1,131 research outputs found
Accumulation of Self-Reactive Naive and Memory B Cell Reveals Sequential Defects in B Cell Tolerance Checkpoints in Sjogren's Syndrome
This work was funded by grants number 18237 and 20089 from Arthritis Research UK (http://www.arthritisresearchuk.org) to MB and the William Harvey Research Foundation. EC was recipient of short-term travel fellowships from EMBO (ASTF 318-2010) and EFIS-IL
A Unique Automation Platform for Measuring Low Level Radioactivity in Metabolite Identification Studies
Generation and interpretation of biotransformation data on drugs, i.e. identification of physiologically relevant metabolites, defining metabolic pathways and elucidation of metabolite structures, have become increasingly important to the drug development process. Profiling using 14C or 3H radiolabel is defined as the chromatographic separation and quantification of drug-related material in a given biological sample derived from an in vitro, preclinical in vivo or clinical study. Metabolite profiling is a very time intensive activity, particularly for preclinical in vivo or clinical studies which have defined limitations on radiation burden and exposure levels. A clear gap exists for certain studies which do not require specialized high volume automation technologies, yet these studies would still clearly benefit from automation. Use of radiolabeled compounds in preclinical and clinical ADME studies, specifically for metabolite profiling and identification are a very good example. The current lack of automation for measuring low level radioactivity in metabolite profiling requires substantial capacity, personal attention and resources from laboratory scientists. To help address these challenges and improve efficiency, we have innovated, developed and implemented a novel and flexible automation platform that integrates a robotic plate handling platform, HPLC or UPLC system, mass spectrometer and an automated fraction collector
‘Sell[ing] what hasn’t got a name’: An exploration of the different understandings and definitions of ‘community engagement’ work in the performing arts
Widely known to promote broader involvement in the processes which define the arts and culture (Webster, 1997), community engagement work in the performing arts — despite employing a set of commonly recognised norms — has tended to be conceptualised differently both historically and contemporarily. Drawing on ethnographic research — particularly semi-structured qualitative interview accounts of numerous British practitioners with a track record of work in the sector, the article explores these different conceptualisations. The article finds that it is the actual ‘work that matters’ and not what it is named, and that the diversity of understandings and definitions among sectoral practitioners is reflective of evolving thinking, values and practice, something that may be destabilising for better or worse
Protecting biodiversity in areas beyond national jurisdiction:An earth system governance perspective
Antibodies in HIV-1 Vaccine Development and Therapy
Despite 30 years of study, there is no HIV-1 vaccine and, until recently, there was little hope
for a protective immunization. Renewed optimism in this area of research comes in part from
the results of a recent vaccine trial and the use of single-cell antibody-cloning techniques that
uncovered naturally arising, broad and potent HIV-1–neutralizing antibodies (bNAbs). These
antibodies can protect against infection and suppress established HIV-1 infection in animal models.
The finding that these antibodies develop in a fraction of infected individuals supports the idea
that new approaches to vaccination might be developed by adapting the natural immune strategies
or by structure-based immunogen design. Moreover, the success of passive immunotherapy in
small-animal models suggests that bNAbs may become a valuable addition to the armamentarium
of drugs that work against HIV-1
Measurement of the B0_s semileptonic branching ratio to an orbitally excited D_s** state, Br(B0_s -> Ds1(2536) mu nu)
In a data sample of approximately 1.3 fb-1 collected with the D0 detector
between 2002 and 2006, the orbitally excited charm state D_s1(2536) has been
observed with a measured mass of 2535.7 +/- 0.6 (stat) +/- 0.5 (syst) MeV via
the decay mode B0_s -> D_s1(2536) mu nu X. A first measurement is made of the
branching ratio product Br(b(bar) -> D_s1(2536) mu nu X).Br(D_s1(2536)->D*
K0_S). Assuming that D_s1(2536) production in semileptonic decay is entirely
from B0_s, an extraction of the semileptonic branching ratio Br(B0_s ->
D_s1(2536) mu nu X) is made.Comment: 7 pages, 2 figures, LaTeX, version with minor changes as accepted by
Phys. Rev. Let
Simultaneous measurement of the ratio B(t->Wb)/B(t->Wq) and the top quark pair production cross section with the D0 detector at sqrt(s)=1.96 TeV
We present the first simultaneous measurement of the ratio of branching
fractions, R=B(t->Wb)/B(t->Wq), with q being a d, s, or b quark, and the top
quark pair production cross section sigma_ttbar in the lepton plus jets channel
using 0.9 fb-1 of ppbar collision data at sqrt(s)=1.96 TeV collected with the
D0 detector. We extract R and sigma_ttbar by analyzing samples of events with
0, 1 and >= 2 identified b jets. We measure R = 0.97 +0.09-0.08 (stat+syst) and
sigma_ttbar = 8.18 +0.90-0.84 (stat+syst)} +/-0.50 (lumi) pb, in agreement with
the standard model prediction.Comment: submitted to Phys.Rev.Letter
Measurements of differential cross sections of Z/gamma*+jets+X events in proton anti-proton collisions at sqrt{s}=1.96 TeV
We present cross section measurements for Z/gamma*+jets+X production,
differential in the transverse momenta of the three leading jets. The data
sample was collected with the D0 detector at the Fermilab Tevatron proton
anti-proton collider at a center-of-mass energy of 1.96 TeV and corresponds to
an integrated luminosity of 1 fb-1. Leading and next-to-leading order
perturbative QCD predictions are compared with the measurements, and agreement
is found within the theoretical and experimental uncertainties. We also make
comparisons with the predictions of four event generators. Two
parton-shower-based generators show significant shape and normalization
differences with respect to the data. In contrast, two generators combining
tree-level matrix elements with a parton shower give a reasonable description
of the the shapes observed in data, but the predicted normalizations show
significant differences with respect to the data, reflecting large scale
uncertainties. For specific choices of scales, the normalizations for either
generator can be made to agree with the measurements.Comment: Published in PLB. 11 pages, 3 figure
Search for charged Higgs bosons decaying to top and bottom quarks in ppbar collisions
We describe a search for production of a charged Higgs boson, q \bar{q'} ->
H^+, reconstructed in the t\bar{b} final state in the mass range 180 <= M_{H^+}
<= 300 GeV. The search was undertaken at the Fermilab Tevatron collider with a
center-of-mass energy sqrt{s} = 1.96 TeV and uses 0.9 fb^{-1} of data collected
with the D0 detector. We find no evidence for charged Higgs boson production
and set upper limits on the production cross section in the Types I, II and III
two-Higgs-doublet models (2HDMs). An excluded region in the (M_{H^+},tan\beta)
plane for Type I 2HDM is presented.Comment: Submitted to Phys. Rev. Letter
Measurement of the forward-backward charge asymmetry and extraction of sin^2Theta^{eff}_W in ppbar -> Z/\gamma^{*}+X -> e+e+X events produced at \sqrt{s}=1.96 TeV
We present a measurement of the forward-backward charge asymmetry ()
in events at a center-of-mass energy
of 1.96 TeV using 1.1 fb of data collected with the D0 detector at the
Fermilab Tevatron collider. is measured as a function of the invariant
mass of the electron-positron pair, and found to be consistent with the
standard model prediction. We use the measurement to extract the
effective weak mixing angle .Comment: 7 Pages, 1 Figure, 3 Tables, Accepted by Phys. Rev. Let
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