9 research outputs found
Embedded neural network for real-time animal behavior classification
Recent biological studies have focused on understanding animal interactions and welfare. To help biolo- gists to obtain animals’ behavior information, resources like wireless sensor networks are needed. More- over, large amounts of obtained data have to be processed off-line in order to classify different behaviors.There are recent research projects focused on designing monitoring systems capable of measuring someanimals’ parameters in order to recognize and monitor their gaits or behaviors. However, network unre- liability and high power consumption have limited their applicability.In this work, we present an animal behavior recognition, classification and monitoring system based ona wireless sensor network and a smart collar device, provided with inertial sensors and an embeddedmulti-layer perceptron-based feed-forward neural network, to classify the different gaits or behaviorsbased on the collected information. In similar works, classification mechanisms are implemented in aserver (or base station). The main novelty of this work is the full implementation of a reconfigurableneural network embedded into the animal’s collar, which allows a real-time behavior classification andenables its local storage in SD memory. Moreover, this approach reduces the amount of data transmittedto the base station (and its periodicity), achieving a significantly improving battery life. The system hasbeen simulated and tested in a real scenario for three different horse gaits, using different heuristics andsensors to improve the accuracy of behavior recognition, achieving a maximum of 81%.Junta de Andalucía P12-TIC-130
Control oficial dels productes vitivinícoles: aplicació del SICA en establiments del sector del vi; criteris de flexibilitat
Petits cellers; Requisits d’higiene; APPCC; Criteris flexibilitat; SICAPequeñas bodegas; Requisitos de higiene; APPCC; Criterios flexibilidad; SICASmall wineries; Hygiene requirements; HACCP; Criteria of flexibility; SICADurant el procés de treball de la comunitat de pràctica (CoP) s’ha establert un cronograma
d’actuacions. Els objectius que s’han prioritzat són:
a) Donar informació sobre la importància dels establiments relacionats amb el món del vi i el vi
escumós a Catalunya i la distribució territorial que tenen.
b) Donar informació sobre els perills que s’han detectat aquests darrers anys en vins i vins escumosos, que han estat motiu de notificacions d’alerta a la Unió Europea o d’alguna incidència a Catalunya.
c) Posar a disposició dels inspectors un recull de la normativa que afecta el sector vitivinícola.
d) Elaborar un protocol d’inspecció que proporcioni una eina eficaç i útil per efectuar el control oficial dels establiments que elaboren i/o envasen productes vitivinícoles.
e) Elaborar material de suport per als inspectors que faciliti la interpretació de les preguntes del protocol que poden generar dubtes en relació amb les pràctiques enològiques i la informació alimentària.
f) Realitzar consultes a Serveis Centrals en relació amb diversos punts de la normativa que presenten dubtes d’interpretació per obtenir criteris homogenis i poder incloure’ls en el material de suport per als inspectors.
g) Elaborar documents que incloguin els requisits mínims que han de tenir els establiments que realitzen activitats relacionades amb productes vitivinícoles i els criteris de flexibilitat que es podrien aplicar en casos determinats.
Aquest ha estat un treball que la CoP ha realitzat durant dos anys.Durante el proceso de trabajo de la comunidad de práctica (CoP) se ha establecido un cronograma
de actuaciones. Los objetivos que se han priorizado son:
a) Dar información sobre la importancia de los establecimientos relacionados con el mundo del vino y el vino
espumoso en Cataluña y su distribución territorial.
b) Dar información sobre los peligros que se han detectado estos últimos años en vinos y vinos espumosos, que han sido motivo de notificaciones de alerta en la Unión Europea o de alguna incidencia en Cataluña.
c) Poner a disposición de los inspectores una recopilación de la normativa que afecta al sector vitivinícola.
d) Elaborar un protocolo de inspección que proporcione una herramienta eficaz y útil para efectuar el control oficial de los establecimientos que elaboren y/o envasen productos vitivinícolas.
e) Elaborar material de soporte para los inspectores que facilite la interpretación de las preguntas del protocolo que pueden generar dudas en relación con las prácticas enológicas y la información alimentaria.
f) Realizar consultas a Servicios Centrales en relación con varios puntos de la normativa que presenten dudas de interpretación para obtener criterios homogéneos y poder incluirlos en el material de soporte para los inspectores.
g) Elaborar documentos que incluyan los requisitos mínimos que deben tener los establecimientos que realizan actividades relacionadas con productos vitivinícolas y los criterios de flexibilidad que podrían aplicarse en casos determinados.
Éste ha sido un trabajo que la CoP ha realizado durante dos años.During the work process of the community of practice (CoP) a schedule has been established
of performances. The objectives that have been prioritized are:
a) Give information about the importance of establishments related to the world of wine and wine
sparkling wine in Catalonia and its territorial distribution.
b) Provide information on the dangers that have been detected in recent years in wines and sparkling wines, which have been the reason for alert notifications in the European Union or an incident in Catalonia.
c) Make a compilation of the regulations that affect the wine sector available to inspectors.
d) Develop an inspection protocol that provides an effective and useful tool for carrying out official control of establishments that produce and/or package wine products.
e) Prepare support material for inspectors that facilitates the interpretation of protocol questions that may raise doubts in relation to oenological practices and food information.
f) Make inquiries to Central Services in relation to various points of the regulations that present doubts of interpretation in order to obtain homogeneous criteria and be able to include them in the support material for inspectors.
g) Prepare documents that include the minimum requirements that must be met by establishments that carry out activities related to wine products and the flexibility criteria that could be applied in specific cases.
This has been work that the CoP has done for two years
Complement component C4 structural variation and quantitative traits contribute to sex-biased vulnerability in systemic sclerosis
Altres ajuts: Fondo Europeo de Desarrollo Regional (FEDER), "A way of making Europe".Copy number (CN) polymorphisms of complement C4 play distinct roles in many conditions, including immune-mediated diseases. We investigated the association of C4 CN with systemic sclerosis (SSc) risk. Imputed total C4, C4A, C4B, and HERV-K CN were analyzed in 26,633 individuals and validated in an independent cohort. Our results showed that higher C4 CN confers protection to SSc, and deviations from CN parity of C4A and C4B augmented risk. The protection contributed per copy of C4A and C4B differed by sex. Stronger protection was afforded by C4A in men and by C4B in women. C4 CN correlated well with its gene expression and serum protein levels, and less C4 was detected for both in SSc patients. Conditioned analysis suggests that C4 genetics strongly contributes to the SSc association within the major histocompatibility complex locus and highlights classical alleles and amino acid variants of HLA-DRB1 and HLA-DPB1 as C4-independent signals
Treatment with tocilizumab or corticosteroids for COVID-19 patients with hyperinflammatory state: a multicentre cohort study (SAM-COVID-19)
Objectives: The objective of this study was to estimate the association between tocilizumab or corticosteroids and the risk of intubation or death in patients with coronavirus disease 19 (COVID-19) with a hyperinflammatory state according to clinical and laboratory parameters.
Methods: A cohort study was performed in 60 Spanish hospitals including 778 patients with COVID-19 and clinical and laboratory data indicative of a hyperinflammatory state. Treatment was mainly with tocilizumab, an intermediate-high dose of corticosteroids (IHDC), a pulse dose of corticosteroids (PDC), combination therapy, or no treatment. Primary outcome was intubation or death; follow-up was 21 days. Propensity score-adjusted estimations using Cox regression (logistic regression if needed) were calculated. Propensity scores were used as confounders, matching variables and for the inverse probability of treatment weights (IPTWs).
Results: In all, 88, 117, 78 and 151 patients treated with tocilizumab, IHDC, PDC, and combination therapy, respectively, were compared with 344 untreated patients. The primary endpoint occurred in 10 (11.4%), 27 (23.1%), 12 (15.4%), 40 (25.6%) and 69 (21.1%), respectively. The IPTW-based hazard ratios (odds ratio for combination therapy) for the primary endpoint were 0.32 (95%CI 0.22-0.47; p < 0.001) for tocilizumab, 0.82 (0.71-1.30; p 0.82) for IHDC, 0.61 (0.43-0.86; p 0.006) for PDC, and 1.17 (0.86-1.58; p 0.30) for combination therapy. Other applications of the propensity score provided similar results, but were not significant for PDC. Tocilizumab was also associated with lower hazard of death alone in IPTW analysis (0.07; 0.02-0.17; p < 0.001).
Conclusions: Tocilizumab might be useful in COVID-19 patients with a hyperinflammatory state and should be prioritized for randomized trials in this situatio
Expression of MALT1 oncogene in hematopoietic stem/progenitor cells recapitulates the pathogenesis of human lymphoma in mice
Chromosomal translocations involving the MALT1 gene are hallmarks of mucosa-associated lymphoid tissue (MALT) lymphoma. To date, targeting these translocations to mouse B cells has failed to reproduce human disease. Here, we induced MALT1 expression in mouse Sca1(+)Lin(-) hematopoietic stem/progenitor cells, which showed NF-κB activation and early lymphoid priming, being selectively skewed toward B-cell differentiation. These cells accumulated in extranodal tissues and gave rise to clonal tumors recapitulating the principal clinical, biological, and molecular genetic features of MALT lymphoma. Deletion of p53 gene accelerated tumor onset and induced transformation of MALT lymphoma to activated B-cell diffuse large-cell lymphoma (ABC-DLBCL). Treatment of MALT1-induced lymphomas with a specific inhibitor of MALT1 proteolytic activity decreased cell viability, indicating that endogenous Malt1 signaling was required for tumor cell survival. Our study shows that human-like lymphomas can be modeled in mice by targeting MALT1 expression to hematopoietic stem/progenitor cells, demonstrating the oncogenic role of MALT1 in lymphomagenesis. Furthermore, this work establishes a molecular link between MALT lymphoma and ABC-DLBCL, and provides mouse models to test MALT1 inhibitors. Finally, our results suggest that hematopoietic stem/progenitor cells may be involved in the pathogenesis of human mature B-cell lymphomas
Control oficial dels productes vitivinícoles: aplicació del SICA en establiments del sector del vi; criteris de flexibilitat
Petits cellers; Requisits d’higiene; APPCC; Criteris flexibilitat; SICAPequeñas bodegas; Requisitos de higiene; APPCC; Criterios flexibilidad; SICASmall wineries; Hygiene requirements; HACCP; Criteria of flexibility; SICAEls objectius d'aquest document son: Actualitzar el document Control oficial dels productes vitivinícoles. Aplicació del
SICA en establiments del sector del vi. Criteris de flexibilitat (revisió 2) amb les modificacions
que s’han dut a terme respecte a les pràctiques enològiques, així com d’altres normatives
sanitàries. Una altre objectiu era revisar els criteris de flexibilitat d’acord amb la nova
comunicació de la Comissió sobre l’aplicació de sistemes de gestió de la seguretat alimentària
que recullen bones pràctiques d’higiene i procediments basats en els principis de l’APPCC. A
més, s’hi han inclòs els criteris sanitaris dels vins desalcoholitzats d’acord amb la normativa que els
és aplicable.Los objetivos de este documento son: Actualizar el documento Control oficial de los productos vitivinícolas. Aplicación del
SICA en establecimientos del sector del vino. Criterios de flexibilidad (revisión 2) con las
modificaciones que se han llevado a cabo con respecto a las prácticas enológicas, así como de
otras normativas sanitarias. Otro objetivo era revisar los criterios de flexibilidad de acuerdo con la
nueva comunicación de la Comisión sobre la aplicación de sistemas de gestión de la seguridad
alimentaria que prevén buenas prácticas de higiene y procedimientos basados en los principios de
APPCC. Además, se han incluido los criterios sanitarios de los vinos desalcoholizado de
acuerdo con la normativa que les es aplicable.The objectives of this document are: - To proceed to updat e the Document "Official control of wine products.
Application of SICA in establishments in the wine sector. Flexibility Criteria (revision 2)",
including the legislative changes.
- To review flexibility criteria in accordance with the Commission's new communication on
the application of food safety management systems that include good hygiene practices and
procedures based on HACCP principles.
- In addition, health criteria for de-alcoholised and partially de-alcoholised wines have
been included in accordance with the regulations that apply to them
Understanding Mediterranean Pasture Dynamics: General Tree Cover vs. Specific Effects of Individual Trees
Guía de Terapéutica Antimicrobiana del Área Aljarafe, 3ª edición
Coordinadora: Rocío Fernández Urrusuno. Co-coordinadora: Carmen Serrano Martino.YesEstas guías son un recurso indispensable en los Programas de Optimización de Antibióticos (PROA). No sólo constituyen una herramienta de ayuda para la toma de decisiones en los principales síndromes infecciosos, proporcionando recomendaciones para el abordaje empírico de dichos procesos, sino que son el patrón/estándar de referencia que permitirá determinar la calidad o adecuación de los tratamientos realizados. Las guías pueden ser utilizadas, además, como herramienta de base para la formación y actualización en antibioterapia, ya que permiten mantener actualizados los conocimientos sobre las nuevas evidencias en el abordaje de las infecciones. Por último, deberían incorporar herramientas que faciliten el proceso de toma de decisiones compartidas con el paciente.
El objetivo de esta guía es proporcionar recomendaciones para el abordaje de las enfermedades infecciosas más prevalentes en la comunidad, basadas en las últimas evidencias disponibles y los datos de resistencias de los principales patógenos que contribuyan a mejorar la calidad de la prescripción de antimicrobianos