Representation theory of some infinite-dimensional algebras arising in continuously controlled algebra and topology

In this paper we determine the representation type of some algebras of infinite matrices continuously controlled at infinity by a compact metrizable space. We explicitly classify their finitely presented modules in the finite and tame cases. The algebra of row-column-finite (or locally finite) matrices over an arbitrary field is one of the algebras considered in this paper, its representation type is shown to be finite.Comment: 33 page

Mechano-Magnetic Telemetry for Underground Water Infrastructure Monitoring

This study reports on the theory of operation, design principles, and results from laboratory and field tests of a magnetic telemetry system for communication with underground infrastructure sensors using rotating permanent magnets as the sources and compact magnetometers as the receivers. Many cities seek ways to monitor underground water pipes with centrally managed Internet of Things (IoT) systems. This requires the development of numerous reliable low-cost wireless sensors, such as moisture sensors and flow meters, which can transmit information from subterranean pipes to surface-mounted receivers. Traditional megahertz radio communication systems are often unable to penetrate through multiple feet of earthen and manmade materials and have impractically large energy requirements which preclude the use of long-life batteries, require complex (and expensive) built-in energy harvesting systems, or long leads that run antennas near to the surface. Low-power magnetic signaling systems do not suffer from this drawback: low-frequency electromagnetic waves readily penetrate through several feet of earth and water. Traditional magnetic telemetry systems that use energy-inefficient large induction coils and antennas as sources and receivers are not practical for underground IoT-type sensing applications. However, rotating a permanent magnet creates a completely reversing oscillating magnetic field. The recent proliferation of strong rare-earth permanent magnets and high-sensitivity magnetometers enables alternative magnetic telemetry system concepts with significantly more compact formats and lower energy consumption. The system used in this study represents a novel combination of megahertz radio and magnetic signaling techniques for the purposes of underground infrastructure monitoring. In this study, two subterranean infrastructure sensors exploit this phenomenon to transmit information to an aboveground radio-networked magnetometer receiver. A flow meter uses a propeller to directly rotate a diametrically magnetized neodymium magnet. A moisture sensor rotates a magnet with a low-power electric motor. Laboratory performance and field tests establish the capabilities of magnetic telemetry for IoT-linked leak-detection sensors. Remote datalogging with encryption demonstrates the viability of integrating sensors and surface receivers into a LoRa wireless IoT network

Charged nanograins in the Enceladus plume

There have been three Cassini encounters with the south-pole eruptive plume of Enceladus for which the Cassini Plasma Spectrometer (CAPS) had viewing in the spacecraft ram direction. In each case, CAPS detected a cold dense population of heavy charged particles having mass-to-charge (m/q) ratios up to the maximum detectable by CAPS ( 104 amu/e). These particles are interpreted as singly charged nanometer-sized water-ice grains. Although they are detected with both negative and positive net charges, the former greatly outnumber the latter, at least in the m/q range accessible to CAPS. On the most distant available encounter (E3, March 2008) we derive a net (negative) charge density of up to 2600 e/cm3 for nanograins, far exceeding the ambient plasma number density, but less than the net (positive) charge density inferred from the RPWS Langmuir probe data during the same plume encounter. Comparison of the CAPS data from the three available encounters is consistent with the idea that the nanograins leave the surface vents largely uncharged, but become increasingly negatively charged by plasma electron impact as they move farther from the satellite. These nanograin

Effect of Biodiversity Changes in Disease Risk: Exploring Disease Emergence in a Plant-Virus System

The effect of biodiversity on the ability of parasites to infect their host and cause disease (i.e. disease risk) is a major question in pathology, which is central to understand the emergence of infectious diseases, and to develop strategies for their management. Two hypotheses, which can be considered as extremes of a continuum, relate biodiversity to disease risk: One states that biodiversity is positively correlated with disease risk (Amplification Effect), and the second predicts a negative correlation between biodiversity and disease risk (Dilution Effect). Which of them applies better to different host-parasite systems is still a source of debate, due to limited experimental or empirical data. This is especially the case for viral diseases of plants. To address this subject, we have monitored for three years the prevalence of several viruses, and virus-associated symptoms, in populations of wild pepper (chiltepin) under different levels of human management. For each population, we also measured the habitat species diversity, host plant genetic diversity and host plant density. Results indicate that disease and infection risk increased with the level of human management, which was associated with decreased species diversity and host genetic diversity, and with increased host plant density. Importantly, species diversity of the habitat was the primary predictor of disease risk for wild chiltepin populations. This changed in managed populations where host genetic diversity was the primary predictor. Host density was generally a poorer predictor of disease and infection risk. These results support the dilution effect hypothesis, and underline the relevance of different ecological factors in determining disease/infection risk in host plant populations under different levels of anthropic influence. These results are relevant for managing plant diseases and for establishing conservation policies for endangered plant species

Pregabalin versus placebo in targeting pro-nociceptive mechanisms to prevent chronic pain after whiplash injury in at-risk individuals – a feasibility study for a randomised controlled trial

Abstract Background Whiplash-associated disorders (WAD) are an enormous and costly burden to Australian society. Up to 50% of people who experience a whiplash injury will never fully recover. Whiplash is resistant to treatment and no early management approach has yet been shown to prevent chronic pain. The early presence of central sensitization is associated with poor recovery. Pregabalin’s effects on central sensitization indicate the potential to prevent or modulate these processes after whiplash injury and to improve health outcomes, but this has not been investigated. This paper describes the protocol for a feasibility study for a randomised controlled trial of pregabalin plus evidence-based advice compared to placebo plus evidence-based advice for individuals with acute whiplash injury who are at risk of poor recovery. Methods This double blind, placebo-controlled randomised feasibility study will examine the feasibility and potential effectiveness of pregabalin and evidence-based advice (intervention) compared to placebo and evidence-based advice (control) for individuals with acute whiplash injury at risk of poor recovery. Thirty participants (15 per group) aged 18–65 years with Grade II WAD, within 48 hours of injury and currently experiencing at least moderate pain (NRS: ≥ 5/10) will be recruited from Emergency Departments of public hospitals in Queensland, Australia. Pregabalin will be commenced at 75 mg bd and titrated up to 300 mg bd as tolerated for 4 weeks followed by 1 week of weaning. Results The feasibility of trial procedures will be tested, as well as the potential effect of the intervention on the outcomes. The primary outcome of neck pain intensity at 3 months from randomisation will be compared between the treatment groups using standard analysis of variance techniques. Discussion Feasibility and potential effectiveness data will inform an appropriately powered full trial, which if successful, will provide an effective and cost-effective intervention for a costly and treatment resistant condition. It will also have implications for the early management of other traumatic conditions beyond whiplash. Trial registration Clinical Trials Primary Registry: Australian and New Zealand Clinical Trials Registry. Clinical Trial Registration Number: ACTRN12617000059369 . Date of Registration: 11/01/2017. Primary Trial Sponsor: The University of Queensland, Brisbane QLD 4072 Australia

Measurement of the Electric Form Factor of the Neutron at Q^2=0.5 and 1.0 (GeV/c)^2

The electric form factor of the neutron was determined from measurements of the \vec{d}(\vec{e},e' n)p reaction for quasielastic kinematics. Polarized electrons were scattered off a polarized deuterated ammonia target in which the deuteron polarization was perpendicular to the momentum transfer. The scattered electrons were detected in a magnetic spectrometer in coincidence with neutrons in a large solid angle detector. We find G_E^n = 0.0526 +/- 0.0033 (stat) +/- 0.0026 (sys) and 0.0454 +/- 0.0054 +/- 0.0037 at Q^2 = 0.5 and 1.0 (GeV/c)^2, respectively.Comment: 5 pages, 2 figures, as publishe

High-potency ligands for DREADD imaging and activation in rodents and monkeys.

Designer Receptors Exclusively Activated by Designer Drugs (DREADDs) are a popular chemogenetic technology for manipulation of neuronal activity in uninstrumented awake animals with potential for human applications as well. The prototypical DREADD agonist clozapine N-oxide (CNO) lacks brain entry and converts to clozapine, making it difficult to apply in basic and translational applications. Here we report the development of two novel DREADD agonists, JHU37152 and JHU37160, and the first dedicated 18F positron emission tomography (PET) DREADD radiotracer, [18F]JHU37107. We show that JHU37152 and JHU37160 exhibit high in vivo DREADD potency. [18F]JHU37107 combined with PET allows for DREADD detection in locally-targeted neurons, and at their long-range projections, enabling noninvasive and longitudinal neuronal projection mapping

High-potency ligands for DREADD imaging and activation in rodents and monkeys

Designer Receptors Exclusively Activated by Designer Drugs (DREADDs) are a popular chemogenetic technology for manipulation of neuronal activity in uninstrumented awake animals with potential for human applications as well. The prototypical DREADD agonist clozapine N-oxide (CNO) lacks brain entry and converts to clozapine, making it difficult to apply in basic and translational applications. Here we report the development of two novel DREADD agonists, JHU37152 and JHU37160, and the first dedicated 18F positron emission tomography (PET) DREADD radiotracer, [18F]JHU37107. We show that JHU37152 and JHU37160 exhibit high in vivo DREADD potency. [18F]JHU37107 combined with PET allows for DREADD detection in locally-targeted neurons, and at their long-range projections, enabling noninvasive and longitudinal neuronal projection mapping