Long term dual antiplatelet therapy after myocardial infarction: retrospective analysis in an outpatient population

Long term treatment with ticagrelor 60 mg and low-dose aspirin are indicated after acute coronary syndrome (ACS). We retrospectively reviewed aggregate data of 187 patients (155 M and 38 F) (mean age 63.8±9 years) in follow up after ACS with at least one high risk condition (Multivessel disease, diabetes, GFR65 years) treated with ticagrelor 60 mg twice daily (after 90 mg twice daily for 12 months). The results were compared with findings (characteristics of the patients at baseline, outcomes, bleeding) of PEGASUS-TIMI 54 trial and Eu Label. The highrisk groups were represented as follows: multivessel disease 105 pts (82%), diabetes 63 pts (33%), GFR65 year aged 85 pts (45%). Treatment was withdrawn in 7 patients: 3 cases showed atrial fibrillation and were placed on oral anticoagulant drugs, one developed intracranial bleeding, in three patients a temporary withdrawal was due to surgery (1 colon polyposis and 2 cases of bladder papilloma). Chest pain without myocardial infarction occurred in 16 patients (revascularization was required in 9 patients). Dyspnea was present in 15 patients, but was not a cause for discontinuation of therapy. Long term treatment with ticagrelor 60 mg twice daily plus aspirin 100 mg/day showed a favourable benefit/risk profile after ACS. In this study all patients had been given ticagrelor 90 mg twice daily for 12 months and the 60 mg twice daily dosage was started immediately thereafter, unlike PEGASUS-TIMI 54 trial in which it was prescribed within a period ranging from 1 day to 1 year after discontinuation of the 90 mg dose. This makes our results more consistent with current clinical practice. However, a careful outpatient follow-up and constant counseling are mandatory to check out compliance to therapy and adverse side effects

Clinical Features, Cardiovascular Risk Profile, and Therapeutic Trajectories of Patients with Type 2 Diabetes Candidate for Oral Semaglutide Therapy in the Italian Specialist Care

Introduction: This study aimed to address therapeutic inertia in the management of type 2 diabetes (T2D) by investigating the potential of early treatment with oral semaglutide. Methods: A cross-sectional survey was conducted between October 2021 and April 2022 among specialists treating individuals with T2D. A scientific committee designed a data collection form covering demographics, cardiovascular risk, glucose control metrics, ongoing therapies, and physician judgments on treatment appropriateness. Participants completed anonymous patient questionnaires reflecting routine clinical encounters. The preferred therapeutic regimen for each patient was also identified. Results: The analysis was conducted on 4449 patients initiating oral semaglutide. The population had a relatively short disease duration (42%  60% of patients, and more often than sitagliptin or empagliflozin. Conclusion: The study supports the potential of early implementation of oral semaglutide as a strategy to overcome therapeutic inertia and enhance T2D management

IRAK-4 and MyD88 deficiencies impair IgM responses against T-independent bacterial antigens

IRAK-4 and MyD88 deficiencies impair interleukin 1 receptor and Toll-like receptor (TLR) signaling and lead to heightened susceptibility to invasive bacterial infections. Individuals with these primary immunodeficiencies have fewer immunoglobulin M (IgM)(+)IgD(+)CD27(+) B cells, a population that resembles murine splenic marginal zone B cells that mount T-independent antibody responses against bacterial antigens. However, the significance of this B-cell subset in humans is poorly understood. Using both a 610 carbohydrate array and enzyme-linked immunosorbent assay, we found that patients with IRAK-4 and MyD88 deficiencies have reduced serum IgM, but not IgG antibody, recognizing T-independent bacterial antigens. Moreover, the quantity of specific IgM correlated with IgM(+)IgD(+)CD27(+) B-cell frequencies. As with mouse marginal zone B cells, human IgM(+)CD27(+) B cells activated by TLR7 or TLR9 agonists produced phosphorylcholine-specific IgM. Further linking splenic IgM(+)IgD(+)CD27(+) B cells with production of T-independent IgM, serum from splenectomized subjects, who also have few IgM(+)IgD(+)CD27(+) B cells, had reduced antibacterial IgM. IRAK-4 and MyD88 deficiencies impaired TLR-induced proliferation of this B-cell subset, suggesting a means by which loss of this activation pathway leads to reduced cell numbers. Thus, by bolstering the IgM(+)IgD(+)CD27(+) B-cell subset, IRAK-4 and MyD88 promote optimal T-independent IgM antibody responses against bacteria in humans.status: publishe

Has VZV epidemiology changed in Italy? Results of a seroprevalence study

The aim of the study was to evaluate if and how varicella prevalence has changed in Italy. In particular a seroprevalence study was performed, comparing it to similar surveys conducted in pre-immunization era. During 2013–2014, sera obtained from blood samples taken for diagnostic purposes or routine investigations were collected in collaboration with at least one laboratory/center for each region, following the approval of the Ethics Committee. Data were stratified by sex and age. All samples were processed in a national reference laboratory by an immunoassay with high sensitivity and specificity. Statutory notifications, national hospital discharge database and mortality data related to VZV infection were analyzed as well. A total of 3707 sera were collected and tested. In the studied period both incidence and hospitalization rates decreased and about 5 deaths per year have been registered. The seroprevalence decreased in the first year of life in subjects passively protected by their mother, followed by an increase in the following age classes. The overall antibody prevalence was 84%. The comparison with surveys conducted with the same methodology in 1996–1997 and 2003–2004 showed significant differences in age groups 1–19 y. The study confirms that in Italy VZV infection typically occurs in children. The impact of varicella on Italian population is changing. The comparison between studies performed in different periods shows a significant increase of seropositivity in age class 1–4 years, expression of vaccine interventions already adopted in some regions

[Sero-epidemiology of VZV infection in Italy: impact evaluation of extensive vaccination]

Eight Italian Regions have begun offering vaccination against varicella to children aged 13-15 months, with a second dose at 5-6 years of age. A serosurvey was conducted to evaluate the impact of extensive vaccination in these "pilot" Regions

Proyecto Orlando : performance transdisciplinar

Actividad del Proyecto de Producción CePIAbierto 2019 “Proyecto Orlando” (RHCD 154/2019). Creación, producción y escenificación de una obra músico-teatral para coro e instrumentos musicales basada en la obra literaria "Orlando" (1928) de Virginia Woolf, a través del procedimiento de la Traducción Intersemiótica (Julio Plaza) y de un proceso de creación colectiva. Al igual que el biógrafo de Orlando, intentaremos contar las aventuras de este joven noble inglés nacido en el siglo XVI que vive más de trescientos años. En su paso por la historia, nuestro héroe atraviesa experiencias transformadoras que nos llenarán de muchas preguntas, algunas respuestas y mucha confusión.Performance transdisciplinar basada en la obra literaria "Orlando", de Virginia Woolf.Fil: Terráneo, Emiliano. Universidad Nacional de Córdoba. Facultad de Artes; Argentina.Fil: Yulitta, Mayra Luz. Universidad Nacional de Córdoba. Facultad de Artes; Argentina.Fil: Pisano, Santiago. Universidad Nacional de Córdoba. Facultad de Artes; Argentina.Fil: Orgaz, Agustina Nahir. Universidad Nacional de Córdoba. Facultad de Artes; Argentina.Fil: Fontanetto, Daniela. Universidad Nacional de Córdoba. Facultad de Artes; Argentina.Fil: González, Lucas Ezequiel. Universidad Nacional de Córdoba. Facultad de Artes; Argentina.Fil: Carvallo, Lorenzo. Universidad Nacional de Córdoba. Facultad de Artes; Argentina.Fil: Jaramillo, Lucas. Universidad Nacional de Córdoba. Facultad de Artes; Argentina.Fil: Fagiano, Lucas. Universidad Nacional de Córdoba. Facultad de Artes; Argentina.Fil: Fagiano, Gastón. Universidad Nacional de Córdoba. Facultad de Artes; Argentina.Fil: Courel, Belén. Universidad Nacional de Córdoba. Facultad de Artes; Argentina.Fil: Maglione, Maria Emilia. Universidad Nacional de Córdoba. Facultad de Artes; Argentina.Fil: Churquina Diaz, Gabriela. Universidad Nacional de Córdoba. Facultad de Artes; Argentina.Fil: Barnes Gormaz, Julia. Universidad Nacional de Córdoba. Facultad de Artes; Argentina.Fil: Velasco Curado, Agustina. Universidad Nacional de Córdoba. Facultad de Artes; Argentina.Fil: Díaz, Ana Victoria. Universidad Nacional de Córdoba. Facultad de Artes; Argentina.Fil: Badini, María Florencia. Universidad Nacional de Córdoba. Facultad de Artes; Argentina.Fil: Bordone Carranza, Florencia Sofía. Universidad Nacional de Córdoba. Facultad de Artes; Argentina.Fil: Boursiac, Ailén. Universidad Nacional de Córdoba. Facultad de Artes; Argentina.Fil: Sdihe Chaij, Camila. Universidad Nacional de Córdoba. Facultad de Artes; Argentina.Fil: Chazarreta, Rocío Carla. Universidad Nacional de Córdoba. Facultad de Artes; Argentina.Fil: Chiapero, Ana Laura. Universidad Nacional de Córdoba. Facultad de Artes; Argentina.Fil: Jaimez Novillo, Zaira. Universidad Nacional de Córdoba. Facultad de Artes; Argentina.Fil: Jobani, Ailin. Universidad Nacional de Córdoba. Facultad de Artes; Argentina.Fil: Martínez, Laura Daniela. Universidad Nacional de Córdoba. Facultad de Artes; Argentina.Fil: Martoglio, Alina. Universidad Nacional de Córdoba. Facultad de Artes; Argentina.Fil: Masino, Chiara. Universidad Nacional de Córdoba. Facultad de Artes; Argentina.Fil: Montenegro, María Pilar. Universidad Nacional de Córdoba. Facultad de Artes; Argentina.Fil: Moreira, Sofia Arianne. Universidad Nacional de Córdoba. Facultad de Artes; Argentina.Fil: Paz Mérida, Ana Lucía. Universidad Nacional de Córdoba. Facultad de Artes; Argentina.Fil: Robledo, Silvia Eliana. Universidad Nacional de Córdoba. Facultad de Artes; Argentina.Fil: Rojas, Azul Agostina. Universidad Nacional de Córdoba. Facultad de Artes; Argentina.Fil: Sargiotto, Carla. Universidad Nacional de Córdoba. Facultad de Artes; Argentina.Fil: Tavip, Valentina. Universidad Nacional de Córdoba. Facultad de Artes; Argentina.Fil: Varela Rinaldoni, Azul Dana. Universidad Nacional de Córdoba. Facultad de Artes; Argentina.Fil: Yulitta, Ayelen. Universidad Nacional de Córdoba. Facultad de Artes; Argentina.Fil: Jobani, Ailín. Universidad Nacional de Córdoba. Facultad de Artes; Argentina.Fil: Bordenabe, Carolina Ruth. Universidad Nacional de Córdoba. Facultad de Artes; Argentina.Fil: Ressio, Tadeo. Universidad Nacional de Córdoba. Facultad de Artes; Argentina.Fil: Sánchez, Pablo. Universidad Nacional de Córdoba. Facultad de Artes; Argentina.Fil: Bonanno, Sascha. Universidad Provincial de Córdoba. Facultad de Arte y Diseño. Escuela Superior Integral de Teatro Roberto Arlt; Argentina