Developing A Road Freight Transport Performance Measurement System To Drive Sustainability:An Empirical Study Of Egyptian Road Freight Transport Companies

While several road freight performance measurement systems have been developed, only a limited number of quantified performance measurement frameworks encompassing diverse sets of performance metrics from multiple sustainable perspectives are available on a technological platform. These sets of metrics could be integrated as crucial performance indicators for assessing the operational performance of various road freight transport companies. These indicators include fuel efficiency, trip duration, vehicle loading, and cargo capacity. The objective of this research is to construct a conceptual road freight performance measurement framework that comprehensively incorporates performance elements from sustainable viewpoints (economic, environmental, and social), leveraging technology to measure the performance of road freight transport companies. This proposed framework aims to aid these companies in gauging their performance using technology, thus enhancing their operations towards sustainability.Within the road freight transport sector, several challenges exist, with congestion, road infrastructure maintenance, and driver training and qualifications being particularly pressing issues. The developed performance measurement framework offers the means for companies to evaluate the effects of technology integration on vehicles and overall performance. This allows companies to measure their performance from an operational standpoint rather than solely a strategic one, thereby identifying areas requiring improvement. Egypt was chosen as the empirical study location due to its relatively low level of technological integration within its road freight sector.This thesis employs an explanatory mixed methods approach, encompassing four distinct phases. The first phase entails a review to formulate the proposed theoretical performance measurement framework. Subsequently, the second phase involves conducting semi-structured interviews using a Delphi method to both develop a conceptual performance measurement framework and explore the present state of Egypt's road freight transport sector. Following this, the third phase encompasses surveys based on the results derived from Delphi analysis, involving diverse participants from the road freight transport industry. The aim is to validate the developed performance measurement framework through an empirical study conducted in Egypt. Lastly, the fourth phase centres around organizing focus groups involving stakeholders within road freight transport companies. The goal here is to propose a roadmap for implementing the developed road freight transport performance measurement framework within the Egyptian context.The primary theoretical contribution of this research is the development of a road freight transport performance measurement framework that integrates the three sustainability dimensions with technology. Additionally, this study offers practical guidance for the application of the developed framework in various countries and contexts. From a practical standpoint, this research aids road freight transport managers in evaluating their operational performance, thereby identifying challenges, devising action plans, and making informed decisions to mitigate these issues and enhance sustainability-oriented performance. Ultimately, the developed road freight transport performance measurement framework is poised to promote performance measurement aligned with technology, fostering progress towards achieving the sustainable development goals by 2030

Prevalence and Risk Factors of Irritable Bowel Syndrome in Female Students of Faculty of Applied Medical Sciences from Umm Al Qura University

Irritable bowel syndrome (IBS) means that the bowel doesn't work or function correctly. This study aimed to determine the prevalence and factors affected irritable bowel syndrome among university students. The present study was carried out during the period from 1432 to 1433 AH among 200 female students. Data was collected through a interview questionnaire Rome III Diagnostic Questionnaires. The present study indicated that mean ± SE values of height, weight and BMI were not significant change in non- IBS and IBS students. The frequency distribution of IBS according to the family number, data showed that 4 %, 6%, 8% and 35% of students live with three, four, five and more than of five members had IBS, respectively. Data with regard to abdominal pain or discomfort in the last three months showed that 30 ,32, 40, 20, 31 and 17 students chooses less than 1d/m, 2 to 3 d/m, 1d/w, more than 1 d/w and every day, respectively. There were 7% was often feel discomfort and have less frequent bowel movement, 13% was feel discomfort in most of the time and have less frequent bowel movement and 6% was always feel discomfort and have less frequent bowel movement. Result showed that 21, 19 and 1% of IBS were eating one, two and three snack foods, respectively, while 7% were eating one, two and three meals out the home daily. Conclusion: Our results concluded that food habits, mother's education, snacks numbers, favorite method of cooking and awareness of food causes had effect on IBS. Keywords: Irritable bowel disorder – Causes– Syndrome – Criteria

Drug Repurposing in Dermatology: Molecular Biology and Omics Approach

The withdrawal of several blockbuster drugs due to severe adverse effects and the failure of several developed drugs in clinical trials raised questions about the efficacy of current approaches of drug discovery. Moreover, the limitation of resources and the long and costive process of drug discovery made a lot of pharmaceutical companies to employ drug repurposing strategies to get new insights about activities that were not considered during their initial discovery. The development of therapeutics for treatment of dermatological condition is not considered as priority although it affects the lifestyle of thousands of people around the world. Serendipity and observations have contributed significantly in this field but immerse efforts have been exerted to find systematic methods to identify new indications for drugs, especially with the unprecedented progress in molecular biology and omics. So, in this chapter, we will emphasize on different approaches used for drug repositioning and how it was applied to find new therapeutics for different dermatoses

Awareness of Basic Life Support among Egyptian Medical Students; a Cross-Sectional Study

Introduction: It is important for all medical and paramedical staff to be aware of basic life support (BLS) maneuvers. In this study, we aimed to evaluate the level of BLS awareness among Egyptian medical students.Methods: The level of BLS knowledge was assessed using a validated questionnaire and the results were analyzed using an answer key, prepared from the Advanced Cardiac Life Support (ACLS) manual. We used the Student's t-test to analyze the association between awareness level and year of study, previous BLS training and practical experience.Results: A total of 823 medical students with the mean age of 20.3 ± 2.7 years, from Al-Azhar medical schools completed the questionnaire (463 and 360 in academic and clinical years, respectively). About 72% and 84% of students failed to recognize the proper point of chest compression in adults and infants, respectively. Moreover, the majority (80%) did not know how to give rescue breathing in infants. Only 18% of students correctly identified early signs of shock and only 22% knew how to help patients with myocardial infarction. Being in clinical years, previous BLS training or practical experience were significantly associated with higher BLS knowledge scores (p < 0.001).Conclusion: The level of BLS awareness among Egyptian medical students is generally poor. Introduction of regular BLS courses into the undergraduate curriculum is a must to increase the level of BLS knowledge among Egyptian future physicians

Palmitoleic acid prevents palmitic acid-induced macrophage activation and consequent p38 MAPK-mediated-skeletal muscle insulin resistance

Obesity and saturated fatty acid (SFA) treatment are both associated with skeletal muscle insulin resistance (IR) and increased macrophage infiltration. However, the relative effects of SFA and unsaturated fatty acid (UFA)-activated macrophages on muscle are unknown. Here, macrophages were treated with palmitic acid, palmitoleic acid or both and the effects of the conditioned medium (CM) on C2C12 myotubes investigated. CM from palmitic acid-treated J774s (palm-mac-CM) impaired insulin signalling and insulin-stimulated glycogen synthesis, reduced Inhibitor κBα and increased phosphorylation of p38 mitogen-activated protein kinase (MAPK) and c-Jun N-terminal kinase in myotubes. p38 MAPK inhibition or siRNA partially ameliorated these defects, as did addition of tumour necrosis factor-α blocking antibody to the CM. Macrophages incubated with both FAs generated CM that did not induce IR, while palmitoleic acid-mac-CM alone was insulin sensitising. Thus UFAs may improve muscle insulin sensitivity and counteract SFA-mediated IR through an effect on macrophage activation

Effect of high-fat diet on the formation of pulmonary neutrophil extracellular traps during influenza pneumonia in BALB/c mice

Obesity is an independent risk factor for severe outcome of influenza infection. Higher dietary fat consumption has been linked to greater morbidity and severe influenza in mouse models. However, the extent of generation of neutrophil extracellular traps (NETs or NETosis) in obese individuals during influenza pneumonia is hitherto unknown. This study investigated pulmonary NETs generation in BALB/c mice fed with high-fat diet (HFD) and low-fat diet (LFD), during the course of influenza pneumonia. Clinical disease progression, histopathology, lung reactive oxygen species, and myeloperoxidase activity were also compared. Consumption of HFD over 18 weeks led to significantly higher body weight, body mass index, and adiposity in BALB/c mice compared with LFD. Lethal challenge of mice (on HFD and LFD) with influenza A/PR/8/34 (H1N1) virus led to similar body weight loss and histopathologic severity. However, NETs were formed at relatively higher levels in mice fed with HFD, despite the absence of significant difference in disease progression between HFD- and LFD-fed mice.Peer reviewedVeterinary Health Science

The macrophage at the intersection of immunity and metabolism in obesity

Obesity is a worldwide pandemic representing one of the major challenges that societies face around the globe. Identifying the mechanisms involved in its development and propagation will help the development of preventative and therapeutic strategies that may help control its rising rates