Endocrine and metabolic traits in goat kids around weaning

Eleven Saanen kids, three days after birth, were divided into two groups: WEAN and MILK. All kids were fed goat milk until the 5th week of age, when the WEAN group began a weaning protocol. MILK group continued to receive goat milk for the entire experimental period, while WEAN group was weaned at 47 days of age. Starting from the 3rd week of age, body weight was recorded and blood samples were taken weekly, before the first meal of the day. Plasma was analysed for glucose, total protein, free aminoacid, insulin, leptin and ghrelin.Weaning did not affect plasma levels of total protein and leptin, but decreased plasma glucose and free aminoacid, and increased ghrelin concentration. Moreover, weaning decreased plasma insulin level more than three times. This result was probably the consequence of the lower concentration of plasma glucose of the WEAN group, but the effect could be enforced by the milk-borne insulin ingested by the MILK kids with the diet. Goat milk contains peptides that can pass across the intestinal epithelium and enter the systemic circulation, suggesting a possible role in accomplishing the immature ability of suckling animals to produce hormones and growth factors

Influence of high levels of beet pulp in the diet on endocrine/metabolic traits, slaughter dressing percentage, and ham quality in Italian heavy pigs

Seventy two Landrace x Large White barrows were divided into three groups and fed different diets: a control traditional diet based on cereals (C) and two with 15 or 30% dried sugar beet pulp (BP15 and BP30, respectively). Animals weighed 106 kg at start and 167 kg at the end of the experiment. Feeding was restricted (2.5 kg DM/head, on average). The aim of the present experiment was to investigate the influence of high levels of beet pulp in the diet of fattening heavy pigs on some endocrine/metabolic traits, on the slaughter dressing percentage and on some parameters related to meat quality, composition and on the ham quality, after 14 months of seasoning. During the experimental period, jugular vein blood samples were collected from C and BP30-fed pigs and plasma was analysed for several metabolic traits. BP30 diet initially increased the plasma glucose level and decreased free amino acids (P<0.05), but this difference disappeared at the end of the experimental period, when insulin level was decreased (P=0.06) by beet pulp administration. During the entire period, 30% beet pulp diet increased total protein and albumin levels (P<0.001) and decreased urea (P<0.05) without affecting plasma leptin. At slaughter, pigs fed BP30 diet were lighter (P<0.001) and with a lower dressing percentage (P<0.001) in comparison with the other two treatments. Pigs fed BP30 diet also had lower ham and loin weights (P<0.05) (but similar ham and loin percentages) and higher liver weight (P<0.05), liver/carcass ratio (P<0.001), gastrointestinal- tract weight (P<0.001) and gastrointestinal-tract/carcass ratio (P<0.001). Pigs fed C diet had a higher dressing percentage in comparison with pigs fed BP15 diet (P<0.01), but no other significant difference was found between pigs fed diets C and BP15. At slaughter, liver samples were taken from C and BP30-fed pigs in order to evaluate the effect of the diet on liver composition. BP30 diet increased dry liver weight (P<0.05) and liver fat content (P<0.01). The iodine value and the fatty acid composition of the backfat revealed no significant difference between pigs fed the control diet and those fed the high fibre diets. Finally, considering the economic importance of ham production, the characteristics of the seasoned hams were evaluated. No difference was observed on ham quality. In conclusion, feeding a diet with a high percentage of dried sugar beet pulp alters protein and energy metabolism and slaughter parameters, without affecting the quality of the seasoned ham

Endocrine pancreas development at weaning in goat kids

Eighteen three-day old Saanen goat kids were divided into MILK and WEAN groups. MILK kids received goat milk to age 48 days; WEAN kids were initially fed milk but started weaning at 25 days and were completely weaned by 40 days. Total intake per group was recorded daily. On day 25, 40 and 48, body weights were recorded, and plasma samples were taken and analyzed for glucose, free amino-acids and insulin. On day 48, all animals were slaughtered and pancreas samples were analyzed for total DNA and RNA content. Histological sections of pancreas were examined by light microscope and images analyzed by dedicated software. Seven days after the beginning of the weaning program, dry matter intake in the WEAN group began to decrease compared to the MILK one. Nonetheless, body weight did not differ throughout the study period. Weaning significantly decreased plasma levels of glucose, amino-acids and insulin. No difference was observed in pancreatic DNA and RNA content. Histological analysis of pancreas showed that the size of pancreatic islets was not different, but islet number per section was lower in the pancreas of WEAN animals. In conclusion, weaning affects glucose and amino-acid metabolism and influences endocrine pancreas activity and morphology

PLASMA INSULIN AND IGF-1 AND HEPATIC ACTIVITY IN SAANEN GOAT KIDS, AROUND WEANING

Weaning is a crucial event in the life of young ruminants. At weaning ruminal and digestive activity are still incomplete, so weaning may coincide with a period of growth stasis. Since insulin and insulin-like growth factor 1 (IGF-1) can play a fundamental role in post-natal development, the aim of the present study was to evaluate plasma variations of insulin and IGF-1 levels and their relationships with the hepatic activity, around weaning.For this purpose, eleven 3-days-old Saanen goat kids were randomly divided into MILK (6 animals) and WMIX (5 animals) groups. All kids were fed goat milk to age 29 days. After that, MILK kids continued to receive milk, while WMIX ones underwent weaning, based on the progressive replacement of milk with solid feed. WMIX kids were completely weaned on day 48. Blood samples were weekly analyzed for metabolic traits, insulin and IGF-1 levels, alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activities. On day 50, all animals were slaughtered, liver weight was recorded and liver samples were analyzed for DNA, RNA, phospholipids, glicogen and soluble protein content, ALT and AST activity.On day 50, plasma insulin and IGF-1 were lower in WMIX group, as possible consequence of the lower plasma glucose and amino acids levels. Liver weight was not different between groups, but liver weight expressed as percentage of body weight was lower in WMIX kids and highly correlated to plasma IGF-1. Liver glycogen was also lower in WMIX kids, as possible consequence of the lower plasma glucose.Hepatic ALT and AST activities were not different between groups and both were strongly correlated to plasma insulin. Moreover, insulin was positively correlated to the proteosynthetic capability per cell (RNA/DNA) of the liver.Our results indicate that the adopted livestock practice permitted the normal development of the animal used, avoiding growth stasis. Anyway, weaning altered plasma insulin and IGF-1, without affecting neither hepatic activity of aminotransferases, nor hepatic DNA and RNA content. Interestingly, plasma insulin was positively correlated to hepatic ALT and AST activity and proteosynthetic capability per cell, suggesting a role for insulin as indicator of hepatic aminotransferase and proteosynthetic activity

Studies on virginiamycin in growing rabbits

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Leptin and puberty in goat

The onset of reproductive function involves activation of the hypothalamic-pituitarygonadal axis and in female results in ovulation of mature oocytes (Gueorguiev et al., 2001). This transition typically occurs at a genetically predetermined age. However, nongenetic variables as photoperiod, body weight (BW), and back fat depth (BFD) can modify the age at which puberty occurs (Cheung et al., 2001; Garcia et al., 2002). Furthermore, feed availability is an important environmental factor affecting the reproductive and somatotropic axis