Propuesta curricular para el desarrollo de habilidades socioemocionales en el área de tutoría en los estudiantes de tercer año de secundaria de una Institución Educativa de Lagunas, Loreto.

En el presente trabajo de investigación, el objetivo fue diseñar una propuesta curricular para el desarrollo de habilidades socioemocionales en el área de Tutoría en los estudiantes de tercer año de secundaria de una institución educativa de la ciudad de Lagunas, en la Región de Loreto. Los fundamentos teóricos están sustentados en el Paradigma Sociocognitivo Humanista. En un recorrido por sus principales representantes, se extrajeron sus aportes más valiosos. En la propuesta se plantea una programación compuesta de varias sesiones de aprendizaje para comprender la dimensión socioemocional propia y colectiva y desarrollar habilidades socioemocionales.In the present research work, the objective was to design a curricular proposal for the development of socio-emotional skills in the area of Tutoring in third-year secondary students of an educational institution in the city of Lagunas, in the Loreto Region. The theoretical foundations are based on the socio-cognitive humanist paradigm. In a tour of its main representatives, their most valuable contributions were extracted. The proposal proposes a program composed of several learning sessions to understand the socio-emotional and collective dimension and develop socio-emotional skills.Trabajo de suficiencia profesiona

Análisis De Las Solicitudes De Hemocomponentes en el Hospital Regional de Ica- Junio ? Diciembre 2017

El presente trabajo de Investigación descriptivo con diseño de investigación transversal, "Análisis De Las Solicitudes De Hemocomponentes en el Hospital Regional de Ica- Junio - Diciembre 2017".El estudio justificó con el análisis de la solicitudes de hemocomponentes en el Hospital Regional de Ica de junio a diciembre del 2017 en la cual se pretende demostrar la importancia de cumplir las Normas Internacionales y Nacionales de transfusión (PRONAHEBAS. Este análisis se realizo con una poblacion de 852 solicitudes y por conveniencia Se evaluó integralmente la situación de las solicitudes y emisión de hemocomponentes en el Banco de Sangre del Hospital Regional de Ica. Se emplearon herramientas especializadas de análisis de procesos de cumplimiento de la norma nacional vigente. Los mismos fueron clasificados, y analizadas.se revisaron todas las solicitudes de hemocomponentes, como resultados del análisis es importante para estimar un porcentaje inadecuado por encima del 70 % que no cumplen con los datos establecidos por la normas de PRONAHEBAS, nuestro estudio encontró mas del 70% de solicitudes inadecuadas y de acuerdo a la solicitud el profesional encargado no cumple con el correcto cargado y de esta manera se verifica una mala información en cuanto a los siempre importantes ítems como diagnóstico, hematocrito, edad, Hcl, sexo, anemia severa, entre otros. concluyendo que mas de 70% de errores verificados en este análisis. Esto evidencia la poca capacitación e información actualizada por parte de los profesionales médicos en temas de terapia transfusional, a pesar que a la fecha contamos con normas nacionales e internacionales donde se señala con claridad la adecuada y correcta formulación de la solicitud.Tesi

Bilingual Comics on the Border as Graphic Medicine: Journaling and Doodling for Dementia Caregiving during the COVID-19 Pandemic

The use of comics can be a powerful tool to expand educational outreach efforts for improving the health and well-being of people everywhere. Dr. Ian Williams coined the term graphic medicine to denote the use of comics in medical education and patient care ( Graphic Medicine ). Alzheimer\u27s disease affects approximately five million Americans and is expected to triple to 13.8 million by 2050. Hispanics and Blacks are disproportionately affected at a higher rate than other groups ( Facts and Figures ). There is a lack of culturally relevant educational materials available for these populations. To address this disparity, an interdisciplinary community engaged collaboration was initiated with the Alzheimer\u27s Association West Texas Chapter, The University of Texas at El Paso (UTEP), and Dukes Comics to produce a series of virtual workshops entitled, Journaling and Doodling for Stress Reduction and Relaxation for caregivers of people living with Alzheimer\u27s and other dementias. These sessions were live-streamed and began during the COVID-19 pandemic. Spanish sessions have also been provided to the public. Health information about the disease process and common caregiver challenges are provided in each session. A guided journaling and doodling activity are also included. Journaling has been shown to be an effective and easy tool to use for stress management (Scott). The impetus behind this project was to address the dire need for increasing access to Alzheimer\u27s disease education and resources in El Paso, Texas, a border community that is also home to Fort Bliss Army base. Hispanics comprise approximately 82% of the population and include a large Spanish-speaking segment. Language is often a barrier to health care access and education. To meet the aim of increasing accessibility, the workshops and comics are available in both English and Spanish and soon in-person. This project received a 2022 joint seed grant from Texas Tech University Health Sciences Center El Paso and UTEP to conduct research and examine data from these workshops that will be provided in-person in marginalized and multilingual Latina communities surrounding El Paso starting in the fall

Early Life Nutrition Modulates Muscle Stem Cell Number: Implications for Muscle Mass and Repair

Suboptimal nutrition during prenatal and early postnatal development is associated with increased risk for type 2 diabetes during adult life. A hallmark of such diabetes risk is altered body composition, including reduced lean mass and increased adiposity. Since stem cell number and activity are important determinants of muscle mass, modulation of perinatal nutrition could alter stem cell number/function, potentially mediating developmentally programmed reductions in muscle mass. Skeletal muscle precursors (SMP) were purified from muscle of mice subjected to prenatal undernutrition and/or early postnatal high-fat diet (HFD)—experimental models that are both associated with obesity and diabetes risk. SMP number was determined by flow cytometry, proliferative capacity measured in vitro, and regenerative capacity of these cells determined in vivo after muscle freeze injury. Prenatally undernutrition (UN) mice showed significantly reduced SMP frequencies [Control (C) $4.8\%\pm0.3\%$ (% live cells) vs. UN $3.2\%\pm0.4\%, P = 0.015$] at 6 weeks; proliferative capacity was unaltered. Reduced SMP in UN was associated with 32% decrease in regeneration after injury ($C 16\%\pm3\%$ of injured area vs. $UN 11\%\pm2\%; P < 0.0001$). SMP frequency was also reduced in HFD-fed mice (chow $6.4\%\pm0.6\% vs. HFD 4.7\% \pm0.4\%, P = 0.03$), and associated with $44\%$ decreased regeneration (chow $16\%\pm2.7\% vs. HFD 9\%\pm2.2\%; P < 0.0001$). Prenatal undernutrition was additive with postnatal HFD. Thus, both prenatal undernutrition and postnatal overnutrition reduce myogenic stem cell frequency and function, indicating that developmentally established differences in muscle-resident stem cell populations may provoke reductions in muscle mass and repair and contribute to diabetes risk.Stem Cell and Regenerative Biolog

Elaboración de un glosario terminológico económico bilingüe relacionado al impacto covid-19, Lima, 2020

La presente investigación tuvo como objetivo comprobar si el uso de un glosario terminológico económico bilingüe facilita la traducción de textos relacionados al impacto covid-19, Lima, 2020. Esta tesis fue de tipo aplicada, nivel descriptivo, enfoque mixto y diseño estrategia secuencial exploratoria. Se aplicaron dos técnicas de recolección de datos, el análisis de contenido y la encuesta, tales datos fueron recolectados en fichas terminológicas y cuestionarios. El corpus de la investigación fue Global Financial Stability Report: Markets in the Time of COVID-19 y los participantes fueron 10 traductores. El resultado general mostró que el glosario terminológico económico bilingüe estuvo compuesto por 6 elementos y que su elaboración sí facilitó la traducción de textos relacionados al impacto covid-19, al reducir el tiempo de esta labor en 13 minutos. De este modo, se concluyó que el uso de un glosario terminológico económico bilingüe, que incluya los 6 elementos propuestos en la presente investigación, fue esencial para facilitar la traducción de textos relacionados al impacto covid-1

La imagen y la narrativa como herramientas para el abordaje Psicosocial en escenarios de violencia en los Departamentos de Atlántico, Bolívar y Cesar (Región Caribe Colombiana).

El presente informe presenta una lectura de la producción académica lograda por este grupo, durante el desarrollo del Diplomado de profundización de Acompañamiento psicosocial en Escenarios de Violencia. El contenido del cursó permite al estudiante en formación una comprensión amplia de a la realidad social que ha vivido el país con situaciones de crisis y violencias, lo cual implica una mayor responsabilidad por parte del psicólogo en formación, sobre la manera de articular metodologías, teorías y estrategias en el momento de realizar acompañamientos en problemáticas psicosociales. Cada una de las diez unidades facilitan la comprensión de los escenarios de violencia, la dimensión psicosocial, a identificar los elementos simbólicos y subjetivos en fenómenos de violencia, la aplicación de la imagen y la narrativa como instrumentos de acción psicosocial y por último el estudiante analiza en hechos reales la perspectiva psicológica. Habría que resaltar que dentro de las actividades propuestas la obra Fragmentos de la artista colombiana Doris Salcedo muestra como las armas de la guerra se convierten en un contra monumento. De igual manera, el ejercicio realizado con la estrategia foto-voz, se convirtió en un verdadero escenario de lecturas de realidades en diferentes contextos y finalmente, los relatos con historias de violencia y esperanza; estas historias permiten, además, conocer la fortaleza de los sobrevivientes, de los resilientes y cómo las personas desarrollan la capacidad de potenciar recursos para el afrontamiento de las situaciones. Para concluir, es importante reconocer el gran apoyo de los recursos educativos brindados por el curso.This report presents the academic production achieved by this group, during the specialized course in psychosocial follow-up in Violent Scenarios. The content of the course allows the student a broad understanding of the social reality that the country has lived through situations of crisis and violence, which implies greater responsibility on the part of the psychologist in training, on the way to articulate methodologies, theories and strategies at the moment of making accompaniments in psychosocial problems. Each of the 10 units facilitates the understanding of the violence scenarios, the psychosocial dimension, to identify the symbolic and subjective elements in violent scenarios, the application of the image and the narrative as instruments of psychosocial action and finally, the student analyzes real events from a psychological perspective. It should be noted that within the proposed activities, the work Fragments by the Colombian artist Doris Salcedo shows how the weapons of war become a counter-monument, in the same way, the exercise was carried out using the photo-voice strategy, it became a true scenario of readings realities in different contexts and finally, the stories with stories of violence and hope; These stories also allow us to know the strength of the survivors, their resilience and how people develop the capacity to enhance resources for coping with situations. To conclude, it is important to recognize the great support of the educational resources provided by the course

An unbiased assessment of the role of imprinted genes in an intergenerational model of developmental programming.

Environmental factors during early life are critical for the later metabolic health of the individual and of future progeny. In our obesogenic environment, it is of great socioeconomic importance to investigate the mechanisms that contribute to the risk of metabolic ill health. Imprinted genes, a class of functionally mono-allelic genes critical for early growth and metabolic axis development, have been proposed to be uniquely susceptible to environmental change. Furthermore, it has also been suggested that perturbation of the epigenetic reprogramming of imprinting control regions (ICRs) may play a role in phenotypic heritability following early life insults. Alternatively, the presence of multiple layers of epigenetic regulation may in fact protect imprinted genes from such perturbation. Unbiased investigation of these alternative hypotheses requires assessment of imprinted gene expression in the context of the response of the whole transcriptome to environmental assault. We therefore analyse the role of imprinted genes in multiple tissues in two affected generations of an established murine model of the developmental origins of health and disease using microarrays and quantitative RT-PCR. We demonstrate that, despite the functional mono-allelicism of imprinted genes and their unique mechanisms of epigenetic dosage control, imprinted genes as a class are neither more susceptible nor protected from expression perturbation induced by maternal undernutrition in either the F1 or the F2 generation compared to other genes. Nor do we find any evidence that the epigenetic reprogramming of ICRs in the germline is susceptible to nutritional restriction. However, we propose that those imprinted genes that are affected may play important roles in the foetal response to undernutrition and potentially its long-term sequelae. We suggest that recently described instances of dosage regulation by relaxation of imprinting are rare and likely to be highly regulated

La imagen y la narrativa como herramientas para el abordaje psicosocial en escenarios de violencia. Departamentos Norte de Santander y Boyacá

tablas, figura, apendiceEste informe se enfoca en el análisis del capítulo 4 de "Historias que retornan de la Comisión de la Verdad", que relata la vida de Nelson, un exiliado colombiano forzado a abandonar su país debido a la violencia de grupos armados. Nelson, buscando una nueva vida, opta por reinventarse a través de un negocio de comida típica colombiana en su nuevo hogar. A pesar de enfrentar desconfianza y prejuicios, demuestra resiliencia al rechazar las etiquetas de "exiliado" o "víctima", centrando sus esfuerzos en la reconstrucción de su vida mediante el trabajo y la interacción social. El análisis emplea preguntas circulares, reflexivas y estratégicas para explorar a fondo la experiencia de Nelson, abordando desafíos al llegar al nuevo país, emociones ante la violencia sufrida y el impacto de la desconfianza en las relaciones interpersonales. Además, propone acciones para fomentar la integración entre exiliados y la comunidad receptora. El documento también examina la masacre en El Salado, evidenciando emergentes psicosociales antes y después del suceso, destacando la violencia, la falta de reparación, la resiliencia y la importancia de la solidaridad y la justicia. Finalmente, se analiza la experiencia en el diplomado, utilizando la foto voz para explorar y reflexionar sobre diversos entornos. Se destaca el poder de esta metodología para dar voz a realidades silenciadas, generando conciencia social y promoviendo la reflexión crítica y la acción transformadora. En conjunto, el informe ofrece una visión integral de las narrativas, abordando aspectos sociales, psicológicos y culturales en el análisis reflexivo del abordaje psicosocial.This report focuses on the analysis of Chapter 4 of "Stories Returning from the Truth Commission," which narrates the life of Nelson, a Colombian exile forced to leave his country due to the violence of armed groups. Seeking a new life, Nelson chooses to reinvent himself through a business of typical Colombian food in his new home. Despite facing mistrust and prejudice, he demonstrates resilience by rejecting the labels of "exile" or "victim," focusing his efforts on rebuilding his life through work and social interaction. The analysis employs circular, reflective, and strategic questions to thoroughly explore Nelson's experience, addressing challenges upon arriving in the new country, emotions in the face of suffered violence, and the impact of mistrust on interpersonal relationships. Additionally, it proposes actions to promote integration between exiles and the receiving community. The document also examines the massacre in El Salado, highlighting psychosocial emergents before and after the event, emphasizing violence, lack of reparation, resilience, and the importance of solidarity and justice. Finally, the experience in the diploma program is analyzed, using the photo voice to explore and reflect on various environments. The power of this methodology to give voice to silenced realities, generate social awareness, and promote critical reflection and transformative action is emphasized. Overall, the report provides a comprehensive view of the narratives, addressing social, psychological, and cultural aspects in the reflective analysis of the psychosocial approach

Clinical characteristics and outcome of drug-induced liver injury in the older patients: from the young-old to the oldest-old

Old patients with hepatotoxicity have been scarcely studied in idiosyncratic drug-induced liver injury (DILI) cohorts. We sought for the distinctive characteristics of DILI in older patients across age groups. A total of 882 DILI patients included in the Spanish DILI Registry (33% ≥65 years) were categorized according to age: “young” (<65y); “young-old” (65-74y); “middle-old” (75-84y); and “oldest-old” (≥85y). All elderly groups had increasingly higher comorbidity burden (p<0.001) and polypharmacy (p<0.001). There was a relationship between jaundice and hospitalization (p<0.001), and both were more prevalent in the elderly age groups, especially in the oldest-old (88% and 69%, respectively) and the DILI episode was more severe (p=0.029). The proportion of females decreased across age groups from the young to the middle-old, yet in the oldest-old there was a distinct female predominance. Pattern of liver injury shifted towards cholestatic with increasing age among top culprit drugs amoxicillin- clavulanate, atorvastatin, levofloxacin, ibuprofen, and ticlopidine. The best cut-off point for increased odds of cholestatic DILI was 65y. Older patients had increased non-liver related mortality (p=0.030) as shown by the predictive capacity of MELD (OR=1.116; p<0.001), and comorbidity burden (OR=4.188; p=0.001) in the 6-month mortality. Older patients with DILI exhibited an increasingly predominant cholestatic phenotype across a range of culprit drugs other that amoxicillin-clavulanate, with increased non-liver related mortality and require a different approach to predict outcome. The oldest DILI patients exhibited a particular phenotype with more severe DILI episodes and need to be considered when stratifying older DILI populations.The present study has been supported by grants of Instituto de Salud Carlos III cofounded by Fondo Europeo de Desarrollo Regional - FEDER (contract numbers: PI 18/01804; PT17/0017/0020) and Agencia Española del Medicamento. SCReN and CIBERehd are funded by ISCIII. JSC holds a Rio Hortega (CM17/00243) and MR a “Joan Rodes” (JR16/00015) research contract from the National Health System, ISCIII. RAW held a University of Málaga visiting scientist scholarship