shortened QT interval on electrocardiogram.</p> <p>Results</p> <p>Our analyses revealed that both genotype and allele frequencies of rs3800779 (c.307+585G>T) were significantly different between populations (<it>P </it>= 0.023 and <it>P </it>= 0.018, respectively). We also identified that two previously undescribed four-marker haplotypes which are nearly allelic opposite of each other and located in chr7:150225599-150302147bp position encompassing <it>HERG1 </it>were either overrepresented (A-A-A-T, the at-risk haplotype, <it>P </it>= 0.0007) or underrepresented (C-A-C-G, the protective haplotype, <it>P </it>= 0.005) in patients compared to controls.</p> <p>Conclusions</p> <p>Our results indicate that the potassium channel gene <it>HERG1 </it>is related to schizophrenia. Our findings may also implicate the whole family of HERG channels (HERG1, HERG2 and HERG3) in the pathogenesis of psychosis and its treatment.</p

Levosimendan accelerates recovery in patients with takotsubo cardiomyopathy

Background: The aim of this study was to determine the efficacy and safety of levosimendanin takotsubo cardiomyopathy (TC).Methods: The study was conducted in a retrospective design and 42 consecutive patients were enrolled in 6 cardiovascular centers in Turkey. The records of TC patients having left ventricular ejection fraction (LVEF) £ 35% were examined at admission, discharge and recovery period including their clinical and echocardiographic data.Results: Of these 42 TC patients, 17 were treated with loading dose and i.v. infusion of levosimendan (group 1) and 25 were treated without levosimendan (group 2). Echocardiographic findings at admission and at discharge were similar and no serious complications were observed in either group. However recovery period including the interval of 50% increase in LVEF, time to achieve the baseline troponin values and hospitalization were significantly lowerin patients taking levosimendan.Conclusions: This is the first study using loading dose and subsequent continuous intravenous administration of levosimendan demonstrating accelerated recovery in patients with TC

Aktivna deformacija Zemljine površine utvrđena preciznim nivelmanskim premjerom u Afyon-Akşehir grabenu u Zapadnoj Anadoliji u Turskoj

In the actively deforming region of western Anatolia, crustal deformation is accommodated by destructive earthquakes and a variety of aseismic events. In this study, we investigated the 2016–2017 aseismic sequence located in the Bolvadin Fault, one of the segments of the Akşehir-Simav Fault System of western Anatolia by analysing surface deformation derived from detailed geological mapping. Our findings suggest that surface deformation in the Bolvadin Fault is accommodated by aseismic episodes. During the field studies in the Bolvadin area, progressive surface deformations, such as surface faults and earth fissures with a length of 800 meters to 3 kilometres and strike of N15°E to N70°E were mapped on a 1/5000 scale. Furthermore, a levelling network was established to calculate the vertical displacements and deformation rate along the surface deformations. Precision level measurements were undertaken in 2016 and 2017. On the routes to the NW of the Bolvadin settlement, a vertical deformation rate of 30 mm/yr was detected in the period of 2016–2017, and a large deformation rate of 40 mm/yr was detected in the same period.Aktivna deformacija Zemljine kore se u regiji Zapadne Anadolije kompenzira razornim potresima i drugim seizmičkim događajima. U ovom smo radu na temelju detaljnog geološkog kartiranja analizirali deformaciju površine kako bismo proučili niza seizmičkih događaja u razdoblju 2016.–2017. na lokaciji rasjeda Bolvadin, jednoga od segmenata rasjednoga sustava Akşehir-Simav u Zapadnoj Anadoliji. Naši rezultati ukazuju na to da se površinska deformacije kompenzira tijekom aseizmičkih epizoda. Tijekom terenskih istraživanja u području Bolvadin, progresivne su površinske deformacije, poput površinskih rasjeda ili pukotina duljina od 800 m do 3 km, pružanja N15°E do N70°E, kartirane u mjerilu 1:5 000. Nadalje, uspostavljena je nivelmanska mreža kako bi se izmjerila brzina pomaka i deformacija. Precizna nivelmanska mjerenja izvedena su 2016. i 2017. godine. Na pravcima usmjerenima SZ od naselja Bolvadin, ustanovljena je brzina vertikalne deformacije od 30 mm/god., a u istom je razdoblju izmjerena i velika brzina deformacije od 40 mm/god

Is Placing Prophylactic Dural Tenting Sutures a Dogma?

Objective In this study, we investigated if and when dural tenting sutures are necessary during craniotomy. Methods Results from 437 patients aged 18 to 91 years (average, 43.5 years) who underwent supratentorial craniotomy between 2014 and 2019 were evaluated. The patients were categorized into 1 of 3 groups, patients who had at least 3 prophylactic dural tenting sutures placed before opening of the dura (group 1), at least 3 dural tenting sutures placed after surgery was completed, during closure (group 2), or no dural tenting sutures (group 3 [control]). All such sutures in groups 1 and 2 were placed in the circumference of the craniotomy and dural junction. No central dural tenting sutures were placed in any of the patients. Results Among the 437 patients, 344 underwent surgery for the first time and 93 were undergoing a second surgery. Cranial computed tomography imaging was performed for each patient 1 hour, 3 days, and 1 month after surgery. In group 1, 3 patients had a cerebral cortex contusion and 2 patients had acute subdural hematoma after the sutures were placed. In groups 2 and 3, none of the patients had a cerebral cortex contusion or acute subdural hematoma. Fewer complications were observed when dural tenting sutures were placed during postsurgical closure. Conclusion Placing dural tenting sutures is an important technique for ensuring hemostasis. However, when not needed, they seem to cause inadvertent complications. As our results suggest, knowing when and where to use them is equally important

EPIdemiology of Surgery-Associated Acute Kidney Injury (EPIS-AKI) : Study protocol for a multicentre, observational trial

More than 300 million surgical procedures are performed each year. Acute kidney injury (AKI) is a common complication after major surgery and is associated with adverse short-term and long-term outcomes. However, there is a large variation in the incidence of reported AKI rates. The establishment of an accurate epidemiology of surgery-associated AKI is important for healthcare policy, quality initiatives, clinical trials, as well as for improving guidelines. The objective of the Epidemiology of Surgery-associated Acute Kidney Injury (EPIS-AKI) trial is to prospectively evaluate the epidemiology of AKI after major surgery using the latest Kidney Disease: Improving Global Outcomes (KDIGO) consensus definition of AKI. EPIS-AKI is an international prospective, observational, multicentre cohort study including 10 000 patients undergoing major surgery who are subsequently admitted to the ICU or a similar high dependency unit. The primary endpoint is the incidence of AKI within 72 hours after surgery according to the KDIGO criteria. Secondary endpoints include use of renal replacement therapy (RRT), mortality during ICU and hospital stay, length of ICU and hospital stay and major adverse kidney events (combined endpoint consisting of persistent renal dysfunction, RRT and mortality) at day 90. Further, we will evaluate preoperative and intraoperative risk factors affecting the incidence of postoperative AKI. In an add-on analysis, we will assess urinary biomarkers for early detection of AKI. EPIS-AKI has been approved by the leading Ethics Committee of the Medical Council North Rhine-Westphalia, of the Westphalian Wilhelms-University Münster and the corresponding Ethics Committee at each participating site. Results will be disseminated widely and published in peer-reviewed journals, presented at conferences and used to design further AKI-related trials. Trial registration number NCT04165369

Controversy and Consensus on Indications for Sperm DNA Fragmentation Testing in Male Infertility: A Global Survey, Current Guidelines, and Expert Recommendations

Purpose: Sperm DNA fragmentation (SDF) testing was recently added to the sixth edition of the World Health Organization laboratory manual for the examination and processing of human semen. Many conditions and risk factors have been associated with elevated SDF; therefore, it is important to identify the population of infertile men who might benefit from this test. The purpose of this study was to investigate global practices related to indications for SDF testing, compare the relevant professional society guideline recommendations, and provide expert recommendations. Materials and Methods: Clinicians managing male infertility were invited to take part in a global online survey on SDF clinical practices. This was conducted following the CHERRIES checklist criteria. The responses were compared to professional society guideline recommendations related to SDF and the appropriate available evidence. Expert recommendations on indications for SDF testing were then formulated, and the Delphi method was used to reach consensus. Results: The survey was completed by 436 experts from 55 countries. Almost 75% of respondents test for SDF in all or some men with unexplained or idiopathic infertility, 39% order it routinely in the work-up of recurrent pregnancy loss (RPL), and 62.2% investigate SDF in smokers. While 47% of reproductive urologists test SDF to support the decision for varicocele repair surgery when conventional semen parameters are normal, significantly fewer general urologists (23%; p=0.008) do the same. Nearly 70% would assess SDF before assisted reproductive technologies (ART), either always or for certain conditions. Recurrent ART failure is a common indication for SDF testing. Very few society recommendations were found regarding SDF testing. Conclusions: This article presents the largest global survey on the indications for SDF testing in infertile men, and demonstrates diverse practices. Furthermore, it highlights the paucity of professional society guideline recommendations. Expert recommendations are proposed to help guide clinicians