528 research outputs found
Relationship of qSOFA values to gastric perforation patients in A. W. Sjahranie General Hospital, Samarinda, Indonesia
Background: Authors hypothesized the qSOFA score would be useful in sepsis patients caused by gastric perforation. The present study investigated the relationship of qSOFA value to outcome of patients with gastric perforation in Samarinda.Methods: This research was analytical, descriptive research method using cross-sectional study design 70 patients. Data analysis was obtained to see the relationship between age, gender, vital sign qSOFA and survival in gastric perforation patients.Results: Mean systolic blood pressure was significantly higher in subjects who lived than those who died, i.e. 105.5 vs 92.5 (p <0.001). Mean diastolic blood pressure was significantly higher in subjects who lived than those who died, ie 80.0 vs 66.8 (p <0.001). The respiration rate was significantly lower in subjects who lived than those who died, namely 22.9 vs 24.6 (p <0.001). The mean GCS score was significantly higher in subjects who lived than those who died, ie 14.2 vs 12.2 (p <0.001).Conclusions: The higher the qSOFA score in the study subjects with gastric perforation, the higher the mortality rate. There was a relationship between the qSOFA value and the outcome of patients with gastric perforation where the mean qSOFA score was significantly lower in subjects who lived than those who died
The Effects Of Beaver Impoundments On Montane Stream Fish Communites
North American beavers (Castor canadensis) are ecological engineers, and their dams alter stream environments. Few studies have examined the effect of beaver dams on Southern Appalachian fishes. I sampled fish communities from 9 streams with active beaver ponds and 7 with inactive beaver ponds. Sediment was taken from all ponds to quantify the abundance of oligochaete worms, potential hosts for the fish parasite Myxobolus cerebralis. I found that both active and inactive beaver impoundments affect water quality, fish communities, and oligochaete prevalence. Generalized linear mixed effect models (GLMMs) indicate reduced fish diversity in streams with active impoundments. The magnitude of this reduction depends on the proximity to an impoundment. Models indicate that site elevation plays the strongest role in determining fish species richness. Active ponds also had lower dissolved oxygen and temperatures. Indicator species analysis found two species associated with active beaver ponds and 8 associated with inactive ponds or unimpounded reaches. Oligochaetes were more prevalent in active ponds, but I detected no abnormal salmonids. My work indicates that Appalachian Mountain streams with active ponds support less diverse fish assemblages than those with inactive ponds. Beaver ponds improve habitat for oligochaetes but their role in fish disease transmission remains unclear
On the binding modes of metal NHC complexes with DNA secondary structures: implications for therapy and imaging
Organometallic compounds currently occupy an important place in the field of medicinal inorganic chemistry due to the unique chemical properties of metal coordination compounds. Particularly, metal compounds ligated by N-heterocyclic carbenes (NHC) have shown high potential for biomedical applications as antimicrobial and anticancer agents during the recent 15 years. Although further studies are necessary to validate the modes of action of this family of compounds, a number of biological targets have been identified, including DNA secondary structures. This perspective review aims at providing an overview of the most representative examples of metal NHC complexes reacting with nucleic acids via different binding modes. It is organized according to the type of DNA secondary structure targeted by metal NHCs, highlighting the possible advantages of biomedical applications, including therapy and imaging
The Disappearance of Moral Choice in Serially Reproduced Narratives
How do narratives influence moral decision-making? Our ongoing studies
use serial reproduction of narratives, that is multiple retellings as
in the telephone game, of morally ambiguous situations. In particular,
we tested stories that include a minor misdemeanor, but leave open
whether the wrongdoer will be punished by a bystander. It turns out
that serial reproduction (retelling) of stories tends to eliminate the
possibility of intervention by the bystander under certain conditions.
We reason that this effect can be explained either by preferences of
the readers or by the reader\u27s discomfort to get involved. A second
finding is that retellings of third-person narratives of moral
situations lead to a higher degree of change and invention of the
outcome than first-person narratives
A Simple Cellular Automaton Model for Influenza A Viral Infections
Viral kinetics have been extensively studied in the past through the use of
spatially homogeneous ordinary differential equations describing the time
evolution of the diseased state. However, spatial characteristics such as
localized populations of dead cells might adversely affect the spread of
infection, similar to the manner in which a counter-fire can stop a forest fire
from spreading. In order to investigate the influence of spatial
heterogeneities on viral spread, a simple 2-D cellular automaton (CA) model of
a viral infection has been developed. In this initial phase of the
investigation, the CA model is validated against clinical immunological data
for uncomplicated influenza A infections. Our results will be shown and
discussed.Comment: LaTeX, 12 pages, 18 EPS figures, uses document class ReTeX4, and
packages amsmath and SIunit
Erosion rate study at the Allchar deposit (Macedonia) based on radioactive and stable cosmogenic nuclides (26Al, 36Cl, 3He, and 21Ne)
This paper focuses on constraining the erosion rate in the area of the Allchar Sb-As-Tl-Au deposit (Macedonia). It contains the largest known reserves of lorandite (TlAsS2), which is essential for the LORanditeEXperiment (LOREX), aimed at determining the long-term solar neutrino flux. Because the erosion history of the Allchar area is crucial for the success of LOREX, we applied terrestrial in situ cosmogenic nuclides including both radioactive (26Al and 36Cl) and stable (3He and 21Ne) nuclides in quartz, dolomite/calcite, sanidine, and diopside. The obtained results suggest that there is accordance in the values obtained by applying 26Al, 36Cl, and 21Ne for around 85% of the entire sample collection, with resulting erosion rates varying from several tens of m/Ma to ∼165 m/Ma. The samples from four locations (L-8 CD, L1b/R, L1c/R, and L-4/ADR) give erosion rates between 300 and 400 m/Ma. Although these localities reveal remarkably higher values, which may be explained by burial events that occurred in part of Allchar, the erosion rate estimates mostly in the range between 50 and 100 m/Ma. This range further enables us to estimate the vertical erosion rate values for the two main ore bodies Crven Dol and Centralni Deo. We also estimate that the lower and upper limits of average paleo-depths for the ore body Centralni Deo from 4.3 Ma to the present are 250–290 and 750–790 m, respectively, whereas the upper limit of paleo-depth for the ore body Crven Dol over the same geological age is 860 m. The estimated paleo-depth values allow estimating the relative contributions of 205Pb derived from pp-neutrino and fast cosmic-ray muons, respectively, which is an important prerequisite for the LOREX experiment
The shapes of bird beaks are highly controlled by nondietary factors
Bird beaks are textbook examples of ecological adaptation to diet, but their shapes are also controlled by genetic and developmental histories. To test the effects of these factors on the avian craniofacial skeleton, we conducted morphometric analyses on raptors, a polyphyletic group at the base of the landbird radiation. Despite common perception, we find that the beak is not an independently targeted module for selection. Instead, the beak and skull are highly integrated structures strongly regulated by size, with axes of shape change linked to the actions of recently identified regulatory genes. Together, size and integration account for almost 80% of the shape variation seen between different species to the exclusion of morphological dietary adaptation. Instead, birds of prey use size as a mechanism to modify their feeding ecology. The extent to which shape variation is confined to a few major axes may provide an advantage in that it facilitates rapid morphological evolution via changes in body size, but may also make raptors especially vulnerable when selection pressures act against these axes. The phylogenetic position of raptors suggests that this constraint is prevalent in all landbirds and that breaking the developmental correspondence between beak and braincase may be the key novelty in classic passerine adaptive radiations
Samuel Beckett’s Krapp’s Last Tape: Remembering Kant, Forgetting Proust
This article draws on Samuel Beckett’s recently published letters
and archival scholarship to consider the place of Immanuel Kant’s
critical epistemology within Beckett’s early thinking and his subsequent
works. Beginning from Beckett’s engagement with Kant’s Critique
of Pure Reason, demonstrated by notes taken from Wilhelm
Windelband’s A History of Philosophy between 1932 and 1933, excerpts
from Jules de Gaultier’s From Kant to Nietzsche in the
“Whoroscope” Notebook, and Beckett’s acquisition of Immanuel
Kants Werke in 1938, I offer a close analysis of the philosophical underpinnings
of Beckett’s parody of Proust’s À la recherche du temps
perdu in Krapp’s Last Tape. The larger purpose of this article is to
argue that a critique of metaphysical thought can be found in Beckett’s
work and to demonstrate that Kant’s influence as a philosophical
source of this critique has been largely overlooked in Beckett criticism
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