Simultaneous Nasopharyngeal Carriage of Two Pneumococcal Multilocus Sequence Types with a Serotype 3 Phenotype

Knowledge of the epidemiology of pneumococcal disease in Bolivia is sparse, and Multilocus Sequence Typing (MLST) of isolates has not been previously possible. Beni state has until recently been a geographically isolated region of the Bolivian Amazon basin and is a region of significant poverty. During June and July 2007, we performed a pneumococcal carriage study recruiting over 600 schoolchildren in two towns in the Beni state. Here, we describe the unique identification of simultaneous nasopharyngeal carriage of two pneumococcal multilocus sequence types with a serotype 3 phenotype within a single subject

Mathematical modeling of cell population dynamics in the colonic crypt and in colorectal cancer

Colorectal cancer is initiated in colonic crypts. A succession of genetic mutations or epigenetic changes can lead to homeostasis in the crypt being overcome, and subsequent unbounded growth. We consider the dynamics of a single colorectal crypt by using a compartmental approach [Tomlinson IPM, Bodmer WF (1995) Proc Natl Acad Sci USA 92: 11130-11134], which accounts for populations of stem cells, differential cells, and transit cells. That original model made the simplifying assumptions that each cell popuation divides synchronously, but we relax these assumptions by adopting an age-structured approach that models asynchronous cell division, and by using a continuum model. We discuss two mechanims that could regulate the growth of cell numbers and maintain the equilibrium that is normally observed in the crypt. The first will always maintain an equilibrium for all parameter values, whereas the second can allow unbounded proliferation if the net per capita growth rates are large enough. Results show that an increase in cell renewal, which is equivalent to a failure of programmed cell death or of differentiation, can lead to the growth of cancers. The second model can be used to explain the long lag phases in tumor growth, during which news, higher equilibria are reached, before unlimited growth in cell number ensues

Effect of planting date and seed treatment on diseases and insect pests of wheat

The Oklahoma Cooperative Extension Service periodically issues revisions to its publications. The most current edition is made available. For access to an earlier edition, if available for this title, please contact the Oklahoma State University Library Archives by email at [email protected] or by phone at 405-744-6311

Hessian fly management in Oklahoma winter wheat

The Oklahoma Cooperative Extension Service periodically issues revisions to its publications. The most current edition is made available. For access to an earlier edition, if available for this title, please contact the Oklahoma State University Library Archives by email at [email protected] or by phone at 405-744-6311

Dilemmatic human-animal boundaries in Britain and Romania: Post-materialist and materialist dehumanization

This is the post-print version of the Article. The official published version can be accessed from the link below - Copyright @ 2007 The British Psychological SocietyTheories of dehumanization generally assume a single clear-cut, value-free and non-dilemmatic boundary between the categories ‘human’ and ‘animal.’ The present study highlights the relevance of dilemmas involved in drawing that boundary. In 6 focus groups carried out in Romania and Britain, 42 participants were challenged to think about dilemmas pertaining to animal and human life. Four themes were identified: rational autonomy, sentience, speciesism, and maintaining materialist and postmaterialist values. Sentience made animals resemble humans, while humans’ rational autonomy made them distinctive. Speciesism underlay the human participants’ prioritization of their own interests over those of animals, and a conservative consensus that the existing social system could not change supported this speciesism when it was challenged. Romanian participants appealed to Romania’s lack of modernity and British participants to Britain’s modernity to justify such conservatism. The findings suggest that the human-animal boundary is not essentialized; rather it seems that such boundary is constructed in a dilemmatic and post hoc way. Implications for theories of dehumanization are discussed

"Il parle normal, il parle comme nous”: self-reported usage and attitudes in a banlieue

We report on a survey of language attitudes carried out as part of a project comparing youth language in Paris and London. As in similar studies carried out in London (Cheshire et al. 2008), Berlin (Wiese 2009) and elsewhere (Boyd et al. 2015), the focus was on features considered typical of ‘contemporary urban vernaculars’ (Rampton 2015). The respondents were pupils aged 15-18 in two secondary schools in a working-class northern suburb of Paris. The survey included (1) a written questionnaire containing examples of features potentially undergoing change in contemporary French; (2) an analysis of reactions to extracts from the project data: participants were asked to comment on the speakers and the features identified. Quantitative analysis had shown that some of these features are more widespread than others and are used by certain categories of speaker more than others (Gardner-Chloros and Secova, 2018). This study provides a qualitative dimension, showing that different features have different degrees of perceptual salience and acceptability. It demonstrates that youth varieties do not involve characteristic features being used as a ‘package’, and that such changes interact in a complex manner with attitudinal factors. The study also provides material for reflection on the role of attitude studies within sociolinguistic surveys

Death or survival from invasive pneumococcal disease in Scotland: associations with serogroups and multilocus sequence types

We describe associations between death from invasive pneumococcal disease (IPD) and particular serogroups and sequence types (STs) determined by multilocus sequence typing (MLST) using data from Scotland. All IPD episodes where blood or cerebrospinal fluid (CSF) culture isolates were referred to the Scottish Haemophilus, Legionella, Meningococcal and Pneumococcal Reference Laboratory (SHLMPRL) from January 1992 to February 2007 were matched to death certification records by the General Register Office for Scotland. This represented 5959 patients. The median number of IPD cases in Scotland each year was 292. Deaths, from any cause, within 30 days of pneumococcal culture from blood or CSF were considered to have IPD as a contributing factor. Eight hundred and thirty-three patients died within 30 days of culture of Streptococcus pneumoniae from blood or CSF [13.95%; 95% confidence interval (13.10, 14.80)]. The highest death rates were in patients over the age of 75. Serotyping data exist for all years but MLST data were only available from 2001 onward. The risk ratio of dying from infection due to particular serogroups or STs compared to dying from IPD due to all other serogroups or STs was calculated. Fisher's exact test with Bonferroni adjustment for multiple testing was used. Age adjustment was accomplished using the Cochran-Mantel-Haenszel test and 95% confidence intervals were reported. Serogroups 3, 11 and 16 have increased probability of causing fatal IPD in Scotland while serogroup 1 IPD has a reduced probability of causing death. None of the 20 most common STs were significantly associated with death within 30 days of pneumococcal culture, after age adjustment. We conclude that there is a stronger association between a fatal outcome and pneumococcal capsular serogroup than there is between a fatal outcome and ST

Joint British Society consensus recommendations for magnetic resonance imaging for patients with cardiac implantable electronic devices

Magnetic Resonance Imaging (MRI) is increasingly a fundamental component of the diagnostic pathway across a range of conditions. Historically, the presence of a cardiac implantable electronic device (CIED) has been a contraindication for MRI, however, development of MR Conditional devices that can be scanned under strict protocols has facilitated the provision of MRI for patients. Additionally, there is growing safety data to support MR scanning in patients with CIEDs that do not have MR safety labelling or with MR Conditional CIEDs where certain conditions are not met, where the clinical justification is robust. This means that almost all patients with cardiac devices should now have the same access to MRI scanning in the National Health Service as the general population. Provision of MRI to patients with CIED, however, remains limited in the UK, with only half of units accepting scan requests even for patients with MR Conditional CIEDs. Service delivery requires specialist equipment and robust protocols to ensure patient safety and facilitate workflows, meanwhile demanding collaboration between healthcare professionals across many disciplines. This document provides consensus recommendations from across the relevant stakeholder professional bodies and patient groups to encourage provision of safe MRI for patients with CIEDs

Spankers and Nonspankers: Where They Get Information on Spanking

Because spanking is common, puts children at risk for harmful side effects, and is ineffective as a positive behavior management tool, it is important to identify the kind of advice families receive about the appropriateness of spanking. Using the health belief model, I examined spankers and nonspankers on the spanking messages they received from eight sources of discipline information and how important they perceived these messages to be. Data from telephone interviews with 998 mothers with children aged 2 to 14 years showed that 33% of mothers rated advice from workshops, pediatricians, newspapers and magazines, and books as ‘‘very important.’’ Less than 15% rated parents and relatives and friends as such. Spankers perceived sources as recommending spanking, whereas nonspankers perceived sources as opposing spanking. Mothers were more likely to spank when they perceived more intense messages to spank, less intense messages opposing spanking, had younger children, and were of lower socioeconomic status