Obesity and metabolic syndrome in adolescent survivors of standard risk childhood acute lymphoblastic leukemia in Saudi Arabia

This study estimated prevalence of unhealthy weight status and metabolic syndrome (MS) amongst Saudi survivors of standard risk ALL. Procedure. We recruited 56 survivors, mean age 13.4 years (SD 4.1), a mean of 9.1 years (SD 4.1) postdiagnosis. The BMI for age was used to define weight status relative to national (Saudi) and international (Cole et al., Cole-IOTF, WHO, and CDC) reference data. We measured body composition by dualenergy X-ray absorptiometry (DXA), waist circumference, blood pressure, lipid profile (HDL-C, Triglycerides), fasting glucose and insulin. Results. According to international definitions based on BMI for age, around half of the sample had unhealthy weight status. All of the approaches based on BMI for age underestimated overfatness, present in 27/51 (53%) of the sample according to DXA. Prevalence of MS was 7.1% (3/42 of those over 9-years old) and 5.4% (3/56) by applying the International Diabetes Federation (IDF) definition and National Cholesterol Education Program Third Adult Treatment panel Guidelines (NCEP III), respectively. However, MS by the NCEP III definition was present in 19% of the overweight and obese survivors and 7.1% of the sample had at least two of the components of MS. Conclusion. Unhealthy body weight and overfatness may be common amongst adolescent Saudi survivors of standard risk ALL, though overweight and obesity may be no more common than in the general Saudi adolescent population. Defining weight status using BMI underestimates overfatness. Ideally, body composition and cardiometabolic risk factors should be monitored at late effects clinics. Pediatr Blood Cancer 2012;59: 133–137. 2011 Wiley Periodicals, Inc

Chondrocytes, synoviocytes and dermal fibroblasts all express PH-20, a hyaluronidase active at neutral pH

Hyaluronan (HA), an important component of connective tissues, is highly metabolically active, but the mechanisms involved in its catabolism are still largely unknown. We hypothesized that a protein similar to sperm PH-20, the only mammalian hyaluronidase known to be active at neutral pH, could be expressed in connective tissue cells. An mRNA transcript similar to that of PH-20 was found in chondrocytes, synoviocytes, and dermal fibroblasts, and its levels were enhanced upon stimulation with IL-1. In cell layers extracted with Triton X-100 – but not with octylglucoside – and in culture media, a polyclonal antipeptide anti-PH-20 antibody identified protein bands with a molecular weight similar to that of sperm PH-20 (60 to 65 kDa) and exhibiting a hyaluronidase activity at neutral pH. Further, upon stimulation with IL-1, the amounts of the neutral-active hyaluronidase increased in both cell layers and culture media. These findings contribute potential important new insights into the biology of connective tissues. It is likely that PH-20 facilitates cell-receptor-mediated uptake of HA, while overexpression or uncontrolled expression of the enzyme can cause great havoc to connective tissues: not only does HA fragmentation compromise the structural integrity of tissues, but also the HA fragments generated are highly angiogenic and are potent inducers of proinflammatory cytokines. On the other hand, the enzyme activity may account for the progressive depletion of HA seen in osteoarthritis cartilage, a depletion that is believed to play an important role in the apparent irreversibility of this disease process

Characterisation of production, marketing and consumption patterns of farmed tilapia in the Nile Delta of Egypt

AbstractEgypt has one of the world’s largest aquaculture sectors which makes a significant contribution to income, employment creation and food security. However, there are very limited data available on the farmed tilapia value chain. The aim of this study therefore was to characterise production, marketing and consumption patterns of farmed tilapia in the Nile Delta of Egypt. A cross sectional study was conducted to collect data from tilapia producers (100), transporters (32), retailers (100), fish fry shops (20) and households (300) in three case study communities (fish producing, peri-urban and rural community). We conducted structured questionnaire interviews and participatory assessments for producers and consumers. Focus group discussions with mothers were also held to collect data for the availability, sources and consumption patterns of tilapia.Results showed that, more than half of producers were small scale, having a farm size of 10feddan or less (1feddan=4200m2). The main water supply for almost all farms was agricultural drain water, a potential source of contamination with chemical and biological hazards. The main production constraints were reported to be feed prices, water quality and availability, land rent, fuel and energy sources and environmental conditions. The farmed tilapia value chain was short with some value added in the form of marketing fresh and live fish as well as selling tilapia in fried or grilled form. The majority of produced tilapia was transported to retail sale and sold to consumers as fresh, while only a small proportion was processed by cleaning, grilling or frying. A lack of hygiene during transportation and marketing of farmed tilapia was found that could be potential sources for post-harvesting contamination. The availability and frequency of tilapia consumption were higher in the community in the production areas than in other communities. In non-producing areas, tilapia may be available in the market once a week during the village market day. Potential areas for further research in order to improve safety, quality and production of farmed tilapia were identified

The Size and Shape of Local Voids

We study the size and shape of low density regions in the local universe which we identify in the smoothed density field of the PSCz flux limited IRAS galaxy catalogue. After quantifying the systematic biases that enter in the detection of voids using our data set and method, we identify, using a smoothing length of 5 $h^{-1}$ Mpc, 14 voids within 80 $h^{-1}$ Mpc and using a smoothing length of 10 $h^{-1}$ Mpc, 8 voids within 130 $h^{-1}$ Mpc. We study the void size distribution and morphologies and find that there is roughly an equal number of prolate and oblate-like spheroidal voids. We compare the measured PSCz void shape and size distributions with those expected in six different CDM models and find that only the size distribution can discriminate between models. The models preferred by the PSCz data are those with intermediate values of $\sigma_{8} (\simeq 0.83)$, independent of cosmology.Comment: final version, Accepted in MNRA

Interactions of inert confiners with explosives

The deformation of an inert confiner by a steady detonation wave in an adjacent explosive is investigated for cases where the confiner is suciently strong (or the explosive suciently weak) such that the overall change in the sound speed of the inert is small. A coupling condition which relates the pressure to the deflection angle along the explosive-inert interface is determined. This includes its dependence on the thickness of the inert, for cases where the initial sound speed of the inert is less than or greater than the detonation speed in the explosive (supersonic and subsonic inert ows, respectively). The deformation of the inert is then solved by prescribing the pressure along the interface. In the supersonic case, the detonation drives a shock into the inert, subsequent to which the ow in the inert consists of alternating regions of compression and tension. In this case reverberations or `ringing' occurs along both the deflected interface and outer edge of the inert. For the subsonic case, the flow in the interior of the inert is smooth and shockless. The detonation in the explosive initially defl ects the smooth interface towards the explosive. For sufficiently thick inerts in such cases, it appears that the deflection of the confiner would either drive the detonation speed in the explosive up to the sound speed of the inert or drive a precursor wave ahead of the detonation in the explosive. Transonic cases, where the inert sound speed is close to the detonation speed, are also considered. It is shown that the confinement affect of the inert on the detonation is enhanced as sonic conditions are approached from either side

An Assessment of the International Space Station's Trace Contaminant Control Subassembly Process Economics

The International Space Station (ISS) Environmental Control and Life Support System includes equipment speci.cally designed to actively remove trace chemical contamination from the cabin atmosphere. In the U.S. on-orbit segment, this function is provided by the trace contaminant control subassembly (TCCS) located in the atmosphere revitalization subsystem rack housed in the laboratory module, Destiny. The TCCS employs expendable adsorbent beds to accomplish its function leading to a potentially signi.cant life cycle cost over the life of the ISS. Because maintaining the TCCSs proper can be logistically intensive, its performance in .ight has been studied in detail to determine where savings may be achieved. Details of these studies and recommendations for improving the TCCS s process economics without compromising its performance or crew health and safety are presented and discussed

An XML based standard to enable bulk project data transfer between heterogeneous systems

The objective of the work reported in this paper was the development of an XML based standard which would enable project data, such as contacts, drawings, documentation, instructions and emails, to be transferred between collaborative systems provided by different software vendors and used by construction organisations. The primary aim being to create a transfer mechanism which would allow project data transfer without modification of existing collaborative system deployed by vendors. This paper discusses the business and technological needs for such a transfer capability between collaborative systems, by examining the current use of these tools and related problems encountered by clients. It sets out the main components that underlie the majority of construction specific collaborative systems which forms the basis of the generic collaborative system model which has been developed, contrasting this with previous data exchange efforts. This paper shows how the XML Schema was developed and the procedures undertaken to ensure that it could be utilised by the maximum possible set of vendors. It sets out the best practice procedure for implementations by vendor organisations and the required testing to confirm a successful transfer. The paper also highlights some of the practical problems that were encountered when transferring projects between heterogeneous systems during the project and in subsequent deployments of the solution. Finally, the paper concludes with methods of taking the work forward as a foundation to allow for greater interoperability between systems in the future

Soliton-mean field interaction in Korteweg-de Vries dispersive hydrodynamics

The propagation of localized solitons in the presence of large-scale waves is a fundamental problem, both physically and mathematically, with applications in fluid dynamics, nonlinear optics and condensed matter physics. Here, the evolution of a soliton as it interacts with a rarefaction wave or a dispersive shock wave, examples of slowly varying and rapidly oscillating dispersive mean fields, for the Korteweg-de Vries equation is studied. Step boundary conditions give rise to either a rarefaction wave (step up) or a dispersive shock wave (step down). When a soliton interacts with one of these mean fields, it can either transmit through (tunnel) or become embedded (trapped) inside, depending on its initial amplitude and position. A comprehensive review of three separate analytical approaches is undertaken to describe these interactions. First, a basic soliton perturbation theory is introduced that is found to capture the solution dynamics for soliton-rarefaction wave interaction in the small dispersion limit. Next, multiphase Whitham modulation theory and its finite-gap description are used to describe soliton-rarefaction wave and soliton-dispersive shock wave interactions. Lastly, a spectral description and an exact solution of the initial value problem is obtained through the Inverse Scattering Transform. For transmitted solitons, far-field asymptotics reveal the soliton phase shift through either type of wave mentioned above. In the trapped case, there is no proper eigenvalue in the spectral description, implying that the evolution does not involve a proper soliton solution. These approaches are consistent, agree with direct numerical simulation, and accurately describe different aspects of solitary wave-mean field interactio