Appropriate Similarity Measures for Author Cocitation Analysis

We provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance

Dimension and bases for geometrically continuous splines on surfaces of arbitrary topology

We analyze the space of geometrically continuous piecewise polynomial functions, or splines, for rectangular and triangular patches with arbitrary topology and general rational transition maps. To define these spaces of G 1 spline functions, we introduce the concept of topological surface with gluing data attached to the edges shared by faces. The framework does not require manifold constructions and is general enough to allow non-orientable surfaces. We describe compatibility conditions on the transition maps so that the space of differentiable functions is ample and show that these conditions are necessary and sufficient to construct ample spline spaces. We determine the dimension of the space of G1 spline functions which are of degree less than or equal to k on triangular pieces and of bi-degree less than or equal to (k, k) on rectangular pieces, for k big enough. A separability property on the edges is involved to obtain the dimension formula. An explicit construction of basis functions attached resspectively to vertices, edges and faces is proposed; examples of bases of G1 splines of small degree for topological surfaces with boundary and without boundary are detailed

ARTEMIN Promotes De Novo Angiogenesis in ER Negative Mammary Carcinoma through Activation of TWIST1-VEGF-A Signalling

10.1371/journal.pone.0050098PLoS ONE711

Формування передумов соціально-політичних конфліктів в українському суспільстві періоду трансформації

У статті на основі емпіричних показників всеукраїнського моніторингового дослідження, проведеного в 1994-2004 рр. Інститутом соціології НАН України з’ясовуються і аналізуються групи факторів, що детермінували появу соціально-політичних конфліктів в сучасному українському суспільстві, зумовили їх природу та характер розвитку.The article empirical indicators nationwide monitoring study conducted in 1994-2004 in the Institute of Sociology of NAS of Ukraine researched and analyzed a group of factors that determinuvaly emergence of socio-political conflicts in modern Ukrainian society, led to their nature and character development

Design and realization of topological {Dirac} fermions on a triangular lattice

Large-gap quantum spin Hall insulators are promising materials for room-temperature applications based on Dirac fermions. Key to engineer the topologically non-trivial band ordering and sizable band gaps is strong spin-orbit interaction. Following Kane and Mele’s original suggestion, one approach is to synthesize monolayers of heavy atoms with honeycomb coordination accommodated on templates with hexagonal symmetry. Yet, in the majority of cases, this recipe leads to triangular lattices, typically hosting metals or trivial insulators. Here, we conceive and realize “indenene”, a triangular monolayer of indium on SiC exhibiting non-trivial valley physics driven by local spin-orbit coupling, which prevails over inversion-symmetry breaking terms. By means of tunneling microscopy of the 2D bulk we identify the quantum spin Hall phase of this triangular lattice and unveil how a hidden honeycomb connectivity emerges from interference patterns in Bloch px ± ipy-derived wave functions

Augmented Atherogenesis in LDL Receptor Deficient Mice Lacking Both Macrophage ABCA1 and ApoE

ABCA1 protects against atherosclerosis by facilitating cholesterol efflux from macrophage foam cells in the arterial wall to extracellular apolipoprotein (apo) A-I. In contrast to apoA-I, apoE is secreted by macrophages and can, like apoA-I, induce ABCA1-mediated cholesterol efflux. Yet, the combined effect of macrophage ABCA1 and apoE on lesion development is unexplored.LDL receptor knockout (KO) mice were transplanted with bone marrow from ABCA1/apoE double KO (dKO) mice, their respective single KO's, and wild-type (WT) controls and were challenged with a high-fat/high-cholesterol diet for 9 weeks. In vitro cholesterol efflux experiments showed no differences between ABCA1 KO and dKO macrophages. The serum non-HDL/HDL ratio in dKO transplanted mice was 1.7-fold and 2.4-fold (p<0.01) increased compared to WT and ABCA1 KO transplanted mice, respectively. The atherosclerotic lesion area in dKO transplanted animals (650±94×10(3) µm(2)), however, was 1.9-fold (p<0.01) and 1.6-fold (p<0.01) increased compared to single knockouts (ABCA1 KO: 341±20×10(3) µm(2); apoE KO: 402±78×10(3) µm(2), respectively) and 3.1-fold increased (p<0.001) compared to WT (211±20×10(3) µm(2)). When normalized for serum cholesterol exposure, macrophage ABCA1 and apoE independently protected against atherosclerotic lesion development (p<0.001). Moreover, hepatic expression levels of TNFα and IL-6 were highly induced in dKO transplanted animals (3.0-fold; p<0.05, and 4.3-fold; p<0.001, respectively). In agreement, serum IL-6 levels were also enhanced in ABCA1 KO transplanted mice (p<0.05) and even further enhanced in dKO transplanted animals (3.1-fold as compared to ABCA1 KO transplanted animals; p<0.05).Combined deletion of macrophage ABCA1 and apoE results in a defect in cholesterol efflux and, compared to ABCA1 KO transplanted mice, elevated serum total cholesterol levels. Importantly, these mice also suffer from enhanced systemic and hepatic inflammation, together resulting in the observed augmented atherosclerotic lesion development