7,993 research outputs found
Surfactant-assisted fabrication of alumina-doped amorphous silica nanofiltration membranes with enhanced water purification performances
Identification of subgroups of early breast cancer patients at high risk of nonadherence to adjuvant hormone therapy: results of an italian survey.
The aim of this study was the identification of subgroups of patients at higher risk of nonadherence to adjuvant
hormone therapy for breast cancer. Using recursive partitioning and amalgamation (RECPAM) analysis, the
highest risk was observed in the group of unmarried, employed women, or housewives. This result might be
functional in designing tailored intervention studies aimed at improvement of adherence.
Background: Adherence to adjuvant endocrine therapy (HT) is suboptimal among breast cancer patients. A high rate
of nonadherence might explain differences in survival between clinical trial and clinical practice. Tailored interventions
aimed at improving adherence can only be implemented if subgroups of patients at higher risk of poor adherence are
identified. Because no data are available for Italy, we undertook a large survey on adherence among women taking
adjuvant HT for breast cancer. Patients and Methods: Patients were recruited from 10 cancer clinics in central Italy.
All patients taking HT for at least 1 year were invited, during one of their follow-up visit, to fill a confidential questionnaire.
The association of sociodemographic and clinical characteristics of participants with adherence was
assessed using logistic regression. The RECPAM method was used to evaluate interactions among variables and to
identify subgroups of patients at different risk of nonadherence. Results: A total of 939 patients joined the study and
18.6% of them were classified as nonadherers. Among possible predictors, only age, working status, and switching
from tamoxifen to an aromatase inhibitor were predictive of nonadherence in multivariate analysis. RECPAM analysis
led to the identification of 4 classes of patients with a different likelihood of nonadherence to therapy, the lowest being
observed in retired women with a low level of education, the highest in the group of unmarried, employed women, or
housewives. Conclusion: The identification of these subgroups of “real life” patients with a high prevalence of
nonadherers might be functional in designing intervention studies aimed at improving adherenc
Hawking radiation, W-infinity algebra and trace anomalies
We apply the "trace anomaly method" to the calculation of moments of the
Hawking radiation of a Schwarzschild black hole. We show that they can be
explained as the fluxes of chiral currents forming a W-infinity algebra. Then
we construct the covariant version of these currents and verify that up to
order 6 they are not affected by any trace anomaly. Using cohomological methods
we show that actually, for the fourth order current, no trace anomalies can
exist. The results reported here are strictly valid in two dimensions.Comment: 22 pages, typos correcte
Infant cortex responds to other humans from shortly after birth
A significant feature of the adult human brain is its ability to selectively process information about conspecifics. Much debate has centred on whether this specialization is primarily a result of phylogenetic adaptation, or whether the brain acquires expertise in processing social stimuli as a result of its being born into an intensely social environment. Here we study the haemodynamic response in cortical areas of newborns (1–5 days old) while they passively viewed dynamic human or mechanical action videos. We observed activation selective to a dynamic face stimulus over bilateral posterior temporal cortex, but no activation in response to a moving human arm. This selective activation to the social stimulus correlated with age in hours over the first few days post partum. Thus, even very limited experience of face-to-face interaction with other humans may be sufficient to elicit social stimulus activation of relevant cortical regions
Limits on decaying dark energy density models from the CMB temperature-redshift relation
The nature of the dark energy is still a mystery and several models have been
proposed to explain it. Here we consider a phenomenological model for dark
energy decay into photons and particles as proposed by Lima (J. Lima, Phys.
Rev. D 54, 2571 (1996)). He studied the thermodynamic aspects of decaying dark
energy models in particular in the case of a continuous photon creation and/or
disruption. Following his approach, we derive a temperature redshift relation
for the CMB which depends on the effective equation of state and on
the "adiabatic index" . Comparing our relation with the data on the CMB
temperature as a function of the redshift obtained from Sunyaev-Zel'dovich
observations and at higher redshift from quasar absorption line spectra, we
find , adopting for the adiabatic index ,
in good agreement with current estimates and still compatible with
, implying that the dark energy content being constant in time.Comment: 8 pages, 1 figur
Asymmetric nuclear matter in a Hartree-Fock approach to non-linear QHD
The Equation of State (EOS) for asymmetric nuclear matter is discussed
starting from a phenomenological hadronic field theory of Serot-Walecka type
including exchange terms. In a model with self interactions of the scalar
sigma-meson we show that the Fock terms naturally lead to isospin effects in
the nuclear EOS. These effects are quite large and dominate over the
contribution due to isovector mesons. We obtain a potential symmetry term of
"stiff" type, i.e. increasing with baryon density and an interesting behaviour
of neutron/proton effective masses of relevance for transport properties of
asymmetric dense matter.Comment: 12 pages (LATEX), 3 Postscript figures, revised versio
CMB Telescopes and Optical Systems
The cosmic microwave background radiation (CMB) is now firmly established as
a fundamental and essential probe of the geometry, constituents, and birth of
the Universe. The CMB is a potent observable because it can be measured with
precision and accuracy. Just as importantly, theoretical models of the Universe
can predict the characteristics of the CMB to high accuracy, and those
predictions can be directly compared to observations. There are multiple
aspects associated with making a precise measurement. In this review, we focus
on optical components for the instrumentation used to measure the CMB
polarization and temperature anisotropy. We begin with an overview of general
considerations for CMB observations and discuss common concepts used in the
community. We next consider a variety of alternatives available for a designer
of a CMB telescope. Our discussion is guided by the ground and balloon-based
instruments that have been implemented over the years. In the same vein, we
compare the arc-minute resolution Atacama Cosmology Telescope (ACT) and the
South Pole Telescope (SPT). CMB interferometers are presented briefly. We
conclude with a comparison of the four CMB satellites, Relikt, COBE, WMAP, and
Planck, to demonstrate a remarkable evolution in design, sensitivity,
resolution, and complexity over the past thirty years.Comment: To appear in: Planets, Stars and Stellar Systems (PSSS), Volume 1:
Telescopes and Instrumentatio
Measurement of single-spin azimuthal asymmetries in semi-inclusive electroproduction of pions and kaons on a longitudinally polarised deuterium target
Single-spin asymmetries have been measured for semi-inclusive
electroproduction of , , and mesons in
deep-inelastic scattering off a longitudinally polarised deuterium target. The
asymmetries appear in the distribution of the hadrons in the azimuthal angle
around the virtual photon direction, relative to the lepton scattering
plane. The corresponding analysing powers in the moment of the
cross section are for ,
for ,
for and for . The moments are
compatible with zero for all particles.Comment: Revised version shortened 9 pages, 3 tables, 7 figure
Assessment of Class Mutation Operators for C++ with the MuCPP Mutation System
Context: Mutation testing has been mainly analyzed regarding traditional mutation operators involving structured programming constructs common in mainstream languages, but mutations at the class level have not been assessed to the same extent. This fact is noteworthy in the case of C++ despite being one of the most relevant languages including object-oriented features. Objective: This paper provides a complete evaluation of class operators for the C++ programming language. MuCPP, a new system devoted to the application of mutation testing to this language, was developed to this end. This mutation system implements class mutation operators in a robust way, dealing with the inherent complexity of the language. Method: MuCPP generates the mutants by traversing the abstract syntax tree of each translation unit with the Clang API, and stores mutants as branches in the Git version control system. The tool is able to detect duplicate mutants, avoid system headers, and drive the compilation process. Then, MuCPP is used to conduct experiments with several open-source C programs. Results: The improvement rules listed in this paper to reduce unproductive class mutants have a significant impact in the computational cost of the technique. We also calculate the quantity and distribution of mutants generated with class operators, which generate far fewer mutants than their traditional counterparts. Conclusions: We show that the tests accompanying these programs cannot detect faults related to particular object-oriented features of C++. In order to increase the mutation score, we create new test scenarios to kill the surviving class mutants for all the applications. The results confirm that, while traditional mutation operators are still needed, class operators can complement them and help testers further improve the test suite
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