Pharmacy Participation in Non-Prescription Syringe Sales in Los Angeles and San Francisco Counties, 2007

Increasing sterile syringe access for injection drug users (IDUs) is one way to prevent HIV and hepatitis C virus (HCV) transmission in this population. In 2005, California Senate Bill 1159 allowed counties to adopt the Disease Prevention Demonstration Project (DPDP). Where enacted, the DPDP allows pharmacies that register with the county to sell up to ten syringes to adults without a prescription. In the current study, we describe pharmacy participation in nonprescription syringe sales (NPSS) in two counties in California and examine factors associated with NPSS. Telephone and in-person interviews were conducted in Los Angeles (LA) and San Francisco (SF) with 238 pharmacies in 2007 (n = 67 in SF; n = 171 in LA). Quantitative survey items captured pharmacy registration with the county, pharmacy policies/practices, episodes and conditions of NPSS and refusals to sell, potential negative consequences of NPSS, and staff attitudes regarding HIV and HCV prevention for IDUs. Overall, 42% of pharmacies reported NPSS (28% in LA and 81% in SF), although only 34% had registered with the county (17% in LA and 76% in SF). Many pharmacies required proof of a medical condition (80% in LA and 30% in SF) and refused NPSS if the customer was a suspected IDU (74% in LA, 33% in SF). Few negative consequences of NPSS were reported. In multivariate logistic regression analysis, we found that the odds of NPSS were significantly higher among pharmacists who thought syringe access was important for preventing HIV among IDUs [adjusted odds ratio (AOR) = 2.95; 95% confidence interval (CI) = 1.10–7.92], were chain pharmacies (AOR = 12.5; 95% CI = 4.55–33.33), and were located in SF (AOR = 4.88; 95% CI = 1.94–12.28). These results suggest that NPSS were influenced by pharmacists’ perception. NPSS might be increased through greater educational efforts directed at pharmacists, particularly those in non-chain pharmacies

CHEMISTRY AND MINERALOGY OF THE MARGIN UNIT, JEZERO CRATER, MARS, OBSERVED BY M2020 / SUPERCAM

International audienceThe Margin Unit of Jezero crater, Mars, was identified from orbit as one of the most carbonate-rich regions of the planet [e.g., 1,2]. Its presence, along with the adjacent fluvial delta [e.g., 3] made Jezero crater the most compelling landing site for the Mars 2020 mission [4]. Investigation of Jezero’s Margin-Unit carbonates provides a unique opportunity to address the formation of carbonates in sedimentary deposits, possibly under a CO2-rich martian atmosphere. Here we report on chemistry and mineralogy of 55 targets observed by the multi-technique SuperCam instrument during Perseverance’s crater-margin campaign

CHEMISTRY AND MINERALOGY OF THE MARGIN UNIT, JEZERO CRATER, MARS, OBSERVED BY M2020 / SUPERCAM

International audienceThe Margin Unit of Jezero crater, Mars, was identified from orbit as one of the most carbonate-rich regions of the planet [e.g., 1,2]. Its presence, along with the adjacent fluvial delta [e.g., 3] made Jezero crater the most compelling landing site for the Mars 2020 mission [4]. Investigation of Jezero’s Margin-Unit carbonates provides a unique opportunity to address the formation of carbonates in sedimentary deposits, possibly under a CO2-rich martian atmosphere. Here we report on chemistry and mineralogy of 55 targets observed by the multi-technique SuperCam instrument during Perseverance’s crater-margin campaign

CHEMISTRY AND MINERALOGY OF THE MARGIN UNIT, JEZERO CRATER, MARS, OBSERVED BY M2020 / SUPERCAM

International audienceThe Margin Unit of Jezero crater, Mars, was identified from orbit as one of the most carbonate-rich regions of the planet [e.g., 1,2]. Its presence, along with the adjacent fluvial delta [e.g., 3] made Jezero crater the most compelling landing site for the Mars 2020 mission [4]. Investigation of Jezero’s Margin-Unit carbonates provides a unique opportunity to address the formation of carbonates in sedimentary deposits, possibly under a CO2-rich martian atmosphere. Here we report on chemistry and mineralogy of 55 targets observed by the multi-technique SuperCam instrument during Perseverance’s crater-margin campaign

CHEMISTRY AND MINERALOGY OF THE MARGIN UNIT, JEZERO CRATER, MARS, OBSERVED BY M2020 / SUPERCAM

International audienceThe Margin Unit of Jezero crater, Mars, was identified from orbit as one of the most carbonate-rich regions of the planet [e.g., 1,2]. Its presence, along with the adjacent fluvial delta [e.g., 3] made Jezero crater the most compelling landing site for the Mars 2020 mission [4]. Investigation of Jezero’s Margin-Unit carbonates provides a unique opportunity to address the formation of carbonates in sedimentary deposits, possibly under a CO2-rich martian atmosphere. Here we report on chemistry and mineralogy of 55 targets observed by the multi-technique SuperCam instrument during Perseverance’s crater-margin campaign

Compositionally and density stratified igneous terrain in Jezero crater, Mars

International audienceBefore Perseverance, Jezero crater’s floor was variably hypothesized to have a lacustrine, lava, volcanic airfall, or aeolian origin. SuperCam observations in the first 286 Mars days on Mars revealed a volcanic and intrusive terrain with compositional and density stratification. The dominant lithology along the traverse is basaltic, with plagioclase enrichment in stratigraphically higher locations. Stratigraphically lower, layered rocks are richer in normative pyroxene. The lowest observed unit has the highest inferred density and is olivine-rich with coarse (1.5 millimeters) euhedral, relatively unweathered grains, suggesting a cumulate origin. This is the first martian cumulate and shows similarities to martian meteorites, which also express olivine disequilibrium. Alteration materials including carbonates, sulfates, perchlorates, hydrated silicates, and iron oxides are pervasive but low in abundance, suggesting relatively brief lacustrine conditions. Orbital observations link the Jezero floor lithology to the broader Nili-Syrtis region,suggesting that density-driven compositional stratification is a regional characteristic

Antidepressive effects of targeting ELK-1 signal transduction

International audienceDepression, a devastating psychiatric disorder, is a leadingcause of disability worldwide. Current antidepressants addressspecific symptoms of the disease, but there is vast roomfor improvement1. In this respect, new compounds that actbeyond classical antidepressants to target signal transductionpathways governing synaptic plasticity and cellular resilienceare highly warranted2–4. The extracellular signal–regulatedkinase (ERK) pathway is implicated in mood regulation5–7, butits pleiotropic functions and lack of target specificity prohibitoptimal drug development. Here, we identified the transcriptionfactor ELK-1, an ERK downstream partner8, as a specificsignaling module in the pathophysiology and treatment ofdepression that can be targeted independently of ERK. ELK1mRNA was upregulated in postmortem hippocampal tissuesfrom depressed suicides; in blood samples from depressedindividuals, failure to reduce ELK1 expression was associatedwith resistance to treatment. In mice, hippocampal ELK-1 overexpressionper se produced depressive behaviors; conversely,the selective inhibition of ELK-1 activation prevented depression-like molecular, plasticity and behavioral states inducedby stress. Our work stresses the importance of target selectivityfor a successful approach for signal-transduction-basedantidepressants, singles out ELK-1 as a depression-relevanttransducer downstream of ERK and brings proof-of-conceptevidence for the druggability of ELK-1