Determination of the deterioration mechanisms caused by seawater corrosion and freeze-thaw action of portland cement solidified and stabilized heavy metal wastes

The use of cement based processes for stabilization-solidification of heavy metal wastes has been extensively studied and characterized. Microstructural characterization of the waste matrix was conducted using X-ray diffraction analysis, scanning electron microscope, energy dispersive spectroscopy, mercury intrusion and helium displacement porosimetry. The physio-chemical characteristics of the solidified waste are affected by the metal type, cement binder, additives, solution to cementitious ratio, and curing regime. All the heavy metals (Cd, Pb, As, Cr) analyzed were detected in the CSH structure; Cr, Cd and As were detected in ettringite, and only Cd was detected in CH. Cd was the only metal detected in the crystalline form as cadmium hydroxide determined by XRD. All metals increased the total porosity and shifted the pore size distribution to the larger pores within the solidified matrix. Porosity and pore size distribution was not the only parameter affecting the unconfined compressive strength and leaching potential of the solidified waste. Different metal solidified wastes having similar pore characterization exhibited different strength and leaching characteristics. The seawater leachability of the solidified waste appears to be a function of the metal complex formed and the microstructural changes that occur. Magnesium hydroxide and carbonation of the surface layer affects the apparent surface porosity and permeability and the heavy metal release. Excessive expansion of the cadmium solidified waste leached in seawater was attributed to a combination of expansive ettringite formation and matrix weakening induced by softening of the CSH phase and gypsum formation. The combined presence of sulfate and chloride solutions is essential for a rapid cadmium waste deterioration as determined by the corrosion in sulfate and chloride solutions. The sonic method proved very successful as a non-destructive technique for evaluating the freeze-thaw durability of cement solidified heavy metal wastes. These cement solidified wastes have very poor resistance to repeated cycles of freezing and thawing. Destructive forces are created during freezing of water and are a combination of expansive, hydraulic and salt crystalization pressures. Air-entrainment improves freeze-thaw characteristics of the cement solidified waste as expected

326: Pulmonary embolysm and thrombolysis

ObjectiveTo determine the value, limitations and complications of thrombolysis in pulmonary embolism.Patients and methodsThis is a descriptive study of all patients admitted to the cardiology department of CHU Ibn Rushd from 2009 to 2011 with pulmonary embolism confirmed by echocardiography and chest CT angiography.ResultThese 68 patients with a mean age of 49 months or over 19 years with a female.The styles of pulmonary embolism vary widely with the management is different.5% of patients with pulmonary embolism occurs in cardiac arrest and fibrinolysis offers better benefits and has no indication cons.10 to 20% of pulmonary embolism with hemodynamic instability occurs PAS ≤ 90mmHg or respiratory distress Quick Installation fibrinolysis in these patients provides better clinical improvement and ultrasound.Pulmonary embolism at low risk and intermediate risk shows no indication for fibrinolysis using simple anticoagulation. The rate of cerebral hemorrhage is zero, 5 cases of gastrointestinal bleeding under control, intra-hospital overall mortality is about 7%.ConclusionThis series demonstrates the value of thrombolysis on the dissolution of stones in the pulmonary arteries and hemodynamic parameters as well as the reduction in mortality despite the slight increased risk of bleeding

Farmacocinética y eficacia de oxitetraciclina tras su administración intramuscular en bovino : depleción tisular /

Consultable des del TDXTítol obtingut de la portada digitalitzadaEl amplio uso de antibióticos en producción animal ha aportado sin duda un importante beneficio para la sanidad y el bienestar de los animales. Aunque, en los últimos años este uso ha sido objeto de duras críticas y presiones legales debido a la controversia originada entre el riesgo y el efecto beneficioso de estas sustancias. La oxitetraciclina, por su amplio espectro bacteriano y por su elevado uso tanto preventivo como terapéutico, se encuentra dentro del grupo de antibióticos que mayores críticas han recibido. Por su posible efecto perjudicial para la salud del consumidor y por su posible fallida de la eficacia nos ha conducido a estudiar en profundidad las características farmacocinéticas que presenta este fármaco después de su administración por vía intramuscular en bovino así como la evaluación de la eficacia del tratamiento y la posible presencia de residuos en los tejidos destinados al consumo. Para realizar el estudio cinético, se administró dos formulaciones comerciales oleosas a terneras de raza Frizona, de peso entre 125 y 130, por vía intramuscular a una dosis de 30 mg/kg, en las tablas del cuello, se tomaron muestras de plasma a diferentes tiempos de muestreo hasta 10 días postadministración y se analizaron por cromatografía liquida de alta eficacia (CLAE) y según un método analítico previamente validado. Se calcularon los parámetros farmacocinéticos siguientes: concentración máxima (Cmax, AUC, MRT, Tmax, T1/2?). Se evaluó la bioequivalencia de ambas especialidades utilizadas y finalmente se evaluó la eficacia terapéutica de este fármaco frente a diferentes microorganismos causantes del complejo respiratorio. Para realizar el estudio de residuos, se administró una formulación oleosa por vía intramuscular (30 mg/kg) a 12 terneras y se sacrificaron a diferentes tiempos (28, 35 y 42 días postadministración), se tomaron muestras de los diferentes tejidos diana y se analizaron por cromatografía líquida de alta eficacia y según un método analítico previamente validado y se calculó el tiempo de espera de esta especialidad. Los resultados del estudio de farmacocinética mostraron que ambas especialidades se correspondían a un perfil cinético de formulación retardada y los valores del t1/2? y el MRT obtenidos después de la administración de las dos especialidades ensayadas fueron significativamente altos, ajustándose el perfil cinético a un proceso de absorción de aplicar la estadística, ambas formulaciones demuestran que son bioequivalentes. Los estudios de eficacia demuestran que ambas formulaciones son eficaces frente a Micoplasma hyopneumoniae y Moraxella Boris. El tiempo de espera fue de 45.5 días para riñón y de 54,6 días para el hígado. No fue posible su cálculo en el caso del músculo y en el punto de inyección debido a que en el último tiempo de sacrificio realizado aún se observaron concentraciones por encima del límite máximo de residuos.The wide use of antibiotics in animal production has contributed an important benefit for the health and the well-being of animals. However, the use of antibiotics has been recently criticized and there have been legal pressures to avoid it, due to the lack of a clear relation between its beneficial effects and its risk. The oxytetracycline, because of its broad bacterial spectrum and its wide prevention and therapeutic use, is within the group of antibiotics that has been mostly criticized. The possible perjudicial effect on the health of the potential consumers and the possible lack of effectiveness, have encouraged us to study in detail the pharmacokinetics characteristics that this group of drugs present after its administration by intramuscular bovine route. We have studied as well the effectiveness of the treatment and the possible presence of residues in animal tissues intended for human consumption. In order to perform the kinetic study, we administered two commercial long acting formulations by intramuscular route at single doses of 30 mg/kg into to neck to 14 cows, whose weight was bet8ween 125 and 130 kg, We took samples from serum at different times from sampling up to 10 days post administration. Those samples were analyzed by high performed liquid chromatography (HPLC) and according to an analytic method previously validated. The following pharmacokinetics parameters were calculated: maximum concentration (Cmax), Area under curve (AUC), Mean residence time (MRT), maximum time (Tmax) and half life (T1/2). The bioequivalence between the two formulations used was evaluated and finally the therapeutic effectiveness of this drug in front of different microorganisms causing the respiratory diseases. In order to study the residues of oxytetracycline, we administered a long acting formulation by intramuscular route (30mg/kg) to 12 cows. The animals were then slaughtered at different times (28, 35 and 42 days following administration). Samples of the different target tissues (muscle, liver and kidney) were collected and they were analyzed using high performance liquid chromatograph in accordance with analytical method previously validated. The withdrawal period was calculated for this speciality. The results of the pharmacokinetic study showed that both formulations belonged to a kinetic profile of a long acting formulation and the values for the t1/2? and the MRT obtained after the administration were highly significant. It was shown that both formulations were bioequivalent. The effectiveness study showed that both formulations were effective against the Mycoplasme hyopneumoniae and Moraxella Boris. The withdrawal period was 45.5 days for the case of kidney and 54.6 days for the case of liver. It was not possible to calculate those values for the case of the muscle and in the injection site due to the presence of concentrations beyond the maximum limit of residues

Identification of centroids of Mohammed V airport arrivals.

This paper presents a flight trajectory data analytics framework for identifying spatial and temporal patterns in aircraft movement and providing a high-fidelity characterization of air traffic flows. The framework includes three modules : Collecting Data, Resampling trajectories, and Clustering air traffic flows at temporal and spacial scale. Different machine learning techniques are especially incorporated into the three modules to process aircraft trajectory data and enable the characterization of traffic flows

Probing DDM and ML quantum concepts in shape phase transitions of γ\gamma-unstable nuclei

In a recent paper (S. Ait El Korchi et al. 2020 EPL 132 52001), we explored, inside the context of Critical Point Symmetries (CPSs) X(3) and Z(4), a correlation between two exceedingly known quantum concepts, the Minimal Length (ML) and the Deformation-Dependent Mass (DDM), that are commonly applied in various areas of physics. Such a correlation has been strongly identified in transition nuclei by calculating some physical observables of that quantum system, like as energy spectra, moments of inertia and transition probabilities. In this paper we extend that study to E(5) dynamical symmetry corresponding to the shape phase transition U(5)$\leftrightarrow$O(6). The experimental realization of the models was found to occur in some nuclei, using the existing phenomenological potentials : Infinite Square Well, Davidson and Kratzer, whose models fits provide the best agreement. Importantly the calculations performed in this work using these potentials corroborate the fact that the revealed correlation between both quantum concepts is not destructively affected by the presence of other model parameters and hence its existence is independent of the form or type of the used potential. Undoubtedly, the present work will open the way for more investigations of this correlation in the limits of other critical points symmetries in nuclear shape phase transitions which play today a major role in nuclear structure research from theoretical as well as experimental point of view.Comment: 31 pages, 3 figures, accepted in Nuclear Physics

Urban and rural differences in needs, service use and satisfaction among caregivers of autistic children in Morocco

Education and Child Studie

Pharmacokinetic–pharmacodynamic integration and modelling of oxytetracycline for the calf pathogens Mannheimia haemolytica and Pasteurella multocida

A calf tissue cage model was used to study the pharmacokinetics (PK) and pharmacodynamics (PD) of oxytetracycline in serum, inflamed (exudate) and noninflamed (transudate) tissue cage fluids. After intramuscular administration, the PK was characterized by a long mean residence time of 28.3 hr. Based on minimum inhibitory concentrations (MICs) for six isolates each of Mannheimia haemolytica and Pasteurella multocida, measured in serum, integration of in vivo PK and in vitro PD data established area under serum concentration–time curve (AUC0–∞)/MIC ratios of 30.0 and 24.3 hr for M. haemolytica and P. multocida, respectively. Corresponding AUC0–∞/MIC ratios based on MICs in broth were 656 and 745 hr, respectively. PK-PD modelling of in vitro bacterial time–kill curves for oxytetracycline in serum established mean AUC0–24 hr/MIC ratios for 3log10 decrease in bacterial count of 27.5 hr (M. haemolytica) and 60.9 hr (P. multocida). Monte Carlo simulations predicted target attainment rate (TAR) dosages. Based on the potency of oxytetracycline in serum, the predicted 50% TAR single doses required to achieve a bacteriostatic action covering 48-hr periods were 197 mg/kg (M. haemolytica) and 314 mg/kg (P. multocida), respectively, against susceptible populations. Dosages based on the potency of oxytetracycline in broth were 25- and 27-fold lower (7.8 and 11.5 mg/kg) for M. haemolytica and P. multocida, respectively

Are You Still With Me? Continuous Engagement Assessment From a Robot's Point of View

Continuously measuring the engagement of users with a robot in a Human-Robot Interaction (HRI) setting paves the way toward in-situ reinforcement learning, improve metrics of interaction quality, and can guide interaction design and behavior optimization. However, engagement is often considered very multi-faceted and difficult to capture in a workable and generic computational model that can serve as an overall measure of engagement. Building upon the intuitive ways humans successfully can assess situation for a degree of engagement when they see it, we propose a novel regression model (utilizing CNN and LSTM networks) enabling robots to compute a single scalar engagement during interactions with humans from standard video streams, obtained from the point of view of an interacting robot. The model is based on a long-term dataset from an autonomous tour guide robot deployed in a public museum, with continuous annotation of a numeric engagement assessment by three independent coders. We show that this model not only can predict engagement very well in our own application domain but show its successful transfer to an entirely different dataset (with different tasks, environment, camera, robot and people). The trained model and the software is available to the HRI community, at https://github.com/LCAS/engagement_detector, as a tool to measure engagement in a variety of settings