Evaluación de una estrategia terapeútica para el cáncer colorectal basada en fototerapia: caracterización y efectos sobre la viabilidad celular de un derivado de las ftalocianinas

La terapia fotodinámica (TFD) es una modalidad fotoquímica aprobada por la FDA (Food and Drug Administration) para el tratamiento de diversos tipos de cáncer y enfermedades que cursan con neovascularización 1,2. La terapia fotodinámica (TFD) tiene el potencial para satisfacer muchas necesidades médicas no cubiertas actualmente. Aunque todavía emergente, ya es una modalidad terapéutica con éxito utilizada para el tratamiento de enfermedades neoplásicas y no neoplásicas.Máster en Investigación Biomédic

Determinacion de la fotoproteccion de lentes de sol fotocromáticos, polarizados y de policarbonato

Para evitar los efectos nocivos sobre la salud ocular de la exposición a dosis elevadas de radiación ultravioleta es imprescindible el uso de lentes oftálmicas solares. La protección que brinda una gafa de sol depende de los materiales y los filtros fotoprotectores que la constituyen. Su determinación se realiza “in Vitro”, a través de espectros de transmisión de radiación en la región ultravioleta y visible. Se presentan mediciones y análisis de transmitancia de lentes de sol comerciales con filtros fotocromáticos, polarizados y de policarbonato adquiridas en el mercado formal de Salta. De acuerdo a los requerimientos de FDA (Food and Drug Administration, USA), los resultados muestran que los lentes de sol de policarbonato y polarizados cumplen con los niveles de protección, mientras que los fotocromáticos solo se aproximan.To avoid adverse effects on eye health from exposure to high doses of ultraviolet radiation, is essential to use solar ophthalmic lenses. The protection provided by a sunglass depends on materials and constituent sunscreen filters. Its determination is made "in vitro", through transmission spectra of radiation in the ultraviolet and visible. We present measurements and analysis of transmittance of sunglasses commercial filters of three types: photochromic, polarized and polycarbonate acquired in Salta, in legal businesses. According to the requirements of FDA (Food and Drug Administration, USA), the results show that sunglasses polarized and polycarbonate meet the standards of protection, while the photochromic single approach.Fil: Cadena, Carlos Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Salta. Instituto de Investigaciones en Energía no Convencional; Argentina. Universidad Nacional de Salta; Argentin

Plasma bioavailability and changes in PBMC gene expression after treatment of ovariectomized rats with a commercial soy supplement

The health effects of soy supplementation in (post)menopausal women are still a controversial issue. The aim of the present study was to establish the effect of the soy isoflavones (SIF) present in a commercially available supplement on ovariectomized rats and to investigate whether these rats would provide an adequate model to predict effects of SIF in (post)menopausal women. Two dose levels (i.e. 2 and 20. mg/kg b.w.) were used to characterize plasma bioavailability, urinary and fecal concentrations of SIF and changes in gene expression in peripheral blood mononuclear cells (PBMC). Animals were dosed at 0 and 48. h and sacrificed 4. h after the last dose. A clear dose dependent increase of SIF concentrations in plasma, urine and feces was observed, together with a strong correlation in changes in gene expression between the two dose groups. All estrogen responsive genes and related biological pathways (BPs) that were affected by the SIF treatment were regulated in both dose groups in the same direction and indicate beneficial effects. However, in general no correlation was found between the changes in gene expression in rat PBMC with those in PBMC of (post)menopausal women exposed to a comparable dose of the same supplement. The outcome of this short-term study in rats indicates that the rat might not be a suitable model to predict effects of SIF in humans. Although the relative exposure period in this rat study is comparable with that of the human study, longer repetitive administration of rats to SIF may be required to draw a final conclusion on the suitability of the rat a model to predict effects of SIF in humans

Персонализированная терапия, основанная на генотипировании

In the postgenome era, clinical medicine is characterized by development of personalized genotypingbased approach to treatment. Clinical stud ies published in 2013–2014 and approved by FDA (Food and Drug Administration, USA) have been analyzed in this review. These include 8 clini cal studies on hematology / oncology, 3 clinical studies on endocrinology, 2 clinical studies on gastroenterology, infection diseases, respiratory dis eases, cardiology, gynecology / obstetrics, neurology and novel diagnostic procedures each and one clinical study on psychiatrics. The analysis demonstrated further development of evidencebased medicine that provided personalized genotypingbased therapy.Клиническая медицина постгеномного периода характеризуется развитием персонализированной терапии, в основу которой положен принцип генотипирования. Данный аналитический обзор посвящен клиническим исследованиям 2013 года, которые были одобрены FDA (Food and Drug Administration – Управление по контролю за продуктами и лекарствами, США), и включает 8 клинических исследований в области гематологии / онкологии, 3 – в области эндокринологии, по 2 клинических исследования в области гастроэнтерологии, инфекционных заболеваний, болезней органов дыхания, кардиологии, акушерства / гинекологии, неврологии и новых диагностических процедур и 1 клиническое исследование в области психиатрии. Проведенный анализ свидетельствует о дальнейшем развитии доказательной медицины, касающейся персонализированной терапии, основанной на генотипировании

IDENTIFIKASI ADVERSE EVENTS YANG TIMBUL KARENA PENGGUNAAN OBAT RANITIDINE MENGGUNAKAN METODE EQUIVALENCE CLASS TRANSFORMATION (ECLAT)

Asam lambung atau yang sering disebutmaag merupakan penyakit yang paling sering terjadi disetiap kalangan”. Carayang biasanya digunakan untuk mengobatipenyakit maagyaitu dengan mengkonsumsi ranitidine. Ranitidinemerupakansalah satu jenis obat yang biasanyadigunakan untuk mengobati ataumencegah sakit maag, rasa panas diperut,dan sakit pada perut yang dikarenakan oleh tukak lambung.“Ranitidine untuk pertamakalidilegalkandi Indonesiapada tahun 1989”. Dalam menggunakan obat-obatan, tubuh dapat merespon dengan efek yang tidak diinginkan yang biasa disebut dengan adverse event.Ada beberapa adverse event yang berbahaya seperti kelumpuhan, perawatan intensif di rumah sakit, hingga kematian.Pada tahun 2019, FDA (Food and Drug Administration) mengumumkan bahwa obat ranitidineditarik karena kadar NDMA(N-nitrosodimethylamin)di dalam lebih tinggi dari batas asupan yang diterima. “Data mengenai adverse event dari ranitidine didapatkan dari semualaporandariRumah Sakit dan Dokter di Amerika Serikat yang berasal dari FDA (Food and Drug Administration) pada tahun 2016hingga 2020”. Data pada penelitian ini berjumlah 2089 data dengan 8 atribut.“Penelitian yang digunakan yaitu association rule dengan algoritma Equivalence Class Transformation (ECLAT)”. Penelitian ini bertujuan untuk mengidentifikasihubungan adverse event pada ranitidine. “Hasil penelitian didapatkan dari pengujianpersentase tertinggiyang memiliki nilaisupport 0.063, nilai confidence 0.82 dan Lift Ratio 1.16”.Kata Kunci: Adverse event,Eclat,Ranitidin

Platinum-based anticancer agents: structure-activity relationship and action mechanism. Research on how to overcome cancer cells resistance

Treballs Finals de Grau de Química, Facultat de Química, Universitat de Barcelona, Any: 2019, Tutor: Ángel Montaña PedreroPlatinum complexes are drugs that are usually used in chemotherapy to try to kill cancerous cells of all kinds and different types of cancers. Even though there are several platinum drugs approved by the FDA (Food and Drug Administration) and in clinical use, there are still thousands of studies trying to develop new platinum complexes. This is due to the existent resistant mechanisms produced by cancerous cells that inhibit these drugs, and for the several side effects that produce towards the human body. The goal of this study is to recollect all the novel platinum complexes developed over the last ten years and organize then depending on their properties