Study of the Nonequilibrium Behavior of Complicated Spin-Valve Structure Described of Anisotropic Heisenberg Model

The Monte Carlo study of spin-valve magnetic structures with non-equilibrium behavior has been performed with the application of an anisotropic Heisenberg model to the description critical properties of ultrathin ferromagnetic layers. Revealed aging effects in magnetization behavior.Исследование выполнено при финансовой поддержке РФФИ, проект № 20-32-70189, Минобрнауки РФ (соглашение 0741-2020-0002) и гранта МД-2229.2020.2 Президента РФ

Extracellular, cell-permeable survivin inhibits apoptosis while promoting proliferative and metastatic potential

The tumour microenvironment is believed to be involved in development, growth, metastasis, and therapy resistance of many cancers. Here we show survivin, a member of the inhibitor of apoptosis protein (IAP) family, implicated in apoptosis inhibition and the regulation of mitosis in cancer cells, exists in a novel extracellular pool in tumour cells. Furthermore, we have constructed stable cell lines that provide the extracellular pool with either wild-type survivin (Surv-WT) or the previously described dominant-negative mutant survivin (Surv-T34A), which has proven pro-apoptotic effects in cancer cells but not in normal proliferating cells. Cancer cells grown in conditioned medium (CM) taken from Surv-WT cells absorbed survivin and experienced enhanced protection against genotoxic stresses. These cells also exhibited an increased replicative and metastatic potential, suggesting that survivin in the tumour microenvironment may be directly associated with malignant progression, further supporting survivin's function in tumourigenesis. Alternatively, cancer cells grown in CM taken from the Surv-T34A cells began to apoptose through a caspase-2- and caspase-9-dependent pathway that was further enhanced by the addition of other chemo- and radiotherapeutic modalities. Together our findings suggest a novel microenvironmental function for survivin in the control of cancer aggressiveness and spread, and should result in the genesis of additional cancer treatment modalities

Скейлинговое поведение сложных низкоразмерных спиновых систем

We studied the non-equilibrium properties of spin-valve structures like a main elements of spintronics. We observed the aging effects in non-equilibrium critical behavior like a two-time dependence of measurement quantities: waiting time and observation time. The other essential property of ageing systems is dynamic scaling which we detected in our systemsИзучены неравновесные свойства спин-вентильных структур как основных элементов спинтроники. Эффекты старения были обнаружены в неравновесном критическом поведении в виде двувременной зависимости измеряемых величин: времени ожидания и времени наблюдения. Другим важным свойством стареющих систем является динамическое масштабирование, которое было обнаружено в рассматриваемых система