The "supporting kids, avoiding problems" (SKIP) study: Relationships between school exclusion, psychopathology, development and attainment - Case control study

PublishedJournal ArticlePurpose - The purpose of this paper is to explore the association between children who are at risk of being or who have been excluded from school between the ages of 4 and 12 years and the role of psychopathology, development and attainment. Design/methodology/approach - A case-control approach was conducted. Cases were children who had been excluded from school compared to those who had no reported exclusions and normative data where possible. A range of measures were used to collect information from the parent, child and teacher on areas covering the child's mental health and well-being. Findings - The findings showed the number of difficulties faced by children who are at risk of being or who have been excluded from school compared to gender- nd age-matched controls and normative data increased. Behavioural difficulties were apparent in the majority of the cases and an alarming number of children reported self-harm. Interestingly nearly all the cases had recognised needs, but not all of them were accessing appropriate services. Practical implications - There have been a number of changes regarding the identification and support of children's mental health and well-being. This study highlights gaps in resources and provision, particularly around behavioural difficulties for children who are presenting as not coping in school. Originality/value - The findings from the SKIP study indicate the complexities and compounded difficulties faced by children who are experiencing exclusion from school. By implementing a systematic group of assessments the study was able to identify these complexities of need across a vulnerable group of children.The authors would like to thank all the children, their families and the schools for taking part in the study. The authors are grateful for all the support that has been provided by a number of services and individuals across the county. The authors are grateful to the Peninsula CLAHRC for funding Claire Parker’s doctoral studentship. This paper presents independent research funded by the National Institute for Health Research (NIHR) Collaboration for Leadership in Applied Health Research and Care (CLAHRC) for the South West Peninsula. The views expressed in this publication are those of the authors and not necessarily those of the NHS, the NIHR or the Department of Health in England

Absorption spectrum in the wings of the potassium second resonance doublet broadened by helium

We have measured the reduced absorption coefficients occurring in the wings of the potassium 4S-5P doublet lines at 404.414 nm and at 404.720 nm broadened by helium gas at pressures of several hundred Torr. At the experimental temperature of 900 K, we have detected a shoulder-like broadening feature on the blue wing of the doublet which is relatively flat between 401.8 nm and 402.8 nm and which drops off rapidly for shorter wavelengths, corresponding to absorption from the X doublet Sigma+ state to the C doublet Sigma+ state of the K-He quasimolecule. The accurate measurements of the line profiles in the present work will sharply constrain future calculations of potential energy surfaces and transition dipole moments correlating to the asymptotes He-K(5p), He-K(5s), and He-K(3d).Comment: 2 figure

Measuring Cosmological Parameters with the JVAS and CLASS Gravitational Lens Surveys

The JVAS (Jodrell Bank-VLA Astrometric Survey) and CLASS (Cosmic Lens All-Sky Survey) are well-defined surveys containing about ten thousand flat-spectrum radio sources. For many reasons, flat-spectrum radio sources are particularly well-suited as a population from which one can obtain unbiased samples of gravitational lenses. These are by far the largest gravitational (macro)lens surveys, and particular attention was paid to constructing a cleanly-defined sample for the survey itself and for the underlying luminosity function. Here we present the constraints on cosmological parameters, particularly the cosmological constant, derived from JVAS and combine them with constraints from optical gravitational lens surveys, `direct' measurements of $\Omega_{0}$, $H_{0}$ and the age of the universe, and constraints derived from CMB anisotropies, before putting this final result into the context of the latest results from other, independent cosmological tests.Comment: LaTeX, 9 pages, 6 PostScript figures, uses texas.sty. To appear in the Proceedings of the 19th Texas Symposium on Relativistic Astrophysics and Cosmology (CD-ROM). Paper version available on request. Actual poster (A0 and A4 versions) available from http://multivac.jb.man.ac.uk:8000/helbig/research/publications/info/ texas98.htm

The Effect of EHR-Integrated Patient Reported Outcomes on Satisfaction with Chronic Pain Care

Objective Given its complexity, chronic noncancer pain presents an opportunity to use health information technology (IT) to improve care experiences. The objective of this study was to assess whether integrating patient-reported outcomes (PRO) data in an electronic health record (EHR) affects providers and patient satisfaction with chronic noncancer pain care. Study Design We conducted a pragmatic cluster randomized trial involving four family medicine clinics. Methods We enrolled primary care providers (PCPs) and their patients with chronic noncancer pain. In the first seven months (education phase), PCPs in intervention practices received education on how to use PROs for pain care. In the second seven months (PRO phase), patients in intervention practices reported pain-related outcomes upon arrival at their visits. PROs were immediately reported to PCPs through the EHR. Control group PCPs provided usual care. We compared intervention and control practices in terms of provider and patient satisfaction with care. Results During the education phase, patients’ mean ratings of their visits did not differ between control and intervention (9.33 vs. 9.08, p=0.20). During the PRO phase, patients’ mean ratings did not differ between control and intervention (9.28 vs 9.01, p=0.20). Similarly, there were no differences between the intervention and control groups in terms of provider satisfaction. Conclusion Delivering EHR-integrated PROs did not consistently improve patient or provider satisfaction. Positively, we found no evidence that the PRO tools negatively affected satisfaction. Future studies and technological innovations are needed to translate point-of-care health IT tools to improvements in patient and provider experiences

Supramolecular Nucleoside-Based Gel:Molecular Dynamics Simulation and Characterization of Its Nanoarchitecture and Self-Assembly Mechanism

Among the diversity of existing supramolecular hydrogels, nucleic acid-based hydrogels are of particular interest for potential drug delivery and tissue engineering applications because of their inherent biocompatibility. Hydrogel performance is directly related to the nanostructure and the self-assembly mechanism of the material, an aspect that is not well-understood for nucleic acid-based hydrogels in general and has not yet been explored for cytosine-based hydrogels in particular. Herein, we use a broad range of experimental characterization techniques along with molecular dynamics (MD) simulation to demonstrate the complementarity and applicability of both approaches for nucleic acid-based gelators in general and propose the self-assembly mechanism for a novel supramolecular gelator, N4-octanoyl-2′-deoxycytidine. The experimental data and the MD simulation are in complete agreement with each other and demonstrate the formation of a hydrophobic core within the fibrillar structures of these mainly water-containing materials. The characterization of the distinct duality of environments in this cytidine-based gel will form the basis for further encapsulation of both small hydrophobic drugs and biopharmaceuticals (proteins and nucleic acids) for drug delivery and tissue engineering applications

Structure and mechanism of acetolactate decarboxylase

Acetolactate decarboxylase catalyzes the conversion of both enantiomers of acetolactate to the (R)-enantiomer of acetoin, via a mechanism that has been shown to involve a prior rearrangement of the non-natural (R)-enantiomer substrate to the natural (S)-enantiomer. In this paper, a series of crystal structures of ALDC complex with designed transition state mimics are reported. These structures, coupled with inhibition studies and site-directed mutagenesis provide an improved understanding of the molecular processes involved in the stereoselective decarboxylation/protonation events. A mechanism for the transformation of each enantiomer of acetolactate is proposed

Minkowski Tensors of Anisotropic Spatial Structure

This article describes the theoretical foundation of and explicit algorithms for a novel approach to morphology and anisotropy analysis of complex spatial structure using tensor-valued Minkowski functionals, the so-called Minkowski tensors. Minkowski tensors are generalisations of the well-known scalar Minkowski functionals and are explicitly sensitive to anisotropic aspects of morphology, relevant for example for elastic moduli or permeability of microstructured materials. Here we derive explicit linear-time algorithms to compute these tensorial measures for three-dimensional shapes. These apply to representations of any object that can be represented by a triangulation of its bounding surface; their application is illustrated for the polyhedral Voronoi cellular complexes of jammed sphere configurations, and for triangulations of a biopolymer fibre network obtained by confocal microscopy. The article further bridges the substantial notational and conceptual gap between the different but equivalent approaches to scalar or tensorial Minkowski functionals in mathematics and in physics, hence making the mathematical measure theoretic method more readily accessible for future application in the physical sciences

Quasielastic K-nucleus scattering

Quasielastic K^+ - nucleus scattering data at q=290, 390 and 480 MeV/c are analyzed in a finite nucleus continuum random phase approximation framework, using a density-dependent particle-hole interaction. The reaction mechanism is consistently treated according to Glauber theory, keeping up to two-step inelastic processes. A good description of the data is achieved, also providing a useful constraint on the strength of the effective particle-hole interaction in the scalar-isoscalar channel at intermediate momentum transfers. We find no evidence for the increase in the effective number of nucleons participating in the reaction which has been reported in the literature.Comment: 21 pages, uses REVTeX and epsfig, 9 postscript figures; replaced version corrects a few minor errors in the tex

NICMOS images of JVAS/CLASS gravitational lens systems

We present Hubble Space Telescope (HST) infrared images of four gravitational lens systems from the JVAS/CLASS gravitational lens survey and compare the new infrared HST pictures with previously published WFPC2 HST optical images and radio maps. Apart from the wealth of information that we get from the flux ratios and accurate positions and separations of the components of the lens systems that we can use as inputs for better constraints on the lens models we are able to discriminate between reddening and optical/radio microlensing as the possible cause of differences observed in the flux ratios of the components across the three wavelength bands. Substantial reddening has been known to be present in the lens system B1600+434 and has been further confirmed by the present infrared data. In the two systems B0712+472 and B1030+074 microlensing has been pinpointed down as the main cause of the flux ratio discrepancy both in the optical/infrared and in the radio, the radio possibly caused by the substructure revealed in the lensing galaxies. In B0218+357 however the results are still not conclusive. If we are actually seeing the two "true" components of the lens system then the flux ratio differences are attributed to a combination of microlensing and reddening or alternatively due to some variability in at least one of the images. Otherwise the second "true" component of B0218+357 maybe completely absorbed by a molecular cloud and the anomalous flux density ratios and large difference in separation between the optical/infrared and radio that we see can be explained by emission from either a foreground object or from part of the lensing galaxy.Comment: 10 pages, 4 figures (original higher resolution figures can be obtained at the e-mail above), to appear in MNRAS (accepted