Effect of feeding system on enteric methane emissions from individual dairy cows on commercial farms

This study investigated the effects of feeding system on diurnal enteric methane (CH4) emissions from individual cows on commercial farms. Data were obtained from 830 cows across 12 farms, and data collated included production records, CH4 measurements (in the breath of cows using CH4 analysers at robotic milking stations for at least seven days) and diet composition. Cows received either a partial mixed ration (PMR) or a PMR with grazing. A linear mixed model was used to describe variation in CH4 emissions per individual cow and assess the effect of feeding system. Methane emissions followed a consistent diurnal pattern across both feeding systems, with emissions lowest between 05:00 and 08:59, and with a peak concentration between 17:00 and 20:59. No overall difference in emissions was found between feeding systems studied; however, differences were found in the diurnal pattern of CH4 emissions between feeding systems. The response in emissions to increasing dry matter intake was higher for cows fed PMR with grazing. This study showed that repeated spot measurements of CH4 emissions whilst cows are milked can be used to assess the effects of feeding system and potentially benchmark farms on level of emissions

Application of 3D Zernike descriptors to shape-based ligand similarity searching

Background: The identification of promising drug leads from a large database of compounds is an important step in the preliminary stages of drug design. Although shape is known to play a key role in the molecular recognition process, its application to virtual screening poses significant hurdles both in terms of the encoding scheme and speed. Results: In this study, we have examined the efficacy of the alignment independent three-dimensional Zernike descriptor (3DZD) for fast shape based similarity searching. Performance of this approach was compared with several other methods including the statistical moments based ultrafast shape recognition scheme (USR) and SIMCOMP, a graph matching algorithm that compares atom environments. Three benchmark datasets are used to thoroughly test the methods in terms of their ability for molecular classification, retrieval rate, and performance under the situation that simulates actual virtual screening tasks over a large pharmaceutical database. The 3DZD performed better than or comparable to the other methods examined, depending on the datasets and evaluation metrics used. Reasons for the success and the failure of the shape based methods for specific cases are investigated. Based on the results for the three datasets, general conclusions are drawn with regard to their efficiency and applicability

Analyse verbreiteter Anwendungen zum Lesen von elektronischen Büchern

Der Marktanteil elektronischer Bucher (E-Books) am Buchmarkt wächst beständig. Um E-Books zu rezipieren, benötigt man spezielle Leseumgebungen, die als Software (im Browser oder als eigene Anwendung) oder als Spezialgerät (E-Reader) realisiert sein können. Diese Leseumgebungen sind geeignet, Daten über das Leseverhalten zu sammeln. Im Rahmen einer universitären Lehrveranstaltung wurden die Software-Leseumgebungen der beiden deutschen Marktführer Kindle und Tolino untersucht. Der vorliegende Bericht fasst die Ergebnisse dieser Analysen zusammen. Das Ergebnis ist eine umfassende Bestandsaufnahme der digitalen Spuren, die durch die Benutzung der Programme entstehen. Betrachtet wurden die zum Untersuchungszeitpunkt aktuellen Versionen der jeweiligen Webanwendungen und Android-Apps sowie des Kindle-Windows-Clients. Die Ergebnisse entstanden im Rahmen einer Übung zur Vorlesung Fortgeschrittene forensische Informatik II im Wintersemester 2018/19 an der Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), die gemeinsam durchgeführt wurde vom Lehrstuhl fur Informatik 1 und dem Institut für Buchwissenschaft an der FAU

Cuidados biomédicos de saúde em Angola e na Companhia de Diamantes de Angola, c. 1910-1970

Pretende-se caracterizar a prestação de cuidados biomédicos em Angola durante a atividade da Companhia de Diamantes de Angola. Uma análise comparativa de políticas e práticas de saúde pública de vários atores coloniais, como os serviços de saúde da Companhia, sua congénere do Estado e outras empresas coloniais, revelará diferenças de investimento na saúde, isto é, instalações e pessoal de saúde, e tratamentos. Este escrutínio bem como as condições de vida iluminarão o carácter idiossincrático e central dos serviços de saúde da Companhia em termos de morbimortalidade em Angola, e a centralidade destes para as representações de um império cuidador