Association Of The Immature Platelet Fraction With Sepsis Diagnosis And Severity

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Management of Sepsis would greatly benefit from the incorporation of simple and informative new biomarkers in clinical practice. Ideally, a sepsis biomarker should segregate infected from non-infected patients, provide information about prognosis and organ-specific damage, and be accessible to most healthcare services. The immature platelet fraction (IPF) and immature reticulocyte fraction (IRF) are new analytical parameters of the complete blood count, that have been studied as biomarkers of several inflammatory conditions. Recently, a study performed in critically-ill patients suggested that IPF could be a more accurate sepsis biomarker than C-reactive protein (CRP) and procalcitonin. In this retrospective study we evaluated the performance of IPF and IRF as biomarkers of sepsis diagnosis and severity. 41 patients admitted to two intensive care units were evaluated, 12 of which with severe sepsis or septic shock, and 11 with non-complicated sepsis. Significantly higher IPF levels were observed in patients with severe sepsis/septic shock. IPF correlated with sepsis severity scores and presented the highest diagnostic accuracy for the presence of sepsis of all studied clinical and laboratory parameters. No significant differences were observed in IRF levels. Our results suggest that IPF levels could be used as a biomarker of sepsis diagnosis and severity.5Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq

Association of the immature platelet fraction with sepsis diagnosis and severity

Management of Sepsis would greatly benefit from the incorporation of simple and informative new biomarkers in clinical practice. Ideally, a sepsis biomarker should segregate infected from non-infected patients, provide information about prognosis and organ-specific damage, and be accessible to most healthcare services. The immature platelet fraction (IPF) and immature reticulocyte fraction (IRF) are new analytical parameters of the complete blood count, that have been studied as biomarkers of several inflammatory conditions. Recently, a study performed in critically-ill patients suggested that IPF could be a more accurate sepsis biomarker than C-reactive protein (CRP) and procalcitonin. In this retrospective study we evaluated the performance of IPF and IRF as biomarkers of sepsis diagnosis and severity. 41 patients admitted to two intensive care units were evaluated, 12 of which with severe sepsis or septic shock, and 11 with non-complicated sepsis. Significantly higher IPF levels were observed in patients with severe sepsis/septic shock. IPF correlated with sepsis severity scores and presented the highest diagnostic accuracy for the presence of sepsis of all studied clinical and laboratory parameters. No significant differences were observed in IRF levels. Our results suggest that IPF levels could be used as a biomarker of sepsis diagnosis and severity

Discursive relations in the religious satire attributed to Gregorio de Matos Guerra (1633-1696): figures and argumentative strategies

O objetivo desta pesquisa é apresentar as relações discursivas nas sátiras a religiosos atribuídas ao poeta baiano Gregório de Matos Guerra (1633-1696), com base na Teoria da Argumentação, a Nova Retórica, de Perelman e Tyteca, e na Retórica da Poesia, do Grupo , de Liège, que abrem espaço para a análise desses textos sem o condicionamento à sua forma versificada. O códice Rabelo, publicado em 1968 por James Amado apresenta em torno de oitenta sátiras contra religiosos. A escolha do corpus se deu em virtude do notável desafeto do enunciador em relação a padres, madres, frades e freiras. Dentro do gênero poético (epidítico), a sátira seiscentista visa não só ao entretenimento, mas à correção dos vícios. A obra satírica atribuída ao Boca do Inferno relata as desvirtudes da sociedade do Brasil-colônia, especialmente da comunidade religiosa católica. Pretendeu-se examinar as sátiras do ponto de vista do argumento e das figuras. A figura é considerada argumentativa quando provoca uma mudança de perspectiva, quando seu emprego parece normal em relação à nova situação sugerida. Perelman e Tyteca propõem a classificação das figuras como de escolha, presença e comunhão, de acordo com sua função na produção discursiva, uma vez que um mesmo recurso nem sempre provoca o mesmo efeito argumentativo. O Grupo estuda as figuras a partir das operações fundamentais que lhe dão origem e as classifica de acordo com o desvio produzido na expressão (metaplasmos e metataxes) ou no conteúdo (metassememas e metalogismos). Nesta pesquisa foram estudados principalmente os tropos, as figuras que implicam uma nova significação das palavras, evidenciando a relação de semelhança, correspondência, conexão e contrariedade. Dentre os tropos, a metáfora tem um papel especial porque é uma das bases da poesia de engenho e agudeza, do período chamado Barroco brasileiro. As análises apresentam o caráter argumentativo das sátiras e pretendem chegar à intenção do enunciador, ou seja, agradar e agir sobre os outros (fazer crer) por meio do discursoThe objective of this research is to present the discursive relations in the religious satire attributed to the poet from Bahia Gregorio de Matos Guerra (1633-1696), based on the Theory of Argumentation, the New Rhetoric, of Perelman and Tyteca, and the Rhetoric of the Poetry of the Group from Liège, which give us the opportunity to analyze these texts independent of their arrangement in verses.The codex Rabelo, published in 1968 by James Amado, has around eighty poems against the religious. The choice of the corpus had its reason in a notable hostility of the enunciator for priests, nuns, friars and monks. Within the poetic genre (epideictic), the seventeenth-century satire is intended not only to entertain, but to correct the immorality. The satirical work attributed to the \"Mouth of Hell\" narrates the misconduct of the society of colonial Brazil, especially the Catholic religious community. It was intended to examine the satire from the standpoint of the argument and figures. The figure is considered argumentative when it causes a perspective change, when its use seems to be normal in relation to the new situation suggested.Perelman and Tyteca propose a classification of figures as being of \"choice\", \"presence\" and \"communion\", according to their function in discourse production, accepting that the same occurrence does not always cause the same argumentative effect. The Group studies the figures from the fundamental operations that give rise to them and classifies them according to the deviation produced in the expression (metaplasms and metataxes) or content (metasememes and metalogisms).This research focused on the tropes, figures that imply a new meaning to words, evidencing the relationship of similarity, correspondence, connection and opposition. Among the tropes, metaphor has a special role because it is characteristic of the poetry of acuteness and ingeniousness, typical from the so called Brazilian Baroque period. Analyses show the argumentative nature of satire and are intended to reach the intention of the enunciator, that is, to please and have an effect on others (make believe) through discours