Constraints on (Omega_m,Omega_Lambda) using distributions of inclination angles for high redshift filaments

In this paper we present a scale free method to determine the cosmological parameters (Omega_m, Omega_Lambda). The method is based on the requirement of isotropy of the distribution of orientations of cosmological filaments. The current structure formation paradigm predicts that the first structures to form are voids and filaments, causing a web-like structure of the matter distribution at high redshifts. Recent observational evidence suggests that the threads, or filaments, of the cosmic web most easily are mapped in Ly-alpha emission. We describe how such a 3D map can be used to constrain the cosmological parameters in a way which, contrary to most other cosmological tests, does not require the use of a standard rod or a standard candle. We perform detailed simulations in order to define the optimal survey parameters for the definition of an observing programme aimed to address this test, and to investigate how statistical and observational errors will influence the results. We conclude that observations should target filaments of comoving size 15-50 Mpc in the redshift range 2-4, and that each filament must be defined by at least four Ly-alpha emitters. Detection of 20 filaments will be sufficient to obtain a result, while 50 filaments will make it possible to place significant new constraints on the values of Omega_m and Omega_Lambda permitted by the current supernova observations. In a future paper we study how robust these conclusions are to systematic velocities in the survey box.Comment: 8 pages, 6 figures, accepted for publication in A&

Genomic analyses of the microsporidian Nosema ceranae, an emergent pathogen of honey bees

Recent steep declines in honey bee health have severely impacted the beekeeping industry, presenting new risks for agricultural commodities that depend on insect pollination. Honey bee declines could reflect increased pressures from parasites and pathogens. The incidence of the microsporidian pathogen Nosema ceranae has increased significantly in the past decade. Here we present a draft assembly (7.86 MB) of the N. ceranae genome derived from pyrosequence data, including initial gene models and genomic comparisons with other members of this highly derived fungal lineage. N. ceranae has a strongly AT-biased genome (74% A+T) and a diversity of repetitive elements, complicating the assembly. Of 2,614 predicted protein-coding sequences, we conservatively estimate that 1,366 have homologs in the microsporidian Encephalitozoon cuniculi, the most closely related published genome sequence. We identify genes conserved among microsporidia that lack clear homology outside this group, which are of special interest as potential virulence factors in this group of obligate parasites. A substantial fraction of the diminutive N. ceranae proteome consists of novel and transposableelement proteins. For a majority of well-supported gene models, a conserved sense-strand motif can be found within 15 bases upstream of the start codon; a previously uncharacterized version of this motif is also present in E. cuniculi. These comparisons provide insight into the architecture, regulation, and evolution of microsporidian genomes, and will drive investigations into honey bee-Nosema interactions

Variable polarization in the optical afterglow of GRB 021004

We present polarimetric observations of the afterglow of gamma-ray burst (GRB) 021004, obtained with the Nordic Optical Telescope (NOT) and the Very Large Telescope (VLT) between 8 and 17 hours after the burst. Comparison among the observations shows a 45 degree change in the position angle from 9 hours after the burst to 16 hours after the burst, and comparison with published data from later epochs even shows a 90 degree change between 9 and 89 hours after the burst. The degree of linear polarization shows a marginal change, but is also consistent with being constant in time. In the context of currently available models for changes in the polarization of GRBs, a homogeneous jet with an early break time of t_b ~ 1 day provides a good explanation of our data. The break time is a factor 2 to 6 earlier than has been found from the analysis of the optical light curve. The change in the position angle of the polarization rules out a structured jet model for the GRB.Comment: 5 pages, 2 figures. Published in A&A letter

The empirical basis for modelling glacial erosion rates

Glaciers are highly effective agents of erosion that have profoundly shaped Earth’s surface, but there is uncertainty about how glacial erosion should be parameterised in landscape evolution models. Glacial erosion rate is usually modelled as a function of glacier sliding velocity, but the empirical basis for this relationship is weak. In turn, climate is assumed to control sliding velocity and hence erosion, but this too lacks empirical scrutiny. Here, we present statistically robust relationships between erosion rates, sliding velocities, and climate from a global compilation of 38 glaciers. We show that sliding is positively and significantly correlated with erosion, and derive a relationship for use in erosion models. Our dataset further demonstrates that the most rapid erosion is achieved at temperate glaciers with high mean annual precipitation, which serve to promote rapid sliding. Precipitation has received little attention in glacial erosion studies, but our data illustrate its importance

Dissolved noble gases and stable isotopes as tracers of preferential fluid flow along faults in the Lower Rhine Embayment, Germany

Groundwater in shallow unconsolidated sedimentary aquifers close to the Bornheim fault in the Lower Rhine Embayment (LRE), Germany, has relatively low δ2H and δ18O values in comparison to regional modern groundwater recharge, and 4He concentrations up to 1.7 × 10−4 cm3 (STP) g–1 ± 2.2 % which is approximately four orders of magnitude higher than expected due to solubility equilibrium with the atmosphere. Groundwater age dating based on estimated in situ production and terrigenic flux of helium provides a groundwater residence time of ∼107 years. Although fluid exchange between the deep basal aquifer system and the upper aquifer layers is generally impeded by confining clay layers and lignite, this study’s geochemical data suggest, for the first time, that deep circulating fluids penetrate shallow aquifers in the locality of fault zones, implying  that sub-vertical fluid flow occurs along faults in the LRE. However, large hydraulic-head gradients observed across many faults suggest that they act as barriers to lateral groundwater flow. Therefore, the geochemical data reported here also substantiate a conduit-barrier model of fault-zone hydrogeology in unconsolidated sedimentary deposits, as well as corroborating the concept that faults in unconsolidated aquifer systems can act as loci for hydraulic connectivity between deep and shallow aquifers. The implications of fluid flow along faults in sedimentary basins worldwide are far reaching and of particular concern for carbon capture and storage (CCS) programmes, impacts of deep shale gas recovery for shallow groundwater aquifers, and nuclear waste storage sites where fault zones could act as potential leakage pathways for hazardous fluids

CD10 is a marker for cycling cells with propensity to apoptosis in childhood ALL

CD10 constitutes a favourable prognostic marker for childhood acute lymphoblastic leukaemia. Since correlations between CD10, cell cycle and apoptotic abilities were demonstrated in various cell types, we investigated whether differences existed in the cycling/apoptotic abilities of CD10-positive and CD10-negative B acute lymphoblastic leukaemia cells. Twenty-eight cases of childhood acute lymphoblastic leukaemia (mean age of 6.8 years) were subdivided into two groups according to high (17 cases, 93.2±4.5%, MRFI 211±82 CD10-positive cells) or low (11 cases, 11.5±6.2%, MRFI 10±7 CD10-negative cells) expression of CD10. CD10-positive acute lymphoblastic leukaemia cells were cycling cells with elevated c-myc levels and propensity to apoptosis, whereas CD10-negative acute lymphoblastic leukaemia cells had lower cycling capacities and c-myc levels, and were resistant to apoptosis in vitro. A close correlation between all these properties was demonstrated by the observations that the few CD10-positive cells found in the CD10-negative acute lymphoblastic leukaemia group displayed elevated c-myc and cycling capacities and were apoptosis prone. Moreover, exposure of CD10-positive acute lymphoblastic leukaemia B cells to a peptide nucleic acid anti-gene specific for the second exon of c-myc caused inhibition of c-myc expression and reduced cell cycling and apoptotic abilities as well as decreased CD10 expression

Deep Ly-alpha imaging of two z=2.04 GRB host galaxy fields

We report on the results of deep narrow-band Ly-alpha, U and I imaging of the fields of two GRBs at z=2.04 (GRB 000301C and GRB 000926). We find that the host galaxy of GRB 000926 is an extended, strong Ly-alpha emitter with a rest-frame equivalent width of 71+20-15 AA. The galaxy consists of two main components and several fainter knots. GRB 000926 occurred in the western component, whereas most of the Ly-alpha luminosity (about 65%) originates in the eastern component. Using archival HST images of the host galaxy we measure the spectral slopes (f_lambda prop. to lambda^beta) of the two components to beta = -2.4+-0.3 (east) and -1.4+-0.2 (west). This implies that both components contain at most small amounts of dust, consistent with the observed strong Ly-alpha emission. The western component has a slightly redder V-I colour than the eastern component, suggesting the presence of at least some dust. We do not detect the host galaxy of GRB 000301C in neither Ly-alpha emission nor in U and I-band images. We infer a limit of U(AB)>27.7 (2-sigma limit per arcsec^2). The upper limits on the Ly-alpha flux implies a Ly-alpha equivalent width upper limit of 150AA. We find 11 and 8 other galaxies with excess emission in the narrow filter in the fields of GRB 000301C and GRB 000926 respectively. Based on these detections we conclude that GRB 000926 occurred in one of the strongest centres of star formation within several Mpc, whereas GRB 000301C occurred in an intrinsically very faint galaxy far from being the strongest centre of star formation in its galactic environment. Under the hypothesis that GRBs trace star formation, the wide range of GRB host galaxy luminosities implies a very steep faint end slope of the high redshift galaxy luminosity function.Comment: 13 pages, 7 figures. Accepted for publication in A&

Diversity of human copy number variation and multicopy genes

Copy number variants affect both disease and normal phenotypic variation, but those lying within heavily duplicated, highly identical sequence have been difficult to assay. By analyzing short-read mapping depth for 159 human genomes, we demonstrated accurate estimation of absolute copy number for duplications as small as 1.9 kilobase pairs, ranging from 0 to 48 copies. We identified 4.1 million singly unique nucleotide positions informative in distinguishing specific copies and used them to genotype the copy and content of specific paralogs within highly duplicated gene families. These data identify human-specific expansions in genes associated with brain development, reveal extensive population genetic diversity, and detect signatures consistent with gene conversion in the human species. Our approach makes ∼1000 genes accessible to genetic studies of disease association