122 research outputs found
Stability of negative ionization fronts: regularization by electric screening?
We recently have proposed that a reduced interfacial model for streamer
propagation is able to explain spontaneous branching. Such models require
regularization. In the present paper we investigate how transversal Fourier
modes of a planar ionization front are regularized by the electric screening
length. For a fixed value of the electric field ahead of the front we calculate
the dispersion relation numerically. These results guide the derivation of
analytical asymptotes for arbitrary fields: for small wave-vector k, the growth
rate s(k) grows linearly with k, for large k, it saturates at some positive
plateau value. We give a physical interpretation of these results.Comment: 11 pages, 2 figure
Branching of negative streamers in free flight
We recently have shown that a negative streamer in a sufficiently high
homogeneous field can branch spontaneously due to a Laplacian instability,
rather than approach a stationary mode of propagation with fixed radius. In our
previous simulations, the streamer started from a wide initial ionization seed
on the cathode. We here demonstrate in improved simulations that a streamer
emerging from a single electron branches in the same way. In fact, though the
evolving streamer is much more narrow, it branches after an even shorter
propagation distance.Comment: 4 pages, 3 figure
Serum N-Terminal propeptide of collagen type I is associated with the number of bone Metastases in breast and prostate cancer and correlates to other bone related markers
Background A number of biomarkers have been proven potentially useful for their ability to indicate bone metastases (BM) in cancer patients. The aim of this study was to investigate the relative utility of a newly developed N-terminal propeptide of collagen type I (PINP) human serum assay for the detection of BM in cancer patients. This assay has a corresponding rat PINP assay which in the future might help in translational science between rodent and human trials. Methods Participants were 161 prostate, lung and breast cancer patients stratified by number of BM(Soloway score). PINP was assessed and correlated to number of BM. Additionally, the PINP marker was correlated to bone resorption of young (ALPHA CTX-I)- and aged bone (BETA CTX-I); number of osteoclasts (Tartrate-resistant acid phosphatase 5b, TRACP5B) and osteoclast activity (CTX-I/TRACP5B). Results PINP was significantly elevated in breast- and prostate cancer patients +BM, compared to –BM ( P < 0.001), however not in lung cancer patients. A strong linear association was seen between PINP and the number of BMs. Significant elevation of PINP was observed at Soloway scores 1–4 (<0 BM) compared with score 0 (0 BM) ( P < 0.001). The correlation between bone resorption of young bone or aged bone and bone formation was highly significant in patients +BM and –BM ( P < 0.0001). Conclusions Data suggest that the present PINP potentially could determine skeletal involvement in patients with breast or prostate cancer. Correlations suggested that coupling between bone resorption and bone formation was maintained in breast- and prostate cancer patients
Propagation and Structure of Planar Streamer Fronts
Streamers often constitute the first stage of dielectric breakdown in strong
electric fields: a nonlinear ionization wave transforms a non-ionized medium
into a weakly ionized nonequilibrium plasma. New understanding of this old
phenomenon can be gained through modern concepts of (interfacial) pattern
formation. As a first step towards an effective interface description, we
determine the front width, solve the selection problem for planar fronts and
calculate their properties. Our results are in good agreement with many
features of recent three-dimensional numerical simulations.
In the present long paper, you find the physics of the model and the
interfacial approach further explained. As a first ingredient of this approach,
we here analyze planar fronts, their profile and velocity. We encounter a
selection problem, recall some knowledge about such problems and apply it to
planar streamer fronts. We make analytical predictions on the selected front
profile and velocity and confirm them numerically.
(abbreviated abstract)Comment: 23 pages, revtex, 14 ps file
D*-->Dpi and D*-->Dgamma decays: Axial coupling and Magnetic moment of D* meson
The axial coupling and the magnetic moment of D*-meson or, more specifically,
the couplings g(D*Dpi) and g(D*Dgamma), encode the non-perturbative QCD effects
describing the decays D*-->Dpi and D*-->Dgamma. We compute these quantities by
means of lattice QCD with Nf=2 dynamical quarks, by employing the Wilson
("clover") action. On our finer lattice (a=0.065 fm) we obtain: g(D*Dpi)=20 +/-
2, and g(D0*D0gamma)=[2.0 +/- 0.6]/GeV. This is the first determination of
g(D0*D0gamma) on the lattice. We also provide a short phenomenological
discussion and the comparison of our result with experiment and with the
results quoted in the literature.Comment: 22 pages, 3 figure
Dynamical stability of infinite homogeneous self-gravitating systems: application of the Nyquist method
We complete classical investigations concerning the dynamical stability of an
infinite homogeneous gaseous medium described by the Euler-Poisson system or an
infinite homogeneous stellar system described by the Vlasov-Poisson system
(Jeans problem). To determine the stability of an infinite homogeneous stellar
system with respect to a perturbation of wavenumber k, we apply the Nyquist
method. We first consider the case of single-humped distributions and show
that, for infinite homogeneous systems, the onset of instability is the same in
a stellar system and in the corresponding barotropic gas, contrary to the case
of inhomogeneous systems. We show that this result is true for any symmetric
single-humped velocity distribution, not only for the Maxwellian. If we
specialize on isothermal and polytropic distributions, analytical expressions
for the growth rate, damping rate and pulsation period of the perturbation can
be given. Then, we consider the Vlasov stability of symmetric and asymmetric
double-humped distributions (two-stream stellar systems) and determine the
stability diagrams depending on the degree of asymmetry. We compare these
results with the Euler stability of two self-gravitating gaseous streams.
Finally, we determine the corresponding stability diagrams in the case of
plasmas and compare the results with self-gravitating systems
Heavy quarkonium: progress, puzzles, and opportunities
A golden age for heavy quarkonium physics dawned a decade ago, initiated by
the confluence of exciting advances in quantum chromodynamics (QCD) and an
explosion of related experimental activity. The early years of this period were
chronicled in the Quarkonium Working Group (QWG) CERN Yellow Report (YR) in
2004, which presented a comprehensive review of the status of the field at that
time and provided specific recommendations for further progress. However, the
broad spectrum of subsequent breakthroughs, surprises, and continuing puzzles
could only be partially anticipated. Since the release of the YR, the BESII
program concluded only to give birth to BESIII; the -factories and CLEO-c
flourished; quarkonium production and polarization measurements at HERA and the
Tevatron matured; and heavy-ion collisions at RHIC have opened a window on the
deconfinement regime. All these experiments leave legacies of quality,
precision, and unsolved mysteries for quarkonium physics, and therefore beg for
continuing investigations. The plethora of newly-found quarkonium-like states
unleashed a flood of theoretical investigations into new forms of matter such
as quark-gluon hybrids, mesonic molecules, and tetraquarks. Measurements of the
spectroscopy, decays, production, and in-medium behavior of c\bar{c}, b\bar{b},
and b\bar{c} bound states have been shown to validate some theoretical
approaches to QCD and highlight lack of quantitative success for others. The
intriguing details of quarkonium suppression in heavy-ion collisions that have
emerged from RHIC have elevated the importance of separating hot- and
cold-nuclear-matter effects in quark-gluon plasma studies. This review
systematically addresses all these matters and concludes by prioritizing
directions for ongoing and future efforts.Comment: 182 pages, 112 figures. Editors: N. Brambilla, S. Eidelman, B. K.
Heltsley, R. Vogt. Section Coordinators: G. T. Bodwin, E. Eichten, A. D.
Frawley, A. B. Meyer, R. E. Mitchell, V. Papadimitriou, P. Petreczky, A. A.
Petrov, P. Robbe, A. Vair
Measurement of the Spectroscopy of Orbitally Excited B Mesons at LEP
We measure the masses, decay widths and relative production rate of orbitally
excited B mesons using 1.25 million hadronic Z decays recorded by the L3
detector. B-meson candidates are inclusively reconstructed and combined with
charged pions produced at the primary event vertex. An excess of events above
the expected background in the B\pi mass spectrum in the region 5.6-5.8 GeV is
interpreted as resulting from the decay B_u,d^** -> B^(*)\pi, where B_u,d^**
denotes a mixture of l=1 B-meson states containing a u or a d quark. A fit to
the mass spectrum yields the masses and decay widths of the B_1^* and B_2^*
spin states, as well as the branching fraction for the combination of l=1
states. In addition, evidence is presented for the existence of an excited
B-meson state or mixture of states in the region 5.9-6.0 GeV
A fully phased accurate assembly of an individual human genome
The prevailing genome assembly paradigm is to produce consensus sequences that "collapse" parental haplotypes into a consensus sequence. Here, we leverage the chromosome-wide phasing and scaffolding capabilities of single-cell strand sequencing (Strand-seq) and combine them with high-fidelity (HiFi) long sequencing reads, in a novel reference-free workflow for diploid de novo genome assembly. Employing this strategy, we produce completely phased de novo genome assemblies separately for each haplotype of a single individual of Puerto Rican origin (HG00733) in the absence of parental data. The assemblies are accurate (QV > 40), highly contiguous (contig N50 > 25 Mbp) with low switch error rates (0.4%) providing fully phased single-nucleotide variants (SNVs), indels, and structural variants (SVs). A comparison of Oxford Nanopore and PacBio phased assemblies identifies 150 regions that are preferential sites of contig breaks irrespective of sequencing technology or phasing algorithms
- …