35 research outputs found
Photodynamic Therapy With Verteporfin for Choroidal Neovascularization in Patients with Angioid Streaks
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Targeting the PD-1/PD-L1 Immune Evasion Axis With DNA Aptamers as a Novel Therapeutic Strategy for the Treatment of Disseminated Cancers
No full textControlling Vascular Endothelial Growth Factor: Therapies for Ocular Diseases Associated with Nevascularization
No full textSubthreshold transpupillary thermotherapy of the retina and experimental choroidal neovascularization in a rat model
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Intravitreal treatment in patients with exudative age-related macular degeneration and visual acuity ≤ 0.05
No full textCopy number variation in VEGF gene as a biomarker of susceptibility to age-related macular degeneration
No full textSelf-assemble gene delivery system for molecular targeting using nucleic acid aptamer.
Get PDFWe have developed a novel vector constructed with pDNA, polyethylenimine (PEI), and mucin 1 (MUC1) aptamer for tumor-targeted gene delivery. The MUC1 aptamer and non-specific aptamer were employed to coat the pDNA/PEI complexes electrostatically and stable nanoparticles were formed. The addition of a non-specific aptamer to the pDNA/PEI complex decreased gene expression in the human lung cancer cell line, A549 cells expressing MUC1 regularly. At the same time, the pDNA/PEI/MUC1 aptamer complex showed higher gene expression than pDNA/PEI/non-specific aptamer complex. Furthermore, the pDNA/PEI/MUC1 aptamer complex showed markedly high gene expression in tumor-bearing mice; thus, pDNA/PEI/MUC1 aptamer complexes are useful as a tumor-targeted gene delivery system with high transfection efficiency
