555 research outputs found
A Strong Sector at the LHC: Top Partners in Same-Sign Dileptons
Heavy partners of the top quark are a common prediction of many models in
which a new strongly-coupled sector is responsible for the breaking of the EW
symmetry. In this paper we investigate their experimental signature at the LHC,
focusing on the particularly clean channel of same-sign dileptons.
We show that, thank to a strong interaction with the top quark which allows
them to be singly produced at a sizable rate, the top partners will be
discovered at the LHC if their mass is below 1.5 TeV, higher masses being
possible in particularly favorable (but plausible) situations. Being the
partners expected to be lighter in both the Higgsless and Composite-Higgs
scenarios, the one of same-sign dileptons is found to be a very promising
channel in which these models could be tested.
We also discuss several experimental signatures which would allow, after the
discovery of the excess, to uniquely attribute it to the top partners
production and to measure the relevant physical parameters, i.e. the top
partners masses and couplings. We believe that our results constitute a valid
starting point for a more detailed experimental study.Comment: Corrected some typos, added a reference, 23 page
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Human Vault Nanoparticle Targeted Delivery of Antiretroviral Drugs to Inhibit Human Immunodeficiency Virus Type 1 Infection.
"Vaults" are ubiquitously expressed endogenous ribonucleoprotein nanoparticles with potential utility for targeted drug delivery. Here, we show that recombinant human vault nanoparticles are readily engulfed by certain key human peripheral blood mononuclear cells (PBMC), predominately dendritic cells, monocytes/macrophages, and activated T cells. As these cell types are the primary targets for human immunodeficiency virus type 1 (HIV-1) infection, we examined the utility of recombinant human vaults for targeted delivery of antiretroviral drugs. We chemically modified three different antiretroviral drugs, zidovudine, tenofovir, and elvitegravir, for direct conjugation to vaults. Tested in infection assays, drug-conjugated vaults inhibited HIV-1 infection of PBMC with equivalent activity to free drugs, indicating vault delivery and drug release in the cytoplasm of HIV-1-susceptible cells. The ability to deliver functional drugs via vault nanoparticle conjugates suggests their potential utility for targeted drug delivery against HIV-1
Unveiling the intruder deformed 0 state in Si
The 0 state in Si has been populated at the {\sc Ganil/Lise3}
facility through the -decay of a newly discovered 1 isomer in
Al of 26(1) ms half-life. The simultaneous detection of pairs
allowed the determination of the excitation energy E(0)=2719(3) keV and
the half-life T=19.4(7) ns, from which an electric monopole strength of
(E0)=13.0(0.9) was deduced. The 2 state is
observed to decay both to the 0 ground state and to the newly observed
0 state (via a 607(2) keV transition) with a ratio
R(2)=1380(717). Gathering all
information, a weak mixing with the 0 and a large deformation parameter
of =0.29(4) are found for the 0 state, in good agreement with
shell model calculations using a new {\sc sdpf-u-mix} interaction allowing
\textit{np-nh} excitations across the N=20 shell gap.Comment: 5 pages, 3 figures, accepted for publication in Physical Review
Letter
Prolate-Spherical Shape Coexistence at N=28 in S
The structure of S has been studied using delayed and
electron spectroscopy at \textsc{ganil}. The decay rates of the 0
isomeric state to the 2 and 0 states have been measured for the
first time, leading to a reduced transition probability
B(E2~:~20= 8.4(26)~efm and a monopole
strength (E0~:~00
=~8.7(7)10. Comparisons to shell model calculations point
towards prolate-spherical shape coexistence and a phenomenological two level
mixing model is used to extract a weak mixing between the two configurations.Comment: 5 pages, 3 figures, accepted for publication in Physical Review
Letter
MCP-1 and CCR2 gene polymorphisms in Czech patients with allergic disorders
Summary Several lines of evidence suggest that chemokines play an important role in asthma and allergy. We analysed polymorphisms at -2518A/G and -2076A/T of MCP-1 and V64I of CCR2 gene in healthy subjects ( n = 306) and allergic patients ( n = 332). Allele and genotype frequencies did not differ significantly between groups. Nevertheless, MCP-1 variants were associated with allergen sensitization. The results suggest that MCP-1, but not CCR2 gene variants, may participate in the pathogenesis of allergic phenotypes at least in the Caucasian population
Collapse of the N=28 shell closure in Si
The energies of the excited states in very neutron-rich Si and
P have been measured using in-beam -ray spectroscopy from the
fragmentation of secondary beams of S at 39 A.MeV. The low 2
energy of Si, 770(19) keV, together with the level schemes of
P provide evidence for the disappearance of the Z=14 and N=28
spherical shell closures, which is ascribed mainly to the action of
proton-neutron tensor forces. New shell model calculations indicate that
Si is best described as a well deformed oblate rotor.Comment: 4 pages, 3 figures, accepted for publication in Phys. Rev. let
Model-Independent Searches for New Quarks at the LHC
New vector-like quarks can have sizable couplings to first generation quarks
without conflicting with current experimental constraints. The coupling with
valence quarks and unique kinematics make single production the optimal
discovery process. We perform a model-independent analysis of the discovery
reach at the Large Hadron Collider for new vector-like quarks considering
single production and subsequent decays via electroweak interactions. An early
LHC run with 7 TeV center of mass energy and 1 fb-1 of integrated luminosity
can probe heavy quark masses up to 1 TeV and can be competitive with the
Tevatron reach of 10 fb-1. The LHC with 14 TeV center of mass energy and 100
fb-1 of integrated luminosity can probe heavy quark masses up to 3.7 TeV for
order one couplings.Comment: 37 pages, 11 figures, 7 table
Generalized methods and solvers for noise removal from piecewise constant signals. II. New methods
Removing noise from signals which are piecewise constant (PWC) is a challenging signal processing problem that arises in many practical scientific and engineering contexts. In the first paper (part I) of this series of two, we presented background theory building on results from the image processing community to show that the majority of these algorithms, and more proposed in the wider literature, are each associated with a special case of a generalized functional, that, when minimized, solves the PWC denoising problem. It shows how the minimizer can be obtained by a range of computational solver algorithms. In this second paper (part II), using this understanding developed in part I, we introduce several novel PWC denoising methods, which, for example, combine the global behaviour of mean shift clustering with the local smoothing of total variation diffusion, and show example solver algorithms for these new methods. Comparisons between these methods are performed on synthetic and real signals, revealing that our new methods have a useful role to play. Finally, overlaps between the generalized methods of these two papers and others such as wavelet shrinkage, hidden Markov models, and piecewise smooth filtering are touched on
Probing Nuclear forces beyond the drip-line using the mirror nuclei N and F
Radioactive beams of O and O were used to populate the resonant
states 1/2, 5/2 and in the unbound F and F
nuclei respectively by means of proton elastic scattering reactions in inverse
kinematics. Based on their large proton spectroscopic factor values, the
resonant states in F can be viewed as a core of O plus a proton
in the 2s or 1d shell and a neutron in 1p. Experimental
energies were used to derive the strength of the 2s-1p and
1d-1p proton-neutron interactions. It is found that the former
changes by 40% compared with the mirror nucleus N, and the second by
10%. This apparent symmetry breaking of the nuclear force between mirror nuclei
finds explanation in the role of the large coupling to the continuum for the
states built on an proton configuration.Comment: 6 pages, 3 figures, 2 tables, accepted for publication as a regular
article in Physical Review
Search for new resonant states in 10C and 11C and their impact on the cosmological lithium problem
The observed primordial 7Li abundance in metal-poor halo stars is found to be
lower than its Big-Bang nucleosynthesis (BBN) calculated value by a factor of
approximately three. Some recent works suggested the possibility that this
discrepancy originates from missing resonant reactions which would destroy the
7Be, parent of 7Li. The most promising candidate resonances which were found
include a possibly missed 1- or 2- narrow state around 15 MeV in the compound
nucleus 10C formed by 7Be+3He and a state close to 7.8 MeV in the compound
nucleus 11C formed by 7Be+4He. In this work, we studied the high excitation
energy region of 10C and the low excitation energy region in 11C via the
reactions 10B(3He,t)10C and 11B(3He,t)11C, respectively, at the incident energy
of 35 MeV. Our results for 10C do not support 7Be+3He as a possible solution
for the 7Li problem. Concerning 11C results, the data show no new resonances in
the excitation energy region of interest and this excludes 7Be+4He reaction
channel as an explanation for the 7Li deficit.Comment: Accepted for publication in Phys. Rev. C (Rapid Communication
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