47 research outputs found
Expression of Foxm1 Transcription Factor in Cardiomyocytes Is Required for Myocardial Development
- Author
- A Parlakian
- A Rojas
- A Vichalkovski
- Craig Bolte
- D Wang
- GC Pipes
- H Doi
- H Ueno
- H Ye
- H Ye
- H Zhang
- H Zhang
- I-Ching Wang
- IC Wang
- IC Wang
- IM Kim
- IM Kim
- Jeffrey D. Molkentin
- JF Chen
- K Krupczak-Hollis
- KA Moses
- L Xue
- M De Falco
- M Murakami
- M Takeda
- M Xin
- MW Hwang
- N Koibuchi
- P Hempel
- PB Bushdid
- Ralf Krahe
- RH Tang
- S Ramakrishna
- SM Savolainen
- T Horsthuis
- T Ueyama
- T Zhang
- Tanya V. Kalin
- TV Kalin
- TV Kalin
- U Schuller
- V Ustiyan
- Vladimir V. Kalinichenko
- VV Kalinichenko
- VV Kalinichenko
- VV Kalinichenko
- W Korver
- W Korver
- X Pan
- X Ren
- Y Yoshida
- Yufang Zhang
- YY Zhao
- Publication venue
- Public Library of Science
- Publication date
- 01/01/2011
- Field of study
Forkhead Box M1 (Foxm1) is a transcription factor essential for organ morphogenesis and development of various cancers. Although complete deletion of Foxm1 in Foxm1â/â mice caused embryonic lethality due to severe abnormalities in multiple organ systems, requirements for Foxm1 in cardiomyocytes remain to be determined. This study was designed to elucidate the cardiomyocyte-autonomous role of Foxm1 signaling in heart development. We generated a new mouse model in which Foxm1 was specifically deleted from cardiomyocytes (Nkx2.5-Cre/Foxm1fl/f mice). Deletion of Foxm1 from cardiomyocytes was sufficient to disrupt heart morphogenesis and induce embryonic lethality in late gestation. Nkx2.5-Cre/Foxm1fl/fl hearts were dilated with thinning of the ventricular walls and interventricular septum, as well as disorganization of the myocardium which culminated in cardiac fibrosis and decreased capillary density. Cardiomyocyte proliferation was diminished in Nkx2.5-Cre/Foxm1fl/fl hearts owing to altered expression of multiple cell cycle regulatory genes, such as Cdc25B, Cyclin B1, Plk-1, nMyc and p21cip1. In addition, Foxm1 deficient hearts displayed reduced expression of CaMKIIÎŽ, Hey2 and myocardin, which are critical mediators of cardiac function and myocardial growth. Our results indicate that Foxm1 expression in cardiomyocytes is critical for proper heart development and required for cardiomyocyte proliferation and myocardial growth
Erratum to: 36th International Symposium on Intensive Care and Emergency Medicine
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- Ă. MartĂnez GonzĂĄlez
- Ă. Ăzdedeoglu
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- Publication venue
- Springer Nature
- Publication date
- 01/01/2016
- Field of study
[This corrects the article DOI: 10.1186/s13054-016-1208-6.]
International Consensus Statement on Rhinology and Allergy: Rhinosinusitis
- Author
- Aanaes K
- Abadie WM
- Abi Najm S
- Abigail P
- Abrahams JJ
- Abrass LJ
- Abreu CB
- Abreu NA
- Abshirini H
- Abuzeid WM
- Abuzeid WM
- Achar P
- Ackerhans M
- Adam P
- Adappa ND
- Adappa ND
- Adappa ND
- Adappa ND
- Adriaensen G
- Agache I
- Aghamohammadi A
- Agius AM
- Agyeman AA
- Ahn CN
- Ahn HJ
- Ahn JC
- Ahn SH
- AhovuoâSaloranta A
- Aitken M
- Ajaiyeoba A
- Akbari E
- Akdis CA
- Akira S
- Akiyama K
- Akiyama K
- Akiyama K
- Al Komser MK
- Alam ES
- Alandejani T
- Alanin MC
- Albritton FDT
- Albu S
- Albu S
- Albu S
- Aldini G
- Alexander NS
- Aljebab F
- Alkire BC
- Allen EK
- Alobid I
- Alobid I
- Alobid I
- Aloulah M
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- Alsaleh S
- Alsharif S
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- Amble FR
- American Academy of Pediatrics Steering Committee on Quality Improvement and Management (AAP SCQIM)
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- Zalmanovici Trestioreanu A
- Zariwala MA
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- Zhao CY
- Zhao K
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- Zhao L
- Zhao YC
- Zhao YC
- Zheng C
- Zheng Z
- Zhou B
- Zia S
- Ziegler CGK
- ZielinskaâBlizniewska H
- Zou L
- Zuckerman JD
- Zurlo JJ
- Zuskin E
- Äulig J
- Publication venue
- 'Wiley'
- Publication date
- 01/01/2021
- Field of study
Background: The 5 years since the publication of the first International Consensus Statement on Allergy and Rhinology: Rhinosinusitis (ICARâRS) has witnessed foundational progress in our understanding and treatment of rhinologic disease. These advances are reflected within the more than 40 new topics covered within the ICARâRSâ2021 as well as updates to the original 140 topics. This executive summary consolidates the evidenceâbased findings of the document. Methods: ICARâRS presents over 180 topics in the forms of evidenceâbased reviews with recommendations (EBRRs), evidenceâbased reviews, and literature reviews. The highest grade structured recommendations of the EBRR sections are summarized in this executive summary. Results: ICARâRSâ2021 covers 22 topics regarding the medical management of RS, which are grade A/B and are presented in the executive summary. Additionally, 4 topics regarding the surgical management of RS are grade A/B and are presented in the executive summary. Finally, a comprehensive evidenceâbased management algorithm is provided. Conclusion: This ICARâRSâ2021 executive summary provides a compilation of the evidenceâbased recommendations for medical and surgical treatment of the most common forms of RS
A note on groups whose proper subgroups are quasihamiltonian-by-finite
- Author
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
BAG3 is a novel serum biomarker for pancreatic adenocarcinomas
- Author
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2013
- Field of study
Letter to the Edito
BAG3 is a novel serum biomarker for pancreatic adenocarcinomas.
- Author
- Publication venue
- Publication date
- 01/01/2013
- Field of study
Letter to the Edito
Erkrankungen der Haare
- Author
- A Bogg
- A Dupré
- A Kuhlwein
- A Tosti
- AJM Penders
- AM Kligman
- AM Reda
- B Lalevic-Vasic
- B Rassner
- BW Baker
- C Schmoeckel
- CM Perret
- D Orentreich
- D Selzle
- DA Whiting
- DA Whiting
- DH Rushton
- DH Rushton
- E Ludwig
- E Ludwig
- EA Olsen
- EB Rest
- EW Netherton
- F Nödl
- FJ Ebling
- G Cotsarelis
- G Lutz
- G Lutz
- H Hamm
- H Hamm
- H Traupe
- H Zaun
- H Zaun
- HC Friederich
- HH Wolff
- HP Baden
- ID Ramsay
- J Knauber
- JA Miller
- JA Zitelli
- JB Hamilton
- JB Schmidt
- JC Kvedar
- JD Stroud
- JDR Peereboom-Wynia
- JH Menkes
- JK Hatzis
- JN Leonard
- K Salman
- L Cusan
- L Dimino-Emme
- L Moltz
- LC Sperling
- LE Golitz
- M Ito
- ME Sawaya
- MS George
- MW Stewart
- N Orentreich
- NB Esterly
- O Braun-Falco
- O Braun-Falco
- O Braun-Falco
- O Braun-Falco
- O Braun-Falco
- O Braun-Falco
- O Braun-Falco
- O Braun-Falco
- P Calzavara-Pinton
- PB Photinos
- PH Itin
- PHM Steen Van der
- PS Friedman
- R Caputo
- R Dawber
- R Degos
- R Happle
- R Happle
- R Happle
- RD Gibbons
- RE Jordon
- RJ Pollit
- RJ Pye
- RPR Dawber
- RR Kurwa
- S Alexander
- S Shuster
- SA Muller
- SA Muller
- SI Cullen
- SL Greene
- T Bergner
- U Gethmann
- V Laing
- VA Randall
- VA Venning
- VH Price
- W Futterweit
- W KĂŒster
- WF Bergfeld
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/1996
- Field of study
Sliding, rolling, leaping and making sand waves
- Author
- ASW Thomas
- AV Jopling
- BR White
- DB Simons
- FDC Hammond
- GM Ashley
- H Ueda
- HM Hill
- J Hardisty
- JB Southard
- JB Southard
- JE Abbott
- JF Kennedy
- JRL Allen
- JRL Allen
- JRL Allen
- JRL Allen
- JS Bridge
- JS Bridge
- KJ Richards
- LM Milne-Thomson
- MC Miller
- MS Yalin
- P Ackers
- PA Mantz
- PA Mantz
- PB Williams
- R Gordon
- RA Bagnold
- RA Bagnold
- RA Bagnold
- RE Falco
- RE Hunter
- RG Jackson
- S Corrsin
- SB Savage
- SB Savage
- SB Savage
- WH Graf
- WR Costello
- WS Chepil
- WS Chepil
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/1985
- Field of study
Thromboelastometric assessment of hemostasis following hydroxyethyl starch (130/0.4) administration as a constant rate infusion in hypoalbuminemic dogs
- Author
- A De Laforcade
- A Kol
- A Reutler
- AK Cook
- Alberto Tarducci
- Angelica Botto
- Antonio Borrelli
- AS Chohan
- B Flatlan
- Barbara Bruno
- C Solomon
- CR White
- Cristiana Maurella
- D McBride
- D McBride
- EK Entholzner
- EM Lennon
- ES Klosterman
- Fulvio Riondato
- G Twig
- Giulio Mengozzi
- J Classen
- J Treib
- J Trieb
- JR Wierenga
- K Adamik
- KA Helmbold
- L Smart
- LM Bacek
- LV Goodwin
- M Griego-Valles
- M McMichael
- MA McMichael
- MJ Huang
- PA Glover
- PB Peterson
- R Goggs
- RA Green
- RA Green
- RM Hanel
- S Falco
- S Falco
- S Kuzi
- S Smith
- SA Kozek-Langenecker
- SA Smith
- SE Bumpus
- SL Vaden
- SP DiBartola
- V Gauthier
- VA Wurlod
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Biogeochemical processes and the diversity of NhecolĂąndia lakes, Brazil
- Author
- ALMEIDA FFM
- ALMEIDA TIR
- ALMEIDA TIR
- Antonio C Paranhos Filho
- ASSINE ML
- ASSUMPĂĂO M
- BARBIERO L
- BARBIERO L
- COSTA MPF
- DE-LAMONICA-FREIRE EM
- DUCKWORTH AW
- Elena Kupriyanova
- ESTEVES FA
- FREEZE A
- FURQUIM SAC
- FURQUIM SAC
- GALVĂO LS
- Joel B Sigolo
- JONES BE
- KUPRIYANOVA E
- Maria do Carmo Calijuri
- MCCONNAUGHEY TA
- MCCULLOUGH JD
- MEDINA-JĂNIOR PB
- MELACK JM
- NUSH EA
- ODUOR SO
- OLIVEIRA MD
- PatrĂcia B Falco
- POR FD
- Reginaldo A Bertolo
- SANTOS KRS
- SANTOS KRS
- SERGEEV VN
- SHAPIRO J
- SILVA JSV
- SILVA LHS
- Simone P Casali
- SMITH KS
- Teodoro I. R Almeida
- THOMPSON JB
- TILMAN DL
- USSAMI N
- Publication venue
- Academia Brasileira de CiĂȘncias
- Publication date
- 01/01/2011
- Field of study
The Pantanal of NhecolĂąndia, the world's largest and most diversified field of tropical lakes, comprises approximately 10,000 lakes, which cover an area of 24,000 kmÂČ and vary greatly in salinity, pH, alkalinity, colour, physiography and biological activity. The hyposaline lakes have variable pHs, low alkalinity, macrophytes and low phytoplankton densities. The saline lakes have pHs above 9 or 10, high alkalinity, a high density of phytoplankton and sand beaches. The cause of the diversity of these lakes has been an open question, which we have addressed in our research. Here we propose a hybrid process, both geochemical and biological, as the main cause, including (1) a climate with an important water deficit and poverty in Ca2+ in both superficial and phreatic waters; and (2) an elevation of pH during cyanobacteria blooms. These two aspects destabilise the general tendency of Earth's surface waters towards a neutral pH. This imbalance results in an increase in the pH and dissolution of previously precipitated amorphous silica and quartzose sand. During extreme droughts, amorphous silica precipitates in the inter-granular spaces of the lake bottom sediment, increasing the isolation of the lake from the phreatic level. This paper discusses this biogeochemical problem in the light of physicochemical, chemical, altimetric and phytoplankton data.<br>O Pantanal da NhecolĂąndia Ă© o maior e mais diversificado campo de lagos da regiĂŁo tropical do planeta, com cerca de 10.000 lagos de variadas salinidade, pH, alcalinidade, cor, fisiografia e atividade biolĂłgica dispostos em uma ĂĄrea de 24.000 kmÂČ. Os lagos hipossalinos tĂȘm pH variĂĄvel, baixa alcalinidade, macrĂłfitas e baixa densidade de fitoplĂąncton. Os lagos salinos tem pH acima de 9 ou 10, elevada alcalinidade, alta densidade de fitoplĂąncton e praias de areia. A causa da diversidade desses lagos Ă© uma questĂŁo ainda em aberto que Ă© abordada nesta pesquisa. PropĂ”e-se como principal causa um processo hĂbrido, geoquĂmico e biolĂłgico, baseado em (1) clima com um dĂ©ficit hĂdrico importante e pobreza em Ca2+na ĂĄgua superficial e do freĂĄtico e (2) na elevação do pH durante floraçÔes de cianobactĂ©rias. Estes dois aspectos desestabilizam a tendĂȘncia geral de pH neutro para as ĂĄguas superficiais da Terra. Este desequilĂbrio resulta em aumento do pH e dissolução da areia quartzosa do fundo dos lagos salino-alcalinos. Durante secas extremas hĂĄ precipitação de sĂlica amorfa nos espaços inter-granulares dos sedimentos de fundo destes lagos, aumentando seu isolamento do freĂĄtico. O artigo discute este processo biogeoquĂmico, Ă luz de dados fĂsico-quĂmicos, quĂmicos, fitoplĂąnctonicos e de altimetria de precisĂŁo