Análisis del relieve y cartografía de procesos geomorfológicos activos mediante SIG en la zona de confluencia de los ríos Tuerto y Porquera (provincia de León, España)

La configuración del relieve terrestre y los cambios que tienen lugar en el entorno natural de los asentamientos humanos tienen una gran trascendencia social y económica debido a que marcan las condiciones de habitabilidad y desarrollo futuro de las actividades antrópicas. Partiendo de este hecho, el principal objetivo de este estudio es la realización de una cartografía geomorfológica en la cual aparezcan reflejados los principales procesos activos de tipo geológico, como base para la realización en el futuro de estudios de susceptibilidad de riesgos geológicos y determinar las zonas en las que la ocupación humana pueda verse afectada por daños relacionados con procesos naturales relacionados con el medio físico. Para la elaboración de esta cartografía geomorfológica se han realizado tareas de fotointerpretación en visión estereoscópica y representación en un Sistema de Información Geográfica (ArcGis 10.1), utilizando como base el Modelo Digital del Terreno MDT05/MDT05-LIDAR con una resolución espacial de 5x5 metros, aplicando distintas herramientas, utilizando también la capa de la BCN25 de curvas de nivel, así como trabajo de campo de comprobación y descripción del relieve y procesos activos. En el mapa obtenido se pueden distinguir tres tipos de dominios geomorfológicos, cada uno con sus procesos geológicos activos predominantes: dominio paleozoico con procesos gravitacionales, dominio neógeno con procesos gravitacionales y de erosión y, por último, dominio fluvial con presencia de abanicos aluviales y llanuras de inundación principalmente

Sex-moderated socio-labor aspects as mediators of a cognitive stimulation program in older adults: randomized clinical trial

Cognitive stimulation is essential for successful aging. The influence of sex and socio-occupational elements on this area remains unknown. This study aimed to analyze the possible mediation of those elements in the effectiveness of a cognitive stimulation program in primary care. A randomized clinical trial was conducted with 232 adults aged 65 years or older without cognitive impairment. The intervention produced significant cognitive improvements. Women improved independently of social and occupational factors, while men’s improvement occurred at a low role level (zero to one), a medium level of interests (two to three), with a medium level of mental occupation (neither high nor low), and with marked personal values. The mediating variables were the intervention group in both sexes and, also in men, a low and medium role level. Therefore, the intervention and roles appear as mediating variables moderated by sex. In conclusion, cognitive stimulation programs should be adapted

Short-term memory, attention, and temporal orientation as predictors of the cognitive impairment in older adults: A cross-sectional observational study

Late-life cognitive decline ranges from the mildest cases of normal, age-related change to mild cognitive impairment to severe cases of dementia. Dementia is the largest global burden for the 21st century welfare and healthcare systems. The aim of this study was to analyze the neuropsychological constructs (temporal orientation (TO), spatial orientation (SO), fixation memory (FM), attention (A), calculation (C), short-term memory (STM), language (L), and praxis (P)), semantic fluency, level of functionality, and mood that reveal the greatest deficit in the different stages ranging from normal cognition (NC) to cognitive impairment in older adults in a primary healthcare setting. The study included 337 participants (102 men, 235 women), having a mean age of 74 ± 6 years. According to their scores on the Spanish version of the Mini-Mental State Examination (MEC-35), subjects were divided into 4 groups: no deterioration (ND) (score 32-35), subtle cognitive impairment (SCI) (score 28- 31), level deterioration (LD) (score 24-27) and moderate deterioration (MD) (score 20-23). The ND group revealed significant differences in TO, STM, C, A, L, P, and S-T as compared to the other groups. The MD group (in all the neuropsychological constructs) and the ND and SCI groups showed significant differences on the Yesavage geriatric depression scale (GDS-15). All except the FM neuropsychological construct were part of the MEC-35 prediction model and all of the regression coefficients were significant for these variables in the model. Furthermore, the highest average percentage of relative deterioration occurs between LD and MD and the greatest deterioration is observed in the STM for all groups, including A and TO for the LD and MD groups. Based on our findings, community programs have been implemented that use cognitive stimulation to prevent cognitive decline and to maintain the neuropsychological constructs. © 2021 Gómez-Soria et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited

Evaluation of primary care responsiveness by people with mental illness in Spain

Background The health system responsiveness is a concept developed by the World Health Organization that measures patients'' expectations for the non-medical care they receive. The aim of this study is to assess primary care responsiveness as seen by people with mental illness and to analyse the factors associated with poor responsiveness. Methods Cross-sectional descriptive study on 426 people with mental illness who had attended primary care consultations at least once in the previous 12 months. The responsiveness of the health system was determined through the short questionnaire "Multi-country Survey Study on Health and Health Systems Responsiveness". Differences in responsiveness by sociodemographic characteristics were compared through the Chi-squared test. Logistic regression identified the factors associated with poor responsiveness. Results Overall responsiveness was measured as good by 77.4% of patients, being this probability higher in the domains: dignity, confidentiality, and communication. The most valued domains by people with mental illness were prompt attention (42.4%), dignity (30.1%), and communication (17%). Only prompt attention scored high importance and poor responsiveness. In patients with an income lower than 900 euros per month and low level of studies, the probability of poor confidentiality responsiveness was multiplied by 3 and 2.7 respectively. Conclusions People with mental illness perceive good responsiveness from primary care in terms of dignity, confidentiality, and communication. Prompt attention, as the domain of greatest importance and worst valuation, should be prioritised through the implementation of organisational measures in health centres to reduce waiting times, especially in urban areas

Structural and photometric properties of barred galaxies from the Auriga cosmological simulations

In this work we analyse the structural and photometric properties of 21 barred simulated galaxies from the Auriga Project. These consist of Milky Way-mass magnetohydrodynamical simulations in a A cold dark matter (ACDM) cosmological context. In order to compare with observations, we generate synthetic SDSS-like broad-band images from the numerical data at z = 0 with different inclinations (from face-on to edge-on). Ellipse fits are used to determine the bar lengths, and 2D bulge/disc/bar decompositions with GALFIT are also performed, modelling the bar component with the modified Ferrer profile. We find a wide range of bar sizes and luminosities in the sample, and their structural parameters are in good agreement with the observations. All bulges present low Sérsic indexes, and are classified as pseudobulges. In regard to the discs, the same breaks in the surface brightness profiles observed in real galaxies are found, and the radii at which these take place are in agreement with the observations. Also, from edge-on unsharp-masked images at z = 0, boxy or peanut-shaped (B/P) structures are clearly identified in the inner part of four bars, and also two more bars are found in buckling phase. The sizes of the B/P match fairly well with those obtained from observations. We thus conclude that the observed photometric and structural properties of galaxies with bars, which are the main drivers of secular evolution, can be developed in present state-of-the-art ACDM cosmological simulations

MEGADES: MEGARA Galaxy Discs Evolution Survey. Data Release I: central fields

The main interest of the Science Team for the exploitation of the MEGARA instrument at the 10.4m Gran Telescopio Canarias (GTC hereafter) is devoted to the study of nearby galaxies, with focus on the research of the history of star formation, and chemical and kinematical properties of disc systems. We refer to this project as MEGADES: MEGARA Galaxy Discs Evolution Survey. The initial goal of MEGADES is to provide a detailed study of the inner regions of nearby disc galaxies, both in terms of their spectrophotometric and chemical evolution, and their dynamical characterisation, by disentangling the contribution of in-situ and ex-situ processes to the history of star formation and effective chemical enrichment of these regions. In addition, the dynamical analysis of these inner regions naturally includes the identification and characterization of galactic winds potentially present in these regions. At a later stage, we will extend this study further out in galactocentric distance. The first stage of this project encompasses the analysis of the central regions of a total of 43 nearby galaxies observed with the MEGARA Integral Field Unit for 114 hours, including both Guaranteed Time and Open Time observations. In this paper we provide a set of all the processed data products available to the community and early results from the analysis of these data regarding stellar continuum, ionized and neutral gas features.Comment: Accepted for publication in Astronomy & Astrophysic

An optical/NIR survey of globular clusters in early-type galaxies. I. Introduction and data reduction procedures

Context: The combination of optical and near-infrared (NIR) colours has the potential to break the age/metallicity degeneracy and offers a better metallicity sensitivity than optical colours alone. Previous studies of extragalactic globular clusters (GCs) with this colour combination, however, have suffered from small samples or have been restricted to a few galaxies. Aims: We compile a homogeneous and representative sample of GC systems with multi-band photometry to be used in subsequent papers where ages and metallicity distributions will be studied. Methods: We acquired deep K-band images of 14 bright nearby early-type galaxies. The images were obtained with the LIRIS near-infrared spectrograph and imager at the William Herschel Telescope (WHT) and combined with optical ACS g and z images from the Hubble Space Telescope public archive. Results: For the first time GC photometry of 14 galaxies are observed and reduced homogeneously in this wavelength regime. We achieved a limiting magnitude of K~20-21. For the majority of the galaxies we detect about 70 GCs each. NGC4486 and NGC4649, the cluster-richest galaxies in the sample contain 301 and 167 GCs, respectively. We present tables containing coordinates, photometry and sizes of the GCs available.Comment: A&A accepted, 18 pages, 13 figure

A pilot clinical study of Δ9-tetrahydrocannabinol in patients with recurrent glioblastoma multiforme

Δ9-Tetrahydrocannabinol (THC) and other cannabinoids inhibit tumour growth and angiogenesis in animal models, so their potential application as antitumoral drugs has been suggested. However, the antitumoral effect of cannabinoids has never been tested in humans. Here we report the first clinical study aimed at assessing cannabinoid antitumoral action, specifically a pilot phase I trial in which nine patients with recurrent glioblastoma multiforme were administered THC intratumoraly. The patients had previously failed standard therapy (surgery and radiotherapy) and had clear evidence of tumour progression. The primary end point of the study was to determine the safety of intracranial THC administration. We also evaluated THC action on the length of survival and various tumour-cell parameters. A dose escalation regimen for THC administration was assessed. Cannabinoid delivery was safe and could be achieved without overt psychoactive effects. Median survival of the cohort from the beginning of cannabinoid administration was 24 weeks (95% confidence interval: 15–33). Δ9-Tetrahydrocannabinol inhibited tumour-cell proliferation in vitro and decreased tumour-cell Ki67 immunostaining when administered to two patients. The fair safety profile of THC, together with its possible antiproliferative action on tumour cells reported here and in other studies, may set the basis for future trials aimed at evaluating the potential antitumoral activity of cannabinoids

Stellar populations across galaxy bars in the MUSE TIMER project

Stellar populations in barred galaxies save an imprint of the influence of the bar on the host galaxy’s evolution. We present a detailed analysis of star formation histories (SFHs) and chemical enrichment of stellar populations in nine nearby barred galaxies from the TIMER project. We used integral field observations with the MUSE instrument to derive unprecedented spatially resolved maps of stellar ages, metallicities, [Mg/Fe] abundances, and SFHs, as well as Hα as a tracer of ongoing star formation. We find a characteristic V-shaped signature in the SFH that is perpendicular to the bar major axis, which supports the scenario where intermediate-age stars (∼2 − 6 Gyr) are trapped on more elongated orbits shaping a thinner part of the bar, while older stars (> 8 Gyr) are trapped on less elongated orbits shaping a rounder and thicker part of the bar. We compare our data to state-of-the-art cosmological magneto-hydrodynamical simulations of barred galaxies and show that such V-shaped SFHs arise naturally due to the dynamical influence of the bar on stellar populations with different ages and kinematic properties. Additionally, we find an excess of very young stars (< 2 Gyr) on the edges of the bars, predominantly on the leading side, thus confirming typical star formation patterns in bars. Furthermore, mass-weighted age and metallicity gradients are slightly shallower along the bar than in the disc, which is likely due to orbital mixing in the bar. Finally, we find that bars are mostly more metal-rich and less [Mg/Fe]-enhanced than the surrounding discs. We interpret this as a signature that the bar quenches star formation in the inner region of discs, usually referred to as star formation deserts. We discuss these results and their implications on two different scenarios of bar formation and evolution