Circumstellar disks and planets. Science cases for next-generation optical/infrared long-baseline interferometers

We present a review of the interplay between the evolution of circumstellar disks and the formation of planets, both from the perspective of theoretical models and dedicated observations. Based on this, we identify and discuss fundamental questions concerning the formation and evolution of circumstellar disks and planets which can be addressed in the near future with optical and infrared long-baseline interferometers. Furthermore, the importance of complementary observations with long-baseline (sub)millimeter interferometers and high-sensitivity infrared observatories is outlined.Comment: 83 pages; Accepted for publication in "Astronomy and Astrophysics Review"; The final publication is available at http://www.springerlink.co

ZMYND10 Is Mutated in Primary Ciliary Dyskinesia and Interacts with LRRC6

Defects of motile cilia cause primary ciliary dyskinesia (PCD), characterized by recurrent respiratory infections and male infertility. Using whole-exome resequencing and high-throughput mutation analysis, we identified recessive biallelic mutations in ZMYND10 in 14 families and mutations in the recently identified LRRC6 in 13 families. We show that ZMYND10 and LRRC6 interact and that certain ZMYND10 and LRRC6 mutations abrogate the interaction between the LRRC6 CS domain and the ZMYND10 C-terminal domain. Additionally, ZMYND10 and LRRC6 colocalize with the centriole markers SAS6 and PCM1. Mutations in ZMYND10 result in the absence of the axonemal protein components DNAH5 and DNALI1 from respiratory cilia. Animal models support the association between ZMYND10 and human PCD, given that zmynd10 knockdown in zebrafish caused ciliary paralysis leading to cystic kidneys and otolith defects and that knockdown in Xenopus interfered with ciliogenesis. Our findings suggest that a cytoplasmic protein complex containing ZMYND10 and LRRC6 is necessary for motile ciliary function

First steps towards an intentional vision system

Contrary to many standard vision systems which proceed in a cascaded feedforward manner, imposing a fixed order in the sequence of visual operations like detection preceding segmentation and classification, we develop here the idea of a vision system that flexibly controls the order and accessibility of visual processes during operation. Vision is hereby understood as the dynamic process of adaptation of visual parameters and modules as a function of underlying goals or intentions. This perspective requires a specific architectural organization, since vision is then a continuous balance between the sensory stimulation and internally generated information. In this paper we present the concept and the necessary main ingredients and show first steps towards the implementation of a real-time intentional vision system

First steps towards an intentional vision system

Contrary to many standard vision systems which proceed in a cascaded feedforward manner, imposing a fixed order in the sequence of visual operations like detection preceding segmentation and classification, we develop here the idea of a vision system that flexibly controls the order and accessibility of visual processes during operation. Vision is hereby understood as the dynamic process of adaptation of visual parameters and modules as a function of underlying goals or intentions. This perspective requires a specific architectural organization, since vision is then a continuous balance between the sensory stimulation and internally generated information. In this paper we present the concept and the necessary main ingredients and show first steps towards the implementation of a real-time intentional vision system

Doesspike-timing-dependent synaptic plasticity couple or decouple neurons firing in synchrony?

Spike synchronization is thought to have a constructive role for feature integration, attention, associative learning, and the formation of bidirectionally connected Hebbian cell assemblies. By contrast, theoretical studies on spike-timing-dependent plasticity (STDP) report an inherently decoupling influence of spike synchronization on synaptic connections of coactivated neurons. For example, bidirectional synaptic connections as found in cortical areas could be reproduced only by assuming realistic models of STDP and rate coding. We resolve this conflict by theoretical analysis and simulation of various simple and realistic STDP models that provide a more complete characterization of conditions when STDP leads to either coupling or decoupling of neurons firing in synchrony. Inparticular, we show that STDP consistently couples synchronized neurons if key model parameters are matched to physiological data: First, synaptic potentiation must be significantly stronger than synaptic depression for small( positive or negative) time lags between presynaptic and postsynaptic spikes. Second, spike synchronization must be sufficiently imprecise, for example, within a time window of 5-10 ms instead of 1 ms. Third, axonal propagation delays should not be much larger than dendritic delays. Under these assumptions synchronized neurons will be strongly coupled leading to a dominance of bidirectional synaptic connections even for simple STDP models and low mean firing rates at the level of spontaneous activity