Allied Air Attacks and Civilian Harm in Italy, 1940–1945

Tens of thousands of Italian civilians perished in the Allied bombing raids of World War II. More of them died after the Armistice of September 1943 than before, when the air attacks were intended to induce Italy’s surrender.　 Allied Air Attacks and Civilian Harm in Italy, 1940–1945 addresses this seeming paradox, by examining the views of Allied political and military leaders, Allied air crews, and Italians on the ground. It tells the stories of a little-known diplomat (Myron Charles Taylor), military strategist (Solly Zuckerman), resistance fighter (Aldo Quaranta), and peace activist (Vera Brittain) – architects and opponents of the bombing strategies. It describes the fate of ordinary civilians, drawing on a wealth of local and digital archival sources, memoir accounts, novels, and films, including Joseph Heller’s Catch-22 and John Huston’s The Battle of San Pietro. The book will be of interest to readers concerned about the ethical, legal, and human dimensions of bombing and its effects on civilians, to students of military strategy and Italian history, and to World War II buffs. They will benefit from a people-focused history that draws on a range of eclectic and rarely used sources in English and Italian

Allied Air Attacks and Civilian Harm in Italy, 1940–1945

Tens of thousands of Italian civilians perished in the Allied bombing raids of World War II. More of them died after the Armistice of September 1943 than before, when the air attacks were intended to induce Italy’s surrender.　 Allied Air Attacks and Civilian Harm in Italy, 1940–1945 addresses this seeming paradox, by examining the views of Allied political and military leaders, Allied air crews, and Italians on the ground. It tells the stories of a little-known diplomat (Myron Charles Taylor), military strategist (Solly Zuckerman), resistance fighter (Aldo Quaranta), and peace activist (Vera Brittain) – architects and opponents of the bombing strategies. It describes the fate of ordinary civilians, drawing on a wealth of local and digital archival sources, memoir accounts, novels, and films, including Joseph Heller’s Catch-22 and John Huston’s The Battle of San Pietro. The book will be of interest to readers concerned about the ethical, legal, and human dimensions of bombing and its effects on civilians, to students of military strategy and Italian history, and to World War II buffs. They will benefit from a people-focused history that draws on a range of eclectic and rarely used sources in English and Italian

Decadence and Translation

Decadence and Translation. Volupté 3.2 (December 2020) - full issue

The view from Strasbourg: translational readings of decadence by the Guest Editors

No abstract available

Local Knowledge of Plants and Their Uses Among Women in the Bale Mountains, Ethiopia

Women’s local ecological knowledge (LEK) is noted by many scholars to be unique and important for local conservation and development planning. Although LEK integration is inherent to ethnobotanical research, in Ethiopia, the knowledge-gender link has not been fully explored, and few studies focus on women’s distinct plant knowledge. We catalogued rural women’s knowledge of a wide range of plant uses in south-central Ethiopia, conducted through picture identification of 337 local plants. Fifty-seven plant species were identified, constituting 38 families, with the top five families being Lamiaceae, Solanaceae, Asteraceae, Rosaceae, and Pteridaceae. An array of uses were identified ranging from food, livestock and wildlife forage, to honey production and cosmetics. The most prevalent use noted (nearly 70%) was human medicine. This study reveals the important contribution of rural women’s plant knowledge in the Bale Mountains, and the potential benefits of including this gender-distinct understanding of local flora in community-based conservation planning

Investigation of seismic response of cantilever retaining walls: limit analysis vs shaking table testing

The earthquake response of cantilever retaining walls is explored by means of theoretical analyses and shaking table testing conducted at University of Bristol (EERC - EQUALS). The theoretical investigations employ both limit analysis and wave-propagation methods, which take into account different aspects of the problem such as inertia, strength, kinematics and compatibility of deformations. The experimental programme encompasses different combinations of retaining wall geometries, soil configurations and input ground motions. The response analysis of the systems at hand aims at shedding light onto salient features of the problem, such as: (1) the magnitude of soil thrust and its point of application; (2) the relative sliding versus rocking of the wall base and the corresponding failure modes; (3) the importance of the interplay between soil stiffness, wall dimensions and excitation characteristics, as affecting the above; (4) the importance of wall dynamics and phase differences between peak stresses and displacements. The results of the experimental investigations are in good agreement with the theoretical models and provide a better understanding on the complex mechanics of the problem

A guide to writing systematic reviews of rare disease treatments to generate FAIR-compliant datasets: building a Treatabolome

Abstract: Background: Rare diseases are individually rare but globally affect around 6% of the population, and in over 70% of cases are genetically determined. Their rarity translates into a delayed diagnosis, with 25% of patients waiting 5 to 30 years for one. It is essential to raise awareness of patients and clinicians of existing gene and variant-specific therapeutics at the time of diagnosis to avoid that treatment delays add up to the diagnostic odyssey of rare diseases’ patients and their families. Aims: This paper aims to provide guidance and give detailed instructions on how to write homogeneous systematic reviews of rare diseases’ treatments in a manner that allows the capture of the results in a computer-accessible form. The published results need to comply with the FAIR guiding principles for scientific data management and stewardship to facilitate the extraction of datasets that are easily transposable into machine-actionable information. The ultimate purpose is the creation of a database of rare disease treatments (“Treatabolome”) at gene and variant levels as part of the H2020 research project Solve-RD. Results: Each systematic review follows a written protocol to address one or more rare diseases in which the authors are experts. The bibliographic search strategy requires detailed documentation to allow its replication. Data capture forms should be built to facilitate the filling of a data capture spreadsheet and to record the application of the inclusion and exclusion criteria to each search result. A PRISMA flowchart is required to provide an overview of the processes of search and selection of papers. A separate table condenses the data collected during the Systematic Review, appraised according to their level of evidence. Conclusions: This paper provides a template that includes the instructions for writing FAIR-compliant systematic reviews of rare diseases’ treatments that enables the assembly of a Treatabolome database that complement existing diagnostic and management support tools with treatment awareness data

Angiotensin receptor blockers and β blockers in Marfan syndrome: an individual patient data meta-analysis of randomised trials

Background: Angiotensin receptor blockers (ARBs) and β blockers are widely used in the treatment of Marfan syndrome to try to reduce the rate of progressive aortic root enlargement characteristic of this condition, but their separate and joint effects are uncertain. We aimed to determine these effects in a collaborative individual patient data meta-analysis of randomised trials of these treatments. Methods: In this meta-analysis, we identified relevant trials of patients with Marfan syndrome by systematically searching MEDLINE, Embase, and CENTRAL from database inception to Nov 2, 2021. Trials were eligible if they involved a randomised comparison of an ARB versus control or an ARB versus β blocker. We used individual patient data from patients with no prior aortic surgery to estimate the effects of: ARB versus control (placebo or open control); ARB versus β blocker; and indirectly, β blocker versus control. The primary endpoint was the annual rate of change of body surface area-adjusted aortic root dimension Z score, measured at the sinuses of Valsalva. Findings: We identified ten potentially eligible trials including 1836 patients from our search, from which seven trials and 1442 patients were eligible for inclusion in our main analyses. Four trials involving 676 eligible participants compared ARB with control. During a median follow-up of 3 years, allocation to ARB approximately halved the annual rate of change in the aortic root Z score (mean annual increase 0·07 [SE 0·02] ARB vs 0·13 [SE 0·02] control; absolute difference –0·07 [95% CI –0·12 to –0·01]; p=0·012). Prespecified secondary subgroup analyses showed that the effects of ARB were particularly large in those with pathogenic variants in fibrillin-1, compared with those without such variants (heterogeneity p=0·0050), and there was no evidence to suggest that the effect of ARB varied with β-blocker use (heterogeneity p=0·54). Three trials involving 766 eligible participants compared ARBs with β blockers. During a median follow-up of 3 years, the annual change in the aortic root Z score was similar in the two groups (annual increase –0·08 [SE 0·03] in ARB groups vs –0·11 [SE 0·02] in β-blocker groups; absolute difference 0·03 [95% CI –0·05 to 0·10]; p=0·48). Thus, indirectly, the difference in the annual change in the aortic root Z score between β blockers and control was –0·09 (95% CI –0·18 to 0·00; p=0·042). Interpretation In people with Marfan syndrome and no previous aortic surgery, ARBs reduced the rate of increase of the aortic root Z score by about one half, including among those taking a β blocker. The effects of β blockers were similar to those of ARBs. Assuming additivity, combination therapy with both ARBs and β blockers from the time of diagnosis would provide even greater reductions in the rate of aortic enlargement than either treatment alone, which, if maintained over a number of years, would be expected to lead to a delay in the need for aortic surgery. Funding: Marfan Foundation, the Oxford British Heart Foundation Centre for Research Excellence, and the UK Medical Research Council