Nutzung von MPI für parallele FEM-Systeme

Der Standard des Message Passing Interfaces (MPI) stellt dem Entwickler paralleler Anwendungen ein mächtiges Werkzeug zur Verfügung, seine Softwa- re effizient und weitgehend unabhängig von Details des parallelen Systems zu entwerfen. Im Rahmen einer Projektarbeit erfolgte die Umstellung der Kommunikationsbibliothek eines bestehenden FEM-Programmes auf den MPI-Mechanismus. Die Ergebnisse werden in der hier gegebenen Beschreibung der Cubecom-Implementierung zusammengefasst. In einem zweiten Teil dieser Arbeit wird untersucht, auf welchem Wege mit der in MPI verfügbaren Funktionalität auch die Koppelrandkommunikation mit einem einheitlichen und effizienten Verfahren durchgeführt werden kann. Sowohl fuer die Basisimplementierung als auch die MPI-basierte Koppelrandkommunikation wird die Effizienz untersucht und ein Ausblick auf weitere Anwendungsmoeglichkeiten gegeben

Utility of Walleyes and Saugeyes as Secondary Predators in Small South Dakota Impoundments

Walleye Stizostedion vitreum and saugeye (walleye x sauger S. canadense) fingerlings were concurrently stocked at equal densities into five small impoundments in 1997, 1988, and 1999 to evaluate relative survival, growth and their ability to restructure existing panfish communities. Prior to stocking, fish were differentially marked on the right or left side with freeze brands or with 700 ppm oxytetracycline hydrochloride (OTC) to allow accurate identification of each fish as a walleye (fry mark) or a saugeye (fingerling mark). Spring and fall night electrofishing was used to sample the stocked percids, as well as potential competing species such as largemouth bass Micropterus salmoides and northern pike Esox lucius. Differences in relative survival (indexed as catch per unit effort [CPUE] from night electrofishing) and growth (mean total length and relative growth) between walleyes and saugeyes were compared within and among water bodies. Visceral-somatic index (VSI), liversomatic index (LSI) and mesenteric fat index (MFI) were calculated for both species to further compare fish condition. Changes in panfish communities (indexed as trap net CPUE, proportional stock density [PSD], relative weight [Wr] and incremental growth) were assessed throughout the study. The 1997 year class of walleyes exhibited better survival than saugeyes in Bode Pond and Jones Lake. Low sample sizes and no significant differences in survival were observed in Hanson, Iroquois or Hayes Lake populations. The 1998 cohort of walleyes had significantly higher survival than saugeyes in Hanson Lake during fall 1999 and spring 2000. Saugeyes survived better than walleyes in Bode Pond during fall 2000. In all other lakes survival of both percids was very low. For the 1999 cohorts, relative survival of walleyes was significantly higher in Lake Iroquois during spring 2000 and in Hanson Lake during fall 2000. Saugeye CPUE in Bode Pond during fall 2000 was significantly greater than the walleye CPUE; however, both catch rates were very low. Survival of both percids in Hayes and Jones Lakes was very low, likely due to competition with and predation by abundant largemouth bass populations. The lack of percid survival in Lake Iroquois appeared linked to summer mortality. Overall, survival of stocked walleyes and saugeyes was low in all study impoundments, with the exception of the introductory stocking in Bode Pond, which produced a high-density percid fishery. Relative growth of walleyes and saugeyes was inconsistent among waters, but was generally similar within each lake for the 1997 year class. Where sympatric populations developed, percid growth always favored walleyes for the 1998 and 1999 year classes. Percid condition was also variable among lakes, but was usually similar within each lake for all year classes. Overall, neither percid demonstrated a substantial advantage in performance in small South Dakota impoundments. Panfish community effects were evaluated in Jones and Hanson lakes. In Jones Lake, the only substantial panfish community effect that may have been caused by stocked percids was the reduction of yellow perch Perea flavescens abundance and the substantial increase in the bluegill Leoomis macrochirus abundance. Such a pronounced shift was most likely a result of selective predation for yellow perch by walleye and saugeye. However, an increase in the largemouth bass population during this study reduced the ability to attribute changes in the panfish community directly to stocked percids. In Hanson Lake, competing predator populations remained low throughout the study, indicating that observed changes in the panfish community were likely a result of predation by the stocked percids. The PSD of all panfish species showed significant improvements between 1997 (pre-stocking) and 2000 (post-stocking). The incremental growth rates of bluegills and black crappies Pomoxis nigromaculatus also exhibited significant increases between 1997 and 2000. These trends indicate that the stocked percids, through increased predation, were able to improve the size structure and growth of panfish in Hanson Lake

A Microscopic Energy- and Density-Dependent Effective Interaction and its Test by Nucleus-Nucleus Scattering

An effective nucleon-nucleon interaction calculated in nuclear matter from the Bonn potential has been parametrized in terms of a local density- and energy-dependent two-body interaction. This allows to calculate the real part of the nucleus-nucleus scattering potential and to test this effective interaction over a wide region of densities ($\rho \leq 3\rho_0$) produced dynamically in scattering experiments. Comparing our calculations with empirical potentials extracted from data on light and heavy ion scattering by model-unrestricted analysis methods, we find quantitative agreement with the exception of proton scattering. The failure in this case may be traced back to the properties of the effective interaction at low densities, for which the nuclear matter results are not reliable. The success of the interaction at high overlap densities confirms the empirical evidence for a soft equation of state for cold nuclear matter.Comment: 8 pages 3 Figures included, to appear in Phys. Lett.

A systematic review of the safety of lisdexamfetamine dimesylate

BACKGROUND: Here we review the safety and tolerability profile of lisdexamfetamine dimesylate (LDX), the first long-acting prodrug stimulant for the treatment of attention-deficit/hyperactivity disorder (ADHD). METHODS: A PubMed search was conducted for English-language articles published up to 16 September 2013 using the following search terms: (lisdexamfetamine OR lisdexamphetamine OR SPD489 OR Vyvanse OR Venvanse OR NRP104 NOT review [publication type]). RESULTS: In short-term, parallel-group, placebo-controlled, phase III trials, treatment-emergent adverse events (TEAEs) in children, adolescents, and adults receiving LDX were typical for those reported for stimulants in general. Decreased appetite was reported by 25-39 % of patients and insomnia by 11-19 %. The most frequently reported TEAEs in long-term studies were similar to those reported in the short-term trials. Most TEAEs were mild or moderate in severity. Literature relating to four specific safety concerns associated with stimulant medications was evaluated in detail in patients receiving LDX. Gains in weight, height, and body mass index were smaller in children and adolescents receiving LDX than in placebo controls or untreated norms. Insomnia was a frequently reported TEAE in patients with ADHD of all ages receiving LDX, although the available data indicated no overall worsening of sleep quality in adults. Post-marketing survey data suggest that the rate of non-medical use of LDX was lower than that for short-acting stimulants and lower than or equivalent to long-acting stimulant formulations. Small mean increases were seen in blood pressure and pulse rate in patients receiving LDX. CONCLUSIONS: The safety and tolerability profile of LDX in individuals with ADHD is similar to that of other stimulants

A team approach to the indication for gender reassignment surgery in transsexuals resulting in long-term outcome improvement

At the University of Basel (Switzerland), a multidisciplinary team was established for pre-operative selection and treatment of patients with gender dysphoria. As a result, the indications for surgical gender reassignment could be judged with considerably greater accuracy than previously possible. In the 9-year period of this prospective study only 14 of 57 patients with gender dysphoria were selected for surgical treatment. At the time of this survey, six patients are still under psychiatric preoperative evaluation, and six further male-to-female transsexuals are under hormonal treatment awaiting surgery. Following the operation, only one of nine male-to-female patients is socially unstable and that patient's quality of life is worse than prior to gender reassignment. Of the female-to-male transsexuals, all four are stable in their professional and family relations. In conclusion, a comprehensive evaluation of patients with gender dysphoria and the conclusive indications established within the team considerably improved the postoperative outcome of gender reassignmen

Efficacy of lisdexamfetamine dimesylate throughout the day in children and adolescents with attention-deficit/hyperactivity disorder:results from a randomized, controlled trial

Lisdexamfetamine dimesylate (LDX) is a long-acting, prodrug stimulant therapy for patients with attention-deficit/hyperactivity disorder (ADHD). This randomized placebo-controlled trial of an optimized daily dose of LDX (30, 50 or 70 mg) was conducted in children and adolescents (aged 6–17 years) with ADHD. To evaluate the efficacy of LDX throughout the day, symptoms and behaviors of ADHD were evaluated using an abbreviated version of the Conners’ Parent Rating Scale-Revised (CPRS-R) at 1000, 1400 and 1800 hours following early morning dosing (0700 hours). Osmotic-release oral system methylphenidate (OROS-MPH) was included as a reference treatment, but the study was not designed to support a statistical comparison between LDX and OROS-MPH. The full analysis set comprised 317 patients (LDX, n = 104; placebo, n = 106; OROS-MPH, n = 107). At baseline, CPRS-R total scores were similar across treatment groups. At endpoint, differences (active treatment − placebo) in least squares (LS) mean change from baseline CPRS-R total scores were statistically significant (P < 0.001) throughout the day for LDX (effect sizes: 1000 hours, 1.42; 1400 hours, 1.41; 1800 hours, 1.30) and OROS-MPH (effect sizes: 1000 hours, 1.04; 1400 hours, 0.98; 1800 hours, 0.92). Differences in LS mean change from baseline to endpoint were statistically significant (P < 0.001) for both active treatments in all four subscales of the CPRS-R (ADHD index, oppositional, hyperactivity and cognitive). In conclusion, improvements relative to placebo in ADHD-related symptoms and behaviors in children and adolescents receiving a single morning dose of LDX or OROS-MPH were maintained throughout the day and were ongoing at the last measurement in the evening (1800 hours)

Rapidly re-computable EEG (electroencephalography) forward models for realistic head shapes

Solution of the EEG source localization (inverse) problem utilizing model-based methods typically requires a significant number of forward model evaluations. For subspace based inverse methods like MUSIC [6], the total number of forward model evaluations can often approach an order of 10{sup 3} or 10{sup 4}. Techniques based on least-squares minimization may require significantly more evaluations. The observed set of measurements over an M-sensor array is often expressed as a linear forward spatio-temporal model of the form: F = GQ + N (1) where the observed forward field F (M-sensors x N-time samples) can be expressed in terms of the forward model G, a set of dipole moment(s) Q (3xP-dipoles x N-time samples) and additive noise N. Because of their simplicity, ease of computation, and relatively good accuracy, multi-layer spherical models [7] (or fast approximations described in [1], [7]) have traditionally been the 'forward model of choice' for approximating the human head. However, approximation of the human head via a spherical model does have several key drawbacks. By its very shape, the use of a spherical model distorts the true distribution of passive currents in the skull cavity. Spherical models also require that the sensor positions be projected onto the fitted sphere (Fig. 1), resulting in a distortion of the true sensor-dipole spatial geometry (and ultimately the computed surface potential). The use of a single 'best-fitted' sphere has the added drawback of incomplete coverage of the inner skull region, often ignoring areas such as the frontal cortex. In practice, this problem is typically countered by fitting additional sphere(s) to those region(s) not covered by the primary sphere. The use of these additional spheres results in added complication to the forward model. Using high-resolution spatial information obtained via X-ray CT or MR imaging, a realistic head model can be formed by tessellating the head into a set of contiguous regions (typically the scalp, outer skull, and inner skull surfaces). Since accurate in vivo determination of internal conductivities is currently not currently possible, the head is typically assumed to consist of a set of contiguous isotropic regions, each with constant conductivity

Gradijentna HPLC analiza raloksifen hidroklorida i primjena u kontroli kvalitete

A rapid, sensitive and selective method for the determination of raloxifene hydrochloride (RLX) in pure drug and in tablets was developed using gradient high performance liquid chromatography (HPLC). The devised method involved separation of RLX on a reversed phase Hypersil ODS column and determination with UV detection at 284 nm. The standard curve was linear (R = 0.999) over the concentration range of 50-600 μg mL1 with a detection limit of 0.04 μg mL1 and a quantification limit of 0.16 μg mL1. Intra-day and inter-day precision and accuracy of the method were established according to the current ICH guidelines. Intra-day RSD values at three QC levels (250, 450 and 550 μg mL1) were 0.20.5% based on the peak area. The intra-day relative error (er) was between 0.2 and 0.5%. The developed method was successfully applied to the determination of RLX in tablets and the results were statistically compared with those obtained by a literature method. Accuracy, evaluated by means of the spike recovery method, was excellent with percent recovery in the range 97.7103.2 with precision in the range 1.62.2%. No interference was observed from the conformulated substances. The method was economical in terms of the time taken and the amount of solvent used.Koristeći gradijentnu tekućinsku kromatografiju visoke učinkovitosti razvijena je brza, osjetljiva i selektivna metoda za određivanje raloksifen hidroklorida (RLX), čiste supstancije i u tabletama. U radu je primijenjena reverzno-fazna kolona Hypersil ODS te UV detekcija pri 284 nm. Standardna krivulja bila je linearna (R = 0,999) u koncentracijskom području 50600 μg mL1. Granica detekcije bila je 0,04 μg mL1 a granica određivanja 0,16 μg mL1. Repetabilnost, intermedijalna preciznost i ispravnost ispitivane su prema važećim ICH uputama. Mjerenjem površine ispod pika na tri koncentracijske razine (250, 450 i 550 μg mL1) procijenjena je repetabilnost na 0,20,5%. Relativna pogreška procijenjena unutar jednog dana (er) bila je između 0,2 i 0,5%. Razvijena metoda uspješno je primijenjena za određivanje RLX u tabletama. Rezultati su statistički uspoređeni s rezultatima dobivenim prema ranije objavljenoj metodi. Analitički povrat bio je u rasponu 97,7103,2 uz preciznost od 1,6 do 2,2%. Nije primijećena interferencija pomoćnih tvari. Metoda je ekonomična s obzirom na utrošeno vrijeme i količine upotrebljenog otapala

Određivanje donepezil hidroklorida u humanoj plazmi i ljekovitim oblicima pomoću HPLC s detekcijom fluorescencije

A sensitive, isocratic reversed-phase high performance liquid chromatographic method involving fluorescence detection was developed for the determination of donepezil hydrochloride in tablets and in human plasma. Pindolol was successfully used as an internal standard. Good chromatographic separation was achieved by using analytical column C18. The system operated at room temperature using a mobile phase consisting of methanol, phosphate buffer (0.02 mol L1) and triethyl amine (pH 3.5) (55: 45: 0.5 V/V/V) at a flow rate 0.9 mL min1. The analyte and internal standard were extracted from human plasma via liquid-liquid extraction. The proposed method was validated for selectivity, linearity, accuracy and precision. The calibration curve was linear over the range of 5-2000 ng mL1 of donepezil with detection limit of 1.5 ng mL1. Intra- and inter-day relative standard deviations were less than 2.5 %. The method was found to be suitable for the quality control of donepezil hydrochloride in bulk drug as well as in human plasma.Ovaj rad opisuje HPLC metodu određivanja donepezil hidroklorida (DP) u tabletama i u ljudskoj plazmi u nano području. Postavljena je osjetljiva metoda izokratične HPLC s fluorescencijskom detekcijom. Kao unutarnji standard upotrebljen je pindolol. Dobro kromatografsko odjeljivanje postignuto je primjenom analitičke kolone C18. Radna temperatura bila je sobna, a kao mobilna faza upotrebljena je smjesa metanola, fosfatnog pufera (0,02 mol L1) i trietilamina (pH 3,5) (55:45:0.5 V/V/V). Analit i unutarnji standard su ekstrahirani iz ljudske plazme ekstrakcijom tekuće-tekuće. Predložena metoda je validirana s obzirom na selektivnost, područje linearnosti, ispravnost i preciznost. Kalibracijska funkcija bila je linearna u području od 5-2000 ng mL1 donepezila, a granica detekcije iznosila je 2 ng mL1. Relativna standardna devijacija za repetabilnost i intermedijarnu preciznost bila je manja od 2,5 %. Metoda je primjenljliva u kontroli kvalitete ljekovitih formulacija s DP-om i u praćenju DP-a u ljudskoj plazmi

Continuous symmetry of C60 fullerene and its derivatives

Conventionally, the Ih symmetry of fullerene C60 is accepted which is supported by numerous calculations. However, this conclusion results from the consideration of the molecule electron system, of its odd electrons in particular, in a close-shell approximation without taking the electron spin into account. Passing to the open-shell approximation has lead to both the energy and the symmetry lowering up to Ci. Seemingly contradicting to a high-symmetry pattern of experimental recording, particularly concerning the molecule electronic spectra, the finding is considered in the current paper from the continuous symmetry viewpoint. Exploiting both continuous symmetry measure and continuous symmetry content, was shown that formal Ci symmetry of the molecule is by 99.99% Ih. A similar continuous symmetry analysis of the fullerene monoderivatives gives a reasonable explanation of a large variety of their optical spectra patterns within the framework of the same C1 formal symmetry exhibiting a strong stability of the C60 skeleton.Comment: 11 pages. 5 figures. 6 table