4U 1909+07: a Hidden Pearl

We present a detailed spectral and timing analysis of the High Mass X-ray Binary (HMXB) 4U 1909+07 with INTEGRAL and RXTE. 4U1909+07 is a persistent accreting X-ray pulsar with a period of approximately 605 s. The period changes erratically consistent with a random walk expected for a wind accreting system. INTEGRAL detects the source with an average of 2.4 cps (corresponding to 15mCrab), but sometimes exhibits flaring activity up to 50 cps (i.e. 300mCrab). The strongly energy dependent pulse profile shows a double peaked structure at low energies and only a single narrow peak at energies above 20 keV. The phase averaged spectrum is well described by a powerlaw modified at higher energies by an exponential cutoff and photoelectric absorption at low energies. In addition at 6.4 keV a strong iron fluorescence line and at lower energies a blackbody component are present. We performed phase resolved spectroscopy to study the pulse phase dependence of the spectral parameters: while most spectral parameters are constant within uncertainties, the blackbody normalization and the cutoff folding energy vary strongly with phase

Timing Analysis with INTEGRAL: Comparing Different Reconstruction Algorithms

INTEGRAL is one of the few instruments capable of detecting X-rays above 20keV. It is therefore in principle well suited for studying X-ray variability in this regime. Because INTEGRAL uses coded mask instruments for imaging, the reconstruction of light curves of X-ray sources is highly non-trivial. We present results from the comparison of two commonly employed algorithms, which primarily measure flux from mask deconvolution (ii-lc-extract) and from calculating the pixel illuminated fraction (ii-light). Both methods agree well for timescales above about 10 s, the highest time resolution for which image reconstruction is possible. For higher time resolution, ii-light produces meaningful results, although the overall variance of the lightcurves is not preserved

Study of the many fluorescent lines and the absorption variability in GX 301-2 with XMM-Newton

We present an in-depth study of the High Mass X-ray Binary (HMXB) GX 301-2 during its pre-periastron flare using data from the XMM-Newton satellite. The energy spectrum shows a power law continuum absorbed by a large equivalent hydrogen column on the order of 10^24 cm^2 and a prominent Fe K-alpha fluorescent emission line. Besides the Fe K-alpha line, evidence for Fe K-beta, Ni K-alpha, Ni K-beta, S K-alpha, Ar K-alpha, Ca K-alpha, and Cr K-alpha fluorescent lines is found. The observed line strengths are consistent with fluorescence in a cold absorber. This is the first time that a Cr K-alpha line is seen in emission in the X-ray spectrum of a HMXB. In addition to the modulation by the strong pulse period of ~685 sec the source is highly variable and shows different states of activity. We perform time-resolved as well as pulse-to-pulse resolved spectroscopy to investigate differences between these states of activity. We find that the fluorescent line fluxes are strongly variable and generally follow the overall flux. The N_H value is variable by a factor of 2, but not correlated to the continuum normalization. We find an interval of low flux in the light curve in which the pulsations cease almost completely, without any indication of an increasing absorption column. We investigate this dip in detail and argue that it is most likely that during the dip the accretion ceased and the afterglow of the fluorescent iron accounted for the main portion of the X-ray flux. A similar dip was found earlier in RXTE data, and we compare our findings to these resultsComment: 13 pages, 13 Figures, published in A&

4U 1909+07: a well-hidden pearl

We present the first detailed spectral and timing analysis of the High Mass X-ray Binary (HMXB) 4U 1909+07 with INTEGRAL and RXTE. 4U 1909+07 is detected in the ISGRI 20-40 keV energy band with an average countrate of 2.6 cps. The pulse period of ~604 sec is not stable, but changing erratically on timescales of years. The pulse profile is strongly energy dependent: it shows a double peaked structure at low energies, the secondary pulse decreases rapidly with increasing energy and above 20 keV only the primary pulse is visible. This evolution is consistent between PCA, HEXTE, and ISGRI. The phase averaged spectrum can be well described by the sum of a photoabsorbed power law with a cutoff at high energies and a blackbody component. To investigate the pulse profile, we performed phase resolved spectral analysis. We find that the changing spectrum can be best described with a variation of the folding energy. We rule out a correlation between the black body component and the continuum variation and discuss possible accretion geometries.Comment: 9 pages, 11 figures, accepted for publication in A&A Sect.

RXTE Discovery of Multiple Cyclotron Lines during the 2004 December Outburst of V0332+53

We present an analysis of the 2-150 keV spectrum of the transient X-ray pulsar V0332+53 taken with the Rossi X-Ray Timing Explorer (RXTE) in 2004 December. We report on the detection of three cyclotron resonance features at 27, 51, and 74 keV in the phase-averaged data, corresponding to a polar magnetic field of 2.7 x 10^12 G. After 4U0115+63, this makes V0332+53 the second accreting neutron star in which more than two cyclotron lines have been detected; this has now also been confirmed by INTEGRAL. Pulse-phase spectroscopy reveals remarkably little variability of the cyclotron line through the 4.4 s X-ray pulse.Comment: 4 pages, 3 figures, accepted for publication in ApJ Letter

A Double-peaked Outburst of A 0535+26 Observed with INTEGRAL, RXTE, and Suzaku

The Be/X-ray binary A 0535+26 showed a normal (type I) outburst in 2009 August. It is the fourth in a series of normal outbursts associated with the periastron, but is unusual because it presented a double-peaked light curve. The two peaks reached a flux of ~450 mCrab in the 15-50 keV range. We present results of the timing and spectral analysis of INTEGRAL, RXTE, and Suzaku observations of the outburst. The energy-dependent pulse profiles and their evolution during the outburst are studied. No significant differences with respect to other normal outbursts are observed. The centroid energy of the fundamental cyclotron line shows no significant variation during the outburst. A spectral hardening with increasing luminosity is observed. We conclude that the source is accreting in the sub-critical regime. We discuss possible explanations for the double-peaked outburst

The relative and absolute timing accuracy of the EPIC-pn camera on XMM-Newton, from X-ray pulsations of the Crab and other pulsars

Reliable timing calibration is essential for the accurate comparison of XMM-Newton light curves with those from other observatories, to ultimately use them to derive precise physical quantities. The XMM-Newton timing calibration is based on pulsar analysis. However, as pulsars show both timing noise and glitches, it is essential to monitor these calibration sources regularly. To this end, the XMM-Newton observatory performs observations twice a year of the Crab pulsar to monitor the absolute timing accuracy of the EPIC-pn camera in the fast Timing and Burst modes. We present the results of this monitoring campaign, comparing XMM-Newton data from the Crab pulsar (PSR B0531+21) with radio measurements. In addition, we use five pulsars (PSR J0537-69, PSR B0540-69, PSR B0833-45, PSR B1509-58 and PSR B1055-52) with periods ranging from 16 ms to 197 ms to verify the relative timing accuracy. We analysed 38 XMM-Newton observations (0.2-12.0 keV) of the Crab taken over the first ten years of the mission and 13 observations from the five complementary pulsars. All the data were processed with the SAS, the XMM-Newton Scientific Analysis Software, version 9.0. Epoch folding techniques coupled with \chi^{2} tests were used to derive relative timing accuracies. The absolute timing accuracy was determined using the Crab data and comparing the time shift between the main X-ray and radio peaks in the phase folded light curves. The relative timing accuracy of XMM-Newton is found to be better than 10^{-8}. The strongest X-ray pulse peak precedes the corresponding radio peak by 306\pm9 \mus, which is in agreement with other high energy observatories such as Chandra, INTEGRAL and RXTE. The derived absolute timing accuracy from our analysis is \pm48 \mus.Comment: 16 pages, 9 figures. Accepted for publication on A&

A Suzaku View of Cyclotron Line Sources and Candidates

Seventeen accreting neutron star pulsars, mostly high mass X-ray binaries with half of them Be-type transients, are known to exhibit Cyclotron Resonance Scattering Features (CRSFs) in their X-ray spectra, with characteristic line energies from 10 to 60 keV. To date about two thirds of them, plus a few similar systems without known CRSFs, have been observed with Suzaku. We present an overview of results from these observations, including the discovery of a CRSF in the transient 1A 1118-61 and pulse phase resolved spectroscopy of GX 301-2. These observations allow for the determination of cyclotron line parameters to an unprecedented degree of accuracy within a moderate amount of observing time. This is important since these parameters vary - e.g., with orbital phase, pulse phase, or luminosity - depending on the geometry of the magnetic field of the pulsar and the properties of the accretion column at the magnetic poles. We briefly introduce a spectral model for CRSFs that is currently being developed and that for the first time is based on these physical properties. In addition to cyclotron line measurements, selected highlights from the Suzaku analyses include dip and flare studies, e.g., of 4U 1907+09 and Vela X-1, which show clumpy wind effects (like partial absorption and/or a decrease in the mass accretion rate supplied by the wind) and may also display magnetospheric gating effects.Comment: 8 pages, 5 figures, 1 table, to appear in the proceedings of the conference "Suzaku 2011 Exploring the X-ray Universe: Suzaku and Beyond" which will be published electronically by AI

KRAS mutation analysis: a comparison between primary tumours and matched liver metastases in 305 colorectal cancer patients

Contains fulltext : 96042.pdf (publisher's version ) (Open Access)BACKGROUND: KRAS mutation is a negative predictive factor for treatment with anti-epidermal growth factor receptor antibody in metastatic colorectal cancer (CRC). KRAS mutation analysis is usually performed on primary tumour tissue because metastatic tissue is often not available. However, controversial data are available on the concordance of test results between primary tumours and corresponding metastases. We assessed the concordance of KRAS mutation status in a study of 305 primary colorectal tumours and their corresponding liver metastases. METHODS: Patients with histologically confirmed CRC who underwent surgical resection of the primary tumour and biopsy or surgical resection of the corresponding liver metastasis were included. KRAS mutation analysis was performed for codons 12 and 13. RESULTS: KRAS mutation was detected in 108 out of 305 primary tumours (35.4%). In 11 cases (3.6%), we found a discordance between primary tumour and metastasis: 5 primary tumours had a KRAS mutation with a wild-type metastasis, 1 primary tumour was wild type with a KRAS mutation in the metastasis, and in 5 cases the primary tumour and the metastasis had a different KRAS mutation. CONCLUSION: We observed a high concordance of KRAS mutation status of 96.4% (95% CI 93.6-98.2%) between primary colorectal tumours and their corresponding liver metastases. In only six patients (2.0%; 95% CI 0.7-4.2%), the discordance was clinically relevant. In this largest and most homogenous study to date, we conclude that both primary tumours and liver metastases can be used for KRAS mutation analysis