145 research outputs found
Cyclooxygenase-2 inhibition decreases primary and metastatic tumor burden in a murine model of orthotopic lung adenocarcinoma
AbstractObjectiveTo assess cyclooxygenase-2 inhibition on primary tumor and mediastinal metastases in a murine model of orthotopic lung adenocarcinoma.MethodsHuman lung adenocarcinoma cells (CRL5908, female nonsmoker with cyclooxygenase-2 expression by Western blot) were implanted under direct visualization through the parietal pleura in the upper lobe of the left lung (2 × 106 cells/animal) of SCID mice. Mice were randomly assigned to 2 groups, either untreated (n = 62) or celecoxib-treated (n = 60). Celecoxib, a selective cyclooxygenase-2 antagonist, was solubilized in the animals' drink (25 mg/kg per day). Mice were arbitrarily killed at 1, 2, 3, and 4 weeks. A blinded observer assessed primary tumor volume and metastatic disease grossly and histologically.ResultsGross metastatic lymph nodes were present at 3 weeks in none of 15 (0%) treated and 12 of 15 (80.0%) untreated animals (P < .0001). Mean primary tumor volumes at 3 weeks for treated mice were 7.9 ± 10.0 mm3 and for untreated mice were 533.1 ± 453.6 mm3 (mean ± SD, P < .0001). Gross metastatic lymph nodes were present at 4 weeks in 3 of 15 (20%) treated and 17 of 17 (100%) untreated animals (P < .0001). Mean primary tumor volumes at 4 weeks for treated mice were 37.1 ± 46.2 mm3 and for untreated mice were 809.6 ± 1226.4 mm3 (mean ± SD, P < .0001). Mean blood levels of celecoxib in treated mice were 236.8 ± 34.2 ng/mL (mean ± SD).ConclusionsCyclooxygenase-2 inhibition results in decreased primary and metastatic tumor burden in a murine model using human lung adenocarcinoma. Cyclooxygenase-2 inhibition has the potential to decrease tumor progression and metastases in patients with lung adenocarcinoma
Testing the Cosmological Constant as a Candidate for Dark Energy
It may be difficult to single out the best model of dark energy on the basis
of the existing and planned cosmological observations, because many different
models can lead to similar observational consequences. However, each particular
model can be studied and either found consistent with observations or ruled
out. In this paper, we concentrate on the possibility to test and rule out the
simplest and by far the most popular of the models of dark energy, the theory
described by general relativity with positive vacuum energy (the cosmological
constant). We evaluate the conditions under which this model could be ruled out
by the future observations made by the Supernova/Acceleration Probe SNAP (both
for supernovae and weak lensing) and by the Planck Surveyor cosmic microwave
background satellite.Comment: 6 pages, 2 figures, revtex
The Atacama Cosmology Telescope: Temperature and Gravitational Lensing Power Spectrum Measurements from Three Seasons of Data
We present the temperature power spectra of the cosmic microwave background
(CMB) derived from the three seasons of data from the Atacama Cosmology
Telescope (ACT) at 148 GHz and 218 GHz, as well as the cross-frequency spectrum
between the two channels. We detect and correct for contamination due to the
Galactic cirrus in our equatorial maps. We present the results of a number of
tests for possible systematic error and conclude that any effects are not
significant compared to the statistical errors we quote. Where they overlap, we
cross-correlate the ACT and the South Pole Telescope (SPT) maps and show they
are consistent. The measurements of higher-order peaks in the CMB power
spectrum provide an additional test of the Lambda CDM cosmological model, and
help constrain extensions beyond the standard model. The small angular scale
power spectrum also provides constraining power on the Sunyaev-Zel'dovich
effects and extragalactic foregrounds. We also present a measurement of the CMB
gravitational lensing convergence power spectrum at 4.6-sigma detection
significance.Comment: 21 pages; 20 figures, Submitted to JCAP, some typos correcte
Observational Bounds on Cosmic Doomsday
Recently it was found, in a broad class of models, that the dark energy
density may change its sign during the evolution of the universe. This may lead
to a global collapse of the universe within the time t_c ~ 10^{10}-10^{11}
years. Our goal is to find what bounds on the future lifetime of the universe
can be placed by the next generation of cosmological observations. As an
example, we investigate the simplest model of dark energy with a linear
potential V(\phi) =V_0(1+\alpha\phi). This model can describe the present stage
of acceleration of the universe if \alpha is small enough. However, eventually
the field \phi rolls down, V(\phi) becomes negative, and the universe
collapses. The existing observational data indicate that the universe described
by this model will collapse not earlier than t_c > 10 billion years from the
present moment. We show that the data from SNAP and Planck satellites may
extend the bound on the "doomsday" time to t_c > 40 billion years at the 95%
confidence level.Comment: 11 pages, 6 figures, revtex
Detection of the Power Spectrum of Cosmic Microwave Background Lensing by the Atacama Cosmology Telescope
We report the first detection of the gravitational lensing of the cosmic
microwave background through a measurement of the four-point correlation
function in the temperature maps made by the Atacama Cosmology Telescope. We
verify our detection by calculating the levels of potential contaminants and
performing a number of null tests. The resulting convergence power spectrum at
2-degree angular scales measures the amplitude of matter density fluctuations
on comoving length scales of around 100 Mpc at redshifts around 0.5 to 3. The
measured amplitude of the signal agrees with Lambda Cold Dark Matter cosmology
predictions. Since the amplitude of the convergence power spectrum scales as
the square of the amplitude of the density fluctuations, the 4-sigma detection
of the lensing signal measures the amplitude of density fluctuations to 12%.Comment: 4 pages, 4 figures, replaced title and author list with version
accepted by Physical Review Letters. Likelihood code can be downloaded from
http://bccp.lbl.gov/~sudeep/ACTLensLike.htm
The Atacama Cosmology Telescope: A Measurement of the Cosmic Microwave Background Power Spectrum at 148 and 218 GHz from the 2008 Southern Survey
We present measurements of the cosmic microwave background (CMB) power
spectrum made by the Atacama Cosmology Telescope at 148 GHz and 218 GHz, as
well as the cross-frequency spectrum between the two channels. Our results
clearly show the second through the seventh acoustic peaks in the CMB power
spectrum. The measurements of these higher-order peaks provide an additional
test of the {\Lambda}CDM cosmological model. At l > 3000, we detect power in
excess of the primary anisotropy spectrum of the CMB. At lower multipoles 500 <
l < 3000, we find evidence for gravitational lensing of the CMB in the power
spectrum at the 2.8{\sigma} level. We also detect a low level of Galactic dust
in our maps, which demonstrates that we can recover known faint, diffuse
signals.Comment: 19 pages, 13 figures. Submitted to ApJ. This paper is a companion to
Hajian et al. (2010) and Dunkley et al. (2010
The Atacama Cosmology Telescope: Data Characterization and Map Making
We present a description of the data reduction and mapmaking pipeline used
for the 2008 observing season of the Atacama Cosmology Telescope (ACT). The
data presented here at 148 GHz represent 12% of the 90 TB collected by ACT from
2007 to 2010. In 2008 we observed for 136 days, producing a total of 1423 hours
of data (11 TB for the 148 GHz band only), with a daily average of 10.5 hours
of observation. From these, 1085 hours were devoted to a 850 deg^2 stripe (11.2
hours by 9.1 deg) centered on a declination of -52.7 deg, while 175 hours were
devoted to a 280 deg^2 stripe (4.5 hours by 4.8 deg) centered at the celestial
equator. We discuss sources of statistical and systematic noise, calibration,
telescope pointing, and data selection. Out of 1260 survey hours and 1024
detectors per array, 816 hours and 593 effective detectors remain after data
selection for this frequency band, yielding a 38% survey efficiency. The total
sensitivity in 2008, determined from the noise level between 5 Hz and 20 Hz in
the time-ordered data stream (TOD), is 32 micro-Kelvin sqrt{s} in CMB units.
Atmospheric brightness fluctuations constitute the main contaminant in the data
and dominate the detector noise covariance at low frequencies in the TOD. The
maps were made by solving the least-squares problem using the Preconditioned
Conjugate Gradient method, incorporating the details of the detector and noise
correlations. Cross-correlation with WMAP sky maps, as well as analysis from
simulations, reveal that our maps are unbiased at multipoles ell > 300. This
paper accompanies the public release of the 148 GHz southern stripe maps from
2008. The techniques described here will be applied to future maps and data
releases.Comment: 20 pages, 18 figures, 6 tables, an ACT Collaboration pape
A measurement of the millimetre emission and the Sunyaev-Zel'dovich effect associated with low-frequency radio sources
We present a statistical analysis of the millimetre-wavelength properties of 1.4GHz-selected sources and a detection of the Sunyaev–Zel’dovich (SZ) effect associated with the haloes that host them. We stack data at 148, 218 and 277GHz from the Atacama Cosmology Telescope at the positions of a large sample of radio AGN selected at 1.4GHz. The thermal SZ effect associated with the haloes that host the AGN is detected at the 5σ level through its spectral signature, representing a statistical detection of the SZ effect in some of the lowest mass haloes (average M 200 ≈ 10 13 M. h −1 70 ) studied to date. The relation between the SZ effect and mass (based on weak lensing measurements of radio galaxies) is consistent with that measured by Planck for local bright galaxies. In the context of galaxy evolution models, this study confirms that galaxies with radio AGN also typically support hot gaseous haloes. Adding Herschel observations allows us to show that the SZ signal is not significantly contaminated by dust emission. Finally, we analyse the contribution of radio sources to the angular power spectrum of the cosmic microwave background
The Atacama Cosmology Telescope: Physical Properties and Purity of a Galaxy Cluster Sample Selected via the Sunyaev-Zel'dovich Effect
We present optical and X-ray properties for the first confirmed galaxy
cluster sample selected by the Sunyaev-Zel'dovich Effect from 148 GHz maps over
455 square degrees of sky made with the Atacama Cosmology Telescope. These
maps, coupled with multi-band imaging on 4-meter-class optical telescopes, have
yielded a sample of 23 galaxy clusters with redshifts between 0.118 and 1.066.
Of these 23 clusters, 10 are newly discovered. The selection of this sample is
approximately mass limited and essentially independent of redshift. We provide
optical positions, images, redshifts and X-ray fluxes and luminosities for the
full sample, and X-ray temperatures of an important subset. The mass limit of
the full sample is around 8e14 Msun, with a number distribution that peaks
around a redshift of 0.4. For the 10 highest significance SZE-selected cluster
candidates, all of which are optically confirmed, the mass threshold is 1e15
Msun and the redshift range is 0.167 to 1.066. Archival observations from
Chandra, XMM-Newton, and ROSAT provide X-ray luminosities and temperatures that
are broadly consistent with this mass threshold. Our optical follow-up
procedure also allowed us to assess the purity of the ACT cluster sample.
Eighty (one hundred) percent of the 148 GHz candidates with signal-to-noise
ratios greater than 5.1 (5.7) are confirmed as massive clusters. The reported
sample represents one of the largest SZE-selected sample of massive clusters
over all redshifts within a cosmologically-significant survey volume, which
will enable cosmological studies as well as future studies on the evolution,
morphology, and stellar populations in the most massive clusters in the
Universe.Comment: 20 pages, 15 figures, 6 tables. Accepted for publication in ApJ.
Higher resolution figures available at:
http://peumo.rutgers.edu/~felipe/e-prints
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