Structure And Dynamics Of Modulated Traveling Waves In Cellular Flames

We describe spatial and temporal patterns in cylindrical premixed flames in the cellular regime, $Le < 1$, where the Lewis number $Le$ is the ratio of thermal to mass diffusivity of a deficient component of the combustible mixture. A transition from stationary, axisymmetric flames to stationary cellular flames is predicted analytically if $Le$ is decreased below a critical value. We present the results of numerical computations to show that as $Le$ is further decreased traveling waves (TWs) along the flame front arise via an infinite-period bifurcation which breaks the reflection symmetry of the cellular array. Upon further decreasing $Le$ different kinds of periodically modulated traveling waves (MTWs) as well as a branch of quasiperiodically modulated traveling waves (QPMTWs) arise. These transitions are accompanied by the development of different spatial and temporal symmetries including period doublings and period halvings. We also observe the apparently chaotic temporal behavior of a disordered cellular pattern involving creation and annihilation of cells. We analytically describe the stability of the TW solution near its onset+ using suitable phase-amplitude equations. Within this framework one of the MTW's can be identified as a localized wave traveling through an underlying stationary, spatially periodic structure. We study the Eckhaus instability of the TW and find that in general they are unstable at onset in infinite systems. They can, however, become stable for larger amplitudes.Comment: to appear in Physica D 28 pages (LaTeX), 11 figures (2MB postscript file

Inverse Problems in a Bayesian Setting

In a Bayesian setting, inverse problems and uncertainty quantification (UQ) --- the propagation of uncertainty through a computational (forward) model --- are strongly connected. In the form of conditional expectation the Bayesian update becomes computationally attractive. We give a detailed account of this approach via conditional approximation, various approximations, and the construction of filters. Together with a functional or spectral approach for the forward UQ there is no need for time-consuming and slowly convergent Monte Carlo sampling. The developed sampling-free non-linear Bayesian update in form of a filter is derived from the variational problem associated with conditional expectation. This formulation in general calls for further discretisation to make the computation possible, and we choose a polynomial approximation. After giving details on the actual computation in the framework of functional or spectral approximations, we demonstrate the workings of the algorithm on a number of examples of increasing complexity. At last, we compare the linear and nonlinear Bayesian update in form of a filter on some examples.Comment: arXiv admin note: substantial text overlap with arXiv:1312.504

A comparative study to the numerical approximation of random Airy differential equation

The aim of this paper is twofold. First, we deal with the extension to the random framework of the piecewise Fröbenius method to solve Airy differential equations. This extension is based on mean square stochastic calculus. Second, we want to explore the capability to provide not only reliable approximations for both the average and the standard deviation functions associated to the solution stochastic process, but also to save computational time as it happens in dealing with the analogous problem in the deterministic scenario. This includes a comparison of the numerical results with respect to those obtained by other commonly used operational methods such as polynomial chaos and Monte Carlo simulations. To conduct this comparative study, we have chosen the Airy random differential equation because it has highly oscillatory solutions. This feature allows us to emphasize differences between all the considered approaches. © 2011 Elsevier Ltd. All rights reserved.This work has been partially supported by the Spanish M.C.Y.T. and FEDER grants MTM2009-08587, DPI2010-20891-C02-01 as well as the Universitat Politecnica de Valencia grant PAID-06-09 (Ref. 2588).Cortés López, JC.; Jódar Sánchez, LA.; Romero Bauset, JV.; Roselló Ferragud, MD. (2011). A comparative study to the numerical approximation of random Airy differential equation. Computers and Mathematics with Applications. 62(9):3411-3417. https://doi.org/10.1016/j.camwa.2011.08.056S3411341762

Some recommendations for applying gPC (generalized polynomial chaos) to modeling: An analysis through the Airy random differential equation

In this paper we study the use of the generalized polynomial chaos method to differential equations describing a model that depends on more than one random input. This random input can be in the form of parameters or of initial or boundary conditions. We investigate the effect of the choice of the probability density functions for the inputs on the output stochastic processes. The study is performed on the Airy¿s differential equation. This equation is a good test case since its solutions are highly oscillatory and errors can develop both in the amplitude and the phase. Several different situations are considered and, finally, conclusions are presented.This work has been partially supported by the Spanish M.C.Y.T. and FEDER Grants MTM2009-08587, DPI2010-20891-C02-01 as well as the Universitat Politecnica de Valencia Grants PAID-00-11 (Ref. 2751) and PAID-06-11 (Ref. 2070).Chen Charpentier, BM.; Cortés López, JC.; Romero Bauset, JV.; Roselló Ferragud, MD. (2013). Some recommendations for applying gPC (generalized polynomial chaos) to modeling: An analysis through the Airy random differential equation. Applied Mathematics and Computation. 219(9):4208-4218. https://doi.org/10.1016/j.amc.2012.11.007S42084218219

How do we get there? Effects of cognitive aging on route memory

© 2017 The Author(s) Research into the effects of cognitive aging on route navigation usually focuses on differences in learning performance. In contrast, we investigated age-related differences in route knowledge after successful route learning. One young and two groups of older adults categorized using different cut-off scores on the Montreal Cognitive Assessment (MoCA), were trained until they could correctly recall short routes. During the test phase, they were asked to recall the sequence in which landmarks were encountered (Landmark Sequence Task), the sequence of turns (Direction Sequence Task), the direction of turn at each landmark (Landmark Direction Task), and to identify the learned routes from a map perspective (Perspective Taking Task). Comparing the young participant group with the older group that scored high on the MoCA, we found effects of typical aging in learning performance and in the Direction Sequence Task. Comparing the two older groups, we found effects of early signs of atypical aging in the Landmark Direction and the Perspective Taking Tasks. We found no differences between groups in the Landmark Sequence Task. Given that participants were able to recall routes after training, these results suggest that typical and early signs of atypical aging result in differential memory deficits for aspects of route knowledge

Development and validation of stability indicating method for determination of sertraline following ICH guidlines and its determination in pharmaceuticals and biological fluids

<p>Abstract</p> <p>Background</p> <p>Sertraline is a well known antidepressant drug which belongs to a class called selective serotonin reuptake inhibitor. Most published methods do not enable studying the stability of this drug in different stress conditions.</p> <p>Results</p> <p>Two new methods were developed for the determination of sertraline (SER). Both methods are based on coupling with 4-chloro-7-nitrobenzo-2-oxa-1,3-diazole (NBD-Cl) in borate buffer of pH 7.8 and measuring the reaction product spectrophotometrically at 395 nm (Method I) or spectrofluorimetrically at 530 nm upon excitation at 480 nm (Method II). The response-concentration plots were rectilinear over the range 2-24 μg/mL and 0.25-5 μg/mL for methods I and II respectively with LOD of 0.18 μg/mL and 0.07 μg/mL, and LOQ of 0.56 μg/mL and 0.21 μg/mL for methods I and II, respectively.</p> <p>Conclusion</p> <p>Both methods were applied to the analysis of commercial tablets and the results were in good agreement with those obtained using a reference method. The fluorimetric method was further applied to the in vivo determination of SER in human plasma. A proposal of the reaction pathway was presented. The spectrophotometric method was extended to stability study of SER. The drug was exposed to alkaline, acidic, oxidative and photolytic degradation according to ICH guidelines. Moreover, the method was utilized to investigate the kinetics of oxidative degradation of the drug. The apparent first order rate constant and t_1/2of the degradation reaction were determined.</p

Crew Resource Management for Automated Teammates (CRM-A)

Crew Resource Management (CRM) is the application of human factors knowledge and skills to ensure that teams make effective use of all resources. This includes ensuring that pilots bring in opinions of other teammates and utilize their unique capabilities. CRM was originally developed 40 years ago in response to a number of airline accidents in which the crew was found to be at fault. The goal was to improve teamwork among airline cockpit crews. The notion of "team" was later expanded to include cabin crew and ground resources. CRM has also been adopted by other industries, most notably medicine. Automation research now finds itself faced with similar issues to those faced by aviation 40 years ago: how to create a more robust system by making full use of both the automation and its human operators. With advances in machine intelligence, processing speed and cheap and plentiful memory, automation has advanced to the point that it can and should be treated as a teammate to fully take advantage of its capabilities and contributions to the system. This area of research is known as Human-Autonomy Teaming (HAT). Research on HAT has identified reusable patterns that can be applied in a wide range of applications. These patterns include features such as bi-directional communication and working agreements. This paper will explore the synergies between CRM and HAT. We believe that HAT research has much to learn from CRM and that there are benefits to expanding CRM to cover automation

The Papanicolaou Smear and the Obstetric Patient: A Simple Test with Great Benefits

No abstract.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/35304/1/1_ftp.pd