Signatures of cosmic tau-neutrinos

The importance and signatures of cosmic tau--(anti)neutrinos have been studied for upward-- and downward--going $\mu^-+\mu^+$ and hadronic shower event rates relevant for present and future underground water or ice detectors, utilizing the unique and reliable ultrasmall--$x$ predictions of the dynamical (radiative) parton model. The upward--going $\mu^- +\mu^+$ event rates calculated just from cosmic $\nu_{\mu}+\bar{\nu}_{\mu}$ fluxes are sizeably enhanced by taking into account cosmic $\nu_{\tau}+ \bar{\nu}_{\tau}$ fluxes and their associated $\tau^- +\tau^+$ fluxes as well. The coupled transport equations for the upward--going $\stackrel{(-)}{\nu}_{\tau}$ flux traversing the Earth imply an enhancement of the attenuated and regenerated $\stackrel{(-)}{\nu}_{\tau}$ flux typically around $10^4-10^5$ GeV with respect to the initial cosmic flux. This enhancement turns out to be smaller than obtained so far, in particular for flatter initial cosmic fluxes behaving like $E_{\nu}^{-1}$. Downward--going $\mu^- +\mu^+$ events and in particular the background--free and unique hadronic `double bang' and `lollipop' events allow to test downward--going cosmic $\nu_{\tau} +\bar{\nu}_{\tau}$ fluxes up to about $10^9$ GeV.Comment: 32 pages, 6 figures; Added reference

Kelvin-Helmholtz instabilities in Smoothed Particle Hydrodynamics

In this paper we investigate whether Smoothed Particle Hydrodynamics (SPH), equipped with artificial conductivity, is able to capture the physics of density/energy discontinuities in the case of the so-called shearing layers test, a test for examining Kelvin-Helmholtz (KH) instabilities. We can trace back each failure of SPH to show KH rolls to two causes: i) shock waves travelling in the simulation box and ii) particle clumping, or more generally, particle noise. The probable cause of shock waves is the Local Mixing Instability (LMI), previously identified in the literature. Particle noise on the other hand is a problem because it introduces a large error in the SPH momentum equation. We also investigate the role of artificial conductivity (AC). Including AC is necessary for the long-term behavior of the simulation (e.g. to get $\lambda=1/2, 1$ KH rolls). In sensitive hydrodynamical simulations great care is however needed in selecting the AC signal velocity, with the default formulation leading to too much energy diffusion. We present new signal velocities that lead to less diffusion. The effects of the shock waves and of particle disorder become less important as the time-scale of the physical problem (for the shearing layers problem: lower density contrast and higher Mach numbers) decreases. At the resolution of current galaxy formation simulations mixing is probably not important. However, mixing could become crucial for next-generation simulations.Comment: 16 pages, 23 figures, accepted for publication in MNRA

Genomic and Phenotypic Analysis of an ESBL-Producing E. coli ST1159 Clonal Lineage From Wild Birds in Mongolia

Background In addition to the broad dissemination of pathogenic extended-spectrum beta-lactamase (ESBL)-producing Escherichia (E.) coli in human and veterinary medicine and the community, their occurrence in wildlife and the environment is a growing concern. Wild birds in particular often carry clinically relevant ESBL-producing E. coli. Objectives We analyzed ESBL-producing and non-ESBL-producing E. coli obtained from wild birds in Mongolia to identify phylogenetic and functional characteristics that would explain the predominance of a particular E. coli clonal lineage in this area. Methods We investigated ESBL-producing E. coli using whole-genome sequencing and phylogenetics to describe the population structure, resistance and virulence features and performed phenotypic experiments like biofilm formation and adhesion to epithelial cells. We compared the phenotypic characteristics to non-ESBL-producing E. coli from the same background (Mongolian wild birds) and genomic results to publicly available genomes. Results and Conclusion We found ESBL-producing E. coli sequence type (ST) 1159 among wild birds in Mongolia. This clonal lineage carried virulence features typical for extra-intestinal pathogenic or enterotoxigenic E. coli. Comparative functional experiments suggested no burden of resistance in the ST1159 isolates, which is despite their carriage of ESBL-plasmids. Wild birds will likely disseminate these antibiotic-resistant pathogens further during migration

Experiences from treating seven adult 5q spinal muscular atrophy patients with Nusinersen

Background: The antisense oligonucleotide Nusinersen recently became the first approved drug against spinal muscular atrophy (SMA). It was approved for all ages, albeit the clinical trials were conducted exclusively on children. Hence, clinical data on adults being treated with Nusinersen is scarce. In this case series, we report on drug application, organizational demands, and preliminary effects during the first 10 months of treatment with Nusinersen in seven adult patients. Methods: All patients received intrathecal injections with Nusinersen. In cases with severe spinal deformities, we performed computed tomography (CT)-guided applications. We conducted a total of 40 administrations of Nusinersen. We evaluated the patients with motor, pulmonary, and laboratory assessments, and tracked patient-reported outcome. Results: Intrathecal administration of Nusinersen was successful in most patients, even though access to the lumbar intrathecal space in adults with SMA is often challenging. No severe adverse events occurred. Six of the seven patients reported stabilization of motor function or reduction in symptom severity. The changes in the assessed scores did not reach a significant level within this short time period. Conclusions: Treating adult SMA patients with Nusinersen is feasible and most patients consider it beneficial. It demands a complex organizational and interdisciplinary effort. Due to the slowly decreasing motor functions in adult SMA patients, long observation phases for this recently approved treatment are needed to allow conclusions about effectiveness of Nusinersen in adults

New perspectives on interdisciplinary earth science at the Dead Sea: The DESERVE project

The Dead Sea region has faced substantial environmental challenges in recent decades, including water resource scarcity, ~ 1 m annual decreases in the water level, sinkhole development, ascending-brine freshwater pollution, and seismic disturbance risks. Natural processes are significantly affected by human interference as well as by climate change and tectonic developments over the long term. To get a deep understanding of processes and their interactions, innovative scientific approaches that integrate disciplinary research and education are required. The research project DESERVE (Helmholtz Virtual Institute Dead Sea Research Venue) addresses these challenges in an interdisciplinary approach that includes geophysics, hydrology, and meteorology. The project is implemented by a consortium of scientific institutions in neighboring countries of the Dead Sea (Israel, Jordan, Palestine Territories) and participating German Helmholtz Centres (KIT, GFZ, UFZ). A new monitoring network of meteorological, hydrological, and seismic/geodynamic stations has been established, and extensive field research and numerical simulations have been undertaken. For the first time, innovative measurement and modeling techniques have been applied to the extreme conditions of the Dead Sea and its surroundings. The preliminary results show the potential of these methods. First time ever performed eddy covariance measurements give insight into the governing factors of Dead Sea evaporation. High-resolution bathymetric investigations reveal a strong correlation between submarine springs and neo-tectonic patterns. Based on detailed studies of stratigraphy and borehole information, the extension of the subsurface drainage basin of the Dead Sea is now reliably estimated. Originality has been achieved in monitoring flash floods in an arid basin at its outlet and simultaneously in tributaries, supplemented by spatio-temporal rainfall data. Low-altitude, high resolution photogrammetry, allied to satellite image analysis and to geophysical surveys (e.g. shear-wave reflections) has enabled a more detailed characterization of sinkhole morphology and temporal development and the possible subsurface controls thereon. All the above listed efforts and scientific results take place with the interdisciplinary education of young scientists. They are invited to attend joint thematic workshops and winter schools as well as to participate in field experiments

Microbial and Chemical Characterization of Underwater Fresh Water Springs in the Dead Sea

Due to its extreme salinity and high Mg concentration the Dead Sea is characterized by a very low density of cells most of which are Archaea. We discovered several underwater fresh to brackish water springs in the Dead Sea harboring dense microbial communities. We provide the first characterization of these communities, discuss their possible origin, hydrochemical environment, energetic resources and the putative biogeochemical pathways they are mediating. Pyrosequencing of the 16S rRNA gene and community fingerprinting methods showed that the spring community originates from the Dead Sea sediments and not from the aquifer. Furthermore, it suggested that there is a dense Archaeal community in the shoreline pore water of the lake. Sequences of bacterial sulfate reducers, nitrifiers iron oxidizers and iron reducers were identified as well. Analysis of white and green biofilms suggested that sulfide oxidation through chemolitotrophy and phototrophy is highly significant. Hyperspectral analysis showed a tight association between abundant green sulfur bacteria and cyanobacteria in the green biofilms. Together, our findings show that the Dead Sea floor harbors diverse microbial communities, part of which is not known from other hypersaline environments. Analysis of the water’s chemistry shows evidence of microbial activity along the path and suggests that the springs supply nitrogen, phosphorus and organic matter to the microbial communities in the Dead Sea. The underwater springs are a newly recognized water source for the Dead Sea. Their input of microorganisms and nutrients needs to be considered in the assessment of possible impact of dilution events of the lake surface waters, such as those that will occur in the future due to the intended establishment of the Red Sea−Dead Sea water conduit

The ScaleX campaign: scale-crossing land-surface and boundary layer processes in the TERENO-preAlpine observatory

Augmenting long-term ecosystem-atmosphere observations with multidisciplinary intensive campaigns aims at closing gaps in spatial and temporal scales of observation for energy- and biogeochemical cycling, and at stimulating collaborative research. ScaleX is a collaborative measurement campaign, co-located with a long-term environmental observatory of the German TERENO (TERrestrial ENvironmental Observatories) network in mountainous terrain of the Bavarian Prealps, Germany. The aims of both TERENO and ScaleX include the measurement and modeling of land-surface atmosphere interactions of energy, water, and greenhouse gases. ScaleX is motivated by the recognition that long-term intensive observational research over years or decades must be based on well-proven, mostly automated measurement systems, concentrated on a small number of locations