Management of a crown-root fracture : a novel technique with interdisciplinary approach

Anterior teeth with subgingival fractures require a complex treatment plan that addresses biologic, functional and aesthetic factors. This case report describes the management of a crown-root fractured maxillary left central incisor. An interdisciplinary approach was used to restore the tooth due to the complex nature of the treatment. Orthodontic extrusion was performed to move the fracture line above the alveolar bone and periodontal surgery to recontour the altered gingival margin. Finally, the incisor was restored performing a root canal retreatment with a fiber post and a full ceramic crown. The treatment resulted in secured periodontal health and good aesthetic

Alzheimer Disease Diagnosis based on Automatic Spontaneous Speech Analysis

Alzheimer’s disease (AD) is the most prevalent form of progressive degenerative dementia and it has a high socio-economic impact in Western countries, therefore is one of the most active research areas today. Its diagnosis is sometimes made by excluding other dementias, and definitive confirmation must be done trough a post-mortem study of the brain tissue of the patient. The purpose of this paper is to contribute to improvement of early diagnosis of AD and its degree of severity, from an automatic analysis performed by non-invasive intelligent methods. The methods selected in this case are Automatic Spontaneous Speech Analysis (ASSA) and Emotional Temperature (ET), that have the great advantage of being non invasive, low cost and without any side effects

Functional brain network centrality is related to APOE genotype in cognitively normal elderly

INTRODUCTION: Amyloid plaque deposition in the brain is an early pathological change in Alzheimer's disease (AD), causing disrupted synaptic connections. Brain network disruptions in AD have been demonstrated with eigenvector centrality (EC), a measure that identifies central regions within networks. Carrying an apolipoprotein (APOE)-ε4 allele is a genetic risk for AD, associated with increased amyloid deposition. We studied whether APOE-ε4 carriership is associated with EC disruptions in cognitively normal individuals. METHODS: A total of 261 healthy middle-aged to older adults (mean age 56.6 years) were divided into high-risk (APOE-ε4 carriers) and low-risk (noncarriers) groups. EC was computed from resting-state functional MRI data. Clusters of between-group differences were assessed with a permutation-based method. Correlations between cluster mean EC with brain volume, CSF biomarkers, and psychological test scores were assessed. RESULTS: Decreased EC in the visual cortex was associated with APOE-ε4 carriership, a genetic risk factor for AD. EC differences were correlated with age, CSF amyloid levels, and scores on the trail-making and 15-object recognition tests. CONCLUSION: Our findings suggest that the APOE-ε4 genotype affects brain connectivity in regions previously found to be abnormal in AD as a sign of very early disease-related pathology. These differences were too subtle in healthy elderly to use EC for single-subject prediction of APOE genotype

Venezuela, April 2002: Coup or Popular Rebellion? The Myth of a United Venezuela

This article assesses the merits of opposing National Assembly reports into the coup against President Chavez of Venezuela in April 2002. Looking at the historical context and the content of the reports, it argues that the two opposing accounts reflect a class division that has always existed in Venezuela but has been officially denied. It concludes that a possible exit from the stalemate could be that the opposition accept the reality of this class division and therefore the Chavez government as a legitimate representative of the popular classes. This, however, is unlikely in the present circumstances

LAST 20 YEARS OF GAS HYDRATES IN THE OIL INDUSTRY: CHALLENGES AND ACHIEVEMENTS IN PREDICTING PIPELINE BLOCKAGE

The continuous effort to understand the complicated behavior of gas hydrates in multiphase flow has led to the evolution of a new paradigm of hydrate blockage. The hydrate community continues to debate the impact of kinetics, agglomeration, and oil chemistry effects on hydrate blockage formation in pipelines and wellbores. However, today’s industry for the most part still continues to rely on thermodynamic means to develop strategies to prevent hydrates altogether in its production systems. These strategies such as thermal insulation of equipment, electric heating, dead oil displacement, and methanol injection add CAPEX, OPEX, and operational complexities to system design. In spite of high oil prices, adopting such strategies to mitigate perceived hydrate blockage risk can end up taxing economics of marginal fields. Developing a comprehensive multiphase flow simulator capable of handling the transient aspects of production operations - shut-in, restart, blowdown and blockage prediction - continues to drive the research in Flow Assurance. New operating strategies based on risk management approach seem to be evolving from the model predictions. A shift in paradigm that allows for operations inside the hydrate region based on sound risk assessment and management principles could be a factor enabling future developments of marginal fields. This paper discusses the challenges and opportunities that have led to the change in focus from prevention of hydrates to prevention of blockage, and describes some initial successes in the development of a first generation empirical tool for the prediction of hydrate blockages in flow lines. Also presented in this article are new experimental data that shed some light on different ways that hydrate blockages can manifest in the field.Non UBCUnreviewe

Accelerated long-term forgetting over three months in asymptomatic APOE ɛ4 carriers

Altres ajuts: Fondo Europeo de Desarrollo Regional (FEDER); Agencia Estatal de Investigación (AEI).Accelerated long-term forgetting (ALF) refers to a rapid loss of information over days or weeks despite normal acquisition/encoding. Notwithstanding its potential relevance as a presymptomatic marker of cognitive dysfunction, no study has addressed the relationship between ALF and Alzheimer's disease (AD) biomarkers. We examined ALF in APOE ɛ4 carriers versus noncarriers, and its relationships with AD cerebrospinal fluid (CSF) biomarkers. We found ALF over three months in APOE ɛ4 carriers (F(1,19) = 5.60; P < 0.05; Cohen's d = 1.08), and this performance was associated with abnormal levels of the CSF Aβ/ptau ratio (r = −.614; P < 0.01). Our findings indicate that ALF is detectable in at-risk individuals, and that there is a relationship between ALF and the pathophysiological processes underlying AD

New Approaches for Alzheimer’s Disease Diagnosis Based on Automatic Spontaneous Speech Analysis and Emotional Temperature

Alzheimer Disease (AD) is one of the most common dementia and their socio-economic relevance is growing. Its diagnosis is sometimes made by excluding other dementias, but definitive confirmation must await the study post-mortem with brain tissue of the patient. According to internationally accepted criteria, we can only speak about probable or possible Alzheimer's disease. The purpose of this paper is to contribute to improve early diagnosis of dementia and severity from automatic analysis performed by non-invasive automated intelligent methods. The methods selected in this case are Automatic Spontaneous Speech Analysis (ASSA) and Emotional Temperature (ET). These methodologies have the great advantage of being non invasive, low cost methodologies and have no side effects

Mechanisms underlying resilience in ageing

Non peer reviewe