Failure of Standard Thermodynamics in Planck Scale Black Hole System

The final stage of the black hole evaporation is a matter of debates in the existing literature. In this paper, we consider this problem within two alternative approaches: noncommutative geometry(NCG) and the generalized uncertainty principle(GUP). We compare the results of two scenarios to find a relation between parameters of these approaches. Our results show some extraordinary thermodynamical behavior for Planck size black hole evaporation. These extraordinary behavior may reflect the need for a fractal nonextensive thermodynamics for Planck size black hole evaporation process.Comment: 26 Pages, 10 Figures, Revised and References adde

Integrating Clinical Trial Imaging Data Resources Using Service-Oriented Architecture and Grid Computing

Clinical trials which use imaging typically require data management and workflow integration across several parties. We identify opportunities for all parties involved to realize benefits with a modular interoperability model based on service-oriented architecture and grid computing principles. We discuss middleware products for implementation of this model, and propose caGrid as an ideal candidate due to its healthcare focus; free, open source license; and mature developer tools and support

Non-invasive index of liver fibrosis induced by alcohol, thioacetamide and schistosomal infection in mice

<p>Abstract</p> <p>Background</p> <p>Non invasive approaches will likely be increasing utilized to assess liver fibrosis. This work provides a new non invasive index to predict liver fibrosis induced in mice.</p> <p>Methods</p> <p>Fibrosis was generated by thioacetamide (TAA), chronic intake of ethanol, or infection with <it>S. mansoni </it>in 240 mice. Both progression and regression of fibrosis (after treatment with silymarin and/or praziquantel) were monitored. The following methods were employed: (i) The METAVIR system was utilized to grade and stage liver inflammation and fibosis; (ii) Determination of hepatic hydroxyproline and collagen; and (iii) Derivation of a new hepatic fibrosis index from the induced changes, and its prospective validation in a group of 70 mice.</p> <p>Results</p> <p>The index is composed of 4 serum variable including total proteins, γ-GT, bilirubin and reduced glutathione (GSH), measured in diseased, treated and normal mice. These parameters were highly correlated with both the histological stage and the grade. They were combined in a logarithmic formula, which non-invasively scores the severity of liver fibrosis through a range (0 to 2), starting with healthy liver (corresponding to stage 0) to advanced fibrosis (corresponding stage 3).Receiver operating characteristic curves (ROC) for the accuracy of the index to predict the histological stages demonstrated that the areas under the curve (AUC) were 0.954, 0.979 and 0.99 for index values corresponding to histological stages 1, 2 and 3, respectively. Also, the index was correlated with stage and grade, (0.947 and 0.859, respectively). The cut off values that cover the range between stages 0-1, 1-2 and 2-3 are 0.4, 1.12 and 1.79, respectively. The results in the validation group confirmed the accuracy of the test. The AUROC was 0.869 and there was good correlation with the stage of fibrosis and grade of inflammation.</p> <p>Conclusion</p> <p>The index fulfils the basic criteria of non-invasive marker of liver fibrosis since it is liver-specific, easy to implement, reliable, and inexpensive. It proved to be accurate in discriminating precirrhotic stages.</p

Issues and Ramifications in Quantized Fractal Space Time: An Interface with Quantum Superstrings

Recently a stochastic underpinning for space time has been considered, what may be called Quantized Fractal Space Time. This leads us to a number of very interesting consequences which are testable, and also provides a rationale for several otherwise inexplicable features in Particle Physics and Cosmology. These matters are investigated in the present paper.Comment: 27 pages, TeX, This is from the forthcoming book The Chaotic Univers

CP Violation in B Decays from Anomalous tbW Interactions

We calculate the effect of new CP violating interactions parameterized by an anomalous $tbW$ coupling on CP-odd observables in B decays. We find that couplings consistent with current bounds induce observable effects in some CP asymmetries that will be measured in B-factories. The new effects are sufficiently large that they can actually test specific models that give rise to these $tbW$ interactions.Comment: We have added a new section showing that the new effects are sufficiently large that they can be measured at a B-factor

Flavor Physics and the CKM Matrix: An Overview

I review the current status of our knowledge of CP violation and flavor physics. I discuss where one should look for future improvements, and outline the experimental and theoretical priorities of the field.Comment: 11 pages. Presentation at the Fifth KEK Topical Conference, "Frontiers in Flavor Physics", November 20-22, 2001. References adde

Time Asymmetric Quantum Mechanics and Shock Waves: Exploring the Irreversibility in Nonlinear Optics

The description of irreversible phenomena is a still debated topic in quantum mechanics. Still nowadays, there is no clear procedure to distinguish the coupling with external baths from the intrinsic irreversibility in isolated systems. In 1928 Gamow introduced states with exponentially decaying observables not belonging to the conventional Hilbert space. These states are named Gamow vectors, and they belong to rigged Hilbert spaces. This review summarizes the contemporary approach using Gamow vectors and rigged Hilbert space formalism as foundations of a generalized “time asymmetric” quantum mechanics. We study the irreversible propagation of specific wave packets and show that the topic is surprisingly related to the problem of irreversibility of shock waves in classical nonlinear evolution. We specifically consider the applications in the field of nonlinear optics. We show that it is possible to emulate irreversible quantum mechanical process by the nonlinear evolution of a laser beam and we provide experimental tests by the generation of dispersive shock waves in highly nonlocal regimes. We demonstrate experimentally the quantization of decay rates predicted by the time-asymmetric quantum mechanics. This work furnishes support to the idea of intrinsically irreversible wave propagation, and to novel tests of the foundations of quantum mechanics

Regulation of expression of the rat orthologue of mouse double minute 2 (MDM2) by H2O2-induced oxidative stress in neonatal rat cardiac myocytes.

The Mdm2 ubiquitin ligase is an important regulator of p53 abundance and p53-dependent apoptosis. Mdm2 expression is frequently regulated by a p53 Mdm2 autoregulatory loop whereby p53 stimulates Mdm2 expression and hence its own degradation. Although extensively studied in cell lines, relatively little is known about Mdm2 expression in heart where oxidative stress (exacerbated during ischemia-reperfusion) is an important pro-apoptotic stimulus. We demonstrate that Mdm2 transcript and protein expression are induced by oxidative stress (0.2 mm H(2)O(2)) in neonatal rat cardiac myocytes. In other cells, constitutive Mdm2 expression is regulated by the P1 promoter (5' to exon 1), with inducible expression regulated by the P2 promoter (in intron 1). In myocytes, H(2)O(2) increased Mdm2 expression from the P2 promoter, which contains two p53-response elements (REs), one AP-1 RE, and two Ets REs. H(2)O(2) did not detectably increase expression of p53 mRNA or protein but did increase expression of several AP-1 transcription factors. H(2)O(2) increased binding of AP-1 proteins (c-Jun, JunB, JunD, c-Fos, FosB, and Fra-1) to an Mdm2 AP-1 oligodeoxynucleotide probe, and chromatin immunoprecipitation assays showed it increased binding of c-Jun or JunB to the P2 AP-1 RE. Finally, antisense oligonucleotide-mediated reduction of H(2)O(2)-induced Mdm2 expression increased caspase 3 activation. Thus, increased Mdm2 expression is associated with transactivation at the P2 AP-1 RE (rather than the p53 or Ets REs), and Mdm2 induction potentially represents a cardioprotective response to oxidative stress